TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 384.494 | Formula: C15H16N2O4S3
H donors: 1 H acceptors: 4 LogP: 3.5 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(c1ccc(cc1)S1=NS(=O)(=O)c2c1cc(cc2)S(=O)(=O)N)C
InChi: 1S/C15H16N2O4S3/c1-10(2)11-3-5-12(6-4-11)22-14-9-13(23(16,18)19)7-8-15(14)24(20,21)17-22/h3-10H,1-2H3,(H2,16,18,19)
InChiKey: LAFXMJXGLYOUHG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	1
Schistosoma mansoni	short chain dehydrogenase	0.0196	0.8679	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	0.8679
Schistosoma mansoni	short chain dehydrogenase	0.0196	0.8679	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0017	0.0421	0.0485
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0017	0.0421	0.0485
Brugia malayi	hypothetical protein	0.0009	0.0045	0.0045
Leishmania major	short chain dehydrogenase/reductase, putative	0.0196	0.8679	0.5
Schistosoma mansoni	retinal dehydrogenase	0.0196	0.8679	1
Brugia malayi	Dehydrogenases, short chain protein 2	0.0196	0.8679	0.8679
Leishmania major	hypothetical protein, conserved	0.0196	0.8679	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	0.8679
Echinococcus multilocularis	retinol dehydrogenase 11	0.0196	0.8679	1
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0196	0.8679	0.5
Loa Loa (eye worm)	hypothetical protein	0.0196	0.8679	0.8679
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.0196	0.8679	0.5
Onchocerca volvulus		0.0196	0.8679	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0009	0.0045	0.0052
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.3283	0.3283
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.0196	0.8679	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0045	0.0045
Echinococcus multilocularis	carbonyl reductase 1	0.0196	0.8679	1
Loa Loa (eye worm)	oxidoreductase	0.0196	0.8679	0.8679
Schistosoma mansoni	hypothetical protein	0.0066	0.2682	0.309
Loa Loa (eye worm)	dehydrogenase	0.0196	0.8679	0.8679
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0017	0.0421	0.0485
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.0196	0.8679	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0196	0.8679	0.5
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.1545	0.178
Leishmania major	quinonoid dihydropteridine reductase	0.0196	0.8679	0.5
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.0196	0.8679	1
Brugia malayi	acetyltransferase, GNAT family protein	0.0142	0.6155	0.6155
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.0196	0.8679	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0196	0.8679	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	0.8679
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	0.8679
Echinococcus granulosus	retinol dehydrogenase 11	0.0196	0.8679	1
Loa Loa (eye worm)	hypothetical protein	0.0196	0.8679	0.8679
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	0.8679
Schistosoma mansoni	short chain dehydrogenase	0.0196	0.8679	1
Echinococcus multilocularis	carbonyl reductase 1	0.0196	0.8679	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0196	0.8679	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.0196	0.8679	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0196	0.8679	1
Leishmania major	quinonoid dihydropteridine reductase	0.0196	0.8679	0.5
Loa Loa (eye worm)	steroid hormone receptor	0.0017	0.0421	0.0421
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	0.8679
Brugia malayi	bZIP transcription factor family protein	0.0082	0.3386	0.3386
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0017	0.0421	0.0485
Mycobacterium tuberculosis	Probable oxidoreductase	0.0196	0.8679	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0196	0.8679	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0017	0.0421	0.0485
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0017	0.0421	0.0421
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0017	0.0421	0.0421
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Brugia malayi	dehydrogenases, short chain protein 9	0.0196	0.8679	0.8679
Schistosoma mansoni	steroid dehydrogenase	0.0196	0.8679	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0196	0.8679	1
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0196	0.8679	0.5
Entamoeba histolytica	short chain dehydrogenase family protein	0.0196	0.8679	1
Loa Loa (eye worm)	hypothetical protein	0.0196	0.8679	0.8679
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.0196	0.8679	1
Schistosoma mansoni	steroid dehydrogenase	0.0196	0.8679	1
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.0196	0.8679	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0017	0.0421	0.0485
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0196	0.8679	1
Mycobacterium ulcerans	ketoacyl reductase	0.0196	0.8679	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Leishmania major	short chain dehydrogenase-like protein	0.0196	0.8679	0.5
Brugia malayi	hypothetical protein	0.0064	0.2579	0.2579
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0009	0.0045	0.0052
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.0196	0.8679	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0196	0.8679	1
Brugia malayi	hypothetical protein	0.0196	0.8679	0.8679
Schistosoma mansoni	coup transcription factor	0.0017	0.0421	0.0485
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.0196	0.8679	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0421	0.0421
Leishmania major	quinonoid dihydropteridine reductase	0.0196	0.8679	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	0.8679
Echinococcus multilocularis	steroid dehydrogenase	0.0196	0.8679	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0017	0.0421	0.0421
Schistosoma mansoni	short chain dehydrogenase	0.0196	0.8679	1
Plasmodium falciparum	oxidoreductase, short-chain dehydrogenase family, putative	0.0196	0.8679	1
Plasmodium vivax	hypothetical protein, conserved	0.0196	0.8679	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0196	0.8679	0.5
Loa Loa (eye worm)	oxidoreductase	0.0196	0.8679	0.8679
Entamoeba histolytica	hypothetical protein, conserved	0.0196	0.8679	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0196	0.8679	0.5
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0196	0.8679	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	0.8679
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0045	0.0045
Echinococcus multilocularis	retinol dehydrogenase 13	0.0196	0.8679	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0017	0.0421	0.0421
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0196	0.8679	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0017	0.0421	0.0421
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.0196	0.8679	1
Onchocerca volvulus		0.0196	0.8679	1
Mycobacterium ulcerans	short-chain dehydrogenase	0.0196	0.8679	0.5
Leishmania major	3-keto-dihydrosphingosine reductase	0.0196	0.8679	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Onchocerca volvulus		0.0196	0.8679	1
Loa Loa (eye worm)	dehydrogenase	0.0196	0.8679	0.8679
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0196	0.8679	1
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0196	0.8679	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0017	0.0421	0.0421
Echinococcus granulosus	WW domain containing oxidoreductase	0.0196	0.8679	1
Schistosoma mansoni	steroid dehydrogenase	0.0196	0.8679	1
Echinococcus multilocularis	conserved hypothetical protein	0.0196	0.8679	1
Brugia malayi	nuclear hormone receptor	0.0017	0.0421	0.0421
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0017	0.0421	0.0485
Onchocerca volvulus		0.0017	0.0421	0.0485
Schistosoma mansoni	short chain dehydrogenase	0.0196	0.8679	1
Schistosoma mansoni	steroid dehydrogenase	0.0196	0.8679	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	0.8679
Loa Loa (eye worm)	oxidoreductase	0.0196	0.8679	0.8679
Onchocerca volvulus		0.0196	0.8679	1
Onchocerca volvulus	Bile acid receptor homolog	0.0017	0.0421	0.0485
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0196	0.8679	0.5
Brugia malayi	Dehydrogenases, short chain protein 30	0.0196	0.8679	0.8679
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0196	0.8679	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.0196	0.8679	0.5
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0017	0.0421	0.0485
Leishmania major	hypothetical protein, conserved	0.0196	0.8679	0.5
Onchocerca volvulus		0.0196	0.8679	1
Schistosoma mansoni	jun-related protein	0.0066	0.2682	0.309
Mycobacterium ulcerans	short-chain dehydrogenase	0.0196	0.8679	0.5
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0196	0.8679	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.0017	0.0421	0.0485
Schistosoma mansoni	short chain dehydrogenase	0.0196	0.8679	1
Loa Loa (eye worm)	hypothetical protein	0.0196	0.8679	0.8679
Loa Loa (eye worm)	oxidoreductase	0.0196	0.8679	0.8679
Echinococcus multilocularis	steroid dehydrogenase	0.0196	0.8679	1
Echinococcus granulosus	carbonyl reductase 1	0.0196	0.8679	1
Schistosoma mansoni	short chain dehydrogenase	0.0196	0.8679	1
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0196	0.8679	0.8679
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.0196	0.8679	1
Leishmania major	hypothetical protein, conserved	0.0196	0.8679	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0196	0.8679	1
Echinococcus granulosus	carbonyl reductase 1	0.0196	0.8679	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0196	0.8679	0.5
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0142	0.6155	0.7092
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0017	0.0421	0.0485
Echinococcus multilocularis	carbonyl reductase 1	0.0196	0.8679	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0009	0.0045	0.0052
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Echinococcus granulosus	hypothetical protein	0.0196	0.8679	1
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0196	0.8679	0.5
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0196	0.8679	1
Onchocerca volvulus		0.0196	0.8679	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0009	0.0045	0.0045
Trypanosoma cruzi	hypothetical protein, conserved	0.0196	0.8679	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0017	0.0421	0.0421
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0196	0.8679	0.5
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0196	0.8679	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0196	0.8679	0.5
Toxoplasma gondii	carbonyl reductase 1, putative	0.0196	0.8679	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.0196	0.8679	1
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0196	0.8679	1
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0196	0.8679	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0196	0.8679	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.0196	0.8679	0.5
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.0196	0.8679	0.5
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0196	0.8679	0.8679
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Echinococcus granulosus	ecdysone induced protein 78C	0.0017	0.0421	0.0485
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0196	0.8679	0.5
Trypanosoma brucei	oxidoreductase-like protein	0.0196	0.8679	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0196	0.8679	0.5
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0017	0.0421	0.0485
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0017	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Mycobacterium ulcerans	carveol-like dehydrogenase	0.0196	0.8679	0.5
Onchocerca volvulus		0.0196	0.8679	1
Echinococcus granulosus	oxidoreductase	0.0196	0.8679	1
Echinococcus granulosus	steroid dehydrogenase	0.0196	0.8679	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0017	0.0421	0.0421
Echinococcus granulosus	carbonyl reductase 1	0.0196	0.8679	1
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.0196	0.8679	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0017	0.0421	0.0485
Schistosoma mansoni	steroid dehydrogenase	0.0196	0.8679	1
Loa Loa (eye worm)	hypothetical protein	0.0196	0.8679	0.8679
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0196	0.8679	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0196	0.8679	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0196	0.8679	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0196	0.8679	1
Onchocerca volvulus		0.0064	0.2579	0.2971
Echinococcus multilocularis	carbonyl reductase 1	0.0196	0.8679	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0196	0.8679	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0196	0.8679	1
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0196	0.8679	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0196	0.8679	0.8679
Toxoplasma gondii	3-ketoacyl-CoA reductase, putative	0.0196	0.8679	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0017	0.0421	0.0485
Mycobacterium ulcerans	short-chain dehydrogenase	0.0196	0.8679	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Trypanosoma cruzi	hypothetical protein, conserved	0.0196	0.8679	0.5
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0082	0.3386	0.3902
Toxoplasma gondii	oxidoreductase, putative	0.0196	0.8679	1
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0196	0.8679	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	0.8679
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Loa Loa (eye worm)	hypothetical protein	0.0196	0.8679	0.8679
Mycobacterium ulcerans	short-chain type oxidoreductase	0.0196	0.8679	0.5
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0017	0.0421	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0196	0.8679	0.8679
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	0.8679
Echinococcus granulosus	FTZ F1 alpha	0.0017	0.0421	0.0485
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0017	0.0421	0.0421
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0017	0.0421	0.0421
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0017	0.0421	0.0421
Loa Loa (eye worm)	oxidoreductase	0.0196	0.8679	0.8679
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	1
Echinococcus multilocularis	FTZ F1 alpha	0.0017	0.0421	0.0485
Mycobacterium tuberculosis	Possible oxidoreductase	0.0196	0.8679	0.5
Echinococcus multilocularis	oxidoreductase	0.0196	0.8679	1
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.0196	0.8679	0.5
Entamoeba histolytica	3-ketodihydrosphingosine reductase protein, putative	0.0196	0.8679	1
Loa Loa (eye worm)	hypothetical protein	0.0196	0.8679	0.8679
Brugia malayi	Steroid receptor seven-up type 2	0.0017	0.0421	0.0421
Loa Loa (eye worm)	acetyltransferase	0.0142	0.6155	0.6155
Giardia lamblia	Reductase, putative	0.0196	0.8679	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	0.8679
Entamoeba histolytica	hypothetical protein, conserved	0.0196	0.8679	1
Echinococcus multilocularis	retinol dehydrogenase 11	0.0196	0.8679	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.0196	0.8679	1
Leishmania major	quinonoid dihydropteridine reductase	0.0196	0.8679	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Schistosoma mansoni	carbonyl reductase	0.0196	0.8679	1
Leishmania major	quinonoid dihydropteridine reductase	0.0196	0.8679	0.5
Brugia malayi	nuclear receptor NHR-88	0.0017	0.0421	0.0421
Echinococcus granulosus	hypothetical protein	0.0196	0.8679	1
Entamoeba histolytica	short chain dehydrogenase family protein	0.0196	0.8679	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0017	0.0421	0.0421
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0196	0.8679	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0017	0.0421	0.0485
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0196	0.8679	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0196	0.8679	1
Toxoplasma gondii	sterol carrier protein-2 HAD-2SCP-2	0.0196	0.8679	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0196	0.8679	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0196	0.8679	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0196	0.8679	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0142	0.6155	0.7092
Schistosoma mansoni	short chain dehydrogenase	0.0196	0.8679	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Brugia malayi	hypothetical protein	0.0009	0.0045	0.0045
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Brugia malayi	dehydrogenases, short chain protein 2	0.0196	0.8679	0.8679
Leishmania major	short chain dehydrogenase, putative	0.0196	0.8679	0.5
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0196	0.8679	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0017	0.0421	0.0421
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.0196	0.8679	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0196	0.8679	0.5
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0017	0.0421	0.0485
Mycobacterium ulcerans	ketoacyl reductase	0.0196	0.8679	0.5
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.0196	0.8679	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0196	0.8679	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Mycobacterium tuberculosis	Possible oxidoreductase	0.0196	0.8679	0.5
Brugia malayi	MH2 domain containing protein	0.0117	0.4997	0.4997
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0196	0.8679	1
Schistosoma mansoni	hypothetical protein	0.0142	0.6182	0.7123
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0196	0.8679	0.5
Onchocerca volvulus		0.0196	0.8679	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0017	0.0421	0.0485
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0196	0.8679	0.5
Loa Loa (eye worm)	hypothetical protein	0.0196	0.8679	0.8679
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0196	0.8679	1
Mycobacterium ulcerans	dehydrogenase/reductase	0.0196	0.8679	0.5
Mycobacterium ulcerans	oxidoreductase	0.0196	0.8679	0.5
Brugia malayi	nuclear receptor RXR	0.0009	0.0045	0.0045
Schistosoma mansoni	RAR-like nuclear receptor	0.0017	0.0421	0.0485
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0196	0.8679	1
Giardia lamblia	Hypothetical protein	0.0196	0.8679	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0017	0.0421	0.0485
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.0196	0.8679	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0017	0.0421	0.0421
Onchocerca volvulus		0.0196	0.8679	1
Loa Loa (eye worm)	oxidoreductase	0.0196	0.8679	0.8679
Schistosoma mansoni	carbonyl reductase	0.0196	0.8679	1
Leishmania major	short chain dehydrogenase/reductase, putative	0.0196	0.8679	0.5
Echinococcus multilocularis	ecdysone induced protein 78C	0.0017	0.0421	0.0485
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	0.8679
Echinococcus granulosus	retinol dehydrogenase 11	0.0196	0.8679	1
Leishmania major	quinonoid dihydropteridine reductase	0.0196	0.8679	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0017	0.0421	0.0421
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0196	0.8679	0.5
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0045	0.0045
Toxoplasma gondii	oxidoreductase, putative	0.0196	0.8679	1
Onchocerca volvulus	Sepiapterin reductase homolog	0.0196	0.8679	1
Brugia malayi	oxidoreductase	0.0196	0.8679	0.8679
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0017	0.0421	0.0485
Giardia lamblia	Short-chain dehydrogenase, putative	0.0196	0.8679	1
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0196	0.8679	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Mycobacterium ulcerans	oxidoreductase	0.0196	0.8679	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0017	0.0421	0.0421
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	0.8679
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0017	0.0421	0.0485
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0009	0.0045	0.0045
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0196	0.8679	0.5
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0196	0.8679	1
Schistosoma mansoni	steroid dehydrogenase	0.0196	0.8679	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0196	0.8679	0.5
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0017	0.0421	0.0485
Echinococcus granulosus	jun protein	0.0082	0.3386	0.3902
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0009	0.0045	0.0052
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.0196	0.8679	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.4997	0.4997
Entamoeba histolytica	hypothetical protein	0.0196	0.8679	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0017	0.0421	0.0485
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0196	0.8679	1
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0196	0.8679	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0017	0.0421	0.0485
Brugia malayi	Retinol dehydrogenase 12	0.0196	0.8679	0.8679
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	0.8679
Leishmania major	pteridine reductase 1	0.0196	0.8679	0.5
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0196	0.8679	0.8679
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0017	0.0421	0.0485
Brugia malayi	ecdysteroid receptor	0.0017	0.0421	0.0421
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	1
Entamoeba histolytica	oxidoreductase, short chain dehydrogenase/reductase family	0.0196	0.8679	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0045	0.0045
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0196	0.8679	1
Brugia malayi	hypothetical protein	0.0196	0.8679	0.8679
Echinococcus multilocularis	jun protein	0.0082	0.3386	0.3902
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0196	0.8679	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0196	0.8679	1
Leishmania major	dehydrogenase-like protein	0.0196	0.8679	0.5
Loa Loa (eye worm)	hypothetical protein	0.0196	0.8679	0.8679
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.0196	0.8679	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0017	0.0421	0.0485
Echinococcus multilocularis	transient receptor potential cation channel	0.0196	0.8679	1
Leishmania major	oxidoreductase-like protein	0.0196	0.8679	0.5
Loa Loa (eye worm)	hypothetical protein	0.0196	0.8679	0.8679
Plasmodium vivax	steroid dehydrogenase, putative	0.0196	0.8679	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	0.8679
Brugia malayi	steroid hormone receptor	0.0017	0.0421	0.0421
Brugia malayi	Nuclear hormone receptor-like 1	0.0009	0.0045	0.0045
Schistosoma mansoni	short chain dehydrogenase	0.0196	0.8679	1
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0196	0.8679	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0196	0.8679	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0196	0.8679	1
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0196	0.8679	0.5
Onchocerca volvulus		0.0196	0.8679	1
Mycobacterium ulcerans	dehydrogenase	0.0196	0.8679	0.5
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0196	0.8679	1
Loa Loa (eye worm)	oxidoreductase	0.0196	0.8679	0.8679
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0138	0.5972	0.6881
Onchocerca volvulus		0.0196	0.8679	1
Mycobacterium leprae	Probable oxidoreductase	0.0196	0.8679	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0196	0.8679	1
Schistosoma mansoni	steroid dehydrogenase	0.0196	0.8679	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0017	0.0421	0.0421
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0196	0.8679	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0017	0.0421	0.0421
Mycobacterium tuberculosis	Probable oxidoreductase	0.0196	0.8679	0.5
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0082	0.3386	0.3902
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0017	0.0421	0.0421
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Leishmania major	hypothetical protein, conserved	0.0196	0.8679	0.5
Loa Loa (eye worm)	oxidoreductase	0.0196	0.8679	0.8679
Schistosoma mansoni	carbonyl reductase	0.0196	0.8679	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0196	0.8679	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0017	0.0421	0.0485
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0196	0.8679	0.5
Leishmania major	short chain dehydrogenase, putative	0.0196	0.8679	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	0.8679
Schistosoma mansoni	steroid dehydrogenase	0.0196	0.8679	1
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.0196	0.8679	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0196	0.8679	1
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0196	0.8679	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0196	0.8679	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0017	0.0421	0.0421
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Plasmodium falciparum	steroid dehydrogenase, putative	0.0196	0.8679	1
Schistosoma mansoni	nuclear hormone receptor	0.0017	0.0421	0.0485
Schistosoma mansoni	steroid dehydrogenase	0.0196	0.8679	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0225	1	1
Loa Loa (eye worm)	oxidoreductase	0.0196	0.8679	0.8679
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Onchocerca volvulus		0.0196	0.8679	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0045	0.0045
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0196	0.8679	0.8679
Mycobacterium ulcerans	short chain dehydrogenase	0.0196	0.8679	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.4997	0.4997
Onchocerca volvulus		0.0196	0.8679	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0196	0.8679	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0196	0.8679	0.5
Leishmania major	hypothetical protein, conserved	0.0196	0.8679	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0196	0.8679	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 10 %	Inhibition of human recombinant COX2 expressed in Sf21 cells assessed as conversion of arachidonic acid to PGE2 at 10 uM preincubated for 15 mins measured after 5 mins by enzyme immunoassay	ChEMBL.	21958737
Inhibition (binding)	= 19 %	Inhibition of recombinant human 5-LOX in human PBML assessed as inhibition of A23187-induced LTB4 production at 10 uM preincubated for 15 mins measured after 15 mins by enzyme immunoassay	ChEMBL.	21958737

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1917072

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1578225