Detailed information for compound 1578753

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 272.342 | Formula: C16H20N2O2
  • H donors: 2 H acceptors: 2 LogP: 0.63 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CN1Cc2[nH]c3c(c2C[C@H]1C(=O)O)cccc3)C
  • InChi: 1S/C16H20N2O2/c1-10(2)8-18-9-14-12(7-15(18)16(19)20)11-5-3-4-6-13(11)17-14/h3-6,10,15,17H,7-9H2,1-2H3,(H,19,20)/t15-/m0/s1
  • InChiKey: CODVNZWRCKMGAX-HNNXBMFYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Leishmania major short chain dehydrogenase, putative 0.0009 0.5 0.5
Trichomonas vaginalis steroid dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans carveol-like dehydrogenase 0.0009 0.5 0.5
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Brugia malayi dehydrogenases, short chain protein 2 0.0009 0.5 0.5
Echinococcus granulosus steroid dehydrogenase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Giardia lamblia Reductase, putative 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Echinococcus multilocularis retinol dehydrogenase 11 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Leishmania major dehydrogenase-like protein 0.0009 0.5 0.5
Plasmodium vivax steroid dehydrogenase, putative 0.0009 0.5 0.5
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0009 0.5 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0009 0.5 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0009 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.5 0.5
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0009 0.5 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Brugia malayi oxidoreductase 0.0009 0.5 0.5
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Leishmania major 3-keto-dihydrosphingosine reductase 0.0009 0.5 0.5
Echinococcus granulosus oxidoreductase 0.0009 0.5 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Echinococcus multilocularis oxidoreductase 0.0009 0.5 0.5
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0009 0.5 0.5
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans dehydrogenase 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0009 0.5 0.5
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0009 0.5 0.5
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.5 0.5
Brugia malayi hypothetical protein 0.0009 0.5 0.5
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0009 0.5 0.5
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0009 0.5 0.5
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0009 0.5 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0009 0.5 0.5
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.5 0.5
Mycobacterium ulcerans dehydrogenase/reductase 0.0009 0.5 0.5
Echinococcus multilocularis retinol dehydrogenase 13 0.0009 0.5 0.5
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Giardia lamblia Hypothetical protein 0.0009 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0009 0.5 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0009 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, putative 0.0009 0.5 0.5
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Echinococcus multilocularis steroid dehydrogenase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Brugia malayi Dehydrogenases, short chain protein 30 0.0009 0.5 0.5
Brugia malayi hypothetical protein 0.0009 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Loa Loa (eye worm) dehydrogenase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0009 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0009 0.5 0.5
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0009 0.5 0.5
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Loa Loa (eye worm) dehydrogenase 0.0009 0.5 0.5
Toxoplasma gondii carbonyl reductase 1, putative 0.0009 0.5 0.5
Brugia malayi Retinol dehydrogenase 12 0.0009 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.5 0.5
Schistosoma mansoni carbonyl reductase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.5 0.5
Echinococcus multilocularis conserved hypothetical protein 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0009 0.5 0.5
Leishmania major pteridine reductase 1 0.0009 0.5 0.5
Brugia malayi Dehydrogenases, short chain protein 2 0.0009 0.5 0.5
Schistosoma mansoni carbonyl reductase 0.0009 0.5 0.5
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0009 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0009 0.5 0.5
Leishmania major oxidoreductase-like protein 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type oxidoreductase 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, putative 0.0009 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Echinococcus granulosus hypothetical protein 0.0009 0.5 0.5
Echinococcus multilocularis retinol dehydrogenase 11 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0009 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0009 0.5 0.5
Schistosoma mansoni carbonyl reductase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0009 0.5 0.5
Mycobacterium ulcerans oxidoreductase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0009 0.5 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0009 0.5 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0009 0.5 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0009 0.5 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans oxidoreductase 0.0009 0.5 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0009 0.5 0.5
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0009 0.5 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0009 0.5 0.5
Brugia malayi dehydrogenases, short chain protein 9 0.0009 0.5 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Trypanosoma brucei oxidoreductase-like protein 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Onchocerca volvulus Sepiapterin reductase homolog 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0009 0.5 0.5
Echinococcus granulosus WW domain containing oxidoreductase 0.0009 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0009 0.5 0.5
Plasmodium falciparum steroid dehydrogenase, putative 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0009 0.5 0.5
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0009 0.5 0.5
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0009 0.5 0.5
Echinococcus multilocularis steroid dehydrogenase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Echinococcus granulosus hypothetical protein 0.0009 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0009 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0009 0.5 0.5
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0009 0.5 0.5
Leishmania major short chain dehydrogenase-like protein 0.0009 0.5 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.0009 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0009 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.5 0.5
Giardia lamblia Short-chain dehydrogenase, putative 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0009 0.5 0.5
Schistosoma mansoni retinal dehydrogenase 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0009 0.5 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0009 0.5 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0009 0.5 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0009 0.5 0.5
Plasmodium vivax hypothetical protein, conserved 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.5 0.5
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0009 0.5 0.5
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium leprae Probable oxidoreductase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Leishmania major short chain dehydrogenase, putative 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0009 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0009 0.5 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0009 0.5 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 72 uM Inhibition of aromatase after 10 mins preincubation by plate reader relative to control ChEMBL. 21978950
Inhibition (binding) = -3.4 % Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells at 50 uM pretreated 15 mins before LPS challenge measured after 20 hrs relative to control ChEMBL. 21978950
Inhibition (binding) = 40 % Inhibition of aromatase at 50 uM after 10 mins preincubation by plate reader relative to control ChEMBL. 21978950
Survival (binding) = 94.2 % Induction of quinone reductase 1 activity in mouse Hepa-1c1c7 cells assessed as cell survival at 50 uM by MTT assay relative to control ChEMBL. 21978950
Survival (functional) = 104.6 % Antiproliferative activity against human MCF7 cells assessed as survival at 50 uM after 72 hrs by SRB assay relative to control ChEMBL. 21978950
Survival (binding) = 137.3 % Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells assessed as cell survival at 50 uM pretreated 15 mins before LPS challenge measured after 20 hrs relative to control ChEMBL. 21978950

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.