Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0341 | 0.9888 | 1 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0266 | 0.688 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.688 | 0.5 |
Echinococcus granulosus | dual specificity | 0.0266 | 0.688 | 0.6923 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0266 | 0.688 | 0.688 |
Echinococcus multilocularis | dual specificity | 0.0266 | 0.688 | 0.6923 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0341 | 0.9888 | 1 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0266 | 0.688 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.688 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0341 | 0.9888 | 1 |
Echinococcus granulosus | dual specificity | 0.0266 | 0.688 | 0.6923 |
Loa Loa (eye worm) | haspin protein kinase | 0.0341 | 0.9888 | 0.9888 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.688 | 0.5 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0266 | 0.688 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0341 | 0.9888 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0097 | 0.0112 | 0.0112 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.688 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0266 | 0.688 | 0.6923 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.688 | 0.5 |
Echinococcus multilocularis | dual specificity | 0.0266 | 0.688 | 0.6923 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0266 | 0.688 | 0.5 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0266 | 0.688 | 0.6923 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.688 | 0.5 |
Echinococcus multilocularis | dual specificity | 0.0266 | 0.688 | 0.6923 |
Brugia malayi | hypothetical protein | 0.0341 | 0.9888 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0266 | 0.688 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0266 | 0.688 | 1 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0266 | 0.688 | 1 |
Brugia malayi | GSG2 | 0.0341 | 0.9888 | 1 |
Echinococcus granulosus | dual specificity | 0.0266 | 0.688 | 0.6923 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0341 | 0.9888 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0341 | 0.9888 | 0.9888 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0341 | 0.9888 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 ratio (binding) | Transcriptional activation activity against retinoic acid receptor RAR alpha; Not active | ChEMBL. | No reference | |
EC50 ratio (binding) | Transcriptional activation activity against retinoic acid receptor RAR gamma; Not active | ChEMBL. | No reference | |
EC50 ratio (binding) | Transcriptional activation activity against retinoic acid receptor RAR beta; Not active | ChEMBL. | No reference | |
EC50 ratio (binding) | 0 | Transcriptional activation activity against retinoic acid receptor RAR alpha; Not active | ChEMBL. | No reference |
EC50 ratio (binding) | 0 | Transcriptional activation activity against retinoic acid receptor RAR beta; Not active | ChEMBL. | No reference |
EC50 ratio (binding) | 0 | Transcriptional activation activity against retinoic acid receptor RAR gamma; Not active | ChEMBL. | No reference |
Max (binding) | = 0 % | Maximum retinoic acid receptor (RAR)-alpha transactivation activity relative to retinoic acid at 10e-6 M | ChEMBL. | No reference |
Max (binding) | = 0 % | Maximum retinoic acid receptor (RAR)-beta transactivation activity relative to retinoic acid at 10e-6 M | ChEMBL. | No reference |
Max (binding) | = 0 % | Maximum RAR-gamma transactivation activity relative to retinoic acid at 10e-6 M | ChEMBL. | No reference |
Max (binding) | = 0 % | Maximum retinoic acid receptor (RAR)-alpha transactivation activity relative to retinoic acid at 10e-6 M | ChEMBL. | No reference |
Max (binding) | = 0 % | Maximum retinoic acid receptor (RAR)-beta transactivation activity relative to retinoic acid at 10e-6 M | ChEMBL. | No reference |
Max (binding) | = 0 % | Maximum RAR-gamma transactivation activity relative to retinoic acid at 10e-6 M | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.