Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | UDP-glucose ceramide glucosyltransferase | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 1 | 0.5 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0288 | 1 | 0.5 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 1 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0015 | 0 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0 | 0.5 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0131 | 0.4236 | 0.5 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0288 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0288 | 1 | 1 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0288 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cp (ADMET) | = 2 uM | Plasma concentration in C57BL/6 mouse at 30 mg/kg, po after 4 hrs | ChEMBL. | 21974949 |
Drug uptake (ADMET) | = 2 uM | Biodistribution in C57BL/6 mouse fat at 30 mg/kg, po after 4 hrs | ChEMBL. | 21974949 |
Drug uptake (ADMET) | = 7 uM | Biodistribution in C57BL/6 mouse muscle at 30 mg/kg, po after 4 hrs | ChEMBL. | 21974949 |
Drug uptake (ADMET) | = 20 uM | Biodistribution in C57BL/6 mouse liver at 30 mg/kg, po after 4 hrs | ChEMBL. | 21974949 |
IC50 (binding) | = 5 nM | Inhibition of GCS activity in human A549 cells assessed as amount of GM1 on the cell membrane after 72 hrs by FL-CTB-based fluorescent microscopy | ChEMBL. | 21974949 |
IC50 (binding) | = 16 nM | Inhibition of GCS assessed as amount of UDP-glucose consumed during enzyme-catalyzed reaction | ChEMBL. | 21974949 |
IC50 (ADMET) | = 12000 nM | Inhibition of CYP3A4 in human liver microsomes assessed as inhibition of oxidative metabolism of testosterone after 45 mins by MS analysis in the presence of 1 mmol NADPH | ChEMBL. | 21974949 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.