Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Endothelin receptor ET-A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | Endothelin receptor ET-A | 426 aa | 412 aa | 20.1 % |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | Endothelin receptor ET-A | 426 aa | 412 aa | 21.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0097 | 1 | 1 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0067 | 0.6427 | 0.6427 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.4736 | 1 |
Echinococcus multilocularis | dual specificity | 0.0052 | 0.4736 | 0.4736 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0097 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0067 | 0.6427 | 0.6427 |
Loa Loa (eye worm) | haspin protein kinase | 0.0067 | 0.6427 | 0.6427 |
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.9888 | 0.9888 |
Echinococcus granulosus | dual specificity | 0.0052 | 0.4736 | 0.4736 |
Echinococcus multilocularis | dual specificity | 0.0052 | 0.4736 | 0.4736 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0097 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0052 | 0.4736 | 0.4736 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0052 | 0.4736 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0067 | 0.6427 | 0.6427 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.4736 | 0.4736 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0097 | 1 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0097 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0067 | 0.6427 | 0.6427 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0052 | 0.4736 | 0.5 |
Echinococcus granulosus | dual specificity | 0.0052 | 0.4736 | 0.4736 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0067 | 0.6427 | 0.6427 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.4736 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.4736 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0068 | 0.6539 | 0.6539 |
Echinococcus granulosus | dual specificity | 0.0052 | 0.4736 | 0.4736 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.9888 | 0.9888 |
Brugia malayi | hypothetical protein | 0.0067 | 0.6427 | 0.6427 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0052 | 0.4736 | 0.4736 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.4736 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.6427 | 0.6427 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0052 | 0.4736 | 0.4736 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0097 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.4736 | 1 |
Brugia malayi | GSG2 | 0.0067 | 0.6427 | 0.6427 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0052 | 0.4736 | 0.4736 |
Plasmodium falciparum | MO15-related protein kinase | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0097 | 1 | 1 |
Echinococcus granulosus | dual specificity | 0.0097 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0097 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0097 | 1 | 1 |
Echinococcus multilocularis | dual specificity | 0.0097 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.4736 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0067 | 0.6427 | 0.6427 |
Entamoeba histolytica | protein kinase, putative | 0.0052 | 0.4736 | 0.4736 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0052 | 0.4736 | 0.4736 |
Echinococcus multilocularis | dual specificity | 0.0052 | 0.4736 | 0.4736 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0052 | 0.4736 | 0.4736 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0097 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0000032 M | Inhibition of specific binding of [125I]-ET-1 (endothelin 1) to the endothelin A receptor of rat aorta membranes | ChEMBL. | No reference |
IC50 (binding) | = 0.0000032 M | Inhibition of specific binding of [125I]-ET-1 (endothelin 1) to the endothelin A receptor of rat aorta membranes | ChEMBL. | No reference |
IC50 (binding) | > 0.0001 M | Inhibition of specific binding of [125I]-ET-1 (endothelin 1) to endothelin B receptor of porcine kidney membranes | ChEMBL. | No reference |
IC50 (binding) | > 0.0001 M | Inhibition of specific binding of [125I]-ET-1 (endothelin 1) to endothelin B receptor of porcine kidney membranes | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.