Detailed information for compound 1582710

Basic information

Technical information
  • TDR Targets ID: 1582710
  • Name: 1-(4-chlorophenyl)-4-oxopyridazine-3-carboxyl ic acid
  • MW: 250.638 | Formula: C11H7ClN2O3
  • H donors: 1 H acceptors: 3 LogP: 2.7 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)n1ccc(=O)c(n1)C(=O)O
  • InChi: 1S/C11H7ClN2O3/c12-7-1-3-8(4-2-7)14-6-5-9(15)10(13-14)11(16)17/h1-6H,(H,16,17)
  • InChiKey: ALSMZXGESQGWEH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4-chlorophenyl)-4-oxo-pyridazine-3-carboxylic acid
  • 1-(4-chlorophenyl)-4-oxo-3-pyridazinecarboxylic acid
  • 1-(4-chlorophenyl)-4-keto-pyridazine-3-carboxylic acid
  • SBB016552
  • 1-(4-Chloro-phenyl)-4-oxo-1,4-dihydro-pyridazine-3-carboxylic acid
  • MLS000075380
  • SMR000013660
  • Oprea1_082724
  • Oprea1_463024
  • ChemDiv2_001732
  • BAS 06260241

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0053 0.0201 0.0291
Trichomonas vaginalis cyclin B, putative 0.0085 0.083 1
Brugia malayi Cation transporter family protein 0.0168 0.2502 0.4682
Loa Loa (eye worm) hypothetical protein 0.0308 0.5288 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0099 0.1108 0.2023
Loa Loa (eye worm) ACC-1 protein 0.0099 0.1108 0.2023
Loa Loa (eye worm) hypothetical protein 0.0099 0.1108 0.2023
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0099 0.1108 0.2023
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0308 0.5288 1
Echinococcus granulosus nAChR subunit 0.0053 0.0201 0.038
Onchocerca volvulus 0.0099 0.1108 0.2023
Loa Loa (eye worm) hypothetical protein 0.0099 0.1108 0.2023
Loa Loa (eye worm) hypothetical protein 0.0099 0.1108 0.2023
Schistosoma mansoni integrin alpha 0.009 0.0933 0.373
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0308 0.5288 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0308 0.5288 1
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0085 0.083 0.5
Entamoeba histolytica cyclin, putative 0.0085 0.083 0.0642
Schistosoma mansoni nAChR subunit 0.0099 0.1108 0.443
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0045 0.0048 0.0092
Loa Loa (eye worm) hypothetical protein 0.0053 0.0201 0.0291
Brugia malayi Integrin alpha pat-2 precursor 0.009 0.0933 0.1688
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0099 0.1108 0.2023
Loa Loa (eye worm) hypothetical protein 0.0099 0.1108 0.2023
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0099 0.1108 0.2023
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0099 0.1108 0.2023
Trypanosoma cruzi CYC2-like cyclin, putative 0.0085 0.083 0.5
Giardia lamblia G2/mitotic-specific cyclin B 0.0085 0.083 0.5
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0045 0.0048 0.0092
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0099 0.1108 0.2023
Loa Loa (eye worm) hypothetical protein 0.0049 0.0126 0.0148
Onchocerca volvulus 0.0168 0.2502 0.4682
Echinococcus multilocularis integrin alpha ps 0.0152 0.2175 0.4114
Trichomonas vaginalis cyclin B, putative 0.0085 0.083 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.1108 0.2023
Loa Loa (eye worm) integrin alpha pat-2 0.009 0.0933 0.1688
Onchocerca volvulus 0.0099 0.1108 0.2023
Trypanosoma cruzi cyclin 6, putative 0.0085 0.083 0.5
Trichomonas vaginalis cyclins, putative 0.0085 0.083 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0053 0.0201 0.0291
Trichomonas vaginalis cyclin B, putative 0.0085 0.083 1
Trichomonas vaginalis cyclins, putative 0.0085 0.083 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.1108 0.2023
Echinococcus granulosus cyclin B 0.0085 0.083 0.157
Loa Loa (eye worm) hypothetical protein 0.0053 0.0201 0.0291
Trypanosoma cruzi cyclin, putative 0.0085 0.083 0.5
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0053 0.0201 0.0291
Schistosoma mansoni nAChR subunit 0.0099 0.1108 0.443
Loa Loa (eye worm) hypothetical protein 0.0168 0.2502 0.4682
Mycobacterium tuberculosis Conserved hypothetical protein 0.0544 1 0.5
Echinococcus multilocularis nAChR subunit 0.0099 0.1108 0.2096
Onchocerca volvulus 0.0053 0.0201 0.0291
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0045 0.0048 0.0092
Loa Loa (eye worm) LGC-31 protein 0.0099 0.1108 0.2023
Echinococcus granulosus glycine receptor subunit alpha 1 0.0099 0.1108 0.2096
Mycobacterium ulcerans hypothetical protein 0.0544 1 0.5
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0099 0.1108 0.2096
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0308 0.5288 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0085 0.083 0.1492
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0099 0.1108 0.443
Schistosoma mansoni nAChR subunit 0.0099 0.1108 0.443
Echinococcus granulosus nAChR subunit 0.0099 0.1108 0.2096
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0099 0.1108 0.2096
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0099 0.1108 0.2096
Schistosoma mansoni nAChR subunit 0.0099 0.1108 0.443
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0168 0.2502 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0168 0.2502 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0053 0.0201 0.0291
Loa Loa (eye worm) ACC-1 protein 0.0099 0.1108 0.2023
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0099 0.1108 0.2023
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0099 0.1108 0.443
Brugia malayi Cation transporter family protein 0.0099 0.1108 0.2023
Loa Loa (eye worm) hypothetical protein 0.0123 0.1594 0.295
Echinococcus granulosus integrin alpha ps 0.0152 0.2175 0.4114
Loa Loa (eye worm) hypothetical protein 0.0099 0.1108 0.2023
Brugia malayi Cyclin, N-terminal domain containing protein 0.0085 0.083 0.1492
Loa Loa (eye worm) hypothetical protein 0.0085 0.083 0.1492
Trichomonas vaginalis cyclin B, putative 0.0085 0.083 1
Schistosoma mansoni integrin alpha-ps 0.009 0.0933 0.373
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0099 0.1108 0.2096
Echinococcus multilocularis nAChR subunit 0.0053 0.0201 0.038
Echinococcus multilocularis glycine receptor subunit beta 0.0099 0.1108 0.2096
Loa Loa (eye worm) hypothetical protein 0.0085 0.083 0.1492
Loa Loa (eye worm) hypothetical protein 0.0062 0.0383 0.0639
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0099 0.1108 0.2096
Brugia malayi Cation transporter family protein 0.0099 0.1108 0.2023
Loa Loa (eye worm) hypothetical protein 0.0053 0.0201 0.0291
Echinococcus granulosus glycine receptor subunit beta 0.0099 0.1108 0.2096
Loa Loa (eye worm) hypothetical protein 0.0053 0.0201 0.0291
Mycobacterium tuberculosis Conserved protein 0.0544 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0109 0.1316 0.242
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0099 0.1108 0.2023
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0099 0.1108 0.2023
Trypanosoma cruzi cyclin, putative 0.0085 0.083 0.5
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0099 0.1108 0.2023
Loa Loa (eye worm) hypothetical protein 0.0168 0.2502 0.4682
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0308 0.5288 1
Mycobacterium leprae conserved hypothetical protein 0.0544 1 0.5
Schistosoma mansoni nAChR subunit 0.0045 0.0048 0.0194
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0099 0.1108 0.2096
Loa Loa (eye worm) hypothetical protein 0.0053 0.0201 0.0291
Trichomonas vaginalis cyclins, putative 0.0085 0.083 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0053 0.0201 0.0803
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0099 0.1108 0.2096
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0099 0.1108 0.2096
Schistosoma mansoni neurotransmitter gated ion channel 0.0045 0.0048 0.0194
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0099 0.1108 0.443
Loa Loa (eye worm) hypothetical protein 0.0099 0.1108 0.2023
Schistosoma mansoni neurotransmitter gated ion channel 0.0045 0.0048 0.0194
Onchocerca volvulus 0.0168 0.2502 0.4682
Schistosoma mansoni integrin alpha-ps 0.0109 0.1316 0.5262
Loa Loa (eye worm) hypothetical protein 0.0099 0.1108 0.2023
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0099 0.1108 0.2023
Loa Loa (eye worm) hypothetical protein 0.0099 0.1108 0.2023
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0099 0.1108 0.2023
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0099 0.1108 0.443
Trypanosoma brucei mitotic cyclin 6 0.0085 0.083 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.0201 0.0291
Leishmania major cyclin 0.0085 0.083 0.5
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0105 0.1242 0.2278
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0053 0.0201 0.0803
Loa Loa (eye worm) GABA receptor subunit 0.0053 0.0201 0.0291
Schistosoma mansoni nAChR subunit 0.0099 0.1108 0.443
Loa Loa (eye worm) hypothetical protein 0.0099 0.1108 0.2023
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0099 0.1108 0.2096
Onchocerca volvulus 0.0085 0.083 0.1492
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0099 0.1108 0.2096
Onchocerca volvulus Putative nachr subunit 0.0308 0.5288 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0074 0.0049
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0099 0.1108 0.2023
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0308 0.5288 1
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0045 0.0048 0.0092
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0099 0.1108 0.2096
Schistosoma mansoni cyclin B 0.0085 0.083 0.3319
Echinococcus multilocularis cyclin B 0.0085 0.083 0.157
Schistosoma mansoni nAChR subunit 0.0045 0.0048 0.0194
Echinococcus multilocularis integrin alpha ps 0.009 0.0933 0.1764
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0099 0.1108 0.2096
Schistosoma mansoni nAChR subunit 0.0099 0.1108 0.443
Echinococcus granulosus glycine receptor subunit beta 0.0099 0.1108 0.2096
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0053 0.0201 0.0803
Schistosoma mansoni acetylcholine receptor-related 0.0045 0.0048 0.0194
Loa Loa (eye worm) hypothetical protein 0.0105 0.1242 0.2278
Loa Loa (eye worm) hypothetical protein 0.0099 0.1108 0.2023
Onchocerca volvulus 0.0168 0.2502 0.4682
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0045 0.0048 0.0092
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0099 0.1108 0.2023
Echinococcus granulosus glycine receptor subunit alpha 1 0.0099 0.1108 0.2096
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0053 0.0201 0.0291
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0308 0.5288 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0201 0.0291
Schistosoma mansoni acetylcholine receptor subunit beta 0.0045 0.0048 0.0194
Mycobacterium ulcerans hypothetical protein 0.0544 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0099 0.1108 0.2023
Onchocerca volvulus 0.0053 0.0201 0.0291
Trichomonas vaginalis cyclins, putative 0.0085 0.083 1
Echinococcus multilocularis glycine receptor subunit beta 0.0099 0.1108 0.2096
Loa Loa (eye worm) hypothetical protein 0.0099 0.1108 0.2023
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0099 0.1108 0.2023
Loa Loa (eye worm) hypothetical protein 0.0099 0.1108 0.2023
Onchocerca volvulus 0.0099 0.1108 0.2023
Echinococcus granulosus glycine receptor subunit alpha 1 0.0099 0.1108 0.2096
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0308 0.5288 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.1242 0.2278
Brugia malayi excitatory GABA receptor EXP-1A 0.0099 0.1108 0.2023
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0099 0.1108 0.2023
Trichomonas vaginalis cyclin A, putative 0.0085 0.083 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0099 0.1108 0.2023
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0099 0.1108 0.2023
Loa Loa (eye worm) hypothetical protein 0.0099 0.1108 0.2023
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0099 0.1108 0.2023
Schistosoma mansoni nAChR subunit 0.0099 0.1108 0.443
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0099 0.1108 0.2023

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 25.9185 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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