Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glucan (1,4 alpha), branching enzyme 1 | 0.0075 | 0.2145 | 0.2145 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0075 | 0.2145 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0075 | 0.2145 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.2145 | 0.2145 |
Trichomonas vaginalis | amylase, putative | 0.0075 | 0.2145 | 0.5 |
Echinococcus granulosus | glucan 14 alpha branching enzyme 1 | 0.0075 | 0.2145 | 0.2145 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.2145 | 0.2145 |
Trichomonas vaginalis | amylase, putative | 0.0075 | 0.2145 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0075 | 0.2145 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.4409 | 0.4409 |
Echinococcus multilocularis | alpha glucosidase | 0.0314 | 1 | 1 |
Schistosoma mansoni | alpha-amylase | 0.0314 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.4409 | 0.4409 |
Trichomonas vaginalis | amylase, putative | 0.0075 | 0.2145 | 0.5 |
Toxoplasma gondii | glycosyltransferase | 0.0075 | 0.2145 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0075 | 0.2145 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0075 | 0.2145 | 0.5 |
Chlamydia trachomatis | 1,4-alpha-glucan branching enzyme | 0.0075 | 0.2145 | 0.5 |
Chlamydia trachomatis | glycogen hydrolase | 0.0075 | 0.2145 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.4409 | 0.4409 |
Loa Loa (eye worm) | alpha amylase | 0.0314 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0075 | 0.2145 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0314 | 1 | 1 |
Schistosoma mansoni | starch branching enzyme II | 0.0075 | 0.2145 | 0.2145 |
Trichomonas vaginalis | starch branching enzyme II, putative | 0.0075 | 0.2145 | 0.5 |
Mycobacterium tuberculosis | Trehalose synthase TreS | 0.0314 | 1 | 1 |
Schistosoma mansoni | alpha-amylase | 0.0314 | 1 | 1 |
Brugia malayi | 1,4-alpha-glucan branching enzyme | 0.0075 | 0.2145 | 0.2145 |
Toxoplasma gondii | Alpha-amylase AMY3, putative | 0.0075 | 0.2145 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0314 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0075 | 0.2145 | 0.5 |
Echinococcus granulosus | alpha glucosidase | 0.0314 | 1 | 1 |
Trichomonas vaginalis | amylase, putative | 0.0075 | 0.2145 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0075 | 0.2145 | 0.5 |
Echinococcus multilocularis | trehalose 6 phosphate hydrolase | 0.0075 | 0.2145 | 0.2145 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0075 | 0.2145 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0314 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0075 | 0.2145 | 0.5 |
Loa Loa (eye worm) | alpha amylase | 0.0314 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0075 | 0.2145 | 0.5 |
Echinococcus granulosus | trehalose 6 phosphate hydrolase | 0.0075 | 0.2145 | 0.2145 |
Mycobacterium tuberculosis | Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas | 0.0314 | 1 | 1 |
Mycobacterium leprae | Putative uncharacterized protein ML2045 | 0.0314 | 1 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0075 | 0.2145 | 0.5 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0314 | 1 | 1 |
Giardia lamblia | 1,4-alpha-glucan branching enzyme | 0.0075 | 0.2145 | 0.5 |
Toxoplasma gondii | 1,4-alpha-glucan-branching enzyme | 0.0075 | 0.2145 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0075 | 0.2145 | 0.5 |
Toxoplasma gondii | alpha amylase, catalytic domain-containing protein | 0.0075 | 0.2145 | 0.5 |
Mycobacterium ulcerans | trehalose synthase TreS | 0.0314 | 1 | 1 |
Entamoeba histolytica | oligo-1,6-glucosidase, putative | 0.0314 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0075 | 0.2145 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.2589 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.