Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Putative uncharacterized protein ML2045 | 0.0261 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.1769 | 0.5 |
Mycobacterium tuberculosis | Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas | 0.0261 | 1 | 1 |
Giardia lamblia | 1,4-alpha-glucan branching enzyme | 0.0062 | 0.1769 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.1769 | 0.5 |
Echinococcus multilocularis | alpha glucosidase | 0.0261 | 1 | 1 |
Toxoplasma gondii | Alpha-amylase AMY3, putative | 0.0062 | 0.1769 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0448 | 0.5 |
Trichomonas vaginalis | amylase, putative | 0.0062 | 0.1769 | 0.5 |
Entamoeba histolytica | oligo-1,6-glucosidase, putative | 0.0261 | 1 | 1 |
Schistosoma mansoni | alpha-amylase | 0.0261 | 1 | 1 |
Toxoplasma gondii | 1,4-alpha-glucan-branching enzyme | 0.0062 | 0.1769 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.1769 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0261 | 1 | 1 |
Trichomonas vaginalis | amylase, putative | 0.0062 | 0.1769 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0448 | 0.5 |
Loa Loa (eye worm) | alpha amylase | 0.0261 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.1769 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.0448 | 0.0448 |
Schistosoma mansoni | alpha-amylase | 0.0261 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.1769 | 0.5 |
Chlamydia trachomatis | 1,4-alpha-glucan branching enzyme | 0.0062 | 0.1769 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0261 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.1769 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.1769 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0448 | 0.5 |
Mycobacterium tuberculosis | Trehalose synthase TreS | 0.0261 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.1769 | 0.5 |
Echinococcus granulosus | alpha glucosidase | 0.0261 | 1 | 1 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0261 | 1 | 1 |
Toxoplasma gondii | alpha amylase, catalytic domain-containing protein | 0.0062 | 0.1769 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.5167 | 0.494 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.1769 | 0.5 |
Loa Loa (eye worm) | alpha amylase | 0.0261 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.1769 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.1769 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0448 | 0.5 |
Trichomonas vaginalis | amylase, putative | 0.0062 | 0.1769 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.1769 | 0.5 |
Trichomonas vaginalis | amylase, putative | 0.0062 | 0.1769 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0261 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.5167 | 0.494 |
Mycobacterium ulcerans | trehalose synthase TreS | 0.0261 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.5167 | 0.5167 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.1769 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0448 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.1769 | 0.5 |
Trichomonas vaginalis | starch branching enzyme II, putative | 0.0062 | 0.1769 | 0.5 |
Toxoplasma gondii | glycosyltransferase | 0.0062 | 0.1769 | 1 |
Brugia malayi | 1,4-alpha-glucan branching enzyme | 0.0062 | 0.1769 | 0.1769 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1769 | 0.1384 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0448 | 0.5 |
Chlamydia trachomatis | glycogen hydrolase | 0.0062 | 0.1769 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.