Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | 1,4-alpha-glucan branching enzyme | 0.0062 | 0.0541 | 0.2092 |
Toxoplasma gondii | 1,4-alpha-glucan-branching enzyme | 0.0062 | 0.0541 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.0541 | 0.5 |
Echinococcus multilocularis | alpha glucosidase | 0.0261 | 0.2587 | 0.2587 |
Echinococcus multilocularis | musashi | 0.0021 | 0.0116 | 0.0116 |
Mycobacterium tuberculosis | 1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme) | 0.0062 | 0.0541 | 0.07 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0095 | 0.0095 |
Mycobacterium ulcerans | maltooligosyltrehalose synthase TreX | 0.0062 | 0.0541 | 0.07 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0047 | 0.0387 | 0.1497 |
Entamoeba histolytica | hypothetical protein | 0.0108 | 0.101 | 0.2293 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.0541 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0021 | 0.0116 | 0.0447 |
Loa Loa (eye worm) | intermediate filament protein | 0.0021 | 0.0116 | 0.0447 |
Mycobacterium ulcerans | glycosidase | 0.0062 | 0.0541 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1005 | 0.3883 |
Brugia malayi | Protein kinase domain containing protein | 0.0108 | 0.101 | 0.3905 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.0541 | 0.5 |
Loa Loa (eye worm) | alpha amylase | 0.0261 | 0.2587 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.0541 | 0.2092 |
Entamoeba histolytica | oligo-1,6-glucosidase, putative | 0.0261 | 0.2587 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0095 | 0.0368 |
Toxoplasma gondii | glycosyltransferase | 0.0062 | 0.0541 | 1 |
Schistosoma mansoni | alpha-amylase | 0.0261 | 0.2587 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0108 | 0.101 | 0.5 |
Mycobacterium ulcerans | maltooligosyltrehalose trehalohydrolase, TreZ | 0.0062 | 0.0541 | 0.07 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0095 | 0.0368 |
Mycobacterium tuberculosis | Probable glucanase GlgE | 0.0062 | 0.0541 | 0.07 |
Echinococcus granulosus | lamin dm0 | 0.0021 | 0.0116 | 0.0447 |
Echinococcus multilocularis | lamin | 0.0021 | 0.0116 | 0.0116 |
Schistosoma mansoni | lamin | 0.0021 | 0.0116 | 0.0447 |
Mycobacterium tuberculosis | Maltooligosyltrehalose synthase TreY | 0.0062 | 0.0541 | 0.07 |
Echinococcus multilocularis | dual specificity | 0.0108 | 0.101 | 0.101 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.201 | 0.7766 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.0541 | 0.5 |
Echinococcus granulosus | trehalose 6 phosphate hydrolase | 0.0062 | 0.0541 | 0.2092 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0047 | 0.0387 | 0.1497 |
Mycobacterium leprae | Putative uncharacterized protein ML2045 | 0.0261 | 0.2587 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.0541 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.0541 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.0541 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0108 | 0.101 | 0.2293 |
Echinococcus multilocularis | geminin | 0.0205 | 0.201 | 0.201 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.052 | 0.2008 |
Echinococcus multilocularis | glucan (1,4 alpha), branching enzyme 1 | 0.0062 | 0.0541 | 0.0541 |
Mycobacterium tuberculosis | Maltooligosyltrehalose trehalohydrolase TreZ | 0.0062 | 0.0541 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0003 | 0.0013 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.052 | 0.2008 |
Entamoeba histolytica | protein kinase, putative | 0.0108 | 0.101 | 0.2293 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.201 | 0.7766 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0261 | 0.2587 | 1 |
Schistosoma mansoni | alpha-amylase | 0.0261 | 0.2587 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0541 | 0.2092 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0095 | 0.0368 |
Trichomonas vaginalis | amylase, putative | 0.0062 | 0.0541 | 0.5 |
Onchocerca volvulus | 0.0021 | 0.0116 | 0.5 | |
Brugia malayi | intermediate filament protein | 0.0021 | 0.0116 | 0.0447 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.0541 | 0.5 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0108 | 0.101 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0261 | 0.2587 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0108 | 0.101 | 0.3905 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0323 | 0.1249 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0108 | 0.101 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.052 | 0.2008 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.0541 | 0.5 |
Onchocerca volvulus | 0.0021 | 0.0116 | 0.5 | |
Chlamydia trachomatis | 1,4-alpha-glucan branching enzyme | 0.0062 | 0.0541 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0112 | 0.0432 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0095 | 0.0368 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.0541 | 0.5 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.001 | 0.0003 | 0.0003 |
Chlamydia trachomatis | glycogen hydrolase | 0.0062 | 0.0541 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0323 | 0.1249 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1005 | 0.3883 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.1386 | 0.5356 |
Echinococcus multilocularis | trehalose 6 phosphate hydrolase | 0.0062 | 0.0541 | 0.0541 |
Mycobacterium ulcerans | trehalose synthase TreS | 0.0261 | 0.2587 | 1 |
Echinococcus granulosus | glucan 14 alpha branching enzyme 1 | 0.0062 | 0.0541 | 0.2092 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.0541 | 0.5 |
Giardia lamblia | 1,4-alpha-glucan branching enzyme | 0.0062 | 0.0541 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0021 | 0.0116 | 0.0447 |
Trichomonas vaginalis | amylase, putative | 0.0062 | 0.0541 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0095 | 0.0368 |
Entamoeba histolytica | protein kinase, putative | 0.0108 | 0.101 | 0.2293 |
Echinococcus granulosus | dual specificity | 0.0108 | 0.101 | 0.3905 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.1386 | 0.5356 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0047 | 0.0387 | 0.0387 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.0541 | 0.5 |
Mycobacterium tuberculosis | Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas | 0.0261 | 0.2587 | 1 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0261 | 0.2587 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0021 | 0.0116 | 0.0116 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.0541 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0095 | 0.0368 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0062 | 0.0541 | 0.5 |
Echinococcus granulosus | alpha glucosidase | 0.0261 | 0.2587 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0021 | 0.0116 | 0.0447 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.052 | 0.2008 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0095 | 0.0368 |
Trichomonas vaginalis | starch branching enzyme II, putative | 0.0062 | 0.0541 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0095 | 0.0368 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0095 | 0.0368 |
Trichomonas vaginalis | amylase, putative | 0.0062 | 0.0541 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0095 | 0.0368 |
Toxoplasma gondii | alpha amylase, catalytic domain-containing protein | 0.0062 | 0.0541 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0011 | 0.0015 | 0.0058 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0108 | 0.101 | 0.3905 |
Echinococcus granulosus | geminin | 0.0205 | 0.201 | 0.7766 |
Mycobacterium ulcerans | glycogen branching protein | 0.0062 | 0.0541 | 0.07 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.001 | 0.0003 | 0.0013 |
Schistosoma mansoni | alpha-amylase | 0.0261 | 0.2587 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0011 | 0.0015 | 0.0058 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0047 | 0.0387 | 0.1497 |
Schistosoma mansoni | starch branching enzyme II | 0.0062 | 0.0541 | 0.2092 |
Echinococcus granulosus | lamin | 0.0021 | 0.0116 | 0.0447 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0323 | 0.1249 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0095 | 0.0368 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0021 | 0.0116 | 0.0447 |
Toxoplasma gondii | Alpha-amylase AMY3, putative | 0.0062 | 0.0541 | 1 |
Mycobacterium ulcerans | maltooligosyltrehalose synthase TreY | 0.0062 | 0.0541 | 0.07 |
Trichomonas vaginalis | amylase, putative | 0.0062 | 0.0541 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | alpha amylase | 0.0261 | 0.2587 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0116 | 0.0447 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.1386 | 0.5356 |
Schistosoma mansoni | alpha-amylase | 0.0261 | 0.2587 | 1 |
Mycobacterium ulcerans | trehalose synthase TreS | 0.0062 | 0.0541 | 0.07 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0108 | 0.101 | 1 |
Schistosoma mansoni | lamin | 0.0021 | 0.0116 | 0.0447 |
Mycobacterium tuberculosis | Trehalose synthase TreS | 0.0261 | 0.2587 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.