TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 338.447 | Formula: C20H26N4O
H donors: 1 H acceptors: 2 LogP: 4.11 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COCCCNc1ccn2c(n1)cc(n2)c1ccc(cc1)CC(C)C
InChi: 1S/C20H26N4O/c1-15(2)13-16-5-7-17(8-6-16)18-14-20-22-19(9-11-24(20)23-18)21-10-4-12-25-3/h5-9,11,14-15H,4,10,12-13H2,1-3H3,(H,21,22)
InChiKey: OCWCLRRKXOLXST-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0066	0.0066
Echinococcus granulosus	cysteine protease	0.0047	0.0066	0.004
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0066	0.0066
Loa Loa (eye worm)	fibroinase	0.0127	0.1589	0.1589
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0127	0.1589	0.4959
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0066	0.0066
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0066	0.0066
Giardia lamblia	Cathepsin B precursor	0.0209	0.3138	1
Plasmodium vivax	vivapain-2	0.0127	0.1589	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0026	0.0026
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0209	0.3138	0.312
Brugia malayi	RNA binding protein	0.0076	0.0627	0.0627
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0047	0.0066	0.004
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0627	0.0627
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.1589	0.4959
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0066	0.0066
Leishmania major	cathepsin L-like protease	0.0127	0.1589	0.4631
Trypanosoma cruzi	cruzipain precursor, putative	0.0127	0.1589	0.1534
Echinococcus multilocularis	geminin	0.0334	0.5499	0.5487
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.1589	0.4959
Schistosoma mansoni	hypothetical protein	0.0334	0.5499	0.5487
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0047	0.0066	0.0066
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0047	0.0066	0.0066
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0127	0.1589	0.1567
Schistosoma mansoni	cathepsin S (C01 family)	0.0047	0.0066	0.004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0127	0.1589	0.4959
Loa Loa (eye worm)	hypothetical protein	0.0127	0.1589	0.1589
Loa Loa (eye worm)	ctsf protein	0.0127	0.1589	0.1589
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0066	0.0066
Loa Loa (eye worm)	prolyl oligopeptidase	0.0169	0.2376	0.2376
Loa Loa (eye worm)	hypothetical protein	0.0572	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0047	0.0066	0.004
Loa Loa (eye worm)	hypothetical protein	0.0127	0.1589	0.1589
Echinococcus multilocularis	cathepsin L	0.0047	0.0066	0.004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.1589	0.4959
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0127	0.1589	0.4959
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0572	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.1589	0.4959
Onchocerca volvulus	Cathepsin F homolog	0.0127	0.1589	0.6596
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0127	0.1589	0.4959
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0057	0.0253	0.0228
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0066	0.0066
Onchocerca volvulus		0.0127	0.1589	0.6596
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0066	0.004
Brugia malayi	Papain family cysteine protease containing protein	0.0127	0.1589	0.1589
Loa Loa (eye worm)	cysteine protease	0.0127	0.1589	0.1589
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0169	0.2376	0.2356
Leishmania major	cysteine peptidase A (CPA)	0.0127	0.1589	0.4631
Trypanosoma cruzi	cysteine peptidase, putative	0.0127	0.1589	0.1534
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.1589	0.4959
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0572	1	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0047	0.0066	0.004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.1589	0.4959
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0169	0.2376	0.2356
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0057	0.0253	0.0611
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0572	1	1
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0057	0.0253	0.0228
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0057	0.0253	0.0228
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.1589	0.4959
Echinococcus granulosus	cathepsin L cysteine protease	0.0047	0.0066	0.004
Schistosoma mansoni	cathepsin F (C01 family)	0.0127	0.1589	0.1567
Leishmania major	cathepsin L-like protease	0.0127	0.1589	0.4631
Brugia malayi	prolyl oligopeptidase family protein	0.0057	0.0253	0.0253
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0047	0.0066	0.0066
Echinococcus multilocularis	cysteine protease	0.0127	0.1589	0.1567
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.1589	0.4959
Schistosoma mansoni	cathepsin F (C01 family)	0.0127	0.1589	0.1567
Schistosoma mansoni	amine GPCR	0.0345	0.5713	0.5702
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0127	0.1589	0.1567
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.1589	0.4959
Leishmania major	cathepsin L-like protease	0.0127	0.1589	0.4631
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0127	0.1589	0.4959
Echinococcus granulosus	cathepsin l1	0.0127	0.1589	0.1567
Brugia malayi	cathepsin L-like cysteine proteinase	0.0047	0.0066	0.0066
Entamoeba histolytica	cysteine proteinase, putative	0.0127	0.1589	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0127	0.1589	0.1534
Echinococcus granulosus	cathepsin b	0.0572	1	1
Brugia malayi	Cathepsin L-like precursor	0.0127	0.1589	0.1589
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0627	0.0627
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.1589	0.4959
Leishmania major	cathepsin L-like protease	0.0127	0.1589	0.4631
Toxoplasma gondii	cathepsin B	0.0209	0.3138	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.1589	0.4959
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0627	0.0602
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0047	0.0066	0.004
Echinococcus multilocularis	cysteine protease	0.0127	0.1589	0.1567
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0209	0.3138	0.3093
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0127	0.1589	1
Brugia malayi	prolyl oligopeptidase family protein	0.0169	0.2376	0.2376
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0209	0.3138	1
Giardia lamblia	Cathepsin B precursor	0.0209	0.3138	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0066	0.004
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0127	0.1589	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0627	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0066	0.0066
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.1589	0.4959
Onchocerca volvulus		0.0127	0.1589	0.6596
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0127	0.1589	0.1589
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0572	1	1
Echinococcus granulosus	cathepsin b	0.0572	1	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0047	0.0066	0.0066
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.1589	0.4959
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0047	0.0066	0.0066
Echinococcus multilocularis	cathepsin L	0.0047	0.0066	0.004
Echinococcus granulosus	geminin	0.0334	0.5499	0.5487
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0127	0.1589	0.1567
Brugia malayi	Cathepsin L-like precursor	0.0127	0.1589	0.1589
Entamoeba histolytica	cysteine proteinase, putative	0.0127	0.1589	1
Brugia malayi	Cathepsin L-like precursor	0.0127	0.1589	0.1589
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0127	0.1589	0.4959
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0209	0.3138	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.1589	0.4959
Echinococcus multilocularis	cathepsin L cysteine protease	0.0127	0.1589	0.1567
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0047	0.0066	0.004
Entamoeba histolytica	cysteine proteinase, putative	0.0127	0.1589	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0047	0.0066	0.004
Brugia malayi	cathepsin F-like cysteine proteinase	0.0047	0.0066	0.0066
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0209	0.3138	1
Onchocerca volvulus		0.0127	0.1589	0.6596
Brugia malayi	cathepsin L-like precursor	0.0127	0.1589	0.1589
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.1589	0.4959
Onchocerca volvulus	Cathepsin L homolog	0.0127	0.1589	0.6596
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0627	0.0602
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.1589	0.4959
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.1589	0.4959
Brugia malayi	Cathepsin L-like precursor	0.0127	0.1589	0.1589
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0127	0.1589	0.4959
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0127	0.1589	0.1534
Giardia lamblia	Cathepsin B precursor	0.0209	0.3138	1
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0057	0.0253	0.0189
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0057	0.0253	0.0611
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.1589	0.4959
Onchocerca volvulus		0.0127	0.1589	0.6596
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0627	0.0602
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0627	0.0602
Trypanosoma cruzi	cysteine peptidase, putative	0.0127	0.1589	0.1534
Echinococcus multilocularis	cathepsin b	0.0572	1	1
Brugia malayi	cathepsin L precursor	0.0047	0.0066	0.0066
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0066	0.004
Onchocerca volvulus		0.0127	0.1589	0.6596
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0047	0.0066	0.004
Schistosoma mansoni	hypothetical protein	0.0334	0.5499	0.5487
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.1589	0.4959
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.1589	0.4959
Toxoplasma gondii	cathepsin CPL	0.0127	0.1589	0.4959
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0572	1	1
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0627	0.0627
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0066	0.0066
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0169	0.2376	0.2356
Brugia malayi	Cathepsin L-like precursor	0.0127	0.1589	0.1589
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0127	0.1589	0.4959
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0627	0.0627
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0127	0.1589	0.1567
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0047	0.0066	0.004
Loa Loa (eye worm)	hypothetical protein	0.0127	0.1589	0.1589
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0169	0.2376	1
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0057	0.0253	0.0189
Echinococcus multilocularis	cathepsin b	0.0572	1	1
Loa Loa (eye worm)	hypothetical protein	0.0127	0.1589	0.1589
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.1589	0.4959
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0057	0.0253	0.0611
Brugia malayi	Cathepsin L-like precursor	0.0127	0.1589	0.1589
Onchocerca volvulus		0.0127	0.1589	0.6596
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0127	0.1589	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.1589	0.4959
Brugia malayi	TAR-binding protein	0.0076	0.0627	0.0627
Entamoeba histolytica	cysteine protease, putative	0.0127	0.1589	1
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0627	0.0602
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.1589	0.4959
Onchocerca volvulus		0.0127	0.1589	0.6596
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0127	0.1589	0.1589
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0127	0.1589	0.4959
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0047	0.0066	0.004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0127	0.1589	0.4959
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0047	0.0066	0.0066
Schistosoma mansoni	cathepsin F (C01 family)	0.0127	0.1589	0.1567
Plasmodium vivax	vivapain-2	0.0127	0.1589	1
Echinococcus granulosus	cathepsin L	0.0047	0.0066	0.004
Onchocerca volvulus	Cathepsin L homolog	0.0127	0.1589	0.6596
Brugia malayi	Cathepsin L-like precursor	0.0127	0.1589	0.1589
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0127	0.1589	0.4959
Schistosoma mansoni	cathepsin C	0.0047	0.0066	0.004
Brugia malayi	Cathepsin L-like precursor	0.0127	0.1589	0.1589
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.1589	0.4959
Leishmania major	cathepsin L-like protease	0.0127	0.1589	0.4631
Loa Loa (eye worm)	cathepsin B	0.0209	0.3138	0.3138
Leishmania major	cathepsin L-like protease	0.0127	0.1589	0.4631
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0066	0.0066
Schistosoma mansoni	cathepsin B (C01 family)	0.0047	0.0066	0.004
Onchocerca volvulus		0.0127	0.1589	0.6596
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.1589	0.4959
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0627	0.0602
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0066	0.0066
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.1589	0.4959
Trypanosoma cruzi	cysteine peptidase, putative	0.0127	0.1589	0.1534
Echinococcus granulosus	cathepsin L	0.0047	0.0066	0.004
Brugia malayi	fibroinase precursor	0.0047	0.0066	0.0066
Echinococcus granulosus	cathepsin l1	0.0127	0.1589	0.1567
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0127	0.1589	0.1589
Leishmania major	cathepsin L-like protease	0.0127	0.1589	0.4631
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.1589	0.4959
Echinococcus multilocularis	cathepsin L cysteine protease	0.0127	0.1589	0.1567
Leishmania major	cathepsin L-like protease	0.0127	0.1589	0.4631

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	17.7828 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	63.0957 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1892724

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1586378