Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Sema domain containing protein | 0.0095 | 0.1954 | 0.1674 |
Schistosoma mansoni | plexin | 0.0228 | 0.8075 | 1 |
Brugia malayi | Sema domain containing protein | 0.0095 | 0.1954 | 0.1674 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0053 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.3682 | 0.3462 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1954 | 0.1674 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1954 | 0.1674 |
Schistosoma mansoni | plexin | 0.0133 | 0.3682 | 0.2822 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0095 | 0.1954 | 0.1674 |
Onchocerca volvulus | 0.0228 | 0.8075 | 1 | |
Echinococcus granulosus | plexin a4 | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1954 | 0.1674 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0095 | 0.1954 | 0.1674 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 0.3682 | 0.2822 |
Brugia malayi | hypothetical protein | 0.0095 | 0.1954 | 0.1674 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1954 | 0.1674 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1954 | 0.1674 |
Echinococcus multilocularis | plexin a4 | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.8075 | 0.8008 |
Loa Loa (eye worm) | plexin A | 0.027 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0095 | 0.1954 | 0.1674 |
Brugia malayi | Plexin repeat family protein | 0.0228 | 0.8075 | 0.8008 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0053 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1954 | 0.1674 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.3323 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.