TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 320.385 | Formula: C20H20N2O2
H donors: 2 H acceptors: 2 LogP: 3.02 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C=Cc1ccccc1)NCCNC(=O)C=Cc1ccccc1
InChi: 1S/C20H20N2O2/c23-19(13-11-17-7-3-1-4-8-17)21-15-16-22-20(24)14-12-18-9-5-2-6-10-18/h1-14H,15-16H2,(H,21,23)(H,22,24)
InChiKey: KRKHZGROVOQDOS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.0378	0.315	0.315
Echinococcus granulosus	SH2 motif	0.0082	0.0326	0.0326
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0499	0.4303	0.4303
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0326	0.0257
Brugia malayi	hypothetical protein	0.0135	0.083	0.0765
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0378	0.315	0.315
Schistosoma mansoni	Dab2-interacting protein-like	0.0378	0.315	0.315
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0082	0.0326	0.0326
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.1097	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0378	0.315	0.3101
Loa Loa (eye worm)	TK/FER protein kinase	0.0121	0.0697	0.063
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0091	0.0412	0.0412
Entamoeba histolytica	hypothetical protein	0.0059	0.0108	0.0108
Trypanosoma cruzi	hypothetical protein, conserved	0.0378	0.315	0.315
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0326	0.0257
Schistosoma mansoni	hypothetical protein	0.0135	0.083	0.083
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0499	0.4303	0.4303
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0121	0.0697	0.0697
Schistosoma mansoni	signal transduction protein lnk-related	0.0082	0.0326	0.0326
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.1097	1	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0082	0.0326	0.0326
Onchocerca volvulus		0.0378	0.315	0.9706
Schistosoma mansoni	eps8-related protein	0.0378	0.315	0.315
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0326	0.0257
Brugia malayi	SH2 domain containing protein	0.0121	0.0697	0.063
Brugia malayi	Protein kinase domain containing protein	0.0121	0.0697	0.063
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.1097	1	1
Echinococcus multilocularis	semaphorin 5B	0.0135	0.083	0.083
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0326	0.0257
Schistosoma mansoni	suppressor of cytokine signaling	0.0082	0.0326	0.0326
Entamoeba histolytica	hypothetical protein, conserved	0.0378	0.315	0.315
Echinococcus multilocularis	tensin	0.0082	0.0326	0.0326
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0082	0.0326	0.0326
Brugia malayi	Src substrate cortactin	0.0378	0.315	0.3101
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0121	0.0697	0.0697
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0071	0.0071
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0378	0.315	0.315
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0326	0.0257
Schistosoma mansoni	hypothetical protein	0.0082	0.0326	0.0326
Schistosoma mansoni	cell polarity protein	0.0378	0.315	0.315
Echinococcus granulosus	src region	0.0378	0.315	0.315
Onchocerca volvulus	Putative cortactin	0.0378	0.315	0.9706
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0071	0.0071
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0082	0.0326	0.0326
Loa Loa (eye worm)	TK/FER protein kinase	0.0121	0.0697	0.063
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0082	0.0326	0.0257
Brugia malayi	SH2 domain containing protein	0.0121	0.0697	0.063
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0082	0.0326	0.0326
Brugia malayi	SRC-1	0.0499	0.4303	0.4262
Toxoplasma gondii	aurora kinase	0.1097	1	1
Brugia malayi	IPT/TIG domain containing protein	0.0059	0.0108	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0378	0.315	0.3076
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0326	0.0257
Entamoeba histolytica	hypothetical protein	0.0378	0.315	0.315
Schistosoma mansoni	hypothetical protein	0.0378	0.315	0.315
Leishmania major	protein kinase, putative	0.1097	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0082	0.0326	0.0257
Loa Loa (eye worm)	TK/FER protein kinase	0.0121	0.0697	0.063
Echinococcus granulosus	semaphorin 5B	0.0135	0.083	0.083
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0499	0.4303	0.4303
Loa Loa (eye worm)	SRC-1	0.0499	0.4303	0.4262
Echinococcus granulosus	expressed protein	0.0378	0.315	0.315
Entamoeba histolytica	protein kinase, putative	0.1097	1	1
Schistosoma mansoni	GTPase activating protein	0.0082	0.0326	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0323	0.2622	0.2569
Brugia malayi	Tyrosine-protein kinase abl-1	0.0499	0.4303	0.4262
Schistosoma mansoni	tyrosine kinase	0.0121	0.0697	0.0697
Schistosoma mansoni	tensin-related	0.0082	0.0326	0.0326
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0378	0.315	0.3101
Loa Loa (eye worm)	TK/FER protein kinase	0.0121	0.0697	0.063
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0378	0.315	0.315
Echinococcus granulosus	expressed conserved protein	0.0082	0.0326	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0378	0.315	0.3101
Echinococcus granulosus	hypothetical protein	0.0082	0.0326	0.0326
Trypanosoma cruzi	paraflagellar rod protein 5, putative	0.0378	0.315	0.315
Brugia malayi	Guanylate kinase family protein	0.0378	0.315	0.3101
Trichomonas vaginalis	conserved hypothetical protein	0.0378	0.315	0.3076
Loa Loa (eye worm)	hypothetical protein	0.0378	0.315	0.3101
Entamoeba histolytica	protein kinase, putative	0.0378	0.315	0.315
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0378	0.315	0.315
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0499	0.4303	0.4303
Echinococcus granulosus	tyrosine kinase	0.0121	0.0697	0.0697
Entamoeba histolytica	tyrosin kinase, putative	0.0098	0.0478	0.0478
Echinococcus multilocularis	transcription factor collier	0.0059	0.0108	0.0108
Schistosoma mansoni	plexin	0.0188	0.1336	0.1336
Echinococcus multilocularis	tyrosine kinase	0.0121	0.0697	0.0697
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0499	0.4303	0.4303
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0499	0.4303	0.4303
Schistosoma mansoni	hypothetical protein	0.0082	0.0326	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0037
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0378	0.315	0.315
Entamoeba histolytica	protein kinase, putative	0.0091	0.0412	0.0412
Echinococcus granulosus	semaphorin 1A	0.0135	0.083	0.083
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0326	0.0257
Loa Loa (eye worm)	TK/FER protein kinase	0.0121	0.0697	0.063
Loa Loa (eye worm)	sema domain-containing protein	0.0135	0.083	0.0765
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0499	0.4303	0.4303
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0121	0.0697	0.0697
Brugia malayi	plexin A	0.0382	0.3186	0.3137
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0326	0.0257
Loa Loa (eye worm)	TK/FER protein kinase	0.0121	0.0697	0.063
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0082	0.0326	0.0326
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0499	0.4303	0.4303
Schistosoma mansoni	vav2	0.0082	0.0326	0.0326
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0378	0.315	0.3101
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0499	0.4303	0.4303
Echinococcus multilocularis	nostrin	0.0378	0.315	0.315
Trichomonas vaginalis	conserved hypothetical protein	0.0378	0.315	0.3076
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.1097	1	1
Echinococcus multilocularis	SH2 motif	0.0082	0.0326	0.0326
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0326	0.0257
Onchocerca volvulus		0.0121	0.0697	0.1272
Brugia malayi	SH3 domain containing protein	0.0378	0.315	0.3101
Brugia malayi	DNA-binding protein LAG-1	0.0059	0.0108	0.0037
Echinococcus multilocularis	SH2 domain containing protein 7	0.0082	0.0326	0.0326
Echinococcus granulosus	exocyst complex component 2	0.0059	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0037
Schistosoma mansoni	tyrosine kinase	0.0499	0.4303	0.4303
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0071	0.0071
Loa Loa (eye worm)	TK/FER protein kinase	0.0121	0.0697	0.063
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0326	0.0257
Trypanosoma cruzi	hypothetical protein, conserved	0.0378	0.315	0.315
Echinococcus granulosus	nostrin	0.0378	0.315	0.315
Schistosoma mansoni	adapter molecule crk	0.046	0.3932	0.3932
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0378	0.315	0.315
Loa Loa (eye worm)	hypothetical protein	0.0188	0.1336	0.1274
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.1097	1	1
Loa Loa (eye worm)	AUR protein kinase	0.1097	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.046	0.3932	0.3932
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0082	0.0326	0.0326
Trichomonas vaginalis	conserved hypothetical protein	0.0378	0.315	0.3076
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0378	0.315	0.315
Leishmania major	hypothetical protein, conserved	0.0378	0.315	0.315
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.0378	0.315	0.315
Brugia malayi	Plexin repeat family protein	0.0323	0.2622	0.2569
Loa Loa (eye worm)	TK/FER protein kinase	0.0121	0.0697	0.063
Brugia malayi	SH2 domain containing protein	0.0082	0.0326	0.0257
Loa Loa (eye worm)	sema domain-containing protein	0.0135	0.083	0.0765
Entamoeba histolytica	hypothetical protein	0.0059	0.0108	0.0108
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0499	0.4303	0.4303
Entamoeba histolytica	protein kinase, putative	0.1097	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0499	0.4303	0.4303
Trypanosoma brucei	conserved protein	0.0378	0.315	0.315
Schistosoma mansoni	dynamin-associated protein	0.0378	0.315	0.315
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.1097	1	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0082	0.0326	0.0257
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0499	0.4303	0.4303
Brugia malayi	Protein kinase domain containing protein	0.0121	0.0697	0.063
Brugia malayi	Myosin tail family protein	0.0378	0.315	0.3101
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0378	0.315	0.315
Brugia malayi	RhoGAP domain containing protein	0.0082	0.0326	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0378	0.315	0.3101
Entamoeba histolytica	hypothetical protein	0.0378	0.315	0.315
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.0378	0.315	0.315
Schistosoma mansoni	run and tbc1 domain containing	0.0378	0.315	0.315
Echinococcus granulosus	c src tyrosine kinase	0.0499	0.4303	0.4303
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0499	0.4303	0.4303
Entamoeba histolytica	hypothetical protein	0.0059	0.0108	0.0108
Loa Loa (eye worm)	TK/ABL protein kinase	0.0121	0.0697	0.063
Loa Loa (eye worm)	hypothetical protein	0.046	0.3932	0.3889
Brugia malayi	hypothetical protein	0.0082	0.0326	0.0257
Entamoeba histolytica	unconventional myosin IB	0.0378	0.315	0.315
Schistosoma mansoni	apoptosis stimulating of P53	0.0378	0.315	0.315
Brugia malayi	Variant SH3 domain containing protein	0.0082	0.0326	0.0257
Echinococcus multilocularis	SH2 motif	0.0082	0.0326	0.0326
Echinococcus multilocularis	tyrosine protein kinase shark	0.0121	0.0697	0.0697
Schistosoma mansoni	dreadlocks/dock	0.0378	0.315	0.315
Entamoeba histolytica	hypothetical protein	0.0378	0.315	0.315
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0082	0.0326	0.0257
Brugia malayi	Variant SH3 domain containing protein	0.0378	0.315	0.3101
Loa Loa (eye worm)	plexin A	0.0382	0.3186	0.3137
Brugia malayi	Variant SH3 domain containing protein	0.0378	0.315	0.3101
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0121	0.0697	0.0697
Brugia malayi	Sex muscle abnormal protein 5	0.046	0.3932	0.3889
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0697	0.063
Loa Loa (eye worm)	TK/FER protein kinase	0.0121	0.0697	0.063
Brugia malayi	SH2 domain containing protein	0.0082	0.0326	0.0257
Echinococcus granulosus	transcription factor collier	0.0059	0.0108	0.0108
Schistosoma mansoni	hypothetical protein	0.0135	0.083	0.083
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0499	0.4303	0.4303
Echinococcus granulosus	SH2 domain containing protein 7	0.0082	0.0326	0.0326
Entamoeba histolytica	hypothetical protein	0.0378	0.315	0.315
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0071	0.0071
Schistosoma mansoni	semaphorin 5-related	0.0135	0.083	0.083
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0326	0.0257
Echinococcus granulosus	aurora kinase A	0.1097	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.046	0.3932	0.3932
Brugia malayi	protein-tyrosine kinase	0.0378	0.315	0.3101
Onchocerca volvulus		0.0387	0.3236	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.046	0.3932	0.3932
Brugia malayi	Protein kinase domain containing protein	0.0121	0.0697	0.063
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0378	0.315	0.315
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0082	0.0326	0.0326
Brugia malayi	serine/threonine kinase 12	0.1097	1	1
Brugia malayi	Tensin	0.0082	0.0326	0.0257
Brugia malayi	Protein kinase domain containing protein	0.0121	0.0697	0.063
Echinococcus granulosus	tyrosine protein kinase Blk	0.0121	0.0697	0.0697
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0326	0.0257
Echinococcus multilocularis	intersectin 2	0.0378	0.315	0.315
Brugia malayi	Variant SH3 domain containing protein	0.0082	0.0326	0.0257
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0082	0.0326	0.0257
Echinococcus granulosus	tyrosine kinase	0.0121	0.0697	0.0697
Loa Loa (eye worm)	AUR protein kinase	0.1097	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0417	0.3521	0.3521
Onchocerca volvulus		0.0121	0.0697	0.1272
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0499	0.4303	0.4303
Brugia malayi	Variant SH3 domain containing protein	0.0378	0.315	0.3101
Echinococcus multilocularis	c src tyrosine kinase	0.0499	0.4303	0.4303
Loa Loa (eye worm)	hypothetical protein	0.0135	0.083	0.0765
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0378	0.315	0.315
Echinococcus multilocularis	signal transduction protein lnk realted	0.0082	0.0326	0.0326
Onchocerca volvulus		0.0378	0.315	0.9706
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0378	0.315	0.3101
Echinococcus multilocularis	tensin	0.0082	0.0326	0.0326
Brugia malayi	Sema domain containing protein	0.0135	0.083	0.0765
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0082	0.0326	0.0326
Echinococcus granulosus	signal transduction protein lnk realted	0.0082	0.0326	0.0326
Giardia lamblia	Aurora kinase	0.1097	1	0.5
Schistosoma mansoni	tensin	0.0082	0.0326	0.0326
Brugia malayi	Variant SH3 domain containing protein	0.046	0.3932	0.3889
Trichomonas vaginalis	conserved hypothetical protein	0.0378	0.315	0.3076
Brugia malayi	Sema domain containing protein	0.0135	0.083	0.0765
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0037
Brugia malayi	Variant SH3 domain containing protein	0.046	0.3932	0.3889
Brugia malayi	protein-tyrosine kinase	0.0121	0.0697	0.063
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0071	0.0071
Schistosoma mansoni	tyrosine kinase	0.0499	0.4303	0.4303
Schistosoma mansoni	nck2/grb4	0.046	0.3932	0.3932
Loa Loa (eye worm)	hypothetical protein	0.0378	0.315	0.3101
Entamoeba histolytica	protein kinase domain containing protein	0.1097	1	1
Trichomonas vaginalis	AGC family protein kinase	0.1097	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0082	0.0326	0.0257
Schistosoma mansoni	C-fyn	0.0378	0.315	0.315
Loa Loa (eye worm)	p53BP2	0.0378	0.315	0.3101
Onchocerca volvulus	LIM and SH3 domain protein homolog	0.0378	0.315	0.9706
Loa Loa (eye worm)	TK/FER protein kinase	0.0121	0.0697	0.063
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0082	0.0326	0.0257
Echinococcus granulosus	NCK adaptor protein	0.046	0.3932	0.3932
Entamoeba histolytica	hypothetical protein	0.0378	0.315	0.315
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0378	0.315	0.3101
Echinococcus granulosus	growth factor receptor bound protein 2	0.046	0.3932	0.3932
Brugia malayi	SH2 domain containing protein	0.0082	0.0326	0.0257
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0082	0.0326	0.0326
Echinococcus granulosus	tyrosine protein kinase shark	0.0121	0.0697	0.0697
Schistosoma mansoni	serine/threonine protein kinase	0.1097	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.0478	0.0478
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0499	0.4303	0.4303
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0082	0.0326	0.0326
Schistosoma mansoni	formin binding protein and related proteins	0.0378	0.315	0.315
Trichomonas vaginalis	AGC family protein kinase	0.1097	1	1
Loa Loa (eye worm)	hypothetical protein	0.0378	0.315	0.3101
Schistosoma mansoni	SH2A	0.0082	0.0326	0.0326
Brugia malayi	Variant SH3 domain containing protein	0.0378	0.315	0.3101
Loa Loa (eye worm)	guanylate kinase	0.0378	0.315	0.3101
Echinococcus multilocularis	NCK adaptor protein	0.046	0.3932	0.3932
Brugia malayi	Peripheral plasma membrane protein CASK	0.0378	0.315	0.3101
Entamoeba histolytica	hypothetical protein	0.0378	0.315	0.315
Echinococcus multilocularis	expressed protein	0.0378	0.315	0.315
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0121	0.0697	0.0697
Trypanosoma cruzi	hypothetical protein, conserved	0.0378	0.315	0.315
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0121	0.0697	0.0697
Echinococcus multilocularis	N chimaerin	0.0082	0.0326	0.0326
Onchocerca volvulus		0.0378	0.315	0.9706
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0121	0.0697	0.0697
Onchocerca volvulus		0.0378	0.315	0.9706
Plasmodium falciparum	serine/threonine protein kinase, putative	0.1097	1	1
Schistosoma mansoni	tyrosine kinase	0.0121	0.0697	0.0697
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0082	0.0326	0.0326
Echinococcus multilocularis	Spectrin alpha actinin	0.0378	0.315	0.315
Echinococcus multilocularis	endophilin A3	0.0378	0.315	0.315
Entamoeba histolytica	hypothetical protein, conserved	0.0378	0.315	0.315
Loa Loa (eye worm)	hypothetical protein	0.0378	0.315	0.3101
Onchocerca volvulus		0.0121	0.0697	0.1272
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0121	0.0697	0.0697
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.046	0.3932	0.3889
Loa Loa (eye worm)	hypothetical protein	0.0378	0.315	0.3101
Schistosoma mansoni	hypothetical protein	0.0059	0.0108	0.0108
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0121	0.0697	0.0697
Brugia malayi	Spectrin alpha chain	0.0378	0.315	0.3101
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0326	0.0257
Schistosoma mansoni	tensin	0.0082	0.0326	0.0326
Trichomonas vaginalis	p67phox protein, putative	0.0378	0.315	0.3076
Onchocerca volvulus		0.0121	0.0697	0.1272
Echinococcus granulosus	SH2 motif	0.0082	0.0326	0.0326
Brugia malayi	Protein kinase domain containing protein	0.0121	0.0697	0.063
Brugia malayi	Probable exocyst complex component Sec5	0.0059	0.0108	0.0037
Echinococcus granulosus	tensin	0.0082	0.0326	0.0326
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0082	0.0326	0.0326
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0082	0.0326	0.0326
Brugia malayi	Variant SH3 domain containing protein	0.0378	0.315	0.3101
Entamoeba histolytica	hypothetical protein	0.0059	0.0108	0.0108
Echinococcus granulosus	tyrosine protein kinase Srms	0.0121	0.0697	0.0697
Loa Loa (eye worm)	AUR protein kinase	0.1097	1	1
Echinococcus multilocularis	transfer RNA-Ala	0.0378	0.315	0.315
Brugia malayi	hypothetical protein	0.0135	0.083	0.0765
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0499	0.4303	0.4303
Echinococcus granulosus	plexin a4	0.0382	0.3186	0.3186
Brugia malayi	serine/threonine-protein kinase 6	0.1097	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0378	0.315	0.3076
Echinococcus multilocularis	aurora kinase A	0.1097	1	1
Trypanosoma cruzi	aurora B kinase, putative	0.1097	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0082	0.0326	0.0326
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0378	0.315	0.315
Schistosoma mansoni	tensin	0.0082	0.0326	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0135	0.083	0.0765
Onchocerca volvulus		0.0121	0.0697	0.1272
Loa Loa (eye worm)	TK protein kinase	0.0121	0.0697	0.063
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0082	0.0326	0.0257
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0499	0.4303	0.4303
Entamoeba histolytica	SH2 domain containing protein	0.0082	0.0326	0.0326
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0378	0.315	0.315
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0071	0.0071
Loa Loa (eye worm)	SH2 domain-containing protein	0.0082	0.0326	0.0257
Trypanosoma brucei	aurora B kinase	0.1097	1	1
Echinococcus granulosus	Spectrin alpha actinin	0.0378	0.315	0.315
Loa Loa (eye worm)	hypothetical protein	0.0135	0.083	0.0765
Brugia malayi	hypothetical protein	0.0121	0.0697	0.063
Trichomonas vaginalis	neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative	0.0378	0.315	0.3076
Echinococcus granulosus	SHC transforming protein 3	0.0082	0.0326	0.0326
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0378	0.315	0.315
Schistosoma mansoni	sorting nexin	0.0378	0.315	0.315
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0082	0.0326	0.0326
Schistosoma mansoni	hypothetical protein	0.0188	0.1336	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0135	0.083	0.0765
Brugia malayi	SH2 domain containing protein	0.0082	0.0326	0.0257
Trichomonas vaginalis	conserved hypothetical protein	0.0378	0.315	0.3076
Schistosoma mansoni	hypothetical protein	0.0059	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0135	0.083	0.0765
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0082	0.0326	0.0326
Echinococcus multilocularis	SH2 motif	0.0082	0.0326	0.0326
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0082	0.0326	0.0326
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0378	0.315	0.315
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0326	0.0257
Entamoeba histolytica	protein kinase , putative	0.1097	1	1
Schistosoma mansoni	tyrosine kinase	0.0499	0.4303	0.4303
Loa Loa (eye worm)	thyroid receptor interactor	0.0378	0.315	0.3101
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0378	0.315	0.315
Echinococcus granulosus	endophilin A3	0.0378	0.315	0.315
Schistosoma mansoni	plexin	0.0323	0.2622	0.2622
Schistosoma mansoni	sorbin	0.0378	0.315	0.315
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0082	0.0326	0.0326
Schistosoma mansoni	hypothetical protein	0.0378	0.315	0.315
Trichomonas vaginalis	AGC family protein kinase	0.1097	1	1
Entamoeba histolytica	cell surface protease gp63, putative	0.0059	0.0108	0.0108
Echinococcus multilocularis		0.0082	0.0326	0.0326
Echinococcus granulosus	intersectin 2	0.0378	0.315	0.315
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0508	0.4388	0.4388
Onchocerca volvulus		0.0121	0.0697	0.1272
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.046	0.3932	0.3889
Trichomonas vaginalis	AGC family protein kinase	0.1097	1	1
Echinococcus multilocularis	SHC transforming protein 3	0.0082	0.0326	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0037
Schistosoma mansoni	shc transforming protein	0.0082	0.0326	0.0326
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0378	0.315	0.315
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0378	0.315	0.315
Schistosoma mansoni	fibrocystin l	0.0059	0.0108	0.0108
Loa Loa (eye worm)	STAT protein	0.0082	0.0326	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0135	0.083	0.0765
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0082	0.0326	0.0326
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0499	0.4303	0.4303
Brugia malayi	SH2 domain containing protein	0.0082	0.0326	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0326	0.0257
Onchocerca volvulus		0.0135	0.083	0.1732
Brugia malayi	SH2 domain containing protein	0.0082	0.0326	0.0257
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.046	0.3932	0.3932
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0082	0.0326	0.0326
Entamoeba histolytica	hypothetical protein	0.0378	0.315	0.315
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0499	0.4303	0.4303
Entamoeba histolytica	hypothetical protein	0.0378	0.315	0.315
Loa Loa (eye worm)	protein-tyrosine kinase	0.0378	0.315	0.3101
Echinococcus multilocularis	hypothetical protein	0.0135	0.083	0.083
Schistosoma mansoni	tyrosine kinase	0.0499	0.4303	0.4303
Echinococcus multilocularis	plexin a4	0.0382	0.3186	0.3186
Brugia malayi	SH2 domain containing protein	0.0082	0.0326	0.0257
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0082	0.0326	0.0326
Echinococcus multilocularis	exocyst complex component 2	0.0059	0.0108	0.0108
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0082	0.0326	0.0257
Schistosoma mansoni	protein kinase	0.1097	1	1
Loa Loa (eye worm)	hypothetical protein	0.0378	0.315	0.3101
Echinococcus granulosus	N chimaerin	0.0082	0.0326	0.0326
Schistosoma mansoni	tensin-related	0.0082	0.0326	0.0326
Onchocerca volvulus		0.0323	0.2622	0.7891
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0082	0.0326	0.0326

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0024 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1885853

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1587072