Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | glucosidase, putative | 0.0809 | 0.1974 | 1 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0126 | 0.0162 | 0.0396 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0809 | 0.1974 | 0.4812 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.0162 | 0.0113 |
Trichomonas vaginalis | trehalase, putative | 0.0128 | 0.0167 | 0.0408 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1612 | 0.4102 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.121 | 0.3035 | 0.3308 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1612 | 0.4102 | 1 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0437 | 0.0987 | 0.4893 |
Echinococcus multilocularis | glycogen debranching enzyme | 0.0126 | 0.0162 | 0.0122 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0809 | 0.1974 | 0.1933 |
Brugia malayi | Trehalase family protein | 0.0128 | 0.0167 | 0.0005 |
Brugia malayi | hypothetical protein | 0.0128 | 0.0167 | 0.0005 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.3838 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0809 | 0.1974 | 0.4812 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1058 | 0.2633 | 0.6418 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0437 | 0.0987 | 0.2406 |
Trichomonas vaginalis | beta-glucosidase, putative | 0.0131 | 0.0176 | 0.0428 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0437 | 0.0987 | 0.2406 |
Echinococcus granulosus | beta galactosidase | 0.0139 | 0.0196 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0716 | 0.1726 | 0.1684 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.106 | 0.2639 | 0.2609 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.121 | 0.3035 | 0.3006 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.121 | 0.3035 | 0.3308 |
Loa Loa (eye worm) | TRE-2 protein | 0.0128 | 0.0167 | 0.0118 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1115 | 0.2783 | 0.6786 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0809 | 0.1974 | 0.4812 |
Schistosoma mansoni | hypothetical protein | 0.0091 | 0.007 | 0.0032 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1058 | 0.2633 | 0.6418 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.1612 | 0.4102 | 0.4005 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0167 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0167 | 0.0118 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.121 | 0.3035 | 0.4195 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1612 | 0.4102 | 1 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0437 | 0.0987 | 0.1199 |
Brugia malayi | Trehalase family protein | 0.0128 | 0.0167 | 0.0005 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.1058 | 0.2633 | 0.3607 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.106 | 0.2639 | 0.2609 |
Trichomonas vaginalis | glycoside hydrolases, putative | 0.0131 | 0.0176 | 0.0428 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1612 | 0.4102 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1058 | 0.2633 | 0.6418 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0437 | 0.0987 | 0.2406 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.078 | 0.1895 | 0.9564 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0809 | 0.1974 | 0.4812 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.3838 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.0258 | 0.0239 |
Schistosoma mansoni | beta-galactosidase | 0.0139 | 0.0196 | 0.0171 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0809 | 0.1974 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.3495 | 0.9092 | 1 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0437 | 0.0987 | 0.4893 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.121 | 0.3035 | 0.3 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0437 | 0.0987 | 0.2406 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0809 | 0.1974 | 0.4812 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.106 | 0.2639 | 0.2609 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.106 | 0.2639 | 0.2871 |
Echinococcus granulosus | glycogen debranching enzyme | 0.0126 | 0.0162 | 0.0122 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1058 | 0.2633 | 0.6418 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0809 | 0.1974 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0809 | 0.1974 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0167 | 0.0118 |
Echinococcus multilocularis | beta galactosidase | 0.0139 | 0.0196 | 0.0156 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.1612 | 0.4102 | 0.4072 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.121 | 0.3035 | 0.3006 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0809 | 0.1974 | 0.1841 |
Trypanosoma brucei | lysosomal alpha-mannosidase precursor, putative | 0.008 | 0.0041 | 0.0178 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0128 | 0.0167 | 0.0408 |
Brugia malayi | Trehalase family protein | 0.0128 | 0.0167 | 0.0005 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.106 | 0.2639 | 0.2871 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0437 | 0.0987 | 0.2406 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1058 | 0.2633 | 0.6418 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0196 | 0.0147 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1058 | 0.2633 | 0.6418 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0809 | 0.1974 | 0.1941 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0548 | 0.1282 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0437 | 0.0987 | 0.2406 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0437 | 0.0987 | 0.2406 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1612 | 0.4102 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0437 | 0.0987 | 0.2406 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0167 | 0.0118 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0809 | 0.1974 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.0987 | 0.0941 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1612 | 0.4102 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0809 | 0.1974 | 1 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0809 | 0.1974 | 0.1941 |
Brugia malayi | Trehalase family protein | 0.0128 | 0.0167 | 0.0005 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.078 | 0.1895 | 0.4619 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0437 | 0.0987 | 0.4551 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0437 | 0.0987 | 0.0838 |
Schistosoma mansoni | alpha-glucosidase | 0.3495 | 0.9092 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0809 | 0.1974 | 0.2135 |
Echinococcus granulosus | bile acid beta glucosidase | 0.106 | 0.2639 | 0.2609 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.3838 | 1 | 1 |
Loa Loa (eye worm) | trehalase | 0.0128 | 0.0167 | 0.0118 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0809 | 0.1974 | 0.4812 |
Loa Loa (eye worm) | trehalase | 0.0128 | 0.0167 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0196 | 0.0147 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0126 | 0.0162 | 0.0396 |
Loa Loa (eye worm) | trehalase | 0.0128 | 0.0167 | 0.0118 |
Brugia malayi | Ceramide glucosyltransferase | 0.121 | 0.3035 | 0.292 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.3838 | 1 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0809 | 0.1974 | 0.4812 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1115 | 0.2783 | 0.6786 |
Onchocerca volvulus | 0.2707 | 0.7003 | 1 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0809 | 0.1974 | 0.4812 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1058 | 0.2633 | 0.6418 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0167 | 0.0118 |
Loa Loa (eye worm) | TRE-1 protein | 0.0128 | 0.0167 | 0.0118 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0437 | 0.0987 | 0.4984 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 50 mM | Compound was tested for inhibitory activity against EPSP(5-enolpyruvylshikimate 3-phosphate) synthase in E. coli. | ChEMBL. | No reference |
IC50 (binding) | = 50 mM | Compound was tested for inhibitory activity against EPSP(5-enolpyruvylshikimate 3-phosphate) synthase in E. coli. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.