TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 248.307 | Formula: C10H12N6S
H donors: 3 H acceptors: 2 LogP: 0.99 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CNC(=S)N/N=C(/c1nc2c([nH]1)nccc2)\C
InChi: 1S/C10H12N6S/c1-6(15-16-10(17)11-2)8-13-7-4-3-5-12-9(7)14-8/h3-5H,1-2H3,(H2,11,16,17)(H,12,13,14)/b15-6+
InChiKey: ZJDYIPJZPKKYQG-GIDUJCDVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	SWI:SNF matrix associated	0.0875	1	1
Brugia malayi	SWIB/MDM2 domain containing protein	0.0875	1	1
Leishmania major	hypothetical protein, conserved	0.0311	0.3264	1
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0311	0.3264	0.3264
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0311	0.3264	0.3264
Loa Loa (eye worm)	brahma associated protein	0.0875	1	1
Onchocerca volvulus		0.0311	0.3264	0.2732
Trypanosoma cruzi	hypothetical protein, conserved	0.0311	0.3264	1
Brugia malayi	YY1-associated factor 2	0.0311	0.3264	0.3264
Loa Loa (eye worm)	hypothetical protein	0.0311	0.3264	0.3264
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0875	1	1
Echinococcus granulosus	ring and YY1 binding protein	0.0311	0.3264	0.3264
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0038	0	0.5
Echinococcus multilocularis	microtubule associated protein 2	0.0727	0.8234	0.8234
Echinococcus granulosus	muscleblind protein	0.0157	0.1426	0.1426
Brugia malayi	brahma associated protein 60 kDa	0.0875	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0875	1	1
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0875	1	1
Schistosoma mansoni	hypothetical protein	0.0875	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0311	0.3264	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0038	0	0.5
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0311	0.3264	0.3264
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0875	1	0.5
Brugia malayi	Muscleblind-like protein	0.0157	0.1426	0.1426
Echinococcus multilocularis	ring and YY1 binding protein	0.0311	0.3264	0.3264
Schistosoma mansoni	zinc finger protein	0.0311	0.3264	0.3264
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0172	0.1596	0.1596
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0311	0.3264	0.3264
Leishmania major	hypothetical protein, conserved	0.0311	0.3264	1
Echinococcus multilocularis	muscleblind protein 1	0.0157	0.1426	0.1426
Schistosoma mansoni	microtubule-associated protein tau	0.0727	0.8234	0.8234
Schistosoma mansoni	hypothetical protein	0.0875	1	1
Leishmania major	hypothetical protein, conserved	0.0311	0.3264	1
Chlamydia trachomatis	DNA topoisomerase I	0.0875	1	0.5
Echinococcus granulosus	SWI:SNF matrix associated	0.0875	1	1
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1426	0.1426
Trypanosoma brucei	hypothetical protein, conserved	0.0311	0.3264	1
Echinococcus granulosus	Zinc finger RanBP2 type	0.0311	0.3264	0.3264
Leishmania major	hypothetical protein, conserved	0.0311	0.3264	1
Schistosoma mansoni	alpha-glucosidase	0.0148	0.1311	0.1311
Schistosoma mansoni	RNA binding protein	0.0311	0.3264	0.3264
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0311	0.3264	1
Echinococcus multilocularis	zinc finger protein Ran binding	0.0311	0.3264	0.3264
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0311	0.3264	1
Schistosoma mansoni	brg-1 associated factor	0.0875	1	1
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0311	0.3264	1
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0875	1	1
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0311	0.3264	1
Echinococcus granulosus	zinc finger protein Ran binding	0.0311	0.3264	0.3264
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0875	1	1
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1426	0.1426
Schistosoma mansoni	hypothetical protein	0.0875	1	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0311	0.3264	0.3264
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0311	0.3264	0.2732
Trypanosoma cruzi	hypothetical protein, conserved	0.0311	0.3264	1
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0875	1	1
Schistosoma mansoni	TRABID protein (C64 family)	0.0311	0.3264	0.3264
Onchocerca volvulus		0.0311	0.3264	0.2732
Echinococcus multilocularis	SWI:SNF matrix associated	0.0875	1	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0172	0.1596	0.1596
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0875	1	1
Echinococcus multilocularis	muscleblind protein	0.0157	0.1426	0.1426
Onchocerca volvulus		0.0311	0.3264	0.2732
Loa Loa (eye worm)	hypothetical protein	0.0311	0.3264	0.3264
Trypanosoma cruzi	WLM domain containing protein, putative	0.0311	0.3264	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0172	0.1596	0.1596
Plasmodium vivax	hypothetical protein, conserved	0.0875	1	0.5
Onchocerca volvulus		0.0875	1	1
Loa Loa (eye worm)	hypothetical protein	0.0311	0.3264	0.3264
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0172	0.1596	0.1596
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0311	0.3264	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0311	0.3264	0.3264
Chlamydia trachomatis	SWIB complex protein	0.0875	1	0.5
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0875	1	1
Echinococcus granulosus	microtubule associated protein 2	0.0727	0.8234	0.8234
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0855	0.9755	0.9755
Toxoplasma gondii	ran binding protein	0.0311	0.3264	0.3264
Loa Loa (eye worm)	hypothetical protein	0.0311	0.3264	0.3264
Leishmania major	hypothetical protein, conserved	0.0311	0.3264	1
Trypanosoma cruzi	WLM domain containing protein, putative	0.0311	0.3264	1
Trypanosoma brucei	hypothetical protein, conserved	0.0311	0.3264	1
Schistosoma mansoni	hypothetical protein	0.0311	0.3264	0.3264
Schistosoma mansoni	fusion	0.0311	0.3264	0.3264
Echinococcus multilocularis	SWI:SNF matrix associated	0.0875	1	1
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0311	0.3264	1
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0311	0.3264	1
Loa Loa (eye worm)	hypothetical protein	0.0311	0.3264	0.3264
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0311	0.3264	0.3264
Schistosoma mansoni	alpha-glucosidase	0.0148	0.1311	0.1311
Onchocerca volvulus		0.0311	0.3264	0.2732
Echinococcus granulosus	lysosomal alpha glucosidase	0.0172	0.1596	0.1596
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0311	0.3264	0.3264

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-5.034	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.754	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.686	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.557	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.534	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.41	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.258	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.152	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.008	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1982964

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1589161