Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dual specificity | 0.0268 | 0.688 | 0.6924 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0268 | 0.688 | 0.688 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0268 | 0.688 | 0.5 |
Echinococcus granulosus | dual specificity | 0.0268 | 0.688 | 0.6924 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0268 | 0.688 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0344 | 0.9888 | 1 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0268 | 0.688 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0344 | 0.9888 | 1 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0268 | 0.688 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0268 | 0.688 | 0.5 |
Loa Loa (eye worm) | haspin protein kinase | 0.0344 | 0.9888 | 0.9888 |
Echinococcus granulosus | dual specificity | 0.0268 | 0.688 | 0.6924 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0344 | 0.9888 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0268 | 0.688 | 0.5 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0098 | 0.0112 | 0.0112 |
Schistosoma mansoni | hypothetical protein | 0.0344 | 0.9888 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0268 | 0.688 | 0.6924 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0268 | 0.688 | 0.5 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0268 | 0.688 | 0.6924 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0268 | 0.688 | 0.5 |
Echinococcus multilocularis | dual specificity | 0.0268 | 0.688 | 0.6924 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0268 | 0.688 | 0.5 |
Brugia malayi | GSG2 | 0.0344 | 0.9888 | 1 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0268 | 0.688 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0268 | 0.688 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0268 | 0.688 | 1 |
Brugia malayi | hypothetical protein | 0.0344 | 0.9888 | 1 |
Echinococcus multilocularis | dual specificity | 0.0268 | 0.688 | 0.6924 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0268 | 0.688 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0344 | 0.9888 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0344 | 0.9888 | 0.9888 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0344 | 0.9888 | 1 |
Echinococcus granulosus | dual specificity | 0.0268 | 0.688 | 0.6924 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.737 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.544 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.463 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.314 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.275 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.248 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.23 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.944 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.