Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3289 | 0.3289 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0066 | 0.3784 | 1 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0066 | 0.3784 | 1 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0025 | 0.0503 | 0.133 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0025 | 0.0503 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0503 | 0.0503 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0066 | 0.3784 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 0.3784 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0025 | 0.0503 | 0.133 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0025 | 0.0503 | 0.133 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Onchocerca volvulus | 0.0041 | 0.1758 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0503 | 0.0503 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0503 | 0.0503 |
Brugia malayi | methionyl-tRNA synthetase | 0.0025 | 0.0503 | 0.0503 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3289 | 0.3289 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 0.3784 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0066 | 0.3784 | 0.5 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0066 | 0.3784 | 1 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0025 | 0.0503 | 0.133 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3289 | 0.3289 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0066 | 0.3784 | 0.5 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0066 | 0.3784 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0066 | 0.3784 | 1 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0025 | 0.0503 | 0.5 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0025 | 0.0503 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1767 | 0.1767 |
Loa Loa (eye worm) | tyrosyl-tRNA synthetase | 0.0041 | 0.1758 | 0.1758 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1767 | 0.4669 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1767 | 0.1767 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0066 | 0.3784 | 1 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0066 | 0.3784 | 0.5 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0025 | 0.0503 | 0.5 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0025 | 0.0503 | 0.5 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0025 | 0.0503 | 0.133 |
Brugia malayi | protein ZK524.3 | 0.0025 | 0.0503 | 0.0503 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.