Detailed information for compound 1591190

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 340.335 | Formula: C20H12N4O2
  • H donors: 1 H acceptors: 4 LogP: 4.5 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc(c2c1cccc2)c1[nH]c2c(n1)cc1c(c2)nccc1
  • InChi: 1S/C20H12N4O2/c25-24(26)19-8-7-15(13-5-1-2-6-14(13)19)20-22-17-10-12-4-3-9-21-16(12)11-18(17)23-20/h1-11H,(H,22,23)
  • InChiKey: PTQNRTGOLOBXAE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0189 0.0189
Schistosoma mansoni nuclear receptor 0.0034 0.0156 0.0247
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0195 0.2076 0.2076
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0071 0.0604 0.1615
Mycobacterium tuberculosis Conserved protein 0.0045 0.0287 0.1037
Loa Loa (eye worm) hypothetical protein 0.0034 0.0156 0.0247
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0052 0.0376 0.0596
Brugia malayi glutaminase DH11.1 0.0552 0.6315 1
Schistosoma mansoni hypothetical protein 0.0079 0.0692 0.1095
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0126 0.02
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.004 0.0233 0.0369
Echinococcus granulosus ecdysone induced protein 78C 0.0071 0.0604 0.1615
Loa Loa (eye worm) glutaminase 2 0.0552 0.6315 1
Schistosoma mansoni hypothetical protein 0.0134 0.1347 0.2132
Brugia malayi Calcitonin receptor-like protein seb-1 0.0115 0.1124 0.1781
Loa Loa (eye worm) hypothetical protein 0.0038 0.0204 0.0323
Schistosoma mansoni lamin 0.0031 0.0126 0.02
Trypanosoma brucei Thiopurine S-methyltransferase (TPMT), putative 0.0045 0.0287 0.4987
Brugia malayi Steroid receptor seven-up type 2 0.0071 0.0604 0.0956
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0023 0.0024 0.0038
Echinococcus multilocularis GPCR, family 2 0.0036 0.0189 0.0189
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0034 0.0156 0.0417
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.0669 0.1789
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0575 0.1303
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0059 0.0462 0.0732
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0252 0.04
Treponema pallidum quinoline 2-oxidoreductase 0.0028 0.0088 0.9035
Brugia malayi nuclear hormone receptor 0.0071 0.0604 0.0956
Loa Loa (eye worm) hypothetical protein 0.0079 0.0692 0.1095
Echinococcus granulosus GPCR family 2 0.0036 0.0189 0.0506
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.004 0.0233 0.0369
Brugia malayi orphan nuclear receptor NR2E1 0.0034 0.0156 0.0247
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0083 0.0742 0.2687
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0034 0.0156 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0071 0.0604 0.0956
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0575 0.2768
Onchocerca volvulus Protein ultraspiracle homolog 0.0071 0.0604 0.5175
Brugia malayi latrophilin 2 splice variant baaae 0.0079 0.0692 0.1095
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0038 0.0204 0.0204
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0189 0.03
Loa Loa (eye worm) hypothetical protein 0.0038 0.0204 0.0323
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0156 0.0247
Leishmania major aldehyde dehydrogenase, putative 0.004 0.0233 0.1123
Schistosoma mansoni alpha-glucosidase 0.0162 0.1681 0.2662
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0014 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0071 0.0604 0.0956
Brugia malayi MH2 domain containing protein 0.0138 0.1395 0.2208
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0023 0.0024 0.0038
Plasmodium falciparum ornithine aminotransferase 0.0023 0.0024 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0189 0.03
Echinococcus granulosus thyroid hormone receptor alpha 0.0034 0.0156 0.0417
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0071 0.0604 0.1615
Loa Loa (eye worm) hypothetical protein 0.0031 0.0126 0.02
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0134 0.1347 0.1347
Leishmania major hypothetical protein, conserved 0.0045 0.0287 0.1381
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0023 0.0024 0.0087
Loa Loa (eye worm) hypothetical protein 0.004 0.0233 0.0369
Echinococcus multilocularis transcription factor Dp 1 0.004 0.023 0.023
Brugia malayi nuclear receptor RXR 0.0038 0.0204 0.0323
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0034 0.0156 0.0247
Loa Loa (eye worm) hypothetical protein 0.0034 0.0156 0.0247
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0071 0.0604 0.0956
Mycobacterium ulcerans aldehyde dehydrogenase 0.0195 0.2076 0.3287
Plasmodium vivax ornithine aminotransferase, putative 0.0023 0.0024 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0254 0.2779 0.44
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0024 0.0024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0156 0.0417
Echinococcus granulosus lysosomal alpha glucosidase 0.0188 0.1992 0.5326
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0038 0.0204 0.0546
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.004 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0034 0.0156 0.0247
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0023 0.0024 0.0038
Loa Loa (eye worm) hypothetical protein 0.0038 0.0204 0.0323
Schistosoma mansoni thyroid hormone receptor 0.0205 0.2194 0.3475
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0156 0.0156
Echinococcus multilocularis nuclear receptor nhr 48 0.0034 0.0156 0.0156
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0014 0.0014
Trypanosoma brucei glucosidase, putative 0.0042 0.0252 0.4392
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0252 0.04
Schistosoma mansoni nuclear receptor 0.0034 0.0156 0.0247
Schistosoma mansoni intermediate filament proteins 0.0031 0.0126 0.02
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0575 0.091
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0023 0.0024 0.0038
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0252 0.1216
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0071 0.0604 0.0956
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0071 0.0604 0.0956
Echinococcus granulosus nuclear receptor nhr 48 0.0034 0.0156 0.0417
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0071 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.0034 0.0156 0.0247
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0034 0.0156 0.0247
Loa Loa (eye worm) hypothetical protein 0.0031 0.012 0.0189
Loa Loa (eye worm) hypothetical protein 0.0034 0.0156 0.0247
Schistosoma mansoni ap endonuclease 0.0022 0.0014 0.0023
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0252 0.0675
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0252 0.04
Echinococcus granulosus ornithine aminotransferase 0.0023 0.0024 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0071 0.0604 0.0956
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0023 0.0024 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0071 0.0604 0.0956
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0189 0.0189
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0083 0.0742 0.1176
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0252 0.4392
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0188 0.1992 0.3155
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0252 0.04
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0575 0.1303
Brugia malayi nuclear receptor NHR-88 0.0071 0.0604 0.0956
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0252 0.4392
Loa Loa (eye worm) hypothetical protein 0.0071 0.0604 0.0956
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0252 0.04
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0156 0.0247
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0071 0.0604 0.0956
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0334 0.0529
Brugia malayi nuclear receptor NHR-67 0.0034 0.0156 0.0247
Onchocerca volvulus 0.0034 0.0156 0.0323
Brugia malayi tailless protein 0.0034 0.0156 0.0247
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0071 0.0604 0.0956
Loa Loa (eye worm) hypothetical protein 0.0034 0.0156 0.0247
Mycobacterium ulcerans L-lysine aminotransferase 0.0253 0.2763 0.4375
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0204 0.0323
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0575 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0126 0.02
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.1395 0.2208
Schistosoma mansoni hypothetical protein 0.0036 0.0189 0.03
Brugia malayi nuclear hormone receptor family member nhr-6 0.0034 0.0156 0.0247
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0189 0.0506
Loa Loa (eye worm) DR-78 0.0034 0.0156 0.0247
Echinococcus multilocularis Aminotransferase class III 0.0023 0.0024 0.0024
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0253 0.2763 0.4375
Schistosoma mansoni nuclear hormone receptor 0.0071 0.0604 0.0956
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0071 0.0604 0.0956
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0071 0.0604 0.0956
Loa Loa (eye worm) hypothetical protein 0.004 0.0233 0.0369
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0071 0.0604 0.0956
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0176 0.1848 0.2926
Schistosoma mansoni zinc finger protein 0.0034 0.0156 0.0247
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0195 0.2076 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0071 0.0604 0.0956
Brugia malayi hypothetical protein 0.0034 0.0156 0.0247
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0014 0.0249
Mycobacterium ulcerans hypothetical protein 0.0023 0.0024 0.0038
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0071 0.0604 0.0604
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0252 0.04
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0334 0.0893
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0034 0.0156 0.0563
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.004 0.0233 0.0844
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.004 0.0233 0.0528
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0134 0.1347 0.36
Trypanosoma cruzi Thiopurine S-methyltransferase (TPMT), putative 0.0045 0.0287 0.065
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0156 0.0417
Loa Loa (eye worm) hypothetical protein 0.0071 0.0604 0.0956
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0204 0.0323
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0334 0.0529
Schistosoma mansoni glutaminase 0.0552 0.6315 1
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0024 0.0038
Schistosoma mansoni steroid hormone receptor ad4bp 0.0071 0.0604 0.0956
Treponema pallidum hypothetical protein 0.0024 0.0036 0.2675
Schistosoma mansoni hypothetical protein 0.0036 0.0189 0.03
Loa Loa (eye worm) hypothetical protein 0.0034 0.0156 0.0247
Loa Loa (eye worm) hypothetical protein 0.0034 0.0156 0.0247
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0252 0.1155
Loa Loa (eye worm) glutaminase 0.0552 0.6315 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0334 0.0529
Trichomonas vaginalis aldehyde oxidase, putative 0.0176 0.1848 0.2926
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0156 0.0247
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0059 0.0462 0.0732
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0189 0.0506
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0014 0.0052
Schistosoma mansoni nuclear receptor nhr-48 0.0034 0.0156 0.0247
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0014 0.0038
Trypanosoma brucei Thiopurine S-methyltransferase (TPMT), putative 0.0045 0.0287 0.4987
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0189 0.03
Schistosoma mansoni alpha-glucosidase 0.0162 0.1681 0.2662
Trypanosoma cruzi Thiopurine S-methyltransferase (TPMT), putative 0.0045 0.0287 0.065
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0071 0.0604 0.1615
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0575 1
Loa Loa (eye worm) steroid hormone receptor 0.0071 0.0604 0.0956
Schistosoma mansoni aldehyde dehydrogenase 0.0195 0.2076 0.3287
Schistosoma mansoni thyroid hormone receptor 0.0205 0.2194 0.3475
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.004 0.0233 0.0369
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0071 0.0604 0.1615
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0071 0.0604 0.1615
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0071 0.0604 0.0956
Brugia malayi hypothetical protein 0.0038 0.0204 0.0323
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.1992 0.1992
Loa Loa (eye worm) hypothetical protein 0.0034 0.0156 0.0247
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.004 0.0233 0.1061
Mycobacterium ulcerans methyltransferase 0.0045 0.0287 0.0454
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0252 0.04
Trichomonas vaginalis glutaminase, putative 0.0552 0.6315 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0334 0.0529
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0083 0.0742 0.1176
Schistosoma mansoni hypothetical protein 0.0335 0.374 0.5923
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0071 0.0604 0.0956
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0252 0.0572
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0115 0.1124 0.1781
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0156 0.0156
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0024 0.0038
Brugia malayi conserved hypotetical protein 0.0034 0.0156 0.0247
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0252 0.04
Loa Loa (eye worm) hypothetical protein 0.0034 0.0156 0.0247
Brugia malayi nuclear hormone receptor family member odr-7 0.0034 0.0156 0.0247
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.004 0.0233 0.0233
Brugia malayi Nuclear hormone receptor-like 1 0.0071 0.0604 0.0956
Echinococcus granulosus FTZ F1 alpha 0.0071 0.0604 0.1615
Echinococcus granulosus lamin dm0 0.0031 0.0126 0.0338
Brugia malayi nuclear receptor NHR-88 0.0034 0.0156 0.0247
Mycobacterium ulcerans glutaminase 0.0552 0.6315 1
Onchocerca volvulus 0.0071 0.0604 0.5175
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0156 0.0323
Schistosoma mansoni hypothetical protein 0.0036 0.0189 0.03
Brugia malayi ecdysteroid receptor 0.0071 0.0604 0.0956
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0575 0.091
Echinococcus multilocularis ecdysone induced protein 78C 0.0071 0.0604 0.0604
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0071 0.0604 0.0956
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0014 0.0069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0334 0.0334
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0023 0.0024 0.5
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0575 0.091
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.03
Mycobacterium ulcerans hypothetical protein 0.0029 0.0096 0.0152
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0034 0.0156 0.0246
Treponema pallidum hypothetical protein 0.0029 0.0096 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0034 0.0156 0.0247
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0195 0.2076 0.555
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0071 0.0604 0.1615
Brugia malayi nuclear receptor RXR 0.0034 0.0156 0.0247
Schistosoma mansoni retinoic acid receptor RXR 0.0071 0.0604 0.0956
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0023 0.0024 0.0038
Echinococcus granulosus intermediate filament protein 0.0031 0.0126 0.0338
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0071 0.0604 0.0604
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0195 0.2076 0.7514
Schistosoma mansoni aldehyde dehydrogenase 0.0195 0.2076 0.3287
Brugia malayi intermediate filament protein 0.0031 0.0126 0.02
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0334 0.0893
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0253 0.2763 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0604 0.0956
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.004 0.0233 1
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0117 0.1142 0.1808
Schistosoma mansoni RAR-like nuclear receptor 0.0071 0.0604 0.0956
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.0669 0.0669
Schistosoma mansoni hypothetical protein 0.0335 0.374 0.5923
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0071 0.0604 0.0604
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0014 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0071 0.0604 0.0956
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0034 0.0156 0.0247
Echinococcus multilocularis FTZ F1 alpha 0.0071 0.0604 0.0604
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0252 0.0572
Echinococcus granulosus geminin 0.0335 0.374 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0071 0.0604 0.0956
Toxoplasma gondii aldehyde dehydrogenase 0.0195 0.2076 1
Schistosoma mansoni hypothetical protein 0.0036 0.0189 0.03
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0023 0.0024 0.0087
Echinococcus multilocularis musashi 0.0031 0.0126 0.0126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0071 0.0604 0.0956
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0071 0.0604 0.0956
Loa Loa (eye worm) hypothetical protein 0.0034 0.0156 0.0247
Loa Loa (eye worm) hypothetical protein 0.0115 0.1124 0.1781
Brugia malayi hypothetical protein 0.0034 0.0156 0.0247
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0252 0.04
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0071 0.0604 0.0604
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0071 0.0604 0.0956
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0071 0.0604 0.0956
Mycobacterium ulcerans acetylornithine aminotransferase 0.0023 0.0024 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0071 0.0604 0.0956
Echinococcus multilocularis geminin 0.0335 0.374 0.374
Schistosoma mansoni alpha glucosidase 0.0042 0.0252 0.04
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0156 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0071 0.0604 0.0956
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0575 0.1536
Loa Loa (eye worm) hypothetical protein 0.0071 0.0604 0.0956
Brugia malayi ecdysone receptor 0.0034 0.0156 0.0247
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0252 0.04
Trypanosoma cruzi hypothetical protein 0.0392 0.4411 1
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0023 0.0024 0.0087
Schistosoma mansoni lamin 0.0031 0.0126 0.02
Mycobacterium ulcerans aldehyde dehydrogenase 0.0195 0.2076 0.3287
Loa Loa (eye worm) hypothetical protein 0.0071 0.0604 0.0956
Onchocerca volvulus 0.0034 0.0156 0.0323
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.1992 0.1992
Loa Loa (eye worm) nuclear hormone receptor 0.0034 0.0156 0.0247
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0204 0.0323
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0014 0.0023
Echinococcus granulosus lamin 0.0031 0.0126 0.0338
Loa Loa (eye worm) hypothetical protein 0.0071 0.0604 0.0956
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.004 0.0233 0.0369
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.004 0.0233 0.0844
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0034 0.0156 0.0247
Onchocerca volvulus 0.0109 0.1049 1
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0023 0.0024 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0071 0.0604 0.0956
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0156 0.0247
Schistosoma mansoni coup transcription factor 0.0071 0.0604 0.0956
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0176 0.1848 0.2926
Loa Loa (eye worm) hypothetical protein 0.0038 0.0204 0.0323
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0071 0.0604 0.0604
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0071 0.0604 0.0956
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0115 0.1124 0.1781
Brugia malayi steroid hormone receptor 0.0071 0.0604 0.0956
Brugia malayi follicle stimulating hormone receptor 0.0254 0.2779 0.44
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0024 0.0024
Mycobacterium tuberculosis Probable aminotransferase 0.0023 0.0024 0.0087
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0014 0.0023
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.004 0.0233 0.0369
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0023 0.0024 1
Schistosoma mansoni ap endonuclease 0.0022 0.0014 0.0023
Onchocerca volvulus Bile acid receptor homolog 0.0071 0.0604 0.5175
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0014 1
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0034 0.0156 0.0246
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0034 0.0156 0.0156
Brugia malayi hypothetical protein 0.0038 0.0204 0.0323
Echinococcus granulosus Aminotransferase class III 0.0023 0.0024 0.0065
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0071 0.0604 0.1615
Mycobacterium ulcerans aldehyde dehydrogenase 0.0195 0.2076 0.3287
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0156 0.0417
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0071 0.0604 0.0956
Brugia malayi Glycosyl hydrolases family 31 protein 0.0188 0.1992 0.3155
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0014 0.0023
Echinococcus multilocularis lamin 0.0031 0.0126 0.0126
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0059 0.0462 0.1674
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0034 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0038 0.0204 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0071 0.0604 0.0956
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0575 0.0575
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0038 0.0204 0.0323
Echinococcus granulosus transcription factor Dp 1 0.004 0.023 0.0615
Echinococcus multilocularis lamin dm0 0.0031 0.0126 0.0126
Trypanosoma brucei aldehyde dehydrogenase, putative 0.004 0.0233 0.4057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0334 0.0529
Loa Loa (eye worm) nuclear receptor NHR-67 0.0034 0.0156 0.0247
Brugia malayi nuclear hormone receptor 0.0034 0.0156 0.0247
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0126 0.02
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0038 0.0204 0.0323
Echinococcus multilocularis thyroid hormone receptor alpha 0.0205 0.2194 0.2194
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0014 0.0023
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0252 0.04
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.004 0.0233 0.0623
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0071 0.0604 0.0956
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0071 0.0604 0.5175
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0334 0.0334
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.1395 0.2208

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 6 uM Cytotoxicity against human MT4 cells after 96 hrs by MTT assay ChEMBL. 22047799

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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