Detailed information for compound 1591485

Basic information

Technical information
  • TDR Targets ID: 1591485
  • Name: 2-[(4-oxo-1H-quinazolin-2-yl)sulfanyl]-N-prop an-2-ylacetamide
  • MW: 277.342 | Formula: C13H15N3O2S
  • H donors: 2 H acceptors: 2 LogP: 1.78 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(NC(=O)CSc1nc2ccccc2c(=O)[nH]1)C
  • InChi: 1S/C13H15N3O2S/c1-8(2)14-11(17)7-19-13-15-10-6-4-3-5-9(10)12(18)16-13/h3-6,8H,7H2,1-2H3,(H,14,17)(H,15,16,18)
  • InChiKey: KDHMVLGOXSXEDP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-isopropyl-2-[(4-oxo-1H-quinazolin-2-yl)sulfanyl]acetamide
  • N-isopropyl-2-[(4-oxo-1H-quinazolin-2-yl)thio]acetamide
  • N-isopropyl-2-[(4-keto-1H-quinazolin-2-yl)thio]acetamide
  • 2-[(4-oxo-1H-quinazolin-2-yl)sulfanyl]-N-propan-2-yl-ethanamide
  • ZINC01325666
  • BAS 07062722
  • N-Isopropyl-2-(4-oxo-3,4-dihydro-quinazolin-2-ylsulfanyl)-acetamide
  • T5261348

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0168 0.0949 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0157 0.0882 0.0965
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0041 0.0125 0.0136
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0205 0.1193 0.1304
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0117 0.0623 0.0681
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0546 0.0597
Leishmania major hypothetical protein, conserved 0.0171 0.0968 0.1059
Brugia malayi translation initiation factor 4E 0.143 0.9146 0.9982
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0062 0.0264 0.0288
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0264 0.0289
Loa Loa (eye worm) hypothetical protein 0.0062 0.0264 0.0154
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0431 0.0471
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0157 0.0882 0.0965
Plasmodium vivax orotate phosphoribosyltransferase, putative 0.01 0.0509 0.4158
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0546 0.0466
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0024 0.0016 0.017
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0062 0.0264 0.0264
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0546 0.0546
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0041 0.0125 0.0136
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0048 0.0173 0.0189
Echinococcus granulosus uridine 5' monophosphate synthase 0.0165 0.0934 0.1021
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0062 0.0264 0.0289
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0125 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0968 0.1059
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Toxoplasma gondii orotate phosphoribosyltransferase 0.01 0.0509 0.0556
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0264 0.0289
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0158 0.0884 0.7367
Loa Loa (eye worm) hypothetical protein 0.0259 0.1546 0.1572
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0021 0.0046
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0048 0.0173 0.0189
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0171 0.0968 0.1059
Trypanosoma brucei RNA helicase, putative 0.0217 0.1273 0.1392
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0046 0.005
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0062 0.0264 0.0288
Echinococcus granulosus bloom syndrome protein 0.0041 0.0125 0.0136
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0171 0.0968 0.1059
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0431 0.0471
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0264 0.0289
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0062 0.0264 0.0289
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0294 0.0321
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0062 0.0264 0.0289
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0046 0.0211
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0264 0.0289
Trypanosoma brucei GMP reductase 0.0168 0.0949 0.1038
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0264 0.0289
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0546 0.0597
Trichomonas vaginalis DNA helicase recq1, putative 0.0041 0.0125 0.0136
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0046 0.005
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0062 0.0264 0.0264
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0062 0.0264 0.0264
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0156 0.017
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0062 0.0264 0.0264
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0264 0.2073
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.143 0.9146 1
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0048 0.0173 0.0189
Leishmania major guanosine monophosphate reductase 0.0168 0.0949 0.1038
Entamoeba histolytica hypothetical protein 0.0171 0.0968 0.1038
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0205 0.1193 0.1304
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0021 0.1786
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0024 0.0016 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0968 0.1059
Leishmania major xanthine phosphoribosyltransferase 0.0205 0.1193 0.1304
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0171 0.0968 0.1038
Mycobacterium leprae PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE) 0.01 0.0509 0.5278
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0264 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0968 0.1059
Trypanosoma brucei ingi protein (ORF1) 0.0026 0.0032 0.0035
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Trichomonas vaginalis hypoxanthine-guanine phosphoribosyltransferase, putative 0.0205 0.1193 0.1304
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0062 0.0264 0.0289
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0546 0.0466
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0156 0.0035
Trichomonas vaginalis DNA helicase recq, putative 0.0041 0.0125 0.0136
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0264 0.0289
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0046 0.005
Treponema pallidum hypothetical protein 0.0048 0.0173 0.3172
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.0546 0.5675
Onchocerca volvulus Putative eukaryotic translation initiation factor 4e 0.0171 0.0968 0.8117
Echinococcus granulosus adenine phosphoribosyltransferase 0.0048 0.0173 0.0189
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0264 0.0289
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0264 0.0289
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0046 0.005
Plasmodium falciparum orotate phosphoribosyltransferase 0.01 0.0509 0.4158
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0062 0.0264 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0038 0.0042
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0294 0.0294
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0171 0.0968 0.1059
Brugia malayi hypothetical protein 0.0259 0.1546 0.1687
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.143 0.9146 1
Wolbachia endosymbiont of Brugia malayi amidophosphoribosyltransferase 0.0048 0.0173 0.1824
Mycobacterium leprae Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (OMPDCase) (OMPdecase) 0.0117 0.0623 0.65
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.143 0.9146 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0264 0.0289
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0028 0.0046 0.0846
Toxoplasma gondii hypothetical protein 0.0171 0.0968 0.1059
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Leishmania major hypothetical protein, conserved 0.0171 0.0968 0.1059
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0048 0.0173 0.0173
Echinococcus multilocularis uridine 5' monophosphate synthase 0.0165 0.0934 0.1021
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0125 0.0136
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0027 0.0038 0.0042
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0264 0.0289
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0048 0.0173 0.0189
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0168 0.0949 0.7928
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0264 0.0289
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.143 0.9146 0.9146
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0546 0.0597
Brugia malayi GTP-binding protein 0.0153 0.0854 0.0932
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0171 0.0968 0.1059
Plasmodium falciparum eukaryotic translation initiation factor 4E 0.0171 0.0968 0.8082
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0041 0.0125 0.0136
Trypanosoma cruzi GMP reductase 0.0168 0.0949 0.1038
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0021 0.0046
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0264 0.0289
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Entamoeba histolytica DNA repair and recombination protein, putative 0.0027 0.0038 0.0019
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase, putative 0.0205 0.1193 0.1304
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0264 0.0289
Brugia malayi eukaryotic translation initiation factor 4E-1 0.0171 0.0968 0.1057
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0168 0.0949 0.1038
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0299 0.1803 0.1972
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0264 0.0289
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.007 0.0313 0.0342
Mycobacterium tuberculosis Conserved protein 0.0048 0.0173 0.1683
Treponema pallidum phosphoribosylpyrophosphate synthetase 0.0048 0.0173 0.3172
Leishmania major eukaryotic translation initiation factor, putative 0.0171 0.0968 0.1059
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0027 0.0038 0.0042
Trichomonas vaginalis sensor histidine kinase, putative 0.0024 0.0016 0.0018
Trichomonas vaginalis DNA helicase recq, putative 0.0041 0.0125 0.0136
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0168 0.0949 0.1038
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0062 0.0264 0.0264
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0157 0.0882 0.0963
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0021 0.0023
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.143 0.9146 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0171 0.0968 0.1059
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0264 0.0289
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0264 0.0289
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0546 0.0574
Echinococcus multilocularis adenine phosphoribosyltransferase 0.0048 0.0173 0.0189
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0168 0.0949 0.0949
Loa Loa (eye worm) translation initiation factor 4E 0.143 0.9146 0.9982
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0171 0.0968 0.1059
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0171 0.0968 0.1059
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0046 0.005
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0158 0.0884 0.7379
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.143 0.9146 1
Echinococcus granulosus eukaryotic translation initiation factor 4E type 0.0171 0.0968 0.1059
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0205 0.1193 0.1304
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0546 0.0597
Giardia lamblia Hypothetical protein 0.0171 0.0968 0.8117
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0299 0.1803 0.1972
Leishmania major cAMP-specific phosphodiesterase, putative 0.0299 0.1803 0.1972
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0264 0.0289
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0048 0.0173 0.0173
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0032 0.0035
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0021 0.0023
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0171 0.0968 0.1038
Leishmania major hypothetical protein, conserved 0.0062 0.0264 0.0289
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.1371 0.876 0.9554
Trypanosoma brucei Eukaryotic translation initiation factor 4E-4 0.0171 0.0968 0.1059
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0027 0.0038 0.0042
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0062 0.0264 0.0289
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0038 0.0019
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0093 0.0102
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0264 0.0289
Mycobacterium tuberculosis Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase) 0.0048 0.0173 0.1683
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0046 0.005
Mycobacterium leprae AMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) (GPATASE) 0.0048 0.0173 0.1683
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0294 0.0321
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0264 0.0289
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0062 0.0264 0.2073
Mycobacterium ulcerans amidophosphoribosyltransferase 0.0048 0.0173 0.1334
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0157 0.0882 0.0965
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0062 0.0264 0.2073
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0062 0.0264 0.0288
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.008 0.0378 0.3879
Toxoplasma gondii IMP dehydrogenas 0.0168 0.0949 0.1038
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0168 0.0949 0.1038
Brugia malayi Eukaryotic translation initiation factor 4E type 3, putative 0.0171 0.0968 0.1057
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0294 0.236
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0171 0.0968 0.1059
Loa Loa (eye worm) orotate phosphoribosyltransferase 0.0165 0.0934 0.0896
Wolbachia endosymbiont of Brugia malayi orotidine-5'-phosphate decarboxylase 0.0066 0.0287 0.3025
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0046 0.0211
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.143 0.9146 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0168 0.0949 0.1038
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0125 0.0136
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0171 0.0968 0.1059
Trypanosoma brucei Eukaryotic translation initiation factor 4E type 5 0.0171 0.0968 0.1059
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Schistosoma mansoni DNA helicase recq1 0.0041 0.0125 0.0125
Brugia malayi 6-phosphofructokinase 0.0105 0.0546 0.0595
Brugia malayi Adenine phosphoribosyltransferase 0.0048 0.0173 0.0189
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0062 0.0264 0.0289
Echinococcus granulosus ras gtpase 0.0153 0.0854 0.0934
Schistosoma mansoni uracil phosphoribosyltransferase 0.0048 0.0173 0.0173
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0062 0.0264 0.0289
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0264 0.0289
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0062 0.0264 0.0288
Entamoeba histolytica hypothetical protein 0.0171 0.0968 0.1038
Loa Loa (eye worm) GTP-binding protein 0.0153 0.0854 0.0807
Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT 0.0205 0.1193 0.1304
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0062 0.0264 0.0154
Leishmania major eukaryotic translation initiation factor-like 0.143 0.9146 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.143 0.9146 1
Mycobacterium leprae conserved hypothetical protein 0.0118 0.0625 0.6528
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0157 0.0882 0.0882
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0205 0.1193 0.1304
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0041 0.0125 0.0136
Mycobacterium ulcerans adenine phosphoribosyltransferase 0.0048 0.0173 0.1334
Schistosoma mansoni hypothetical protein 0.0217 0.1273 0.1273
Loa Loa (eye worm) hypothetical protein 0.0088 0.0431 0.0339
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0062 0.0264 0.0264
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0062 0.0264 0.2216
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0546 0.0597
Mycobacterium leprae Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho 0.0157 0.0881 0.9272
Entamoeba histolytica translation initiation factor 4e, putative 0.0171 0.0968 0.1038
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0062 0.0264 0.0289
Brugia malayi 6-phosphofructokinase 0.0105 0.0546 0.0595
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.143 0.9146 1
Echinococcus granulosus survival motor neuron protein 1 0.0259 0.1546 0.169
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0156 0.0156
Giardia lamblia Hypothetical protein 0.0171 0.0968 0.8117
Giardia lamblia hypothetical protein 0.0171 0.0968 0.8117
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0171 0.0968 0.1059
Loa Loa (eye worm) PDE1B protein 0.0157 0.0882 0.0838
Treponema pallidum response regulatory protein (atoC) 0.0024 0.0016 0.0295
Leishmania major inosine-5-monophosphate dehydrogenase 0.0168 0.0949 0.1038
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0171 0.0968 0.1038
Brugia malayi hypothetical protein 0.0036 0.0093 0.0102
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0156 0.0156
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.008 0.0378 0.3075
Mycobacterium tuberculosis Conserved protein 0.0048 0.0173 0.1683
Onchocerca volvulus 0.0205 0.1193 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0062 0.0264 0.2073
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0157 0.0882 0.0965
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0156 0.0171
Mycobacterium tuberculosis Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (ompdecase) 0.0052 0.0197 0.1936
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0024 0.0016 0.0018
Entamoeba histolytica hypothetical protein 0.0036 0.0093 0.0078
Wolbachia endosymbiont of Brugia malayi response regulator 0.0024 0.0016 0.017
Trichomonas vaginalis receptor histidine kinase, putative 0.0024 0.0016 0.0018
Echinococcus multilocularis bloom syndrome protein 0.0041 0.0125 0.0136
Brugia malayi GMP reductase 0.007 0.0313 0.0342
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0062 0.0264 0.0289
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0062 0.0264 0.0289
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0046 0.005
Trichomonas vaginalis ribose-phosphate pyrophosphokinase, putative 0.0048 0.0173 0.0189
Schistosoma mansoni hypothetical protein 0.0036 0.0093 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0264 0.0289
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0048 0.0173 0.0173
Leishmania major orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative 0.0165 0.0934 0.1021
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0046 0.0211
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0021 0.0058
Leishmania major hypoxanthine-guanine phosphoribosyltransferase 0.0205 0.1193 0.1304
Loa Loa (eye worm) hypothetical protein 0.1433 0.9163 1
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0546 0.0574
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0157 0.0882 0.0965
Giardia lamblia Rrm3p helicase 0.0027 0.0038 0.0322
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0021 0.0023
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0157 0.0882 0.0965
Trichomonas vaginalis hypothetical protein 0.0171 0.0968 0.1059
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.143 0.9146 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0062 0.0264 0.0289
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0264 0.0289
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0062 0.0264 0.0289
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0027 0.0038 0.0042
Loa Loa (eye worm) hypothetical protein 0.0062 0.0264 0.0154
Onchocerca volvulus 0.0088 0.0431 0.3611
Giardia lamblia Adenine phosphoribosyltransferase 0.0048 0.0173 0.1451
Giardia lamblia hypothetical protein 0.0062 0.0264 0.2216
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0093 0.0093
Trichomonas vaginalis Ribose-phosphate pyrophosphokinase, putative 0.0048 0.0173 0.0189
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0171 0.0968 0.1059
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0431 0.047
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0546 0.0597
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0546 0.45
Trypanosoma brucei unspecified product 0.0026 0.0032 0.0035
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0048 0.0173 0.0173
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0205 0.1193 0.1304
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0157 0.0882 0.0965
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0157 0.0882 0.0965
Mycobacterium ulcerans orotidine 5'-phosphate decarboxylase 0.0117 0.0623 0.5153
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0041 0.0125 0.0136
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0093 0.0102
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0062 0.0264 0.0289
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0171 0.0968 0.1059
Echinococcus multilocularis survival motor neuron protein 1 0.0259 0.1546 0.169
Plasmodium vivax phosphodiesterase gamma, putative 0.0062 0.0264 0.2073
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0062 0.0264 0.0289
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0171 0.0968 0.1059
Entamoeba histolytica hypothetical protein 0.0036 0.0093 0.0078
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0027 0.0038 0.0042
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0026 0.0032 0.0035
Mycobacterium ulcerans hypoxanthine-guanine phosphoribosyltransferase Hpt 0.0205 0.1193 1
Loa Loa (eye worm) eukaryotic translation initiation factor 4E-1 0.0171 0.0968 0.0933
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0546 0.0597
Mycobacterium tuberculosis Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase) 0.0048 0.0173 0.1683
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0024 0.0016 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0156 0.0171
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0171 0.0968 0.1059
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0086 0.0419 0.0458
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0062 0.0264 0.0289
Schistosoma mansoni sensor histidine kinase/response regulator 0.0024 0.0016 0.0016
Trypanosoma brucei ingi protein (ORF1) 0.0026 0.0032 0.0035
Leishmania major hypothetical protein, conserved 0.0062 0.0264 0.0289
Onchocerca volvulus 0.0053 0.0205 0.1717
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.143 0.9146 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0171 0.0968 0.1059
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0062 0.0264 0.0289
Loa Loa (eye worm) eukaryotic translation initiation factor 4E type 3 0.0171 0.0968 0.0933
Mycobacterium ulcerans orotate phosphoribosyltransferase 0.01 0.0509 0.4185
Mycobacterium tuberculosis Conserved hypothetical protein 0.0048 0.0173 0.1683
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.143 0.9146 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0205 0.0224
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0168 0.0949 1
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase, putative 0.0205 0.1193 1
Loa Loa (eye worm) adenine phosphoribosyltransferase 0.0048 0.0173 0.0054
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0088 0.0432 0.4463
Entamoeba histolytica hypothetical protein 0.0036 0.0093 0.0078
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0041 0.0125 0.0136
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0041 0.0125 0.0881
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0062 0.0264 0.0289
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0264 0.2073
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0171 0.0968 0.1059
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0062 0.0264 0.0289
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0294 0.236
Mycobacterium leprae conserved hypothetical protein 0.0118 0.0625 0.6528
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0046 0.0387
Leishmania major eukaryotic translation initiation factor 4e, putative 0.0171 0.0968 0.1059
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0157 0.0882 0.0965
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Loa Loa (eye worm) hypothetical protein 0.0062 0.0264 0.0154
Plasmodium falciparum phosphodiesterase gamma, putative 0.0062 0.0264 0.2073
Mycobacterium tuberculosis Conserved hypothetical protein 0.0118 0.0625 0.6528
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0171 0.0968 0.1038
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.007 0.0313 0.0342
Onchocerca volvulus Adenine phosphoribosyltransferase homolog 0.0048 0.0173 0.1451
Plasmodium falciparum orotidine 5'-phosphate decarboxylase 0.0117 0.0623 0.5131
Schistosoma mansoni cell polarity protein 0.0153 0.0854 0.0854
Giardia lamblia Guanine phosphoribosyltransferase 0.0205 0.1193 1
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0205 0.1193 0.1304
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0165 0.0934 0.1021
Loa Loa (eye worm) IMP dehydrogenase 1 0.0168 0.0949 0.0912
Mycobacterium tuberculosis Conserved hypothetical protein 0.0118 0.0625 0.6528
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0264 0.0289
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0264 0.0289
Giardia lamblia Translation elongation factor 0.0171 0.0968 0.8117
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-3 0.0171 0.0968 0.1059
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0294 0.0321
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0046 1
Entamoeba histolytica hypothetical protein 0.0036 0.0093 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0264 0.0289
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0048 0.0173 0.0189
Plasmodium vivax orotidine 5'-phosphate decarboxylase, putative 0.0117 0.0623 0.5131
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0264 0.0289
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0046 0.005
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Trichomonas vaginalis sensor histidine kinase, putative 0.0024 0.0016 0.0018
Mycobacterium ulcerans bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 0.0048 0.0173 0.1334
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0168 0.0949 0.1038
Plasmodium vivax translation initiation factor 4E, putative 0.0171 0.0968 0.8082
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0264 0.0289
Brugia malayi GTP-binding protein, identical 0.0153 0.0854 0.0932
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0062 0.0264 0.0289
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0125 0.0136
Plasmodium falciparum eukaryotic translation initiation factor 4E, putative 0.0171 0.0968 0.8082
Schistosoma mansoni hypothetical protein 0.0027 0.0038 0.0038
Trichomonas vaginalis receptor histidine kinase, putative 0.0024 0.0016 0.0018
Brugia malayi orotate phosphoribosyltransferase family protein 0.0165 0.0934 0.102
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0264 0.0289
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Giardia lamblia Sgs1 DNA helicase, putative 0.0041 0.0125 0.1045
Giardia lamblia Hypothetical protein 0.0062 0.0264 0.2216
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0062 0.0264 0.0289
Entamoeba histolytica recQ family helicase, putative 0.0041 0.0125 0.0113
Schistosoma mansoni cell polarity protein 0.0153 0.0854 0.0854
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0041 0.0125 0.0881
Toxoplasma gondii orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase 0.0117 0.0623 0.0681
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0062 0.0264 0.0264
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0264 0.2073
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.143 0.9146 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0546 0.0466
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0062 0.0264 0.0289
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0264 0.0289
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0205 0.1193 0.1193
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0431 0.0431
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0546 0.0546
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0264 0.0289
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0062 0.0264 0.0289
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0021 0.0226
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.143 0.9146 1
Treponema pallidum chemotaxis response regulator (cheY) 0.0024 0.0016 0.0295
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0021 0.0058
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0046 0.0027
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0062 0.0264 0.0264
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0062 0.0264 0.0289
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0294 0.0294
Plasmodium vivax hypothetical protein, conserved 0.0171 0.0968 0.8082
Echinococcus multilocularis expressed protein 0.041 0.252 0.2755
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0027 0.0038 0.0042
Leishmania major adenine phosphoribosyltransferase 0.0048 0.0173 0.0189
Wolbachia endosymbiont of Brugia malayi response regulator PleD 0.0024 0.0016 0.017
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0062 0.0264 0.0289
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0021 0.0393
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0062 0.0264 0.0264
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0546 0.0574
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0546 0.0597
Mycobacterium tuberculosis Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase) 0.01 0.0509 0.5278
Mycobacterium tuberculosis Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor 0.0157 0.0881 0.9272
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0205 0.1193 0.1304
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0264 0.0289
Brugia malayi Bloom's syndrome protein homolog 0.0041 0.0125 0.0136
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0021 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0156 0.0171
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0294 0.2977
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0046 0.005
Trypanosoma brucei Eukaryotic translation initiation factor 4E-3 0.0171 0.0968 0.1059
Schistosoma mansoni survival motor neuron protein 0.0053 0.0205 0.0205
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Brugia malayi Phosphoribosyl transferase domain containing protein 0.0205 0.1193 0.1302
Trypanosoma cruzi GMP reductase 0.0168 0.0949 0.1038
Trypanosoma brucei hypothetical protein, conserved 0.0062 0.0264 0.0289
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0062 0.0264 0.0264
Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase 0.0205 0.1193 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0088 0.0432 0.4463
Schistosoma mansoni hypothetical protein 0.0053 0.0205 0.0205
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0294 0.236
Wolbachia endosymbiont of Brugia malayi orotate phosphoribosyltransferase 0.01 0.0509 0.5358
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0062 0.0264 0.2073
Mycobacterium ulcerans hypothetical protein 0.0048 0.0173 0.1334
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0546 1
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0205 0.1193 0.1304
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0046 0.0211
Mycobacterium tuberculosis Probable pyrimidine operon regulatory protein PyrR 0.0048 0.0173 0.1683
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0024 0.0016 0.0018
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0046 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Trypanosoma brucei Eukaryotic translation initiation factor 4E-2 0.0171 0.0968 0.1059
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0027 0.0038 0.0042
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0205 0.1193 0.1304
Trypanosoma brucei orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0165 0.0934 0.1021
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0168 0.0949 0.1036
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0171 0.0968 0.1059
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0041 0.0125 0.0136
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0294 0.0321
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0546 0.5675
Treponema pallidum adenine phosphoribosyltransferase 0.0048 0.0173 0.3172
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0264 0.0289
Schistosoma mansoni DNA helicase recq5 0.0041 0.0125 0.0125
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0027 0.0038 0.0042
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0168 0.0949 0.1038
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0165 0.0934 0.1021
Schistosoma mansoni orotidine 5'-phosphate decarboxylase 0.0165 0.0934 0.0934
Echinococcus multilocularis ras gtpase 0.0153 0.0854 0.0934
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0171 0.0968 0.1059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0264 0.0289
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0157 0.0882 0.7348
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0168 0.0949 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0062 0.0264 0.0289
Loa Loa (eye worm) GMP reductase 0.007 0.0313 0.0209
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0171 0.0968 0.1059
Leishmania major eukaryotic translation initiation factor-like protein 0.143 0.9146 1
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0205 0.1193 0.1304
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0205 0.1193 0.1193
Brugia malayi phosphofructokinase 0.0105 0.0546 0.0595
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0046 0.005
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0546 0.0597
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0264 0.0289
Echinococcus granulosus expressed protein 0.041 0.252 0.2755
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0157 0.0882 0.0965
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0171 0.0968 0.1038
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0027 0.0038 0.0042
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0158 0.0884 0.7367
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0062 0.0264 0.0289
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0048 0.0173 0.0189
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0171 0.0968 0.1059
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1433 0.9163 1
Onchocerca volvulus Putative GMP reductase 0.007 0.0313 0.2627
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0264 0.0289
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0156 0.0171
Treponema pallidum protein-glutamate methylesterase (cheB) 0.0024 0.0016 0.0295

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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