Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.054 | 0.2542 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 0.2542 | 0.2542 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1519 | 1 | 1 |
Schistosoma mansoni | fusion | 0.054 | 0.2542 | 0.2542 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0266 | 0.045 | 0.5 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.054 | 0.2542 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1519 | 1 | 1 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.1519 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1519 | 1 | 1 |
Onchocerca volvulus | 0.054 | 0.2542 | 0.2542 | |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.054 | 0.2542 | 0.5 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.054 | 0.2542 | 0.2542 |
Schistosoma mansoni | zinc finger protein | 0.054 | 0.2542 | 0.2542 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 0.2542 | 0.2542 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.054 | 0.2542 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.054 | 0.2542 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1519 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.1519 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.054 | 0.2542 | 0.5 |
Chlamydia trachomatis | DNA topoisomerase I | 0.1519 | 1 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.054 | 0.2542 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1519 | 1 | 0.5 |
Onchocerca volvulus | 0.1519 | 1 | 1 | |
Loa Loa (eye worm) | brahma associated protein | 0.1519 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.054 | 0.2542 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1519 | 1 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.1519 | 1 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.054 | 0.2542 | 0.5 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.054 | 0.2542 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.054 | 0.2542 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.1413 | 0.9192 | 0.8916 |
Trypanosoma brucei | hypothetical protein, conserved | 0.054 | 0.2542 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.1413 | 0.9192 | 0.8916 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.1519 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.054 | 0.2542 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 0.2542 | 0.2542 |
Schistosoma mansoni | RNA binding protein | 0.054 | 0.2542 | 0.2542 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.1519 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1519 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 0.2542 | 0.2542 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.054 | 0.2542 | 0.5 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.1519 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.054 | 0.2542 | 0.5 |
Onchocerca volvulus | 0.054 | 0.2542 | 0.2542 | |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.1519 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.054 | 0.2542 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.054 | 0.2542 | 0.2542 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.1519 | 1 | 1 |
Onchocerca volvulus | 0.054 | 0.2542 | 0.2542 | |
Onchocerca volvulus | 0.054 | 0.2542 | 0.2542 | |
Schistosoma mansoni | brg-1 associated factor | 0.1519 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1519 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1519 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.054 | 0.2542 | 0.5 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.1519 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 0.2542 | 0.2542 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.1519 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.054 | 0.2542 | 0.5 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.054 | 0.2542 | 0.2542 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.054 | 0.2542 | 0.5 |
Chlamydia trachomatis | SWIB complex protein | 0.1519 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log 1/C (binding) | = 7.31 | Inhibition of dihydrofolate reductase from rat Walker 256 leukaemia tumors | ChEMBL. | 1895302 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.