Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0078 | 1 | 1 |
Entamoeba histolytica | DNA-directed DNA polymerase, putative | 0.0018 | 0 | 0.5 |
Trypanosoma brucei | mitochondrial structure specific endonuclease I (SSE-1), putative | 0.0044 | 0.4413 | 1 |
Plasmodium falciparum | 5'-3' exonuclease, N-terminal resolvase-like domain, putative | 0.0044 | 0.4413 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0078 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0063 | 0.7448 | 1 |
Plasmodium vivax | 5'-3' exonuclease, N-terminal resolvase-like domain, putative | 0.0044 | 0.4413 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0078 | 1 | 0.5 |
Treponema pallidum | DNA polymerase I (polA) | 0.0063 | 0.7448 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0078 | 1 | 1 |
Leishmania major | mitochondrial structure specific endonuclease I (SSE-1), putative | 0.0044 | 0.4413 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0078 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0063 | 0.7448 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0078 | 1 | 1 |
Trypanosoma cruzi | mitochondrial structure specific endonuclease I (SSE-1), putative | 0.0044 | 0.4413 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0078 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0078 | 1 | 0.5 |
Trypanosoma cruzi | mitochondrial structure specific endonuclease I (SSE-1), putative | 0.0044 | 0.4413 | 1 |
Mycobacterium ulcerans | DNA polymerase I | 0.0063 | 0.7448 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0063 | 0.7448 | 0.5 |
Chlamydia trachomatis | DNA polymerase I | 0.0063 | 0.7448 | 0.5 |
Trichomonas vaginalis | DNA polymerase I, putative | 0.0018 | 0 | 0.5 |
Toxoplasma gondii | 5'-3' exonuclease, N-terminal resolvase family domain-containing protein | 0.0022 | 0.0613 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0078 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.657 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.212 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.208 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.