Detailed information for compound 1595504

Basic information

Technical information
  • TDR Targets ID: 1595504
  • Name: N-(2-diethylaminoethyl)-2-(3-ethyl-4-oxophtha lazin-1-yl)acetamide
  • MW: 330.425 | Formula: C18H26N4O2
  • H donors: 1 H acceptors: 2 LogP: 1.79 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCNC(=O)Cc1nn(CC)c(=O)c2c1cccc2)CC
  • InChi: 1S/C18H26N4O2/c1-4-21(5-2)12-11-19-17(23)13-16-14-9-7-8-10-15(14)18(24)22(6-3)20-16/h7-10H,4-6,11-13H2,1-3H3,(H,19,23)
  • InChiKey: YDGQHBZUOIFECH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-diethylaminoethyl)-2-(3-ethyl-4-oxo-phthalazin-1-yl)acetamide
  • N-(2-diethylaminoethyl)-2-(3-ethyl-4-oxo-1-phthalazinyl)acetamide
  • N-(2-diethylaminoethyl)-2-(3-ethyl-4-keto-phthalazin-1-yl)acetamide
  • N-(2-diethylaminoethyl)-2-(3-ethyl-4-oxo-phthalazin-1-yl)ethanamide
  • BAS 02824469

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Acyltransferase family protein 0.0006 0.5 0.5
Chlamydia trachomatis glycerol-3-phosphate acyltransferase 0.0006 0.5 0.5
Entamoeba histolytica 1-acyl-glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Trypanosoma brucei acyltransferase, putative 0.0006 0.5 0.5
Mycobacterium ulcerans glycerol-3-phosphate acyltransferase 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Schistosoma mansoni 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon 0.0006 0.5 0.5
Loa Loa (eye worm) acyltransferase 0.0006 0.5 0.5
Mycobacterium ulcerans hypothetical protein 0.0006 0.5 0.5
Echinococcus granulosus acetyltransferase 0.0006 0.5 0.5
Mycobacterium tuberculosis Possible acyltransferase 0.0006 0.5 0.5
Echinococcus granulosus lysocardiolipin acyltransferase 1 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Loa Loa (eye worm) acyltransferase 0.0006 0.5 0.5
Mycobacterium leprae POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERI 0.0006 0.5 0.5
Mycobacterium leprae Probable 1-acylglycerol-3-phosphate O-acyltransferase 0.0006 0.5 0.5
Mycobacterium tuberculosis Conserved protein 0.0006 0.5 0.5
Echinococcus granulosus tafazzin 0.0006 0.5 0.5
Mycobacterium tuberculosis Possible acyltransferase 0.0006 0.5 0.5
Leishmania major acyltransferase-like protein, copy 2 0.0006 0.5 0.5
Plasmodium vivax glycerol-3-phosphate 1-O-acyltransferase, putative 0.0006 0.5 0.5
Plasmodium vivax 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Mycobacterium leprae conserved hypothetical protein 0.0006 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Giardia lamblia Lysophosphatidic acid acyltransferase, putative 0.0006 0.5 0.5
Echinococcus granulosus 1 acyl sn glycerol 3 phosphate acyltransferase 0.0006 0.5 0.5
Onchocerca volvulus Transmembrane protein 68 homolog 0.0006 0.5 0.5
Schistosoma mansoni 1-acylglycerol-3-phosphate acyltransferase 0.0006 0.5 0.5
Mycobacterium ulcerans hypothetical protein 0.0006 0.5 0.5
Brugia malayi Acyltransferase family protein 0.0006 0.5 0.5
Brugia malayi Acyltransferase-like protein 4 0.0006 0.5 0.5
Toxoplasma gondii acyltransferase domain-containing protein 0.0006 0.5 0.5
Mycobacterium ulcerans hypothetical protein 0.0006 0.5 0.5
Mycobacterium tuberculosis 1-acylglycerol-3-phosphate O-acyltransferase 0.0006 0.5 0.5
Giardia lamblia Hypothetical protein 0.0006 0.5 0.5
Mycobacterium ulcerans acyltransferase 0.0006 0.5 0.5
Echinococcus granulosus Phospholipid glycerol acyltransferase 0.0006 0.5 0.5
Mycobacterium leprae Possible acyltransferase 0.0006 0.5 0.5
Trypanosoma brucei dihydroxyacetone phosphate acyltransferase, putative 0.0006 0.5 0.5
Trichomonas vaginalis 1-acyl-sn-glycerol-3-phosphate acyltransferase eta, putative 0.0006 0.5 0.5
Wolbachia endosymbiont of Brugia malayi 1-acyl-sn-glycerol-3-phosphate acyltransferase 0.0006 0.5 0.5
Mycobacterium ulcerans acyltransferase 0.0006 0.5 0.5
Chlamydia trachomatis glycerol-3-phosphate acyltransferase 0.0006 0.5 0.5
Plasmodium falciparum phospholipid or glycerol acyltransferase, putative 0.0006 0.5 0.5
Plasmodium vivax phospholipid or glycerol acyltransferase, putative 0.0006 0.5 0.5
Trypanosoma brucei 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Mycobacterium ulcerans bifunctional transmembrane phospholipid biosynthesis enzyme PlsC 0.0006 0.5 0.5
Echinococcus multilocularis 1 acyl sn glycerol 3 phosphate acyltransferase 0.0006 0.5 0.5
Leishmania major hypothetical protein, unknown function 0.0006 0.5 0.5
Entamoeba histolytica acyl-CoA:1-acylglycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Mycobacterium tuberculosis Probable membrane protein 0.0006 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.5 0.5
Schistosoma mansoni acetyltransferase-related 0.0006 0.5 0.5
Giardia lamblia Hypothetical protein 0.0006 0.5 0.5
Giardia lamblia Hypothetical protein 0.0006 0.5 0.5
Echinococcus multilocularis 1 acyl sn glycerol 3 phosphate acyltransferase 0.0006 0.5 0.5
Echinococcus granulosus 1 acyl sn glycerol 3 phosphate acyltransferase 0.0006 0.5 0.5
Brugia malayi Acyltransferase family protein 0.0006 0.5 0.5
Schistosoma mansoni taz protein (tafazzin) 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Mycobacterium ulcerans 1-acylglycerol-3-phosphate O-acyltransferase 0.0006 0.5 0.5
Toxoplasma gondii acyltransferase domain-containing protein 0.0006 0.5 0.5
Echinococcus multilocularis Phospholipid glycerol acyltransferase 0.0006 0.5 0.5
Trypanosoma cruzi acyltransferase, putative 0.0006 0.5 0.5
Echinococcus multilocularis glycerol 3 phosphate acyltransferase 3 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Trichomonas vaginalis 1-acylglycerophosphocholine O-acyltransferase, putative 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Trypanosoma brucei acyltransferase, putative 0.0006 0.5 0.5
Leishmania major acyltransferase-like protein, copy 1 0.0006 0.5 0.5
Echinococcus granulosus 1 acyl sn glycerol 3 phosphate acyltransferase 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Trichomonas vaginalis 1-acyl-sn-glycerol-3-phosphate acyltransferase eta, putative 0.0006 0.5 0.5
Loa Loa (eye worm) acyltransferase 0.0006 0.5 0.5
Brugia malayi Acyltransferase family protein 0.0006 0.5 0.5
Echinococcus multilocularis acetyltransferase 0.0006 0.5 0.5
Trypanosoma brucei glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Schistosoma mansoni acyl-CoA:glycerol-3-phosphate acyltransferase 0.0006 0.5 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0006 0.5 0.5
Giardia lamblia Hypothetical protein 0.0006 0.5 0.5
Treponema pallidum hypothetical protein 0.0006 0.5 0.5
Mycobacterium ulcerans acyltransferase 0.0006 0.5 0.5
Onchocerca volvulus 0.0006 0.5 0.5
Trypanosoma cruzi 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Plasmodium falciparum 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Toxoplasma gondii acyltransferase domain-containing protein 0.0006 0.5 0.5
Plasmodium falciparum glycerol-3-phosphate 1-O-acyltransferase 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Mycobacterium tuberculosis Possible acyltransferase 0.0006 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0006 0.5 0.5
Echinococcus multilocularis 1 acyl sn glycerol 3 phosphate acyltransferase 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Toxoplasma gondii acyltransferase domain-containing protein 0.0006 0.5 0.5
Loa Loa (eye worm) acyltransferase 0.0006 0.5 0.5
Loa Loa (eye worm) acyltransferase 0.0006 0.5 0.5
Chlamydia trachomatis sn=glycerol 3-phosphate acyltransferase 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Toxoplasma gondii glycerol-3-phosphate-acyltransferase 0.0006 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.5 0.5
Schistosoma mansoni 1-acyl-sn-glycerol-3-phosphate o-acyltransferase 0.0006 0.5 0.5
Trypanosoma brucei acetyltransferase, putative 0.0006 0.5 0.5
Toxoplasma gondii acyltransferase domain-containing protein 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Leishmania major dihydroxyacetonephosphate acyltransferase 0.0006 0.5 0.5
Treponema pallidum lysophosphatidic acid acyltransferase 0.0006 0.5 0.5
Trypanosoma cruzi dihydroxyacetone phosphate acyltransferase, putative 0.0006 0.5 0.5
Mycobacterium tuberculosis Possible acyltransferase PlsB1 0.0006 0.5 0.5
Loa Loa (eye worm) ACL-5 protein 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Plasmodium falciparum glycerol-3-phosphate 1-O-acyltransferase 0.0006 0.5 0.5
Brugia malayi Acyltransferase family protein 0.0006 0.5 0.5
Leishmania major glycerol-3-phosphate acyl transferase 0.0006 0.5 0.5
Mycobacterium ulcerans hypothetical protein 0.0006 0.5 0.5
Trypanosoma cruzi glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Mycobacterium ulcerans hypothetical protein 0.0006 0.5 0.5
Trypanosoma cruzi acyltransferase, putative 0.0006 0.5 0.5
Leishmania major 1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative 0.0006 0.5 0.5
Loa Loa (eye worm) ACL-8 protein 0.0006 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0006 0.5 0.5
Brugia malayi Acyltransferase family protein 0.0006 0.5 0.5
Schistosoma mansoni acetyltransferase-related 0.0006 0.5 0.5
Trypanosoma cruzi glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Mycobacterium ulcerans hypothetical protein 0.0006 0.5 0.5
Echinococcus multilocularis tafazzin 0.0006 0.5 0.5
Trypanosoma cruzi dihydroxyacetone phosphate acyltransferase, putative 0.0006 0.5 0.5
Echinococcus multilocularis lysocardiolipin acyltransferase 1 0.0006 0.5 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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