Detailed information for compound 1595685

Basic information

Technical information
  • TDR Targets ID: 1595685
  • Name: N-(2-diethylaminoethyl)-2-(3-ethyl-4-oxophtha lazin-1-yl)propanamide
  • MW: 344.451 | Formula: C19H28N4O2
  • H donors: 1 H acceptors: 2 LogP: 2.36 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCNC(=O)C(c1nn(CC)c(=O)c2c1cccc2)C)CC
  • InChi: 1S/C19H28N4O2/c1-5-22(6-2)13-12-20-18(24)14(4)17-15-10-8-9-11-16(15)19(25)23(7-3)21-17/h8-11,14H,5-7,12-13H2,1-4H3,(H,20,24)
  • InChiKey: ADQLZUNQGOZRLA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-diethylaminoethyl)-2-(3-ethyl-4-oxo-phthalazin-1-yl)propanamide
  • N-(2-diethylaminoethyl)-2-(3-ethyl-4-oxo-1-phthalazinyl)propanamide
  • N-(2-diethylaminoethyl)-2-(3-ethyl-4-keto-phthalazin-1-yl)propionamide
  • BAS 02824444

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Phospholipid glycerol acyltransferase 0.0006 0.5 0.5
Trypanosoma cruzi acyltransferase, putative 0.0006 0.5 0.5
Trypanosoma brucei acyltransferase, putative 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Trichomonas vaginalis 1-acylglycerophosphocholine O-acyltransferase, putative 0.0006 0.5 0.5
Leishmania major acyltransferase-like protein, copy 1 0.0006 0.5 0.5
Echinococcus multilocularis glycerol 3 phosphate acyltransferase 3 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Echinococcus multilocularis acetyltransferase 0.0006 0.5 0.5
Brugia malayi Acyltransferase family protein 0.0006 0.5 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0006 0.5 0.5
Schistosoma mansoni acyl-CoA:glycerol-3-phosphate acyltransferase 0.0006 0.5 0.5
Trypanosoma brucei glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Echinococcus granulosus 1 acyl sn glycerol 3 phosphate acyltransferase 0.0006 0.5 0.5
Loa Loa (eye worm) acyltransferase 0.0006 0.5 0.5
Trichomonas vaginalis 1-acyl-sn-glycerol-3-phosphate acyltransferase eta, putative 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Plasmodium falciparum 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Trypanosoma cruzi 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Onchocerca volvulus 0.0006 0.5 0.5
Mycobacterium ulcerans acyltransferase 0.0006 0.5 0.5
Treponema pallidum hypothetical protein 0.0006 0.5 0.5
Giardia lamblia Hypothetical protein 0.0006 0.5 0.5
Plasmodium falciparum glycerol-3-phosphate 1-O-acyltransferase 0.0006 0.5 0.5
Toxoplasma gondii acyltransferase domain-containing protein 0.0006 0.5 0.5
Loa Loa (eye worm) acyltransferase 0.0006 0.5 0.5
Echinococcus multilocularis 1 acyl sn glycerol 3 phosphate acyltransferase 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Toxoplasma gondii acyltransferase domain-containing protein 0.0006 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0006 0.5 0.5
Mycobacterium tuberculosis Possible acyltransferase 0.0006 0.5 0.5
Leishmania major dihydroxyacetonephosphate acyltransferase 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Toxoplasma gondii acyltransferase domain-containing protein 0.0006 0.5 0.5
Trypanosoma cruzi dihydroxyacetone phosphate acyltransferase, putative 0.0006 0.5 0.5
Treponema pallidum lysophosphatidic acid acyltransferase 0.0006 0.5 0.5
Toxoplasma gondii glycerol-3-phosphate-acyltransferase 0.0006 0.5 0.5
Loa Loa (eye worm) acyltransferase 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Chlamydia trachomatis sn=glycerol 3-phosphate acyltransferase 0.0006 0.5 0.5
Trypanosoma brucei acetyltransferase, putative 0.0006 0.5 0.5
Schistosoma mansoni 1-acyl-sn-glycerol-3-phosphate o-acyltransferase 0.0006 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.5 0.5
Brugia malayi Acyltransferase family protein 0.0006 0.5 0.5
Plasmodium falciparum glycerol-3-phosphate 1-O-acyltransferase 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Leishmania major glycerol-3-phosphate acyl transferase 0.0006 0.5 0.5
Mycobacterium tuberculosis Possible acyltransferase PlsB1 0.0006 0.5 0.5
Loa Loa (eye worm) ACL-5 protein 0.0006 0.5 0.5
Mycobacterium ulcerans hypothetical protein 0.0006 0.5 0.5
Schistosoma mansoni acetyltransferase-related 0.0006 0.5 0.5
Trypanosoma cruzi glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Brugia malayi Acyltransferase family protein 0.0006 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0006 0.5 0.5
Echinococcus multilocularis lysocardiolipin acyltransferase 1 0.0006 0.5 0.5
Trypanosoma cruzi dihydroxyacetone phosphate acyltransferase, putative 0.0006 0.5 0.5
Echinococcus multilocularis tafazzin 0.0006 0.5 0.5
Mycobacterium ulcerans hypothetical protein 0.0006 0.5 0.5
Trypanosoma cruzi glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Mycobacterium ulcerans hypothetical protein 0.0006 0.5 0.5
Loa Loa (eye worm) ACL-8 protein 0.0006 0.5 0.5
Leishmania major 1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative 0.0006 0.5 0.5
Trypanosoma cruzi acyltransferase, putative 0.0006 0.5 0.5
Schistosoma mansoni 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Loa Loa (eye worm) acyltransferase 0.0006 0.5 0.5
Trypanosoma brucei acyltransferase, putative 0.0006 0.5 0.5
Entamoeba histolytica 1-acyl-glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Chlamydia trachomatis glycerol-3-phosphate acyltransferase 0.0006 0.5 0.5
Brugia malayi Acyltransferase family protein 0.0006 0.5 0.5
Mycobacterium ulcerans glycerol-3-phosphate acyltransferase 0.0006 0.5 0.5
Echinococcus granulosus lysocardiolipin acyltransferase 1 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Echinococcus granulosus acetyltransferase 0.0006 0.5 0.5
Mycobacterium ulcerans hypothetical protein 0.0006 0.5 0.5
Mycobacterium tuberculosis Possible acyltransferase 0.0006 0.5 0.5
Plasmodium vivax 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Mycobacterium leprae Probable 1-acylglycerol-3-phosphate O-acyltransferase 0.0006 0.5 0.5
Mycobacterium leprae POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERI 0.0006 0.5 0.5
Loa Loa (eye worm) acyltransferase 0.0006 0.5 0.5
Plasmodium vivax glycerol-3-phosphate 1-O-acyltransferase, putative 0.0006 0.5 0.5
Leishmania major acyltransferase-like protein, copy 2 0.0006 0.5 0.5
Mycobacterium tuberculosis Possible acyltransferase 0.0006 0.5 0.5
Echinococcus granulosus tafazzin 0.0006 0.5 0.5
Mycobacterium tuberculosis Conserved protein 0.0006 0.5 0.5
Echinococcus granulosus 1 acyl sn glycerol 3 phosphate acyltransferase 0.0006 0.5 0.5
Onchocerca volvulus Transmembrane protein 68 homolog 0.0006 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0006 0.5 0.5
Mycobacterium leprae conserved hypothetical protein 0.0006 0.5 0.5
Giardia lamblia Lysophosphatidic acid acyltransferase, putative 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Mycobacterium ulcerans hypothetical protein 0.0006 0.5 0.5
Toxoplasma gondii acyltransferase domain-containing protein 0.0006 0.5 0.5
Brugia malayi Acyltransferase-like protein 4 0.0006 0.5 0.5
Mycobacterium ulcerans hypothetical protein 0.0006 0.5 0.5
Schistosoma mansoni 1-acylglycerol-3-phosphate acyltransferase 0.0006 0.5 0.5
Brugia malayi Acyltransferase family protein 0.0006 0.5 0.5
Mycobacterium ulcerans acyltransferase 0.0006 0.5 0.5
Chlamydia trachomatis glycerol-3-phosphate acyltransferase 0.0006 0.5 0.5
Wolbachia endosymbiont of Brugia malayi 1-acyl-sn-glycerol-3-phosphate acyltransferase 0.0006 0.5 0.5
Trichomonas vaginalis 1-acyl-sn-glycerol-3-phosphate acyltransferase eta, putative 0.0006 0.5 0.5
Trypanosoma brucei dihydroxyacetone phosphate acyltransferase, putative 0.0006 0.5 0.5
Mycobacterium leprae Possible acyltransferase 0.0006 0.5 0.5
Plasmodium vivax phospholipid or glycerol acyltransferase, putative 0.0006 0.5 0.5
Plasmodium falciparum phospholipid or glycerol acyltransferase, putative 0.0006 0.5 0.5
Mycobacterium ulcerans acyltransferase 0.0006 0.5 0.5
Echinococcus granulosus Phospholipid glycerol acyltransferase 0.0006 0.5 0.5
Giardia lamblia Hypothetical protein 0.0006 0.5 0.5
Mycobacterium tuberculosis 1-acylglycerol-3-phosphate O-acyltransferase 0.0006 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.5 0.5
Mycobacterium tuberculosis Probable membrane protein 0.0006 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.5 0.5
Echinococcus multilocularis 1 acyl sn glycerol 3 phosphate acyltransferase 0.0006 0.5 0.5
Echinococcus granulosus 1 acyl sn glycerol 3 phosphate acyltransferase 0.0006 0.5 0.5
Giardia lamblia Hypothetical protein 0.0006 0.5 0.5
Giardia lamblia Hypothetical protein 0.0006 0.5 0.5
Schistosoma mansoni acetyltransferase-related 0.0006 0.5 0.5
Echinococcus multilocularis 1 acyl sn glycerol 3 phosphate acyltransferase 0.0006 0.5 0.5
Mycobacterium ulcerans bifunctional transmembrane phospholipid biosynthesis enzyme PlsC 0.0006 0.5 0.5
Trypanosoma brucei 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Entamoeba histolytica acyl-CoA:1-acylglycerol-3-phosphate acyltransferase, putative 0.0006 0.5 0.5
Leishmania major hypothetical protein, unknown function 0.0006 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.5 0.5
Schistosoma mansoni taz protein (tafazzin) 0.0006 0.5 0.5
Brugia malayi Acyltransferase family protein 0.0006 0.5 0.5
Toxoplasma gondii acyltransferase domain-containing protein 0.0006 0.5 0.5
Mycobacterium ulcerans 1-acylglycerol-3-phosphate O-acyltransferase 0.0006 0.5 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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