Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0442 | 0.4923 | 1 |
Leishmania major | serine/threonine kinase-like protein, putative | 0.0102 | 0.0223 | 0.0337 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 0.0077 | 0.5 |
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.0102 | 0.0223 | 1 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0102 | 0.0223 | 0.0332 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.0164 | 0.0105 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0442 | 0.4923 | 1 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0442 | 0.4923 | 0.7376 |
Echinococcus multilocularis | Cell division cycle 2 protein kinase | 0.0102 | 0.0223 | 0.0165 |
Echinococcus granulosus | carboxylesterase 5A | 0.0398 | 0.4308 | 0.4274 |
Echinococcus granulosus | dual specificity | 0.0442 | 0.4923 | 0.4893 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0442 | 0.4923 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0568 | 0.6654 | 0.6634 |
Echinococcus multilocularis | acetylcholinesterase | 0.0398 | 0.4308 | 0.4274 |
Brugia malayi | Carboxylesterase family protein | 0.0398 | 0.4308 | 0.6443 |
Loa Loa (eye worm) | CMGC/CDK/CRK7 protein kinase | 0.0102 | 0.0223 | 0.0332 |
Echinococcus multilocularis | dual specificity | 0.0442 | 0.4923 | 0.4893 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.4308 | 0.6418 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0442 | 0.4923 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0398 | 0.4308 | 0.6443 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0568 | 0.6654 | 0.6634 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.081 | 1 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0572 | 0.6713 | 1 |
Schistosoma mansoni | protein kinase | 0.0102 | 0.0223 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0077 | 0.0114 |
Entamoeba histolytica | protein kinase, putative | 0.0442 | 0.4923 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0398 | 0.4308 | 0.4274 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 0.0077 | 0.5 |
Brugia malayi | GSG2 | 0.0568 | 0.6654 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 0.0077 | 0.5 |
Echinococcus granulosus | dual specificity | 0.0442 | 0.4923 | 0.4893 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0398 | 0.4308 | 0.4274 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0102 | 0.0223 | 0.0337 |
Echinococcus granulosus | Cell division cycle 2 protein kinase | 0.0102 | 0.0223 | 0.0165 |
Schistosoma mansoni | serine/threonine kinase | 0.0102 | 0.0223 | 0.0165 |
Loa Loa (eye worm) | haspin protein kinase | 0.0568 | 0.6654 | 0.9912 |
Brugia malayi | Probable ClpP-like protease | 0.0092 | 0.0077 | 0.0026 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0092 | 0.0077 | 0.0018 |
Echinococcus multilocularis | dual specificity | 0.0442 | 0.4923 | 0.4893 |
Loa Loa (eye worm) | haspin protein kinase | 0.0568 | 0.6654 | 0.9912 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0442 | 0.4923 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 0.0077 | 0.5 |
Echinococcus granulosus | Pfam-B_8186 domain containing protein | 0.0098 | 0.0164 | 0.0105 |
Schistosoma mansoni | microtubule-associated protein tau | 0.081 | 1 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0442 | 0.4923 | 1 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0102 | 0.0223 | 0.0165 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0102 | 0.0223 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0398 | 0.4308 | 0.6418 |
Echinococcus granulosus | mitogen activated protein kinase 15 | 0.0102 | 0.0223 | 0.0165 |
Trypanosoma cruzi | Mitogen-activated protein kinase 10, putative | 0.0102 | 0.0223 | 0.0337 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0092 | 0.0077 | 0.5 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 0.0077 | 0.5 |
Trypanosoma cruzi | Mitogen-activated protein kinase 10, putative | 0.0102 | 0.0223 | 0.0337 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0568 | 0.6654 | 0.6634 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0092 | 0.0077 | 0.0018 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0442 | 0.4923 | 0.7334 |
Plasmodium falciparum | MO15-related protein kinase | 0.0102 | 0.0223 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0102 | 0.0223 | 0.0165 |
Leishmania major | mitogen-activated protein kinase, putative,map kinase-like protein | 0.0102 | 0.0223 | 0.0337 |
Echinococcus granulosus | acetylcholinesterase | 0.0398 | 0.4308 | 0.4274 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0568 | 0.6654 | 0.6634 |
Echinococcus multilocularis | hypothetical protein | 0.0098 | 0.0164 | 0.0105 |
Echinococcus multilocularis | dual specificity | 0.0442 | 0.4923 | 0.4893 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0442 | 0.4923 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0568 | 0.6654 | 0.6634 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0102 | 0.0223 | 0.0165 |
Schistosoma mansoni | hypothetical protein | 0.0568 | 0.6654 | 0.6634 |
Trypanosoma brucei | Mitogen-activated protein kinase 10, putative | 0.0102 | 0.0223 | 0.0337 |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0102 | 0.0223 | 0.0249 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0442 | 0.4923 | 1 |
Brugia malayi | Cell division protein kinase 2 | 0.0102 | 0.0223 | 0.0249 |
Trypanosoma brucei | protein kinase, putative | 0.0102 | 0.0223 | 0.0337 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0442 | 0.4923 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0442 | 0.4923 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0442 | 0.4923 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase NLK | 0.0102 | 0.0223 | 0.0165 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.009 | 0.0059 | 0.0088 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0442 | 0.4923 | 0.4893 |
Brugia malayi | Protein kinase domain containing protein | 0.0102 | 0.0223 | 0.0249 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 0.0077 | 0.5 |
Echinococcus granulosus | dual specificity | 0.0442 | 0.4923 | 0.4893 |
Loa Loa (eye worm) | carboxylesterase | 0.0398 | 0.4308 | 0.6418 |
Echinococcus granulosus | serine:threonine protein kinase NLK | 0.0102 | 0.0223 | 0.0165 |
Trypanosoma cruzi | serine/threonine protein kinase, putative | 0.0102 | 0.0223 | 0.0337 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0092 | 0.0077 | 0.0018 |
Echinococcus granulosus | acetylcholinesterase | 0.0398 | 0.4308 | 0.4274 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0442 | 0.4923 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0102 | 0.0223 | 0.0337 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.4308 | 0.6418 |
Echinococcus multilocularis | acetylcholinesterase | 0.0398 | 0.4308 | 0.4274 |
Brugia malayi | hypothetical protein | 0.0568 | 0.6654 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0098 | 0.0164 | 0.0216 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
DIZ (functional) | Antibacterial activity against Escherichia coli at 10 mg/ml after 24 hrs by cut-plug method | ChEMBL. | 22178093 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.