TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 219.089 | Formula: C6H6NO6P--
H donors: 3 H acceptors: 6 LogP: -1.62 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: [O-]C(=O)c1[nH]cc(c1)C(P(=O)(O)[O-])O
InChi: 1S/C6H8NO6P/c8-5(9)4-1-3(2-7-4)6(10)14(11,12)13/h1-2,6-7,10H,(H,8,9)(H2,11,12,13)/p-2
InChiKey: FUIBIIXRDPUFOF-UHFFFAOYSA-L

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	jmjC domain containing protein	0.0015	0.0173	0.0201
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0276	0.1235
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.143	1
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0263	0.0718
Mycobacterium ulcerans	3-phosphoshikimate 1-carboxyvinyltransferase	0.0357	0.9002	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0774	0.5305
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0064	0.143	0.1661
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0263	0.026
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.016	0.0186
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0032	0.0597	0.0594
Loa Loa (eye worm)	hypothetical protein	0.0015	0.016	0.0183
Brugia malayi	jmjC domain containing protein	0.0058	0.1291	0.1502
Schistosoma mansoni	hypothetical protein	0.0396	1	1
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.019	0.4678	0.4676
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0973	0.0951
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0276	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.0691
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0263	0.024
Brugia malayi	Fibronectin type III domain containing protein	0.0032	0.0597	0.0694
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.0735	0.0733
Schistosoma mansoni	cell adhesion molecule	0.0015	0.016	0.0137
Onchocerca volvulus		0.0028	0.0498	0.0441
Schistosoma mansoni	hypothetical protein	0.0035	0.0673	0.065
Schistosoma mansoni	tyrosine kinase	0.0017	0.0208	0.0185
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.016	0.0186
Echinococcus multilocularis	phd:f box containing protein	0.0015	0.0173	0.017
Schistosoma mansoni	jumonji domain containing protein	0.0057	0.125	0.123
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0263	0.1645
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.1291	0.1499
Brugia malayi	Peroxidasin	0.0015	0.016	0.0186
Echinococcus multilocularis	jumonji domain containing 1A	0.0015	0.0173	0.017
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0058	0.1291	0.1271
Toxoplasma gondii	exonuclease III APE	0.0038	0.0774	0.0836
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0673	0.0779
Echinococcus multilocularis	Immunoglobulin	0.0032	0.0597	0.0594
Echinococcus granulosus	roundabout 2	0.0015	0.016	0.0157
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0064	0.143	0.1428
Schistosoma mansoni	ap endonuclease	0.0038	0.0774	0.0752
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.0035
Loa Loa (eye worm)	mbt repeat family protein	0.0046	0.0973	0.1128
Echinococcus multilocularis	neuroglian	0.0015	0.016	0.0157
Schistosoma mansoni	septate junction protein	0.0015	0.016	0.0137
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0263	0.0718
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0015	0.0173	0.0166
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0098	0.2299	0.2297
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0058	0.1291	0.1271
Echinococcus multilocularis	roundabout 2	0.0015	0.016	0.0157
Trichomonas vaginalis	DNA helicase recq1, putative	0.0019	0.0276	0.002
Trichomonas vaginalis	DNA helicase recq, putative	0.0019	0.0276	0.002
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0033	0.0011
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0263	0.1136
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.143	1
Echinococcus granulosus	roundabout 2	0.0015	0.016	0.0157
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0498	0.0577
Mycobacterium ulcerans	glutaminase	0.0264	0.6611	0.7263
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.001	0.0033	0.0128
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0015	0.0173	0.0166
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0019	0.0276	0.0273
Schistosoma mansoni	jumonji domain containing protein	0.0015	0.0173	0.0149
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0098	0.2299	0.2297
Giardia lamblia	Sgs1 DNA helicase, putative	0.0019	0.0276	0.0254
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0038	0.0774	0.0585
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0015	0.016	0.0157
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.019	0.4678	0.4676
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0015	0.016	0.0137
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.016	0.0186
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.016	0.0186
Echinococcus granulosus	GPCR family 2	0.0035	0.0673	0.067
Echinococcus granulosus	contactin	0.0015	0.016	0.0157
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.001	0.0037	0.0034
Brugia malayi	glutaminase DH11.1	0.0264	0.6611	0.7689
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0276	0.0822
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0019	0.0276	0.1718
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0276	0.0321
Echinococcus multilocularis	roundabout 2	0.0015	0.016	0.0157
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0015	0.0173	0.0149
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.016	0.0157
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.016	0.0186
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0263	0.0303
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0015	0.0173	0.0998
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0774	0.0805
Echinococcus multilocularis	roundabout 2	0.0046	0.0976	0.0974
Trypanosoma brucei	unspecified product	0.0019	0.0263	0.1136
Echinococcus granulosus	lysine specific demethylase 6a	0.0015	0.0173	0.017
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.0673	0.0779
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0046	0.0973	0.097
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0276	0.0281
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0015	0.016	0.0157
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0263	0.0306
Echinococcus granulosus	cpg binding protein	0.0029	0.0539	0.0537
Schistosoma mansoni	titin	0.0015	0.016	0.0137
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0038	0.0774	0.1377
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0046	0.0973	0.0951
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0768	0.089
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0263	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.0691
Schistosoma mansoni	ap endonuclease	0.0038	0.0774	0.0752
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0017	0.0214	0.0211
Echinococcus granulosus	lysine specific demethylase 5A	0.0058	0.1291	0.1289
Loa Loa (eye worm)	TK protein kinase	0.0106	0.2507	0.2914
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0276	0.0321
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0263	0.1136
Entamoeba histolytica	recQ family helicase, putative	0.0019	0.0276	0.1794
Schistosoma mansoni	glutaminase	0.0264	0.6611	0.6603
Leishmania major	DNA polymerase eta, putative	0.0019	0.0263	0.0718
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.0673	0.0782
Echinococcus granulosus	peroxidasin	0.0015	0.016	0.0157
Schistosoma mansoni	hypothetical protein	0.0075	0.1707	0.1688
Echinococcus granulosus	JmjC domain containing protein 4	0.0015	0.0173	0.017
Echinococcus granulosus	tyrosine protein kinase otk	0.0015	0.016	0.0157
Loa Loa (eye worm)	MBCTL1	0.0053	0.1138	0.132
Echinococcus granulosus	phd:f box containing protein	0.0015	0.0173	0.017
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0098	0.2299	0.2297
Schistosoma mansoni	blooms syndrome DNA helicase	0.001	0.0033	0.001
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0015	0.0173	0.0451
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0038	0.0774	0.0772
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0015	0.016	0.0157
Echinococcus granulosus	polycomb protein SCMH1	0.0046	0.0973	0.097
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0109	0.2599	0.3023
Loa Loa (eye worm)	glutaminase	0.0264	0.6611	0.7689
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0038	0.0774	1
Echinococcus granulosus	roundabout 2	0.0046	0.0976	0.0974
Schistosoma mansoni	septate junction protein	0.0015	0.016	0.0137
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.016	0.0186
Echinococcus multilocularis	lysine specific demethylase 6a	0.0015	0.0173	0.017
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0263	0.024
Echinococcus multilocularis	lysine specific demethylase 5A	0.0057	0.125	0.1248
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0973	0.0951
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.1138	0.1135
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0263	0.1702
Echinococcus granulosus	jumonji domain containing 1A	0.0015	0.0173	0.017
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0173	0.0198
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0263	0.026
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0173	0.0198
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0015	0.016	0.0183
Brugia malayi	hypothetical protein	0.0032	0.0597	0.0694
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1138	0.132
Mycobacterium leprae	probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS	0.0357	0.9002	1
Brugia malayi	Prion-like-	0.0015	0.016	0.0186
Brugia malayi	Bloom's syndrome protein homolog	0.0019	0.0276	0.0321
Schistosoma mansoni	vesicular amine transporter	0.0032	0.0597	0.0575
Schistosoma mansoni	cpg binding protein	0.0028	0.0498	0.0476
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0263	0.1136
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0019	0.0276	0.0273
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0064	0.143	0.141
Loa Loa (eye worm)	hypothetical protein	0.0015	0.016	0.0183
Echinococcus granulosus	defective proboscis extension response	0.0032	0.0597	0.0594
Echinococcus granulosus	dna polymerase eta	0.0019	0.0263	0.026
Schistosoma mansoni	phosphatidylserine receptor	0.0015	0.0173	0.0149
Echinococcus multilocularis	dnaJ subfamily B	0.0396	1	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0263	0.1645
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0032	0.0597	0.0575
Schistosoma mansoni	tyrosine kinase	0.0098	0.2299	0.2281
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0498	0.058
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1707	0.1983
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0019	0.0276	0.0273
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Schistosoma mansoni	cpg binding protein	0.0029	0.0539	0.0517
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0019	0.0276	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0109	0.2599	0.3021
Schistosoma mansoni	roundabout	0.0015	0.016	0.0137
Schistosoma mansoni	cpg binding protein	0.0029	0.0539	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0976	0.1133
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0035	0.0673	0.067
Echinococcus multilocularis	polycomb protein SCMH1	0.0046	0.0973	0.097
Brugia malayi	mbt repeat family protein	0.0046	0.0973	0.1131
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.1138	0.1117
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0057	0.125	0.1248
Mycobacterium tuberculosis	3-dehydroquinate synthase AroB	0.0139	0.337	1
Chlamydia trachomatis	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.0218	0.5413	0.3627
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0263	0.026
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0276	0.1738
Schistosoma mansoni	cell adhesion molecule	0.0015	0.016	0.0137
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0064	0.143	1
Schistosoma mansoni	cell adhesion molecule	0.0038	0.0768	0.0746
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.0691
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.1303	0.1282
Loa Loa (eye worm)	RecQ helicase	0.0019	0.0276	0.0318
Chlamydia trachomatis	phosphoshikimate 1-carboxyl vinyltransferase	0.0357	0.9002	1
Onchocerca volvulus		0.0301	0.7562	0.9666
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0038	0.0774	0.5337
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0046	0.0973	0.1061
Loa Loa (eye worm)	hypothetical protein	0.0015	0.016	0.0183
Toxoplasma gondii	shikimate dehydrogenase substrate binding domain-containing protein	0.0357	0.9002	1
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.0735	0.0733
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0015	0.016	0.0157
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0015	0.016	0.0157
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0173	0.0198
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0263	0.026
Loa Loa (eye worm)	hypothetical protein	0.0015	0.016	0.0183
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.1138	0.1323
Schistosoma mansoni	hypothetical protein	0.0035	0.0673	0.065
Echinococcus multilocularis	lachesin	0.0015	0.016	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.0691
Schistosoma mansoni	phd/f-box containing protein	0.0015	0.0173	0.0149
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0038	0.0774	0.0772
Schistosoma mansoni	neuroglian	0.0015	0.016	0.0137
Schistosoma mansoni	nephrin	0.0015	0.016	0.0137
Echinococcus multilocularis	JmjC domain containing protein 4	0.0015	0.0173	0.017
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.016	0.0186
Trichomonas vaginalis	DNA helicase recq, putative	0.0019	0.0276	0.002
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0035	0.0673	0.067
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.0597	0.0694
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.001	0.0037	0.0034
Schistosoma mansoni	3-dehydroquinate synthase	0.0139	0.337	0.3355
Mycobacterium ulcerans	3-dehydroquinate synthase	0.0139	0.337	0.3556
Loa Loa (eye worm)	hypothetical protein	0.0015	0.016	0.0183
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0774	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0976	0.1133
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0263	0.1645
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0064	0.143	0.1663
Echinococcus multilocularis	Immunoglobulin	0.0032	0.0597	0.0594
Loa Loa (eye worm)	glutaminase 2	0.0264	0.6611	0.7689
Plasmodium vivax	JmjC domain containing protein	0.0015	0.0173	0.1986
Wolbachia endosymbiont of Brugia malayi	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.0218	0.5413	1
Onchocerca volvulus		0.0046	0.0973	0.1061
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0015	0.016	0.0137
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0774	0.0805
Schistosoma mansoni	hypothetical protein	0.0288	0.7226	0.7219
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0038	0.0774	0.1645
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.1138	0.1135
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0057	0.125	0.1248
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0038	0.0768	0.0765
Brugia malayi	jmjC domain containing protein	0.0057	0.125	0.1454
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0019	0.0276	0.0318
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0015	0.0173	0.0998
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0341	0.8597	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0035	0.0673	0.067
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0263	0.0303
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.143	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0015	0.016	0.0183
Echinococcus multilocularis	peroxidasin	0.0015	0.016	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0015	0.016	0.0183
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0017	0.0214	0.0211
Mycobacterium tuberculosis	3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS)	0.0139	0.337	1
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.1138	0.1135
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.0673	0.0782
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0173	0.0198
Echinococcus multilocularis	hemicentin 1	0.0015	0.016	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.0691
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0038	0.0774	0.5305
Echinococcus granulosus	SAM and MBT domain containing protein	0.0046	0.0973	0.097
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0774	1
Echinococcus granulosus	twitchin	0.004	0.0805	0.0803
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0263	0.1645
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0263	0.026
Schistosoma mansoni	hypothetical protein	0.0035	0.0673	0.065
Onchocerca volvulus	Tyrosine kinase homolog	0.0311	0.7818	1
Brugia malayi	jmjC domain containing protein	0.0015	0.0173	0.0201
Treponema pallidum	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.0218	0.5413	1
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.1138	0.1135
Echinococcus granulosus	lachesin	0.0015	0.016	0.0157
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0109	0.2599	0.3023
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0038	0.0774	0.4784
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0015	0.016	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0015	0.016	0.0183
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0341	0.8597	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0276	0.0318
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0263	0.1645
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0173	0.0198
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0064	0.143	0.1428
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0173	0.0198
Schistosoma mansoni	nephrin	0.004	0.0805	0.0783
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0263	0.1136
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.016	0.0186
Brugia malayi	mbt repeat family protein	0.0046	0.0973	0.1131
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0098	0.2299	0.2297
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0064	0.143	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0038	0.0774	0.0898
Schistosoma mansoni	hypothetical protein	0.0035	0.0673	0.065
Echinococcus multilocularis	neuroglian	0.004	0.0805	0.0803
Schistosoma mansoni	protein phosphatase 2C	0.0015	0.0173	0.0149
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.114	0.1244
Brugia malayi	jmjC domain containing protein	0.0015	0.0173	0.0201
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Entamoeba histolytica	recQ family DNA helicase	0.001	0.0033	0.0068
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0035	0.0673	0.067
Trichomonas vaginalis	glutaminase, putative	0.0264	0.6611	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.0035
Loa Loa (eye worm)	TK/ROR protein kinase	0.001	0.0037	0.004
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0973	0.1128
Echinococcus granulosus	neuroglian	0.004	0.0805	0.0803
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0106	0.2507	0.2916
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0109	0.2599	0.3021
Loa Loa (eye worm)	hypothetical protein	0.0015	0.016	0.0183
Echinococcus granulosus	hemicentin 1	0.0015	0.016	0.0157
Echinococcus multilocularis	hemicentin 1	0.0015	0.016	0.0157
Schistosoma mansoni	DNA helicase recq5	0.0019	0.0276	0.0253
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0774	0.5019
Echinococcus granulosus	Immunoglobulin	0.0032	0.0597	0.0594
Brugia malayi	jmjC domain containing protein	0.0015	0.0173	0.0201
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0263	0.024
Echinococcus multilocularis	tyrosine protein kinase otk	0.0015	0.016	0.0157
Echinococcus multilocularis	cpg binding protein	0.0029	0.0539	0.0537
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.016	0.0186
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0015	0.016	0.0183
Schistosoma mansoni	DNA helicase recq1	0.0019	0.0276	0.0253
Schistosoma mansoni	cell adhesion molecule	0.0015	0.016	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.0691
Echinococcus granulosus	neuroglian	0.0015	0.016	0.0157
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Echinococcus granulosus	bloom syndrome protein	0.0019	0.0276	0.0273
Echinococcus multilocularis	bloom syndrome protein	0.0019	0.0276	0.0273
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0263	0.1136
Brugia malayi	exodeoxyribonuclease III family protein	0.0038	0.0774	0.0901
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0019	0.0276	0.1718
Brugia malayi	latrophilin 2 splice variant baaae	0.0075	0.1707	0.1986
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0032	0.0597	0.0575
Echinococcus multilocularis	GPCR, family 2	0.0035	0.0673	0.067
Mycobacterium ulcerans	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.0218	0.5413	0.5893

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki app (binding)	= 14.5 nM	Compound was tested for inhibitory activity against EPSP(5-enolpyruvylshikimate 3-phosphate) synthase in E. coli.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 257484

Bibliographic References

No literature references available for this target.

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Detailed information for compound 160051