Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0504 | 0.3096 | 0.3091 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0504 | 0.3096 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1417 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0504 | 0.3096 | 0.3091 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0504 | 0.3096 | 1 |
Toxoplasma gondii | ran binding protein | 0.0504 | 0.3096 | 0.3091 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0504 | 0.3096 | 0.3091 |
Schistosoma mansoni | hypothetical protein | 0.1417 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0504 | 0.3096 | 0.3091 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0504 | 0.3096 | 0.3091 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0504 | 0.3096 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1417 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1417 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0096 | 0.0008 | 0.0008 |
Leishmania major | hypothetical protein, conserved | 0.0504 | 0.3096 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.3096 | 0.3096 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.1417 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1417 | 1 | 1 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0504 | 0.3096 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1417 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0272 | 0.1338 | 0.1332 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.1417 | 1 | 1 |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.0504 | 0.3096 | 0.3091 |
Loa Loa (eye worm) | brahma associated protein | 0.1417 | 1 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0504 | 0.3096 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0096 | 0.0008 | 0.0008 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0096 | 0.0008 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 5 activator 1 | 0.0567 | 0.3575 | 0.357 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 0.0567 | 0.3575 | 0.357 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0504 | 0.3096 | 0.3091 |
Schistosoma mansoni | fusion | 0.0504 | 0.3096 | 0.3091 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0504 | 0.3096 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0504 | 0.3096 | 1 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0504 | 0.3096 | 0.3091 |
Plasmodium vivax | hypothetical protein, conserved | 0.1417 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0096 | 0.0008 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1417 | 1 | 1 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0504 | 0.3096 | 0.3091 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.1338 | 0.1338 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0504 | 0.3096 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0504 | 0.3096 | 0.3091 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0504 | 0.3096 | 0.3091 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0096 | 0.0008 | 0.5 |
Brugia malayi | YY1-associated factor 2 | 0.0504 | 0.3096 | 0.3091 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.1338 | 0.1338 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0504 | 0.3096 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0504 | 0.3096 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0504 | 0.3096 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0504 | 0.3096 | 1 |
Schistosoma mansoni | brg-1 associated factor | 0.1417 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.3096 | 0.3096 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0504 | 0.3096 | 0.3091 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.1417 | 1 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.1417 | 1 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.1417 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0504 | 0.3096 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 0.0567 | 0.3575 | 0.357 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.3096 | 0.3096 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.1417 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0096 | 0.0008 | 0.0008 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0504 | 0.3096 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0504 | 0.3096 | 0.3091 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0504 | 0.3096 | 0.3091 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0504 | 0.3096 | 0.3091 |
Onchocerca volvulus | 0.1417 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.3096 | 0.3096 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0504 | 0.3096 | 1 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.1417 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1417 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.1417 | 1 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.1417 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0504 | 0.3096 | 1 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0504 | 0.3096 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.3096 | 0.3096 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0504 | 0.3096 | 1 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.1417 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0567 | 0.3575 | 0.3575 |
Plasmodium falciparum | zinc finger Ran-binding domain-containing protein 2, putative | 0.0504 | 0.3096 | 0.3091 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0504 | 0.3096 | 0.3091 |
Giardia lamblia | Kinase, CMGC CDK | 0.0096 | 0.0008 | 0.5 |
Schistosoma mansoni | RNA binding protein | 0.0504 | 0.3096 | 0.3091 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1417 | 1 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.1417 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.382 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.158 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.078 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.014 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.005 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.