Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.092 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.092 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.092 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0145 | 0.1191 | 0.1191 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0145 | 0.1191 | 0.3653 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0327 | 0.3261 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0145 | 0.1191 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0327 | 0.3261 | 0.3261 |
Chlamydia trachomatis | DNA topoisomerase I | 0.092 | 1 | 0.5 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0145 | 0.1191 | 0.3653 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0327 | 0.3261 | 0.3261 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0145 | 0.1191 | 0.1191 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0327 | 0.3261 | 0.3261 |
Giardia lamblia | Kinase, CMGC CDK | 0.0145 | 0.1191 | 1 |
Plasmodium falciparum | protein kinase 5 | 0.0145 | 0.1191 | 0.1191 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0327 | 0.3261 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.2642 | 0.2642 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0145 | 0.1191 | 0.1191 |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.0327 | 0.3261 | 0.235 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.092 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.057 | 0.6019 | 0.6019 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0327 | 0.3261 | 1 |
Onchocerca volvulus | 0.092 | 1 | 1 | |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.092 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0145 | 0.1191 | 0.1191 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0327 | 0.3261 | 0.3261 |
Schistosoma mansoni | zinc finger protein | 0.0327 | 0.3261 | 0.3261 |
Chlamydia trachomatis | SWIB complex protein | 0.092 | 1 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.092 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0145 | 0.1191 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0327 | 0.3261 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0145 | 0.1191 | 0.3653 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0327 | 0.3261 | 0.3261 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0327 | 0.3261 | 0.3261 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.092 | 1 | 1 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0145 | 0.1191 | 0.1191 |
Onchocerca volvulus | 0.0327 | 0.3261 | 0.3261 | |
Leishmania major | hypothetical protein, conserved | 0.0327 | 0.3261 | 1 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0327 | 0.3261 | 1 |
Schistosoma mansoni | brg-1 associated factor | 0.092 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.3261 | 0.3261 |
Onchocerca volvulus | 0.0327 | 0.3261 | 0.3261 | |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0145 | 0.1191 | 0.1191 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0145 | 0.1191 | 0.1191 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 0.057 | 0.6019 | 0.6019 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.2642 | 0.2642 |
Schistosoma mansoni | hypothetical protein | 0.092 | 1 | 1 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0327 | 0.3261 | 0.3261 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.3261 | 0.3261 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0145 | 0.1191 | 0.1191 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0327 | 0.3261 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.092 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0273 | 0.2642 | 0.2642 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.092 | 1 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0279 | 0.2706 | 0.2706 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.3261 | 0.3261 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0327 | 0.3261 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0327 | 0.3261 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.092 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.092 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 activator 1 | 0.057 | 0.6019 | 0.6019 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 0.057 | 0.6019 | 0.6019 |
Toxoplasma gondii | ran binding protein | 0.0327 | 0.3261 | 0.235 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0327 | 0.3261 | 0.3261 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0145 | 0.1191 | 0.1191 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0145 | 0.1191 | 0.1191 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.3261 | 0.3261 |
Giardia lamblia | Kinase, CMGC CDK | 0.0145 | 0.1191 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0327 | 0.3261 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0327 | 0.3261 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0327 | 0.3261 | 0.3261 |
Plasmodium falciparum | zinc finger Ran-binding domain-containing protein 2, putative | 0.0327 | 0.3261 | 0.3261 |
Brugia malayi | cell division control protein 2 homolog | 0.0145 | 0.1191 | 0.1191 |
Schistosoma mansoni | hypothetical protein | 0.092 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0327 | 0.3261 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0145 | 0.1191 | 0.1191 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0145 | 0.1191 | 0.3653 |
Onchocerca volvulus | 0.0327 | 0.3261 | 0.3261 | |
Schistosoma mansoni | hypothetical protein | 0.0327 | 0.3261 | 0.3261 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0327 | 0.3261 | 0.3261 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0145 | 0.1191 | 0.3653 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0327 | 0.3261 | 0.3261 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0279 | 0.2706 | 0.2706 |
Onchocerca volvulus | 0.0327 | 0.3261 | 0.3261 | |
Schistosoma mansoni | fusion | 0.0327 | 0.3261 | 0.3261 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0145 | 0.1191 | 0.1191 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0327 | 0.3261 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0145 | 0.1191 | 0.3653 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0327 | 0.3261 | 1 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0327 | 0.3261 | 0.3261 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0327 | 0.3261 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.092 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.1174 | 0.1174 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.092 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0327 | 0.3261 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0327 | 0.3261 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0145 | 0.1191 | 0.3653 |
Schistosoma mansoni | RNA binding protein | 0.0327 | 0.3261 | 0.3261 |
Schistosoma mansoni | hypothetical protein | 0.092 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.092 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0327 | 0.3261 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0145 | 0.1191 | 0.1191 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0145 | 0.1191 | 0.1191 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0327 | 0.3261 | 0.3261 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0327 | 0.3261 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0327 | 0.3261 | 0.3261 |
Loa Loa (eye worm) | brahma associated protein | 0.092 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase | 0.0145 | 0.1191 | 0.1191 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.3261 | 0.3261 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0145 | 0.1191 | 0.3653 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.092 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0327 | 0.3261 | 0.3261 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.092 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0145 | 0.1191 | 0.1191 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0145 | 0.1191 | 0.1191 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.627 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.453 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.303 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.286 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.278 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.157 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.053 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.