Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bradykinin receptor B1 | Starlite/ChEMBL | References |
Homo sapiens | bradykinin receptor B2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | bradykinin receptor B2 | 391 aa | 354 aa | 19.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0136 | 0 | 0.5 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0382 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0382 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0136 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0382 | 1 | 1 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0382 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0382 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0382 | 1 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0382 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0382 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0136 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0136 | 0 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0136 | 0 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0368 | 0.9431 | 0.9431 |
Echinococcus granulosus | tumor protein p63 | 0.0368 | 0.9431 | 0.9431 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0136 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.4683 | 0.4683 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0382 | 1 | 1 |
Onchocerca volvulus | 0.0382 | 1 | 1 | |
Loa Loa (eye worm) | brahma associated protein | 0.0382 | 1 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0382 | 1 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0251 | 0.4683 | 0.4683 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0136 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0251 | 0.4683 | 0.4683 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0136 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0136 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0136 | 0 | 0.5 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0382 | 1 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0382 | 1 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0136 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0136 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0136 | 0 | 0.5 |
Chlamydia trachomatis | SWIB complex protein | 0.0382 | 1 | 0.5 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0136 | 0 | 0.5 |
Schistosoma mansoni | brg-1 associated factor | 0.0382 | 1 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0382 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0136 | 0 | 0.5 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0382 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0136 | 0 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0382 | 1 | 1 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0136 | 0 | 0.5 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0382 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0136 | 0 | 0.5 |
Echinococcus granulosus | hormone sensitive lipase | 0.0251 | 0.4683 | 0.4683 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0382 | 1 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0251 | 0.4683 | 0.4683 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0251 | 0.4683 | 0.4683 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0382 | 1 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0136 | 0 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0382 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0382 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 8.6 | Antagonist activity at human bradykinin B2 receptor expressed in dhfr-deficient CHO cells assessed as inhibition of bradykinin-induced inositol monophosphate accumulation preincubated for 15 mins prior bradykinin induction measured after 40 mins by liquid scintillation spectrometry | ChEMBL. | 22342268 |
Ki (binding) | > 5 | Displacement of [3H][desArg9]Lys-Bradykinin from human bradykinin B1 receptor expressed in CHO cells | ChEMBL. | 22342268 |
Ki (binding) | = 10.3 | Displacement of [3H]-Bradykinin from human bradykinin B2 receptor expressed in CHO cells membrane after 60 mins by scintillation counting | ChEMBL. | 22342268 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.