Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | ecotin, putative | 0.0014 | 0.0054 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0014 | 0.0054 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0014 | 0.0054 | 0.5 |
Brugia malayi | aryl-acylamidase | 0.0014 | 0.0054 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0014 | 0.0054 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0014 | 0.0054 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0014 | 0.0054 | 0.5 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0014 | 0.0054 | 0.5 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0014 | 0.0054 | 0.5 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0014 | 0.0054 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0014 | 0.0054 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0014 | 0.0054 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0014 | 0.0054 | 0.5 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0014 | 0.0054 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.0014 | 0.0054 | 0.5 |
Mycobacterium ulcerans | esterase LipW | 0.0014 | 0.0054 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0851 | 1 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0014 | 0.0054 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0014 | 0.0054 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0014 | 0.0054 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.0014 | 0.0054 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0851 | 1 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0014 | 0.0054 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0014 | 0.0054 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0287 | 0.0234 |
Mycobacterium ulcerans | lipase LipH | 0.0014 | 0.0054 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0014 | 0.0054 | 0.5 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0014 | 0.0054 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0014 | 0.0054 | 0.5 |
Mycobacterium ulcerans | lipase LipI | 0.0014 | 0.0054 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0851 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0054 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0014 | 0.0054 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0119 | 0.1299 | 1 |
Trichomonas vaginalis | Esterase, putative | 0.0014 | 0.0054 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0014 | 0.0054 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0014 | 0.0054 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0851 | 1 | 1 |
Mycobacterium ulcerans | lipase LipU | 0.0014 | 0.0054 | 0.5 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0014 | 0.0054 | 0.0418 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.0038 | 0.0332 | 0.028 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0851 | 1 | 1 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0014 | 0.0054 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.0054 | 0.5 | |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0014 | 0.0054 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0014 | 0.0054 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0014 | 0.0054 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0014 | 0.0054 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0014 | 0.0054 | 0.5 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0038 | 0.0332 | 0.028 |
Mycobacterium ulcerans | lipase LipU | 0.0014 | 0.0054 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.