Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Esterase, putative | 0.0022 | 0.008 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0022 | 0.008 | 0.5 |
Leishmania major | ecotin, putative | 0.0022 | 0.008 | 0.5 |
Brugia malayi | aryl-acylamidase | 0.0022 | 0.008 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0022 | 0.008 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0022 | 0.008 | 0.5 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0022 | 0.008 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0022 | 0.008 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0022 | 0.008 | 0.5 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0022 | 0.008 | 0.5 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0022 | 0.008 | 0.5 |
Mycobacterium ulcerans | esterase LipW | 0.0022 | 0.008 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.1326 | 1 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0022 | 0.008 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0022 | 0.008 | 0.5 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0022 | 0.008 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0022 | 0.008 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.0022 | 0.008 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0022 | 0.008 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0022 | 0.008 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0224 | 0.0145 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0022 | 0.008 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0022 | 0.008 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0022 | 0.008 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1326 | 1 | 1 |
Mycobacterium ulcerans | esterase LipC | 0.0022 | 0.008 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0022 | 0.008 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0.008 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1326 | 1 | 1 |
Mycobacterium ulcerans | lipase LipI | 0.0022 | 0.008 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0022 | 0.008 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0022 | 0.008 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0022 | 0.008 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0145 | 0.1011 | 1 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0022 | 0.008 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0022 | 0.008 | 0.5 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.0046 | 0.0259 | 0.018 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0022 | 0.008 | 0.079 |
Mycobacterium ulcerans | lipase LipU | 0.0022 | 0.008 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1326 | 1 | 1 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0022 | 0.008 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0022 | 0.008 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1326 | 1 | 1 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0022 | 0.008 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0022 | 0.008 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0022 | 0.008 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0022 | 0.008 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0022 | 0.008 | 0.5 |
Onchocerca volvulus | 0.0022 | 0.008 | 0.5 | |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0046 | 0.0259 | 0.018 |
Mycobacterium ulcerans | lipase LipU | 0.0022 | 0.008 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.