Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0319 | 0.3438 | 0.3438 |
Onchocerca volvulus | 0.0319 | 0.3438 | 0.3438 | |
Mycobacterium ulcerans | lipoprotein LppD | 0.0037 | 0.0231 | 0.5 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0017 | 0.0005 | 0.0005 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0319 | 0.3438 | 0.3438 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0319 | 0.3438 | 0.3438 |
Brugia malayi | Appr-1-p processing enzyme family protein | 0.0037 | 0.0231 | 0.0231 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0037 | 0.0231 | 1 |
Onchocerca volvulus | 0.0017 | 0.0005 | 0.0005 | |
Leishmania major | hypothetical protein, conserved | 0.0319 | 0.3438 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0017 | 0.0005 | 0.0014 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0897 | 1 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0319 | 0.3438 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0319 | 0.3438 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0037 | 0.0231 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0319 | 0.3438 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0017 | 0.0005 | 0.0005 |
Plasmodium falciparum | zinc finger Ran-binding domain-containing protein 2, putative | 0.0319 | 0.3438 | 0.3438 |
Loa Loa (eye worm) | brahma associated protein | 0.0897 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0005 | 0.0005 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Schistosoma mansoni | brg-1 associated factor | 0.0897 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0017 | 0.0005 | 0.0014 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0017 | 0.0005 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.3438 | 0.3438 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0037 | 0.0231 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0897 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Schistosoma mansoni | fusion | 0.0319 | 0.3438 | 0.3438 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0319 | 0.3438 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | ctsf protein | 0.0017 | 0.0005 | 0.0005 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0005 | 0.0005 |
Plasmodium falciparum | Appr-1-p processing domain protein | 0.0037 | 0.0231 | 0.0231 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0319 | 0.3438 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Onchocerca volvulus | 0.0017 | 0.0005 | 0.0005 | |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0005 | 0.0005 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0319 | 0.3438 | 0.3438 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0897 | 1 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0017 | 0.0005 | 0.0014 |
Leishmania major | cathepsin L-like protease | 0.0017 | 0.0005 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.3438 | 0.3438 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Onchocerca volvulus | 0.0319 | 0.3438 | 0.3438 | |
Echinococcus granulosus | ring and YY1 binding protein | 0.0319 | 0.3438 | 0.3438 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0017 | 0.0005 | 0.0014 |
Schistosoma mansoni | hypothetical protein | 0.0897 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.3438 | 0.3438 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Trypanosoma brucei | Macro domain containing protein, putative | 0.0037 | 0.0231 | 0.0671 |
Toxoplasma gondii | cathepsin CPL | 0.0017 | 0.0005 | 0.0005 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Plasmodium vivax | vivapain-2 | 0.0017 | 0.0005 | 0.0005 |
Brugia malayi | YY1-associated factor 2 | 0.0319 | 0.3438 | 0.3438 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0017 | 0.0005 | 0.0005 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.0037 | 0.0231 | 0.0231 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0005 | 0.0005 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.0037 | 0.0231 | 0.0231 |
Leishmania major | hypothetical protein, conserved | 0.0319 | 0.3438 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Giardia lamblia | Protein LRP16 | 0.0037 | 0.0231 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0897 | 1 | 1 |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.0319 | 0.3438 | 0.3438 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0319 | 0.3438 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0017 | 0.0005 | 0.0005 |
Toxoplasma gondii | ran binding protein | 0.0319 | 0.3438 | 0.3438 |
Leishmania major | cathepsin L-like protease | 0.0017 | 0.0005 | 0.0014 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.0037 | 0.0231 | 0.0231 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0319 | 0.3438 | 0.3438 |
Onchocerca volvulus | 0.0017 | 0.0005 | 0.0005 | |
Echinococcus granulosus | cathepsin l1 | 0.0017 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.3438 | 0.3438 |
Leishmania major | cysteine peptidase A (CPA) | 0.0017 | 0.0005 | 0.0014 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0897 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0897 | 1 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0897 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0005 | 0.0005 |
Echinococcus granulosus | MACRO domain containing protein 2 | 0.0037 | 0.0231 | 0.0231 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0319 | 0.3438 | 0.3438 |
Trypanosoma cruzi | Macro domain containing protein, putative | 0.0037 | 0.0231 | 0.0671 |
Schistosoma mansoni | RNA binding protein | 0.0319 | 0.3438 | 0.3438 |
Leishmania major | cathepsin L-like protease | 0.0017 | 0.0005 | 0.0014 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0897 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0319 | 0.3438 | 0.3438 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0005 | 0.0005 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0319 | 0.3438 | 0.3438 |
Leishmania major | cathepsin L-like protease | 0.0017 | 0.0005 | 0.0014 |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0005 | 0.0005 |
Leishmania major | cathepsin L-like protease | 0.0017 | 0.0005 | 0.0014 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0319 | 0.3438 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0017 | 0.0005 | 0.0014 |
Onchocerca volvulus | 0.0017 | 0.0005 | 0.0005 | |
Onchocerca volvulus | 0.0319 | 0.3438 | 0.3438 | |
Loa Loa (eye worm) | cysteine protease | 0.0017 | 0.0005 | 0.0005 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0319 | 0.3438 | 0.3438 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0319 | 0.3438 | 1 |
Onchocerca volvulus | 0.0017 | 0.0005 | 0.0005 | |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0319 | 0.3438 | 0.3438 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0017 | 0.0005 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0231 | 0.0231 |
Schistosoma mansoni | zinc finger protein | 0.0319 | 0.3438 | 0.3438 |
Echinococcus multilocularis | MACRO domain containing protein 2 | 0.0037 | 0.0231 | 0.0231 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0897 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0017 | 0.0005 | 0.0014 |
Onchocerca volvulus | 0.0897 | 1 | 1 | |
Echinococcus multilocularis | MACRO domain containing protein 2 | 0.0037 | 0.0231 | 0.0231 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0319 | 0.3438 | 0.3438 |
Mycobacterium tuberculosis | Possible lipoprotein LppD | 0.0037 | 0.0231 | 0.5 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0319 | 0.3438 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Echinococcus granulosus | MACRO domain containing protein 2 | 0.0037 | 0.0231 | 0.0231 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0017 | 0.0005 | 0.0014 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0319 | 0.3438 | 0.3438 |
Onchocerca volvulus | 0.0017 | 0.0005 | 0.0005 | |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0897 | 1 | 1 |
Onchocerca volvulus | 0.0319 | 0.3438 | 0.3438 | |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0897 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0231 | 0.0231 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0017 | 0.0005 | 0.0213 |
Leishmania major | hypothetical protein, conserved | 0.0319 | 0.3438 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0897 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0005 | 0.0005 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0231 | 0.0231 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0017 | 0.0005 | 0.0014 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Schistosoma mansoni | hypothetical protein | 0.0897 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0017 | 0.0005 | 0.0005 |
Plasmodium vivax | vivapain-2 | 0.0017 | 0.0005 | 0.0005 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Onchocerca volvulus | Cathepsin L homolog | 0.0017 | 0.0005 | 0.0005 |
Leishmania major | hypothetical protein, conserved | 0.0319 | 0.3438 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0017 | 0.0005 | 0.0005 |
Onchocerca volvulus | Cathepsin F homolog | 0.0017 | 0.0005 | 0.0005 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0005 | 0.0005 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0319 | 0.3438 | 1 |
Leishmania major | cathepsin L-like protease | 0.0017 | 0.0005 | 0.0014 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0017 | 0.0005 | 0.0005 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0319 | 0.3438 | 0.3438 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0017 | 0.0005 | 0.0014 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0897 | 1 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0897 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0017 | 0.0005 | 0.0014 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0319 | 0.3438 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0005 | 0.0005 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Onchocerca volvulus | 0.0017 | 0.0005 | 0.0005 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Toxoplasma gondii | macro domain-containing protein | 0.0037 | 0.0231 | 0.0231 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0017 | 0.0005 | 0.0014 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0017 | 0.0005 | 0.0014 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0319 | 0.3438 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0017 | 0.0005 | 0.0005 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0017 | 0.0005 | 0.0014 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0231 | 0.0231 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0005 | 0.0005 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0897 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0005 | 0.0005 |
Plasmodium vivax | hypothetical protein, conserved | 0.0897 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0017 | 0.0005 | 0.0213 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0017 | 0.0005 | 0.0213 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0017 | 0.0005 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.3438 | 0.3438 |
Leishmania major | hypothetical protein, conserved | 0.0319 | 0.3438 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0017 | 0.0005 | 0.0014 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0319 | 0.3438 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0897 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0017 | 0.0005 | 0.0014 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0319 | 0.3438 | 0.3438 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0005 | 0.0005 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0319 | 0.3438 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0897 | 1 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.0897 | 1 | 0.5 |
Trypanosoma cruzi | Macro domain containing protein, putative | 0.0037 | 0.0231 | 0.0671 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0005 | 0.0005 |
Onchocerca volvulus | Cathepsin L homolog | 0.0017 | 0.0005 | 0.0005 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.796 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.776 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.758 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.752 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.744 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.737 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.724 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.696 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.629 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.566 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.545 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.