Detailed information for compound 1606391

Basic information

Technical information
  • TDR Targets ID: 1606391
  • Name: [[7-(3,4-dimethoxyphenyl)-6,7-dihydro-5H-benz o[f][1,3]benzodioxol-8-ylidene]amino] acetate
  • MW: 383.395 | Formula: C21H21NO6
  • H donors: 0 H acceptors: 1 LogP: 3.84 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)C1CCc2c(/C/1=N/OC(=O)C)cc1c(c2)OCO1
  • InChi: 1S/C21H21NO6/c1-12(23)28-22-21-15(13-5-7-17(24-2)18(8-13)25-3)6-4-14-9-19-20(10-16(14)21)27-11-26-19/h5,7-10,15H,4,6,11H2,1-3H3/b22-21+
  • InChiKey: ZLNILMHQBVKPMC-QURGRASLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • acetic acid [[7-(3,4-dimethoxyphenyl)-6,7-dihydro-5H-benzo[f][1,3]benzodioxol-8-ylidene]amino] ester
  • [[7-(3,4-dimethoxyphenyl)-6,7-dihydro-5H-benzo[f][1,3]benzodioxol-8-ylidene]amino] ethanoate
  • 54785-15-8
  • 6-(3,4-Dimethoxyphenyl)-7,8-dihydronaphtho(2,3-d)(1,3)dioxol-5(6H)-one O-acetyloxime
  • NSC 162497
  • 6-(3,4-Dimethoxyphenyl)-7,8-dihydronaphtho[2,3-d][1,3]dioxol-5(6H)-one O-acetyloxime
  • AIDS-127431
  • AIDS127431
  • NSC162497

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Leishmania major cathepsin L-like protease 0.0023 0.0066 0.0044
Schistosoma mansoni RNA binding protein 0.0416 0.3472 0.3472
Schistosoma mansoni hypothetical protein 0.0019 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Giardia lamblia Kinase 0.0021 0.0051 0.5
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0021 0.0051 0.0018
Entamoeba histolytica cysteine protease, putative 0.0023 0.0066 1
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0416 0.3472 0.3472
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0224 0.0224
Giardia lamblia Kinase, NEK 0.0021 0.0051 0.5
Leishmania major hypothetical protein, conserved 0.0416 0.3472 1
Schistosoma mansoni hypothetical protein 0.1169 1 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0416 0.3472 1
Trichomonas vaginalis hypothetical protein 0.0021 0.0051 0.0051
Leishmania major cathepsin L-like protease 0.0023 0.0066 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0066 0.0066
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0066 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0066 0.0189
Onchocerca volvulus 0.0021 0.0051 0.0051
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0416 0.3472 0.3472
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0021 0.0051 0.0051
Echinococcus granulosus cathepsin l1 0.0023 0.0066 0.0066
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.1169 1 1
Brugia malayi Cathepsin L-like precursor 0.0023 0.0066 0.0066
Echinococcus multilocularis ring and YY1 binding protein 0.0416 0.3472 0.3451
Echinococcus multilocularis SWI:SNF matrix associated 0.1169 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0066 0.0044
Echinococcus multilocularis 0.0021 0.0051 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Entamoeba histolytica zinc finger domain containing protein 0.0021 0.0051 0.7729
Schistosoma mansoni hypothetical protein 0.0019 0.0032 0.0032
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Brugia malayi Cathepsin L-like precursor 0.0023 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0019 0.0032 0.0032
Toxoplasma gondii ran binding protein 0.0416 0.3472 0.3438
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Brugia malayi brahma associated protein 60 kDa 0.1169 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0066 0.0066
Echinococcus granulosus zinc finger protein Ran binding 0.0416 0.3472 0.3472
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0021 0.0051 0.0018
Brugia malayi Cathepsin L-like precursor 0.0023 0.0066 0.0066
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Giardia lamblia E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B 0.0021 0.0051 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Onchocerca volvulus 0.0023 0.0066 0.0066
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0051 0.0146
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0389 0.0389
Trypanosoma cruzi WLM domain containing protein, putative 0.0416 0.3472 1
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0416 0.3472 1
Leishmania major hypothetical protein, conserved 0.0416 0.3472 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0389 0.0389
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Giardia lamblia Hypothetical protein 0.0021 0.0051 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.1169 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0051 0.0146
Onchocerca volvulus 0.0023 0.0066 0.0066
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0416 0.3472 1
Entamoeba histolytica zinc finger domain containing protein 0.0021 0.0051 0.7729
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0051
Onchocerca volvulus RING finger protein 141 homolog 0.0021 0.0051 0.0051
Brugia malayi hypothetical protein 0.0021 0.0051 0.0051
Giardia lamblia Hypothetical protein 0.0021 0.0051 0.5
Entamoeba histolytica zinc finger domain containing protein 0.0021 0.0051 0.7729
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Leishmania major cathepsin L-like protease 0.0023 0.0066 0.0044
Onchocerca volvulus 0.0416 0.3472 0.3472
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.1169 1 1
Brugia malayi hypothetical protein 0.0021 0.0051 0.0051
Giardia lamblia Ribonuclease 0.0021 0.0051 0.5
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0416 0.3472 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0051 0.0146
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0066 0.0189
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0051 0.0146
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0416 0.3472 0.3472
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0066 0.0189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0066 0.0044
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Trypanosoma cruzi hypothetical protein 0.0021 0.0051 0.0146
Plasmodium falciparum cysteine proteinase falcipain 3 0.0023 0.0066 0.0015
Entamoeba histolytica hypothetical protein 0.0021 0.0051 0.7729
Onchocerca volvulus 0.0023 0.0066 0.0066
Leishmania major cathepsin L-like protease 0.0023 0.0066 0.0044
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0389 0.0389
Leishmania major cathepsin L-like protease 0.0023 0.0066 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0066 0.0066
Loa Loa (eye worm) fibroinase 0.0023 0.0066 0.0066
Echinococcus multilocularis RING finger protein 185 0.0021 0.0051 0.0018
Schistosoma mansoni hypothetical protein 0.0019 0.0032 0.0032
Onchocerca volvulus 0.0416 0.3472 0.3472
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0066 0.0044
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0416 0.3472 1
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0066 0.0189
Echinococcus multilocularis cysteine protease 0.0023 0.0066 0.0033
Echinococcus multilocularis zinc finger protein Ran binding 0.0416 0.3472 0.3451
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Brugia malayi hypothetical protein 0.0021 0.0051 0.0051
Brugia malayi Cathepsin L-like precursor 0.0023 0.0066 0.0066
Echinococcus granulosus GPCR family 2 0.0019 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Onchocerca volvulus 0.1169 1 1
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Echinococcus granulosus ring and YY1 binding protein 0.0416 0.3472 0.3472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0021 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0416 0.3472 0.3472
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Onchocerca volvulus 0.0021 0.0051 0.0051
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0066 0.0066
Echinococcus granulosus ring finger protein 170 0.0021 0.0051 0.0051
Entamoeba histolytica zinc finger domain containing protein 0.0021 0.0051 0.7729
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0066 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0066 0.0044
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0021 0.0051 0.0146
Brugia malayi Zinc finger protein 183 homolog 0.0021 0.0051 0.0051
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0021 0.0051 0.0051
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1169 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Onchocerca volvulus Protein neuralized homolog 0.0021 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Schistosoma mansoni ring finger protein 151 0.0021 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0066 0.0066
Entamoeba histolytica hypothetical protein 0.0021 0.0051 0.7729
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.0066 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0066 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Echinococcus granulosus cathepsin L cysteine proteinase 0.0023 0.0066 0.0066
Giardia lamblia Hypothetical protein 0.0021 0.0051 0.5
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0021 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Brugia malayi hypothetical protein 0.0021 0.0051 0.0051
Leishmania major cathepsin L-like protease 0.0023 0.0066 0.0044
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0021 0.0051 0.0051
Schistosoma mansoni zinc finger protein 0.0416 0.3472 0.3472
Loa Loa (eye worm) RiNg Finger protein family member 0.0021 0.0051 0.0051
Giardia lamblia Kinase, NEK 0.0021 0.0051 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0416 0.3472 1
Trypanosoma cruzi hypothetical protein 0.0021 0.0051 0.0146
Chlamydia trachomatis DNA topoisomerase I 0.1169 1 0.5
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0021 0.0051 0.0051
Trichomonas vaginalis ion channel nompc, putative 0.0021 0.0051 0.0051
Onchocerca volvulus 0.0021 0.0051 0.0051
Onchocerca volvulus 0.0023 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.1169 1 1
Giardia lamblia Ser/Thr protein kinase 0.0021 0.0051 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0032 0.0032
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.0066 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0051
Trypanosoma brucei hypothetical protein, conserved 0.0416 0.3472 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0066 0.0066
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0416 0.3472 1
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Loa Loa (eye worm) hypothetical protein 0.0041 0.0224 0.0224
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Loa Loa (eye worm) ctsf protein 0.0023 0.0066 0.0066
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0416 0.3472 0.3472
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0021 0.0051 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0051 0.0146
Giardia lamblia Zinc finger domain 0.0021 0.0051 0.5
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Schistosoma mansoni hypothetical protein 0.0416 0.3472 0.3472
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0021 0.0051 0.0051
Trypanosoma brucei hypothetical protein, conserved 0.0416 0.3472 1
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0021 0.0051 0.0051
Trypanosoma cruzi WLM domain containing protein, putative 0.0416 0.3472 1
Trichomonas vaginalis ankyrin, putative 0.0021 0.0051 0.0051
Echinococcus granulosus Upstream activation factor subunit UAF30 0.1169 1 1
Onchocerca volvulus Cathepsin L homolog 0.0023 0.0066 0.0066
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0416 0.3472 0.3472
Schistosoma mansoni hypothetical protein 0.0021 0.0051 0.0051
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0032 0.0032
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0066 0.0044
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.1169 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0416 0.3472 1
Schistosoma mansoni brg-1 associated factor 0.1169 1 1
Toxoplasma gondii cathepsin CPL 0.0023 0.0066 0.0015
Echinococcus granulosus cathepsin l cysteine peptidase 0.0023 0.0066 0.0066
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0021 0.0051 0.0018
Entamoeba histolytica zinc finger domain containing protein 0.0021 0.0051 0.7729
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0023 0.0066 0.0066
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0021 0.0051 0.0051
Brugia malayi Cathepsin L-like precursor 0.0023 0.0066 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0066 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0066 0.0066
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0416 0.3472 0.3451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0066 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0021 0.0051 0.0018
Schistosoma mansoni rnf5 0.0021 0.0051 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0051 0.0051
Brugia malayi Neuralized family protein 0.0021 0.0051 0.0051
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0021 0.0051 0.0051
Giardia lamblia Hypothetical protein 0.0021 0.0051 0.5
Leishmania major cathepsin L-like protease 0.0023 0.0066 0.0044
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0021 0.0051 0.0051
Schistosoma mansoni mind bomb 0.0021 0.0051 0.0051
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0021 0.0051 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0051 0.0146
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0066
Giardia lamblia Hypothetical protein 0.0021 0.0051 0.5
Echinococcus granulosus Zinc finger RanBP2 type 0.0416 0.3472 0.3472
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0066 0.0066
Leishmania major cysteine peptidase A (CPA) 0.0023 0.0066 0.0044
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0066 0.0066
Plasmodium vivax vivapain-2 0.0023 0.0066 0.0015
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.1169 1 1
Brugia malayi B-box zinc finger family protein 0.0021 0.0051 0.0051
Onchocerca volvulus Cathepsin L homolog 0.0023 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0416 0.3472 0.3472
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0416 0.3472 0.3472
Entamoeba histolytica zinc finger domain containing protein 0.0021 0.0051 0.7729
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.0066 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0021 0.0051 0.0051
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0021 0.0051 0.0051
Onchocerca volvulus 0.0021 0.0051 0.0051
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0066 0.0066
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0051
Brugia malayi Cathepsin L-like precursor 0.0023 0.0066 0.0066
Schistosoma mansoni peter pan-related 0.0021 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0416 0.3472 0.3472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0066 0.0066
Onchocerca volvulus Cathepsin F homolog 0.0023 0.0066 0.0066
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0416 0.3472 0.3438
Schistosoma mansoni hypothetical protein 0.0041 0.0224 0.0224
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0021 0.0051 0.0051
Brugia malayi hypothetical protein 0.0021 0.0051 0.0051
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0416 0.3472 0.3451
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Echinococcus multilocularis cysteine protease 0.0023 0.0066 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Echinococcus granulosus RING finger protein 185 0.0021 0.0051 0.0051
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Brugia malayi Zinc finger, C2H2 type family protein 0.0021 0.0051 0.0051
Echinococcus granulosus cell growth regulator with ring finger domain 0.0021 0.0051 0.0051
Loa Loa (eye worm) brahma associated protein 0.1169 1 1
Giardia lamblia Hypothetical protein 0.0021 0.0051 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0032 0.0032
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0416 0.3472 0.3438
Trichomonas vaginalis ankyrin, putative 0.0021 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0416 0.3472 0.3472
Entamoeba histolytica SPRY domain protein 0.0021 0.0051 0.7729
Schistosoma mansoni hypothetical protein 0.1169 1 1
Brugia malayi RING finger protein 20 0.0021 0.0051 0.0051
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0032 0.0032
Plasmodium vivax vivapain-2 0.0023 0.0066 0.0015
Brugia malayi SWIB/MDM2 domain containing protein 0.1169 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0066 0.0066
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Leishmania major hypothetical protein, conserved 0.0416 0.3472 1
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Brugia malayi hypothetical protein 0.0021 0.0051 0.0051
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Onchocerca volvulus 0.0023 0.0066 0.0066
Schistosoma mansoni zinc finger protein 0.0021 0.0051 0.0051
Giardia lamblia Zinc finger domain 0.0021 0.0051 0.5
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Giardia lamblia Hypothetical protein 0.0021 0.0051 0.5
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0051
Schistosoma mansoni fusion 0.0416 0.3472 0.3472
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Onchocerca volvulus 0.0416 0.3472 0.3472
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0066 0.0066
Schistosoma mansoni peter pan-related 0.0021 0.0051 0.0051
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0021 0.0051 0.0051
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1169 1 1
Onchocerca volvulus 0.0023 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0066 0.0066
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0021 0.0051 0.0146
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0066 0.0066
Echinococcus multilocularis SWI:SNF matrix associated 0.1169 1 1
Onchocerca volvulus 0.0416 0.3472 0.3472
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0066 0.0066
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.0066 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0066 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0066 0.0066
Chlamydia trachomatis SWIB complex protein 0.1169 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0416 0.3472 0.3472
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0416 0.3472 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.1169 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0023 0.0066 0.0066
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0066 0.0044
Brugia malayi RING zinc finger protein 0.0021 0.0051 0.0051
Leishmania major hypothetical protein, conserved 0.0416 0.3472 1
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0021 0.0051 0.0051
Onchocerca volvulus 0.0021 0.0051 0.0051
Onchocerca volvulus Putative RING finger protein 207 0.0021 0.0051 0.0051
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0021 0.0051 0.0051
Echinococcus granulosus ring finger protein 113a 0.0021 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Echinococcus multilocularis ring finger protein 170 0.0021 0.0051 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0021 0.0051 0.0051
Trichomonas vaginalis ankyrin, putative 0.0021 0.0051 0.0051
Trypanosoma cruzi cruzipain precursor, putative 0.0023 0.0066 0.0189
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0389 0.0389
Brugia malayi YY1-associated factor 2 0.0416 0.3472 0.3472
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Leishmania major cathepsin L-like protease 0.0023 0.0066 0.0044
Plasmodium vivax hypothetical protein, conserved 0.1169 1 1
Entamoeba histolytica zinc finger domain containing protein 0.0021 0.0051 0.7729
Schistosoma mansoni TRABID protein (C64 family) 0.0416 0.3472 0.3472
Trypanosoma cruzi hypothetical protein, conserved 0.0416 0.3472 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0066 0.0066
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.0051
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0032 0.0032
Onchocerca volvulus 0.0023 0.0066 0.0066
Loa Loa (eye worm) RING finger protein 20 0.0021 0.0051 0.0051
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0066 1
Echinococcus granulosus SWI:SNF matrix associated 0.1169 1 1
Echinococcus multilocularis SWI:SNF matrix associated 0.1169 1 1
Loa Loa (eye worm) cysteine protease 0.0023 0.0066 0.0066
Echinococcus multilocularis ring finger protein 113a 0.0021 0.0051 0.0018
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0023 0.0066 0.0015
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.0066 0.0033
Entamoeba histolytica zinc finger domain containing protein 0.0021 0.0051 0.7729
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0021 0.0051 0.0146
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0051 0.0146
Giardia lamblia Protein 21.1 0.0021 0.0051 0.5
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0023 0.0066 0.0015
Leishmania major hypothetical protein, conserved 0.0416 0.3472 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0066 0.0066
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0021 0.0051 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0066 0.0066
Onchocerca volvulus 0.0021 0.0051 0.0051

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.063 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.983 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.764 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.746 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.697 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.637 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.57 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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