Detailed information for compound 1606399

Basic information

Technical information
  • TDR Targets ID: 1606399
  • Name: N-(1-pyrimidin-4-ylethylideneamino)-1,3-benzo thiazol-2-amine
  • MW: 269.325 | Formula: C13H11N5S
  • H donors: 1 H acceptors: 3 LogP: 3.16 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C(=N\Nc1nc2c(s1)cccc2)/c1ccncn1
  • InChi: 1S/C13H11N5S/c1-9(10-6-7-14-8-15-10)17-18-13-16-11-4-2-3-5-12(11)19-13/h2-8H,1H3,(H,16,18)/b17-9+
  • InChiKey: ZMEIUSLAHMLILY-RQZCQDPDSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[1-(4-pyrimidinyl)ethylideneamino]-1,3-benzothiazol-2-amine
  • 1,3-benzothiazol-2-yl-(1-pyrimidin-4-ylethylideneamino)amine
  • NSC693632
  • NCI60_033528
  • NCIChal_000042
  • NCIMech_000097

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Brugia malayi hypothetical protein 0.0043 0.0658 0.0658
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0189 0.0189
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.0189 0.0189
Brugia malayi brahma associated protein 60 kDa 0.0389 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni biogenic amine receptor 0.0026 0.0189 0.0189
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0026 0.0189 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Brugia malayi neuropeptide F receptor 0.0026 0.0189 0.0189
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0138 0.3225 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Brugia malayi Dopamine receptor protein 2 0.0026 0.0189 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0189 0.0189
Echinococcus granulosus g-protein coupled receptor 0.0026 0.0189 0.0189
Brugia malayi neuropeptide F receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0189 0.0189
Echinococcus granulosus g protein coupled receptor 0.0026 0.0189 0.0189
Schistosoma mansoni amine GPCR 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Brugia malayi RE15519p 0.0026 0.0189 0.0189
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.0189 0.0189
Echinococcus granulosus geminin 0.0205 0.5014 0.5014
Echinococcus multilocularis geminin 0.0205 0.5014 0.5014
Brugia malayi sulfakinin receptor protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0389 1 1
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0138 0.3225 0.3225
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0189 0.0189
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0138 0.3225 0.3225
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0658 0.0658
Brugia malayi SWIB/MDM2 domain containing protein 0.0389 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0189 0.0189
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0307 0.0307
Echinococcus granulosus g protein coupled receptor 0.0026 0.0189 0.0189
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0189 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0389 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Leishmania major hypothetical protein, conserved 0.0138 0.3225 1
Leishmania major hypothetical protein, conserved 0.0138 0.3225 1
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Trypanosoma brucei hypothetical protein, conserved 0.0138 0.3225 1
Brugia malayi G-protein coupled receptor 0.0026 0.0189 0.0189
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Onchocerca volvulus 0.0389 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0138 0.3225 0.3225
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0189 0.0189
Plasmodium vivax hypothetical protein, conserved 0.0389 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0189 0.0189
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.0189 0.0189
Brugia malayi larval opioid receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0138 0.3225 0.3225
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Brugia malayi Serotonin receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0138 0.3225 0.3225
Loa Loa (eye worm) hypothetical protein 0.003 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0189 0.0189
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.0189 0.0189
Echinococcus granulosus SWI:SNF matrix associated 0.0389 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Brugia malayi Dopamine receptor protein 1 0.0026 0.0189 0.0189
Loa Loa (eye worm) brahma associated protein 0.0389 1 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.3225 0.3225
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0189 0.0189
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.338 0.338
Brugia malayi hypothetical protein 0.003 0.0307 0.0307
Echinococcus granulosus hypothetical protein 0.0026 0.0189 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Chlamydia trachomatis SWIB complex protein 0.0389 1 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis allatostatin A receptor 0.0026 0.0189 0.0189
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0 0.5
Brugia malayi GnHR receptor homolog 0.0026 0.0189 0.0189
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.3225 1
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Entamoeba histolytica hypothetical protein 0.0043 0.0658 0.5
Brugia malayi ORL1-like opioid receptor 0.0026 0.0189 0.0189
Brugia malayi YY1-associated factor 2 0.0138 0.3225 0.3225
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0138 0.3225 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Entamoeba histolytica hypothetical protein 0.0043 0.0658 0.5
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0138 0.3225 0.3225
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus granulosus neuropeptide receptor 0.0026 0.0189 0.0189
Onchocerca volvulus 0.0138 0.3225 0.3095
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0026 0.0189 0.0189
Echinococcus granulosus orexin receptor type 2 0.0026 0.0189 0.0189
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0189 0.0189
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0389 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.0189 0.0189
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0043 0.0658 0.0658
Schistosoma mansoni hypothetical protein 0.0205 0.5014 0.5014
Schistosoma mansoni hypothetical protein 0.0026 0.0189 0.0189
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0307 0.0307
Echinococcus granulosus zinc finger protein Ran binding 0.0138 0.3225 0.3225
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.0189 0.0189
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0189 0.0189
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0189 0.0189
Brugia malayi AKH receptor 0.0026 0.0189 0.0189
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0307 0.0952
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni histamine h1 receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0189 0.0189
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0189 0.0189
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0189 0.0189
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus granulosus serotonin receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Echinococcus multilocularis serotonin receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.0189 0.0189
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0189 0.0189
Brugia malayi putative neuropeptide receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0138 0.3225 0.3225
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0389 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.0189 0.0189
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Brugia malayi G-protein coupled receptor 0.0026 0.0189 0.0189
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0307 0.0952
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0389 1 1
Schistosoma mansoni zinc finger protein 0.0138 0.3225 0.3225
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0138 0.3225 0.3095
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0189 0.0189
Schistosoma mansoni adenoreceptor 0.0026 0.0189 0.0189
Schistosoma mansoni neuropeptide receptor 0.0026 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0389 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Entamoeba histolytica hypothetical protein 0.0043 0.0658 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Trypanosoma cruzi WLM domain containing protein, putative 0.0138 0.3225 1
Schistosoma mansoni brg-1 associated factor 0.0389 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni amine GPCR 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0189 0.0189
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.0189 0.0189
Leishmania major hypothetical protein, conserved 0.0138 0.3225 1
Onchocerca volvulus 0.0138 0.3225 0.3095
Schistosoma mansoni opsin-like receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0026 0.0189 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0189 0.0189
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0138 0.3225 1
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0189 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0138 0.3225 0.3225
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Schistosoma mansoni neuropeptide receptor 0.0026 0.0189 0.0189
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0138 0.3225 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.0189 0.0189
Trypanosoma cruzi WLM domain containing protein, putative 0.0138 0.3225 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0189 0.0189
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0189 0.0189
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0138 0.3225 0.3225
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.0189 0.0189
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis orexin receptor type 2 0.0026 0.0189 0.0189
Echinococcus granulosus g protein coupled receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.0189 0.0189
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0138 0.3225 0.3225
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis SWI:SNF matrix associated 0.0389 1 1
Echinococcus granulosus fmrfamide receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0138 0.3225 0.3225
Schistosoma mansoni amine GPCR 0.0026 0.0189 0.0189
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.0189 0.0189
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.0189 0.0189
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0307 0.0307
Schistosoma mansoni opsin-like receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis SWI:SNF matrix associated 0.0389 1 1
Schistosoma mansoni neuropeptide receptor 0.0026 0.0189 0.0189
Brugia malayi Dopamine receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0389 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Schistosoma mansoni amine GPCR 0.0026 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0026 0.0189 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.0189 0.0189
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.0189 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.0189 0.0189
Echinococcus granulosus sex peptide receptor 0.0026 0.0189 0.0189
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0189 0.0189
Echinococcus multilocularis neuropeptide receptor A26 0.0026 0.0189 0.0189
Echinococcus granulosus allatostatin A receptor 0.0026 0.0189 0.0189
Entamoeba histolytica hypothetical protein 0.0043 0.0658 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.0189 0.0189
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0189 0.0189
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0138 0.3225 0.3225
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.0189 0.0189
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0189 0.0189
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0189 0.0189
Schistosoma mansoni myosin xvIII 0.0026 0.0189 0.0189
Brugia malayi Melatonin receptor type 1A 0.0026 0.0189 0.0189
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.0189 0.0189
Brugia malayi follicle stimulating hormone receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis ring and YY1 binding protein 0.0138 0.3225 0.3225
Brugia malayi G protein-coupled receptor 0.0026 0.0189 0.0189
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0189 0.0189
Schistosoma mansoni fusion 0.0138 0.3225 0.3225
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis serotonin receptor 0.0026 0.0189 0.0189
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0138 0.3225 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0389 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Toxoplasma gondii ran binding protein 0.0138 0.3225 0.3225
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0189 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0189 0.0189
Schistosoma mansoni amine GPCR 0.0026 0.0189 0.0189
Schistosoma mansoni opsin-like receptor 0.0026 0.0189 0.0189
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0138 0.3225 1
Schistosoma mansoni RNA binding protein 0.0138 0.3225 0.3225
Schistosoma mansoni neuropeptide receptor 0.0026 0.0189 0.0189
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0138 0.3225 0.3225
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.338 0.338
Echinococcus granulosus neuropeptide receptor 0.0026 0.0189 0.0189
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.0189 0.0189
Leishmania major hypothetical protein, conserved 0.003 0.0307 0.0952
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.0189 0.0189
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0189 0.0189
Echinococcus granulosus somatostatin receptor 0.0026 0.0189 0.0189
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0389 1 1
Echinococcus multilocularis zinc finger protein Ran binding 0.0138 0.3225 0.3225
Brugia malayi Serotonin receptor 0.0026 0.0189 0.0189
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0307 0.0952
Onchocerca volvulus 0.0138 0.3225 0.3095
Echinococcus multilocularis sex peptide receptor 0.0026 0.0189 0.0189
Trypanosoma brucei hypothetical protein, conserved 0.0138 0.3225 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0189 0.0189
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.3225 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0189 0.0189
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0189 0.0189
Echinococcus multilocularis SWI:SNF matrix associated 0.0389 1 1
Leishmania major hypothetical protein, conserved 0.0138 0.3225 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0189 0.0189
Echinococcus multilocularis somatostatin receptor 0.0026 0.0189 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Schistosoma mansoni biogenic amine receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0189 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0189 0.0189
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.0189 0.0189
Echinococcus granulosus Zinc finger RanBP2 type 0.0138 0.3225 0.3225
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0189 0.0189
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0189 0.0189
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0189 0.0189
Schistosoma mansoni biogenic amine receptor 0.0026 0.0189 0.0189
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0189 0.0189
Chlamydia trachomatis DNA topoisomerase I 0.0389 1 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni TRABID protein (C64 family) 0.0138 0.3225 0.3225
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.0189 0.0189
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0138 0.3225 0.3225
Brugia malayi MH2 domain containing protein 0.0144 0.338 0.338
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0189 0.0189
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0658 0.0658
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Onchocerca volvulus 0.0138 0.3225 0.3095
Schistosoma mansoni hypothetical protein 0.0389 1 1
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0205 0.5014 0.5014
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0658 0.0658
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.3225 1
Leishmania major hypothetical protein, conserved 0.0138 0.3225 1
Brugia malayi hypothetical protein 0.002 0.0015 0.0015
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0307 0.0307
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0189 0.0189
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0189 0.0189
Echinococcus granulosus ring and YY1 binding protein 0.0138 0.3225 0.3225
Echinococcus granulosus neuropeptide s receptor 0.0026 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0389 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0189 0.0189
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0138 0.3225 1
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0389 1 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -7.172 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.421 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.412 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.252 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.207 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.152 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.088 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.857 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.451 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.025 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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