Detailed information for compound 1606884

Basic information

Technical information
  • TDR Targets ID: 1606884
  • Name: 2,4-dimethyl-7-piperazin-1-yl-1,8-naphthyridi ne
  • MW: 242.32 | Formula: C14H18N4
  • H donors: 1 H acceptors: 2 LogP: 2.02 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)c2c(n1)nc(cc2)N1CCNCC1
  • InChi: 1S/C14H18N4/c1-10-9-11(2)16-14-12(10)3-4-13(17-14)18-7-5-15-6-8-18/h3-4,9,15H,5-8H2,1-2H3
  • InChiKey: YRGOAYZJMMYXBM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,4-dimethyl-7-(1-piperazinyl)-1,8-naphthyridine
  • AIDS150484
  • NSC687679
  • NCI60_031599
  • 2,4-Dimethyl-7-(1-piperazinyl)[1,8]naphthyridine
  • AIDS-150484

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0577 0.3257 0.3257
Schistosoma mansoni vam6/vps39 related 0.0115 0.0275 0.0275
Echinococcus granulosus poly (ADP ribose) polymerase 0.0212 0.0902 0.0902
Loa Loa (eye worm) hypothetical protein 0.0577 0.3257 0.3257
Loa Loa (eye worm) hypothetical protein 0.0115 0.0275 0.0275
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0185 0.073 0.073
Echinococcus multilocularis SWI:SNF matrix associated 0.1621 1 1
Leishmania major hypothetical protein, conserved 0.0577 0.3257 1
Loa Loa (eye worm) hypothetical protein 0.0749 0.4371 0.4371
Loa Loa (eye worm) tnks protein 0.0101 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0577 0.3257 0.3257
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0537 0.3003 0.3003
Schistosoma mansoni cellular tumor antigen P53 0.0199 0.082 0.082
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0648 0.3718 0.3718
Echinococcus multilocularis tumor protein p63 0.1361 0.8317 0.8317
Echinococcus granulosus tumor protein p63 0.1361 0.8317 0.8317
Loa Loa (eye worm) hypothetical protein 0.0251 0.1157 0.1157
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0577 0.3257 0.7453
Schistosoma mansoni RNA binding protein 0.0577 0.3257 0.3257
Trypanosoma cruzi hypothetical protein, conserved 0.0577 0.3257 0.7453
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0115 0.0275 0.0275
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1621 1 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0105 0.0212 0.0212
Brugia malayi Temporarily assigned gene name protein 59 0.0115 0.0275 0.0275
Echinococcus granulosus SWI:SNF matrix associated 0.1621 1 1
Loa Loa (eye worm) hypothetical protein 0.0577 0.3257 0.3257
Echinococcus granulosus tankyrase 0.0101 0.0187 0.0187
Echinococcus multilocularis SWI:SNF matrix associated 0.1621 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0212 0.0212
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0577 0.3257 0.3257
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0313 0.1554 0.1554
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0577 0.3257 0.3257
Schistosoma mansoni brg-1 associated factor 0.1621 1 1
Onchocerca volvulus 0.0577 0.3257 0.3129
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0185 0.073 0.073
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0371 0.1928 0.1928
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.1621 1 1
Schistosoma mansoni fusion 0.0577 0.3257 0.3257
Brugia malayi Protein kinase domain containing protein 0.0105 0.0212 0.0212
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0185 0.073 0.0553
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0298 0.0298
Onchocerca volvulus 0.0577 0.3257 0.3129
Echinococcus granulosus poly (ADP ribose) polymerase 0.0212 0.0902 0.0902
Schistosoma mansoni hypothetical protein 0.0115 0.0275 0.0275
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0105 0.0212 0.0486
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0115 0.0275 0.063
Echinococcus multilocularis ring and YY1 binding protein 0.0577 0.3257 0.3257
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0185 0.073 0.073
Brugia malayi Protein kinase domain containing protein 0.0185 0.073 0.073
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1621 1 1
Plasmodium vivax hypothetical protein, conserved 0.1621 1 1
Leishmania major hypothetical protein, conserved 0.0577 0.3257 1
Entamoeba histolytica protein kinase, putative 0.0105 0.0212 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0187 0.0187
Schistosoma mansoni protein kinase 0.014 0.0439 0.0439
Schistosoma mansoni zinc finger protein 0.0577 0.3257 0.3257
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0118 0.0298 0.0298
Trypanosoma brucei hypothetical protein, conserved 0.0577 0.3257 0.7453
Brugia malayi probable protein kinase 0.0255 0.118 0.118
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0577 0.3257 0.3257
Onchocerca volvulus 0.0199 0.082 0.0645
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0577 0.3257 0.3257
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0105 0.0212 0.0486
Trypanosoma brucei DNA repair protein, putative 0.0105 0.0212 0.0486
Echinococcus multilocularis tankyrase 0.0101 0.0187 0.0187
Echinococcus multilocularis 0.014 0.0439 0.0439
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0118 0.0298 0.0298
Chlamydia trachomatis SWIB complex protein 0.1621 1 0.5
Onchocerca volvulus 0.0115 0.0275 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0187 0.0187
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.1187 0.1187
Schistosoma mansoni TRABID protein (C64 family) 0.0577 0.3257 0.3257
Trypanosoma cruzi WLM domain containing protein, putative 0.0577 0.3257 0.7453
Loa Loa (eye worm) hypothetical protein 0.0577 0.3257 0.3257
Leishmania major hypothetical protein, conserved 0.0105 0.0212 0.0652
Echinococcus granulosus Upstream activation factor subunit UAF30 0.1621 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0187 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0199 0.082 0.082
Echinococcus granulosus zinc finger protein Ran binding 0.0577 0.3257 0.3257
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0187 0.0187
Echinococcus granulosus WGR domain containing protein 0.0424 0.2269 0.2269
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.1621 1 1
Chlamydia trachomatis DNA topoisomerase I 0.1621 1 0.5
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0185 0.073 0.073
Onchocerca volvulus DNA ligase 3 homolog 0.0105 0.0212 0.0026
Schistosoma mansoni hypothetical protein 0.1621 1 1
Brugia malayi Tnks protein 0.0101 0.0187 0.0187
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0251 0.1157 0.1157
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0749 0.4371 0.4371
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.1621 1 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0577 0.3257 0.3257
Brugia malayi Protein kinase domain containing protein 0.0371 0.1928 0.1928
Echinococcus granulosus Zinc finger RanBP2 type 0.0577 0.3257 0.3257
Trypanosoma cruzi WLM domain containing protein, putative 0.0577 0.3257 0.7453
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0187 0.0187
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0577 0.3257 0.3257
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0577 0.3257 0.7453
Trypanosoma brucei poly(adp-ribose) polymerase 0.0749 0.4371 1
Brugia malayi WGR domain containing protein 0.0749 0.4371 0.4371
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0577 0.3257 0.3129
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0371 0.1928 0.1928
Entamoeba histolytica hypothetical protein 0.0212 0.0902 0.1095
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.014 0.0439 0.0439
Toxoplasma gondii ran binding protein 0.0577 0.3257 0.3257
Schistosoma mansoni poly [ADP-ribose] polymerase 0.1112 0.671 0.671
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0577 0.3257 0.7453
Brugia malayi SWIB/MDM2 domain containing protein 0.1621 1 1
Echinococcus multilocularis dual specificity 0.0105 0.0212 0.0212
Schistosoma mansoni rap gtpase-activating protein 0.0115 0.0275 0.0275
Echinococcus granulosus dual specificity 0.0105 0.0212 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0187 0.0187
Onchocerca volvulus 0.0577 0.3257 0.3129
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0577 0.3257 0.7453
Echinococcus granulosus protein kinase 0.014 0.0439 0.0439
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0115 0.0275 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.1621 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0577 0.3257 0.7453
Echinococcus granulosus poly (ADP ribose) polymerase 0.0212 0.0902 0.0902
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0475 0.2598 0.2598
Brugia malayi YY1-associated factor 2 0.0577 0.3257 0.3257
Loa Loa (eye worm) hypothetical protein 0.0105 0.0212 0.0212
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0115 0.0275 0.0275
Schistosoma mansoni serine/threonine protein kinase 0.0185 0.073 0.073
Echinococcus multilocularis zinc finger protein Ran binding 0.0577 0.3257 0.3257
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0102 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0786 0.4608 0.4608
Loa Loa (eye worm) brahma associated protein 0.1621 1 1
Entamoeba histolytica hypothetical protein 0.0105 0.0212 0.0039
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0577 0.3257 0.7453
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0105 0.0212 0.0486
Onchocerca volvulus 0.1621 1 1
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0577 0.3257 0.7453
Brugia malayi WGR domain containing protein 0.1112 0.671 0.671
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0105 0.0212 0.0486
Brugia malayi hypothetical protein 0.0115 0.0275 0.0275
Schistosoma mansoni protein kinase 0.0371 0.1928 0.1928
Giardia lamblia Kinase, CMGC CLK 0.0072 0 0.5
Leishmania major hypothetical protein, conserved 0.0577 0.3257 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0577 0.3257 0.3257
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.1621 1 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0118 0.0298 0.0298
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0577 0.3257 0.3257
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0749 0.4371 0.4371
Loa Loa (eye worm) hypothetical protein 0.0115 0.0275 0.0275
Entamoeba histolytica protein kinase, putative 0.0105 0.0212 0.0039
Trypanosoma brucei hypothetical protein, conserved 0.0577 0.3257 0.7453
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0118 0.0298 0.0298
Leishmania major hypothetical protein, conserved 0.0577 0.3257 1
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0187 0.0187
Onchocerca volvulus 0.0577 0.3257 0.3129
Trypanosoma cruzi hypothetical protein, conserved 0.0577 0.3257 0.7453
Echinococcus granulosus ring and YY1 binding protein 0.0577 0.3257 0.3257
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.1143 0.6913 0.6913
Schistosoma mansoni hypothetical protein 0.1621 1 1
Trypanosoma cruzi DNA repair protein, putative 0.0105 0.0212 0.0486
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0105 0.0212 0.0486
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.1112 0.671 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.0275 0.0275
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0577 0.3257 0.3257
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.1621 1 1
Leishmania major DNA repair protein, putative 0.0105 0.0212 0.0652
Brugia malayi brahma associated protein 60 kDa 0.1621 1 1
Schistosoma mansoni hypothetical protein 0.1621 1 1
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0105 0.0212 0.0652
Schistosoma mansoni hypothetical protein 0.0577 0.3257 0.3257
Schistosoma mansoni protein kinase 0.0255 0.118 0.118
Loa Loa (eye worm) hypothetical protein 0.0102 0.019 0.019
Echinococcus granulosus poly (ADP ribose) polymerase 0.0424 0.2269 0.2269
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0749 0.4371 1
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0115 0.0275 0.0275
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0185 0.073 0.073
Schistosoma mansoni tankyrase 0.0101 0.0187 0.0187
Echinococcus multilocularis SWI:SNF matrix associated 0.1621 1 1
Echinococcus granulosus Vam6:Vps39 protein 0.0115 0.0275 0.0275
Echinococcus granulosus poly adp ribose polymerase 2 0.0749 0.4371 0.4371
Leishmania major hypothetical protein, conserved 0.0577 0.3257 1
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0115 0.0275 0.063
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0577 0.3257 0.7453
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.1112 0.671 0.671
Echinococcus granulosus poly ADP ribose polymerase 1 0.1112 0.671 0.671
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0115 0.0275 0.063
Entamoeba histolytica protein kinase domain containing protein 0.0105 0.0212 0.0039
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0371 0.1928 0.1928
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0749 0.4371 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.38 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.254 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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