Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.145 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.145 | 1 | 0.5 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0516 | 0.3074 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0516 | 0.3074 | 1 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0516 | 0.3074 | 0.2886 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0516 | 0.3074 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0333 | 0.1721 | 0.1721 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 0.3074 | 0.2681 |
Schistosoma mansoni | hypothetical protein | 0.0516 | 0.3074 | 0.247 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.145 | 1 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0516 | 0.3074 | 0.2267 |
Schistosoma mansoni | brg-1 associated factor | 0.145 | 1 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0242 | 0.1045 | 0.0263 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0516 | 0.3074 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.08 | 0.0277 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0516 | 0.3074 | 1 |
Schistosoma mansoni | hypothetical protein | 0.145 | 1 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0314 | 0.158 | 0.0845 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0242 | 0.1045 | 0.1045 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0516 | 0.3074 | 0.2267 |
Leishmania major | hypothetical protein, conserved | 0.0516 | 0.3074 | 0.5 |
Schistosoma mansoni | fusion | 0.0516 | 0.3074 | 0.247 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0516 | 0.3074 | 0.2886 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.1045 | 0.0536 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 0.3074 | 0.2681 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0314 | 0.158 | 0.158 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0516 | 0.3074 | 0.3074 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0516 | 0.3074 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0516 | 0.3074 | 0.2267 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0516 | 0.3074 | 1 |
Schistosoma mansoni | hypothetical protein | 0.145 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0516 | 0.3074 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0516 | 0.3074 | 1 |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.0516 | 0.3074 | 0.1729 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0314 | 0.158 | 0.1351 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.145 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 0.3074 | 0.2681 |
Leishmania major | hypothetical protein, conserved | 0.0516 | 0.3074 | 0.5 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.145 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.145 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0516 | 0.3074 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.145 | 1 | 1 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0242 | 0.1045 | 0.0801 |
Trichomonas vaginalis | conserved hypothetical protein | 0.145 | 1 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0516 | 0.3074 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.145 | 1 | 1 |
Brugia malayi | WGR domain containing protein | 0.0314 | 0.158 | 0.0597 |
Leishmania major | hypothetical protein, conserved | 0.0516 | 0.3074 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0516 | 0.3074 | 0.247 |
Chlamydia trachomatis | SWIB complex protein | 0.145 | 1 | 0.5 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0314 | 0.158 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0516 | 0.3074 | 0.5 |
Loa Loa (eye worm) | brahma associated protein | 0.145 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.145 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.145 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0516 | 0.3074 | 1 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0516 | 0.3074 | 0.247 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.145 | 1 | 1 |
Onchocerca volvulus | 0.145 | 1 | 1 | |
Schistosoma mansoni | RNA binding protein | 0.0516 | 0.3074 | 0.247 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0516 | 0.3074 | 0.3074 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.145 | 1 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0333 | 0.1721 | 0.1495 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0516 | 0.3074 | 0.2267 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0516 | 0.3074 | 0.3074 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0516 | 0.3074 | 1 |
Toxoplasma gondii | ran binding protein | 0.0516 | 0.3074 | 0.1729 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.145 | 1 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.145 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.145 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 0.3074 | 0.2681 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0516 | 0.3074 | 0.2886 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0516 | 0.3074 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.145 | 1 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0516 | 0.3074 | 0.2267 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0516 | 0.3074 | 1 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0516 | 0.3074 | 0.2886 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.145 | 1 | 1 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0516 | 0.3074 | 0.3074 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 0.3074 | 0.2681 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.879 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.718 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.345 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.283 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.209 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.206 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.199 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.963 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.