Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.014 | 0.0282 | 0.684 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.015 | 0.0307 | 0.0999 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.014 | 0.0282 | 0.684 |
Schistosoma mansoni | protein kinase | 0.1197 | 0.2933 | 0.2933 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.1183 | 0.2897 | 0.2897 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0189 | 0.0403 | 0.1334 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0051 | 0.0057 | 0.0976 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.014 | 0.0282 | 0.684 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0063 | 0.0088 | 0.1803 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0019 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0019 | 0.0019 |
Echinococcus granulosus | serine:threonine protein kinase SMG1 | 0.0036 | 0.0019 | 0.0019 |
Brugia malayi | hypothetical protein | 0.1183 | 0.2897 | 0.2897 |
Echinococcus granulosus | protein kinase | 0.2831 | 0.7033 | 0.7058 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.1197 | 0.2933 | 0.327 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0189 | 0.0403 | 0.1334 |
Schistosoma mansoni | fkbp-rapamycin associated protein | 0.0036 | 0.0019 | 0.0019 |
Echinococcus granulosus | serine:threonine protein kinase mig 15 | 0.3999 | 0.9964 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0034 | 0.0015 | 0.0015 |
Echinococcus multilocularis | tumor protein p63 | 0.0715 | 0.1723 | 0.1921 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0063 | 0.0088 | 0.0089 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0036 | 0.0019 | 0.0019 |
Giardia lamblia | GTOR | 0.0189 | 0.0403 | 0.5 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0078 | 0.0126 | 0.0372 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0034 | 0.0015 | 0.0015 |
Onchocerca volvulus | 0.0105 | 0.0192 | 0.0664 | |
Schistosoma mansoni | smad1 5 8 and | 0.0034 | 0.0015 | 0.0015 |
Schistosoma mansoni | vam6/vps39 related | 0.1183 | 0.2897 | 0.2897 |
Echinococcus granulosus | serine protein kinase ATM | 0.0036 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.3999 | 0.9964 | 1 |
Brugia malayi | Temporarily assigned gene name protein 59 | 0.1183 | 0.2897 | 0.2897 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0112 | 0.021 | 0.4963 |
Schistosoma mansoni | hypothetical protein | 0.1183 | 0.2897 | 0.2897 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0029 | 0.003 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.014 | 0.0282 | 0.684 |
Toxoplasma gondii | non-specific serine/threonine protein kinase | 0.004 | 0.0029 | 0.039 |
Echinococcus granulosus | tumor protein p63 | 0.0715 | 0.1723 | 0.173 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0019 | 0.0019 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0102 | 0.0185 | 0.4327 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0161 | 0.0334 | 0.8197 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.015 | 0.0306 | 0.7477 |
Entamoeba histolytica | hypothetical protein | 0.0149 | 0.0302 | 0.7378 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0102 | 0.0185 | 0.4327 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0149 | 0.0302 | 0.0304 |
Brugia malayi | Protein kinase domain containing protein | 0.1197 | 0.2933 | 0.2933 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0102 | 0.0185 | 0.4327 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.0103 | 0.0103 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0189 | 0.0403 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0113 | 0.0213 | 0.5037 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0149 | 0.0302 | 0.0302 |
Echinococcus granulosus | GTPase activating Rap:RanGAP domain 3 | 0.1183 | 0.2897 | 0.2908 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0063 | 0.0088 | 0.0241 |
Echinococcus multilocularis | GTPase activating Rap:RanGAP domain 3 | 0.1183 | 0.2897 | 0.323 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.014 | 0.0282 | 0.684 |
Trypanosoma brucei | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.1183 | 0.2897 | 1 |
Echinococcus granulosus | Smad4 | 0.0034 | 0.0015 | 0.0015 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0189 | 0.0403 | 1 |
Loa Loa (eye worm) | STE/STE20/KHS protein kinase | 0.1197 | 0.2933 | 0.2944 |
Schistosoma mansoni | smad1 5 8 and | 0.0034 | 0.0015 | 0.0015 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0036 | 0.0019 | 0.0019 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0063 | 0.0088 | 0.1803 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.3603 | 0.897 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.015 | 0.0306 | 0.7477 |
Echinococcus multilocularis | serine:threonine protein kinase SMG1 | 0.0036 | 0.0019 | 0.0021 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.015 | 0.0306 | 0.7477 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.0103 | 0.0104 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.006 | 0.006 |
Loa Loa (eye worm) | STE/STE20/MSN protein kinase | 0.2831 | 0.7033 | 0.7058 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0189 | 0.0403 | 0.1334 |
Schistosoma mansoni | smad | 0.0034 | 0.0015 | 0.0015 |
Echinococcus multilocularis | smad | 0.0034 | 0.0015 | 0.0017 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.1183 | 0.2897 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0034 | 0.0015 | 0.0015 |
Entamoeba histolytica | hypothetical protein | 0.0149 | 0.0302 | 0.7378 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.0103 | 0.0104 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0105 | 0.0192 | 0.0192 |
Schistosoma mansoni | smad1 5 8 and | 0.0034 | 0.0015 | 0.0015 |
Echinococcus granulosus | Vam6:Vps39 protein | 0.1183 | 0.2897 | 0.2908 |
Brugia malayi | hypothetical protein | 0.0149 | 0.0302 | 0.0302 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0019 | 0.0019 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0102 | 0.0185 | 0.4316 |
Brugia malayi | MH2 domain containing protein | 0.0034 | 0.0015 | 0.0015 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.0302 | 0.0302 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.1197 | 0.2933 | 0.2944 |
Schistosoma mansoni | Smad4 | 0.0034 | 0.0015 | 0.0015 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.015 | 0.0307 | 0.0999 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0113 | 0.0213 | 0.5037 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0189 | 0.0403 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0063 | 0.0088 | 0.1803 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0499 | 0.1183 | 0.1187 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1197 | 0.2933 | 0.2933 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0063 | 0.0088 | 0.1803 |
Echinococcus multilocularis | Smad4 | 0.0034 | 0.0015 | 0.0017 |
Entamoeba histolytica | hypothetical protein | 0.0149 | 0.0302 | 0.7378 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0034 | 0.0015 | 0.0017 |
Schistosoma mansoni | rap gtpase-activating protein | 0.1183 | 0.2897 | 0.2897 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.1197 | 0.2933 | 0.327 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.0063 | 0.0088 | 0.0089 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0189 | 0.0403 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0063 | 0.0088 | 0.0241 |
Echinococcus multilocularis | 0.2831 | 0.7033 | 0.784 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0063 | 0.0088 | 0.1803 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0113 | 0.0213 | 0.5037 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0103 | 0.0103 |
Entamoeba histolytica | hypothetical protein | 0.0149 | 0.0302 | 0.7378 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0089 | 0.0154 | 0.0467 |
Loa Loa (eye worm) | Smad1 | 0.0034 | 0.0015 | 0.0015 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0127 | 0.0247 | 0.594 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0034 | 0.0015 | 0.0015 |
Brugia malayi | MH1 domain containing protein | 0.0034 | 0.0015 | 0.0015 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.006 | 0.006 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0102 | 0.0185 | 0.4327 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0189 | 0.0403 | 0.0403 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0034 | 0.0015 | 0.0015 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.015 | 0.0307 | 0.6934 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0189 | 0.0403 | 0.1334 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.0103 | 0.0103 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.1197 | 0.2933 | 0.2944 |
Schistosoma mansoni | protein kinase | 0.2831 | 0.7033 | 0.7033 |
Loa Loa (eye worm) | hypothetical protein | 0.1183 | 0.2897 | 0.2908 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0192 | 0.0193 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0034 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.0103 | 0.0104 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.015 | 0.0306 | 0.7477 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0103 | 0.0103 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.1183 | 0.2897 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1197 | 0.2933 | 0.2933 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0063 | 0.0088 | 0.0241 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.006 | 0.006 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0103 | 0.0103 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0189 | 0.0403 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0063 | 0.0088 | 0.0088 |
Echinococcus multilocularis | serine protein kinase ATM | 0.0036 | 0.0019 | 0.0021 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0189 | 0.0403 | 0.0449 |
Onchocerca volvulus | 0.1183 | 0.2897 | 1 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0112 | 0.021 | 0.4963 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0189 | 0.0403 | 1 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.014 | 0.0282 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.1197 | 0.2933 | 0.327 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0189 | 0.0403 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.014 | 0.0282 | 0.684 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0149 | 0.0302 | 0.0337 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.1197 | 0.2933 | 0.2944 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0036 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.1183 | 0.2897 | 0.2908 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.1183 | 0.2897 | 0.2897 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.0103 | 0.0104 |
Brugia malayi | MH2 domain containing protein | 0.0499 | 0.1183 | 0.1183 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0103 | 0.0103 |
Schistosoma mansoni | protein kinase | 0.4014 | 1 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0189 | 0.0403 | 0.0405 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0026 | 0.0026 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0123 | 0.0237 | 0.5673 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0034 | 0.0015 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.1183 | 0.2897 | 0.2908 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0034 | 0.0015 | 0.0015 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0189 | 0.0403 | 0.0405 |
Echinococcus granulosus | microtubule associated protein 2 | 0.3603 | 0.897 | 0.9002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0499 | 0.1183 | 0.1187 |
Schistosoma mansoni | microtubule-associated protein tau | 0.3603 | 0.897 | 0.897 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0102 | 0.0185 | 0.4316 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.014 | 0.0282 | 0.684 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0102 | 0.0185 | 0.4316 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0189 | 0.0403 | 0.0403 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.0063 | 0.0088 | 0.0088 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.0103 | 0.0115 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.0063 | 0.0088 | 0.0241 |
Brugia malayi | Smad1 | 0.0034 | 0.0015 | 0.0015 |
Brugia malayi | RNA binding protein | 0.0069 | 0.0103 | 0.0103 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.015 | 0.0306 | 0.7477 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.0063 | 0.0088 | 0.0099 |
Echinococcus granulosus | smad | 0.0034 | 0.0015 | 0.0015 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.0029 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.006 | 0.006 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.698 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.617 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.568 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.555 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.49 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.471 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.464 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.424 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.345 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.294 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.282 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.