Detailed information for compound 1608380

Basic information

Technical information
  • TDR Targets ID: 1608380
  • Name: ethyl 8-methoxy-2-phenylimidazo[3,2-a]pyrazin e-3-carboxylate
  • MW: 297.309 | Formula: C16H15N3O3
  • H donors: 0 H acceptors: 3 LogP: 3.21 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(nc2n1ccnc2OC)c1ccccc1
  • InChi: 1S/C16H15N3O3/c1-3-22-16(20)13-12(11-7-5-4-6-8-11)18-14-15(21-2)17-9-10-19(13)14/h4-10H,3H2,1-2H3
  • InChiKey: UMVSNCJSEKJWAG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ethyl 8-methoxy-2-phenyl-imidazo[3,2-a]pyrazine-3-carboxylate
  • 8-methoxy-2-phenyl-3-imidazo[3,2-a]pyrazinecarboxylic acid ethyl ester
  • 8-methoxy-2-phenyl-imidazo[3,2-a]pyrazine-3-carboxylic acid ethyl ester
  • NCI60_025016
  • AIDS-145683
  • AIDS145683
  • Ethyl 8-methoxy-2-phenylimidazo[1,2-a]pyrazine-3-carboxylate
  • NSC670997

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0134 0.0401 0.1393
Brugia malayi intermediate filament protein 0.0026 0.0004 0.0004
Echinococcus granulosus lamin dm0 0.0026 0.0004 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0817 0.2917 0.2917
Trypanosoma cruzi target of rapamycin kinase 3 0.0107 0.03 0.1043
Loa Loa (eye worm) hypothetical protein 0.273 0.9964 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0007
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0045 0.0072 0.0072
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0107 0.03 0.6934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.03 0.7477
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0106 0.0296 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0329 0.8197
Entamoeba histolytica hypothetical protein 0.0106 0.0296 0.7367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0173 0.4316
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0817 0.2917 0.2921
Brugia malayi hypothetical protein 0.0106 0.0296 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0202 0.5037
Loa Loa (eye worm) hypothetical protein 0.0807 0.2881 0.2891
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0045 0.0072 0.0251
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0146 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0173 0.4316
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0134 0.0401 0.1393
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0807 0.2881 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0275 0.684
Loa Loa (eye worm) hypothetical protein 0.0807 0.2881 0.2891
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0202 0.5037
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0107 0.03 0.1043
Loa Loa (eye worm) MH2 domain-containing protein 0.0357 0.122 0.1224
Loa Loa (eye worm) phosphatidylinositol 3 0.0134 0.0401 0.0403
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0045 0.0072 0.0251
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0817 0.2917 0.2921
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0807 0.2881 0.2885
Echinococcus granulosus protein kinase 0.1933 0.7026 0.7036
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0134 0.0401 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0056 0.0112 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0072 0.1803
Entamoeba histolytica hypothetical protein 0.0106 0.0296 0.7367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0174 0.4327
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0146 0.0146
Echinococcus granulosus lamin 0.0026 0.0004 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0146 0.0146
Brugia malayi hypothetical protein 0.0807 0.2881 0.2881
Schistosoma mansoni hypothetical protein 0.0106 0.0296 0.0296
Schistosoma mansoni protein kinase 0.0817 0.2917 0.2917
Entamoeba histolytica hypothetical protein 0.0106 0.0296 0.7367
Brugia malayi Protein kinase domain containing protein 0.0817 0.2917 0.2917
Echinococcus multilocularis 0.1933 0.7026 0.7036
Schistosoma mansoni microtubule-associated protein tau 0.2736 0.9985 0.9985
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0134 0.0401 0.1393
Schistosoma mansoni intermediate filament proteins 0.0026 0.0004 0.0004
Echinococcus multilocularis musashi 0.0026 0.0004 0.0004
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0086 0.0086
Brugia malayi MH2 domain containing protein 0.0357 0.122 0.122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0174 0.4327
Brugia malayi TAR-binding protein 0.0065 0.0146 0.0146
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0134 0.0401 1
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0817 0.2917 0.2921
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0807 0.2881 0.2881
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0134 0.0401 0.0402
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0275 0.684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.03 0.7477
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0275 0.684
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0045 0.0072 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0275 0.684
Echinococcus multilocularis lamin dm0 0.0026 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0039 0.0976
Onchocerca volvulus 0.0807 0.2881 1
Echinococcus granulosus intermediate filament protein 0.0026 0.0004 0.0004
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0033 0.0029 0.0029
Loa Loa (eye worm) transcription factor SMAD2 0.0357 0.122 0.1224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0173 0.4316
Schistosoma mansoni lamin 0.0026 0.0004 0.0004
Schistosoma mansoni vam6/vps39 related 0.0807 0.2881 0.2881
Echinococcus multilocularis lamin 0.0026 0.0004 0.0004
Echinococcus multilocularis microtubule associated protein 2 0.2736 0.9985 1
Schistosoma mansoni rap gtpase-activating protein 0.0807 0.2881 0.2881
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0807 0.2881 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0199 0.4963
Loa Loa (eye worm) hypothetical protein 0.0033 0.0029 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0275 0.684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0199 0.4963
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.0401 1
Brugia malayi Temporarily assigned gene name protein 59 0.0807 0.2881 0.2881
Toxoplasma gondii target of rapamycin (TOR), putative 0.01 0.0275 1
Schistosoma mansoni serine/threonine protein kinase 0.0817 0.2917 0.2917
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0817 0.2917 0.2921
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0028 0.0011 0.039
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0134 0.0401 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0275 0.684
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0106 0.0296 0.0296
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0146 0.0146
Echinococcus granulosus Vam6:Vps39 protein 0.0807 0.2881 0.2885
Loa Loa (eye worm) hypothetical protein 0.0807 0.2881 0.2891
Echinococcus multilocularis tumor protein p63 0.0347 0.1185 0.1187
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0064 0.014 0.0488
Loa Loa (eye worm) hypothetical protein 0.0049 0.0086 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0072 0.1803
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0134 0.0401 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0146 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0011 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.0401 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0045 0.0072 0.0072
Echinococcus granulosus tar DNA binding protein 0.0065 0.0146 0.0146
Giardia lamblia GTOR 0.0134 0.0401 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0072 0.1803
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0086 0.0086
Schistosoma mansoni lamin 0.0026 0.0004 0.0004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.03 0.7477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0072 0.1803
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0004 0.0004
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0029 0.0029
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.0228 0.5673
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0807 0.2881 0.2885
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.0401 1
Schistosoma mansoni protein kinase 0.274 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0011 0.0011
Echinococcus granulosus tumor protein p63 0.0347 0.1185 0.1187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0174 0.4327
Echinococcus granulosus microtubule associated protein 2 0.2736 0.9985 1
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0094 0.0094
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0134 0.0401 0.1393
Echinococcus granulosus serine:threonine protein kinase mig 15 0.273 0.9964 0.9978
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0275 0.684
Brugia malayi RNA binding protein 0.0065 0.0146 0.0146
Schistosoma mansoni protein kinase 0.1933 0.7026 0.7026
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0045 0.0072 0.0251
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0072 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0238 0.594
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0202 0.5037
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0146 0.0146
Entamoeba histolytica hypothetical protein 0.0106 0.0296 0.7367
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0146 0.0147
Loa Loa (eye worm) RNA binding protein 0.0065 0.0146 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0072 0.1803
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0045 0.0072 0.0251
Schistosoma mansoni transcription factor LCR-F1 0.0106 0.0296 0.0296
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0817 0.2917 0.2921
Schistosoma mansoni hypothetical protein 0.0807 0.2881 0.2881
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0072 0.0072
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0134 0.0401 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0002 0.0002
Onchocerca volvulus 0.0051 0.0094 0.0313
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0807 0.2881 0.2881
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.1933 0.7026 0.7051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0174 0.4327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.03 0.7477
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0807 0.2881 1
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0146 0.0146
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0817 0.2917 0.2928
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0134 0.0401 0.0401
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.03 0.7477
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0134 0.0401 0.0402
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0146 0.0146
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0817 0.2917 0.2921

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.688 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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