Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0181 | 0.253 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0209 | 0.4722 |
Schistosoma mansoni | protein kinase | 0.0183 | 0.2563 | 0.2563 |
Echinococcus granulosus | Vam6:Vps39 protein | 0.0181 | 0.253 | 0.253 |
Brugia malayi | Protein kinase domain containing protein | 0.0183 | 0.2563 | 0.2811 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0044 | 0.0442 | 0.1749 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0035 | 0.0307 | 0.6934 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0272 | 0.6145 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0032 | 0.0272 | 0.5 |
Brugia malayi | hypothetical protein | 0.0035 | 0.031 | 0.034 |
Onchocerca volvulus | 0.0181 | 0.253 | 1 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0044 | 0.0442 | 1 |
Brugia malayi | probable protein kinase | 0.0613 | 0.912 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0175 | 0.3945 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0171 | 0.3855 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0044 | 0.0442 | 0.0442 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0306 | 0.6922 |
Echinococcus multilocularis | 0.0432 | 0.6367 | 0.6367 | |
Loa Loa (eye worm) | STE/STE20/KHS protein kinase | 0.0183 | 0.2563 | 0.2821 |
Echinococcus granulosus | protein kinase | 0.0432 | 0.6367 | 0.6367 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0136 | 0.3078 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0044 | 0.0442 | 0.0487 |
Brugia malayi | Temporarily assigned gene name protein 59 | 0.0181 | 0.253 | 0.2774 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0671 | 1 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0509 | 0.0509 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0044 | 0.0442 | 0.1749 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.031 | 0.031 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0181 | 0.253 | 0.253 |
Echinococcus granulosus | tumor protein p63 | 0.0328 | 0.4783 | 0.4783 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0272 | 0.6145 |
Echinococcus multilocularis | GTPase activating Rap:RanGAP domain 3 | 0.0181 | 0.253 | 0.253 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0181 | 0.253 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0136 | 0.3078 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0044 | 0.0442 | 0.1749 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0183 | 0.2563 | 0.2563 |
Schistosoma mansoni | protein kinase | 0.0432 | 0.6367 | 0.6367 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0136 | 0.3066 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0021 | 0.0092 | 0.0362 |
Echinococcus multilocularis | tumor protein p63 | 0.0328 | 0.4783 | 0.4783 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.253 | 0.253 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.253 | 0.2784 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0044 | 0.0442 | 0.1749 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0136 | 0.3078 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0306 | 0.6922 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0183 | 0.2563 | 0.2563 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0035 | 0.0307 | 0.1213 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0306 | 0.6922 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0044 | 0.0442 | 1 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0044 | 0.0442 | 0.0442 |
Schistosoma mansoni | rap gtpase-activating protein | 0.0181 | 0.253 | 0.253 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0181 | 0.253 | 0.253 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0272 | 0.6145 |
Trypanosoma brucei | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0181 | 0.253 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0306 | 0.6922 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0171 | 0.3855 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0018 | 0.0053 | 0.0211 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0044 | 0.0442 | 1 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0183 | 0.2563 | 0.2563 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0183 | 0.2563 | 0.2563 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0272 | 0.6145 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0509 | 0.0561 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0136 | 0.3066 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0044 | 0.0442 | 0.0485 |
Schistosoma mansoni | vam6/vps39 related | 0.0181 | 0.253 | 0.253 |
Brugia malayi | hypothetical protein | 0.0181 | 0.253 | 0.2774 |
Echinococcus granulosus | GTPase activating Rap:RanGAP domain 3 | 0.0181 | 0.253 | 0.253 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0035 | 0.0307 | 0.1213 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.1545 | 0.1695 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0183 | 0.2563 | 0.2563 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.031 | 0.031 |
Loa Loa (eye worm) | hypothetical protein | 0.0611 | 0.9086 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0272 | 0.6145 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0044 | 0.0442 | 0.0442 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0272 | 0.6145 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0136 | 0.3066 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0306 | 0.6922 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0044 | 0.0442 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0175 | 0.3945 |
Loa Loa (eye worm) | STE/STE20/MSN protein kinase | 0.0432 | 0.6367 | 0.7007 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.253 | 0.2784 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0183 | 0.2563 | 0.2563 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0044 | 0.0442 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0671 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0183 | 0.2563 | 0.2563 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0223 | 0.5047 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0272 | 0.6145 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.1545 | 0.1701 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0136 | 0.3078 |
Schistosoma mansoni | protein kinase | 0.0613 | 0.912 | 0.912 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.253 | 0.2784 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.031 | 0.031 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0044 | 0.0442 | 1 |
Echinococcus granulosus | serine:threonine protein kinase mig 15 | 0.0611 | 0.9086 | 0.9086 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0175 | 0.3945 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.031 | 0.031 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0044 | 0.0442 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.1545 | 0.1701 |
Giardia lamblia | GTOR | 0.0044 | 0.0442 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0183 | 0.2563 | 0.2563 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0345 | 0.78 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.517 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.315 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.217 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.