Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.0105 | 0.0115 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.0064 | 0.0088 | 0.0089 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0191 | 0.0406 | 0.0406 |
Brugia malayi | Smad1 | 0.0035 | 0.0015 | 0.0015 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.0064 | 0.0088 | 0.0088 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.0064 | 0.0088 | 0.0097 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0152 | 0.0309 | 0.6934 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0029 | 0.0029 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0035 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.1186 | 0.2896 | 0.2907 |
Echinococcus granulosus | Smad4 | 0.0035 | 0.0015 | 0.0015 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0124 | 0.0238 | 0.5673 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0026 | 0.0026 |
Schistosoma mansoni | protein kinase | 0.4024 | 1 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0191 | 0.0406 | 0.0407 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0035 | 0.0015 | 0.0015 |
Schistosoma mansoni | microtubule-associated protein tau | 0.3686 | 0.9155 | 0.9155 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0103 | 0.0186 | 0.4316 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0511 | 0.1207 | 0.1211 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0105 | 0.0105 |
Echinococcus granulosus | microtubule associated protein 2 | 0.3686 | 0.9155 | 0.9188 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0191 | 0.0406 | 0.0407 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0103 | 0.0186 | 0.4316 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0142 | 0.0284 | 0.684 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0191 | 0.0406 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0113 | 0.0211 | 0.4963 |
Onchocerca volvulus | 0.1186 | 0.2896 | 1 | |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.12 | 0.2932 | 0.3203 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0142 | 0.0284 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0036 | 0.0019 | 0.0019 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.12 | 0.2932 | 0.2943 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0152 | 0.0309 | 0.1008 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0142 | 0.0284 | 0.684 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0191 | 0.0406 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0105 | 0.0105 |
Brugia malayi | RNA binding protein | 0.0071 | 0.0105 | 0.0105 |
Brugia malayi | MH2 domain containing protein | 0.0511 | 0.1207 | 0.1207 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.1186 | 0.2896 | 0.2896 |
Loa Loa (eye worm) | hypothetical protein | 0.1186 | 0.2896 | 0.2907 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.0105 | 0.0106 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0191 | 0.0406 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0064 | 0.0088 | 0.0089 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0061 | 0.0061 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0191 | 0.0406 | 0.0443 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0036 | 0.0019 | 0.0019 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0064 | 0.0088 | 0.0243 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.0105 | 0.0106 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0035 | 0.0015 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0192 | 0.0193 |
Schistosoma mansoni | protein kinase | 0.2838 | 0.7032 | 0.7032 |
Loa Loa (eye worm) | hypothetical protein | 0.1186 | 0.2896 | 0.2907 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0152 | 0.0308 | 0.7477 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.1186 | 0.2896 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0105 | 0.0105 |
Schistosoma mansoni | serine/threonine protein kinase | 0.12 | 0.2932 | 0.2932 |
Entamoeba histolytica | hypothetical protein | 0.0152 | 0.0309 | 0.7488 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0035 | 0.0015 | 0.0015 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0191 | 0.0406 | 0.0406 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0191 | 0.0406 | 0.1346 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.0105 | 0.0106 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.12 | 0.2932 | 0.2943 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0064 | 0.0088 | 0.1803 |
Echinococcus multilocularis | 0.2838 | 0.7032 | 0.7682 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0064 | 0.0088 | 0.1803 |
Echinococcus multilocularis | smad | 0.0035 | 0.0015 | 0.0017 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0128 | 0.0249 | 0.594 |
Echinococcus granulosus | smad | 0.0035 | 0.0015 | 0.0015 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0152 | 0.0308 | 0.7477 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.009 | 0.0154 | 0.0471 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.0105 | 0.0106 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0114 | 0.0214 | 0.5037 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0103 | 0.0186 | 0.4327 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0061 | 0.0061 |
Brugia malayi | MH1 domain containing protein | 0.0035 | 0.0015 | 0.0015 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0035 | 0.0015 | 0.0015 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0152 | 0.0309 | 0.031 |
Echinococcus multilocularis | Smad4 | 0.0035 | 0.0015 | 0.0017 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0064 | 0.0088 | 0.1803 |
Schistosoma mansoni | rap gtpase-activating protein | 0.1186 | 0.2896 | 0.2896 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.12 | 0.2932 | 0.3203 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0064 | 0.0088 | 0.0088 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0191 | 0.0406 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0114 | 0.0214 | 0.5037 |
Brugia malayi | hypothetical protein | 0.0152 | 0.0309 | 0.0309 |
Schistosoma mansoni | serine/threonine protein kinase | 0.12 | 0.2932 | 0.2932 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0511 | 0.1207 | 0.1211 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0064 | 0.0088 | 0.1803 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0191 | 0.0406 | 1 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.1186 | 0.2896 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0035 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | STE/STE20/MSN protein kinase | 0.2838 | 0.7032 | 0.7058 |
Schistosoma mansoni | smad | 0.0035 | 0.0015 | 0.0015 |
Brugia malayi | MH2 domain containing protein | 0.0035 | 0.0015 | 0.0015 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0191 | 0.0406 | 0.1346 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0061 | 0.0061 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.0105 | 0.0105 |
Brugia malayi | MH1 domain containing protein | 0.0035 | 0.0015 | 0.0015 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0105 | 0.0192 | 0.0192 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0152 | 0.0308 | 0.7477 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0105 | 0.0105 |
Brugia malayi | MH2 domain containing protein | 0.0035 | 0.0015 | 0.0015 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0036 | 0.0019 | 0.0019 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0103 | 0.0186 | 0.4316 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.0309 | 0.0309 |
Echinococcus granulosus | Vam6:Vps39 protein | 0.1186 | 0.2896 | 0.2907 |
Loa Loa (eye worm) | Smad1 | 0.0035 | 0.0015 | 0.0015 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.12 | 0.2932 | 0.2943 |
Entamoeba histolytica | hypothetical protein | 0.0152 | 0.0309 | 0.7488 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0191 | 0.0406 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0035 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | STE/STE20/KHS protein kinase | 0.12 | 0.2932 | 0.2943 |
Schistosoma mansoni | smad1 5 8 and | 0.0035 | 0.0015 | 0.0015 |
Echinococcus multilocularis | serine:threonine protein kinase SMG1 | 0.0036 | 0.0019 | 0.002 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0152 | 0.0309 | 0.1008 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.3686 | 0.9155 | 1 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0064 | 0.0088 | 0.0243 |
Entamoeba histolytica | hypothetical protein | 0.0152 | 0.0309 | 0.7488 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0152 | 0.0309 | 0.0309 |
Entamoeba histolytica | hypothetical protein | 0.0152 | 0.0309 | 0.7488 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0163 | 0.0336 | 0.8197 |
Brugia malayi | Protein kinase domain containing protein | 0.12 | 0.2932 | 0.2932 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0103 | 0.0186 | 0.4327 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0152 | 0.0309 | 0.0337 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0064 | 0.0088 | 0.1803 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0114 | 0.0214 | 0.5037 |
Echinococcus granulosus | GTPase activating Rap:RanGAP domain 3 | 0.1186 | 0.2896 | 0.2907 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0152 | 0.0308 | 0.7477 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0191 | 0.0406 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0103 | 0.0186 | 0.4327 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0105 | 0.0105 |
Trypanosoma brucei | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.1186 | 0.2896 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0142 | 0.0284 | 0.684 |
Echinococcus multilocularis | GTPase activating Rap:RanGAP domain 3 | 0.1186 | 0.2896 | 0.3163 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.0029 | 0.0266 |
Echinococcus granulosus | tumor protein p63 | 0.0719 | 0.1729 | 0.1735 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0103 | 0.0186 | 0.4327 |
Echinococcus granulosus | serine protein kinase ATM | 0.0036 | 0.0019 | 0.0019 |
Schistosoma mansoni | vam6/vps39 related | 0.1186 | 0.2896 | 0.2896 |
Loa Loa (eye worm) | hypothetical protein | 0.401 | 0.9964 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0019 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.1186 | 0.2896 | 0.2896 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0113 | 0.0211 | 0.4963 |
Brugia malayi | Temporarily assigned gene name protein 59 | 0.1186 | 0.2896 | 0.2896 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0142 | 0.0284 | 0.684 |
Toxoplasma gondii | non-specific serine/threonine protein kinase | 0.004 | 0.0029 | 0.039 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.12 | 0.2932 | 0.3203 |
Echinococcus granulosus | protein kinase | 0.2838 | 0.7032 | 0.7058 |
Schistosoma mansoni | Smad4 | 0.0035 | 0.0015 | 0.0015 |
Echinococcus granulosus | serine:threonine protein kinase mig 15 | 0.401 | 0.9964 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0019 | 0.0019 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0191 | 0.0406 | 0.1346 |
Echinococcus multilocularis | serine protein kinase ATM | 0.0036 | 0.0019 | 0.002 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.0064 | 0.0088 | 0.0243 |
Echinococcus multilocularis | tumor protein p63 | 0.0719 | 0.1729 | 0.1888 |
Schistosoma mansoni | smad1 5 8 and | 0.0035 | 0.0015 | 0.0015 |
Onchocerca volvulus | 0.0105 | 0.0192 | 0.0662 | |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0035 | 0.0015 | 0.0017 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0079 | 0.0127 | 0.0376 |
Giardia lamblia | GTOR | 0.0191 | 0.0406 | 0.5 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0191 | 0.0406 | 0.1346 |
Schistosoma mansoni | protein kinase | 0.12 | 0.2932 | 0.2932 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.1186 | 0.2896 | 0.2896 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0142 | 0.0284 | 0.684 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0152 | 0.0308 | 0.7477 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0142 | 0.0284 | 0.684 |
Echinococcus granulosus | serine:threonine protein kinase SMG1 | 0.0036 | 0.0019 | 0.0019 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0142 | 0.0284 | 0.684 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0064 | 0.0088 | 0.0243 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0051 | 0.0056 | 0.0976 |
Brugia malayi | hypothetical protein | 0.1186 | 0.2896 | 0.2896 |
Schistosoma mansoni | fkbp-rapamycin associated protein | 0.0036 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0019 | 0.0019 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.531 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.436 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.357 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.233 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.092 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.