Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0153 | 0.0345 | 0.7477 |
Echinococcus multilocularis | serine:threonine protein kinase SMG1 | 0.0036 | 0.0023 | 0.0023 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0153 | 0.0345 | 0.7477 |
Loa Loa (eye worm) | hypothetical protein | 0.3643 | 0.9964 | 1 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0065 | 0.01 | 0.0271 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0036 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | STE/STE20/KHS protein kinase | 0.1091 | 0.2928 | 0.2939 |
Schistosoma mansoni | smad1 5 8 and | 0.0035 | 0.0017 | 0.0017 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0193 | 0.0453 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0035 | 0.0017 | 0.0018 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0143 | 0.0317 | 0.684 |
Trypanosoma brucei | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.1077 | 0.2892 | 1 |
Echinococcus multilocularis | GTPase activating Rap:RanGAP domain 3 | 0.1077 | 0.2892 | 0.2896 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0065 | 0.01 | 0.1803 |
Echinococcus granulosus | GTPase activating Rap:RanGAP domain 3 | 0.1077 | 0.2892 | 0.2896 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0151 | 0.0338 | 0.0338 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0115 | 0.024 | 0.5037 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0193 | 0.0453 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0114 | 0.0114 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0104 | 0.0209 | 0.4327 |
Brugia malayi | Protein kinase domain containing protein | 0.1091 | 0.2928 | 0.2928 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0104 | 0.0209 | 0.4327 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0151 | 0.0338 | 0.0339 |
Entamoeba histolytica | hypothetical protein | 0.0151 | 0.0338 | 0.7326 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0153 | 0.0345 | 0.7477 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0164 | 0.0376 | 0.8197 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1091 | 0.2928 | 0.2928 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0507 | 0.1319 | 0.1324 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0193 | 0.0453 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0065 | 0.01 | 0.1803 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0153 | 0.0345 | 0.1123 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0115 | 0.024 | 0.5037 |
Loa Loa (eye worm) | Smad1 | 0.0035 | 0.0017 | 0.0018 |
Schistosoma mansoni | protein kinase | 0.1091 | 0.2928 | 0.2928 |
Schistosoma mansoni | hypothetical protein | 0.0151 | 0.0338 | 0.0338 |
Brugia malayi | MH2 domain containing protein | 0.0035 | 0.0017 | 0.0017 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0104 | 0.0209 | 0.4316 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0036 | 0.0023 | 0.0023 |
Brugia malayi | hypothetical protein | 0.0151 | 0.0338 | 0.0338 |
Echinococcus granulosus | Vam6:Vps39 protein | 0.1077 | 0.2892 | 0.2896 |
Brugia malayi | MH1 domain containing protein | 0.0035 | 0.0017 | 0.0017 |
Entamoeba histolytica | hypothetical protein | 0.0151 | 0.0338 | 0.7326 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0109 | 0.0222 | 0.0222 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0114 | 0.0114 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.1077 | 0.2892 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0035 | 0.0017 | 0.0017 |
Echinococcus granulosus | protein kinase | 0.2579 | 0.703 | 0.704 |
Brugia malayi | MH2 domain containing protein | 0.0035 | 0.0017 | 0.0017 |
Schistosoma mansoni | smad | 0.0035 | 0.0017 | 0.0017 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0193 | 0.0453 | 0.15 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.0065 | 0.0976 |
Brugia malayi | TAR-binding protein | 0.007 | 0.0114 | 0.0114 |
Schistosoma mansoni | smad1 5 8 and | 0.0035 | 0.0017 | 0.0017 |
Onchocerca volvulus | 0.0109 | 0.0222 | 0.0769 | |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0035 | 0.0017 | 0.0018 |
Giardia lamblia | GTOR | 0.0193 | 0.0453 | 0.5 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.008 | 0.0143 | 0.0419 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0036 | 0.0023 | 0.0023 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.0065 | 0.01 | 0.0271 |
Echinococcus multilocularis | tumor protein p63 | 0.0744 | 0.1973 | 0.1975 |
Schistosoma mansoni | Smad4 | 0.0035 | 0.0017 | 0.0017 |
Echinococcus granulosus | microtubule associated protein 2 | 0.3651 | 0.9986 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.002 | 0.002 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0193 | 0.0453 | 0.15 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.1091 | 0.2928 | 0.2932 |
Echinococcus multilocularis | 0.2579 | 0.703 | 0.704 | |
Brugia malayi | hypothetical protein | 0.1077 | 0.2892 | 0.2892 |
Schistosoma mansoni | fkbp-rapamycin associated protein | 0.0036 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.002 | 0.0021 |
Echinococcus granulosus | serine:threonine protein kinase SMG1 | 0.0036 | 0.0023 | 0.0023 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0143 | 0.0317 | 0.684 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0065 | 0.01 | 0.0271 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0066 | 0.0066 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0193 | 0.0453 | 0.15 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.1077 | 0.2892 | 0.2892 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.1091 | 0.2928 | 0.2932 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0143 | 0.0317 | 0.684 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0153 | 0.0345 | 0.1123 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0143 | 0.0317 | 0.684 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0104 | 0.0209 | 0.4327 |
Echinococcus granulosus | serine protein kinase ATM | 0.0036 | 0.0023 | 0.0023 |
Echinococcus granulosus | tumor protein p63 | 0.0744 | 0.1973 | 0.1975 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0034 | 0.0034 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0143 | 0.0317 | 0.684 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0034 | 0.0266 |
Schistosoma mansoni | hypothetical protein | 0.1077 | 0.2892 | 0.2892 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0114 | 0.0236 | 0.4963 |
Brugia malayi | Temporarily assigned gene name protein 59 | 0.1077 | 0.2892 | 0.2892 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.3651 | 0.9986 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.002 | 0.002 |
Schistosoma mansoni | vam6/vps39 related | 0.1077 | 0.2892 | 0.2892 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0114 | 0.0114 |
Brugia malayi | RNA binding protein | 0.007 | 0.0114 | 0.0114 |
Brugia malayi | MH2 domain containing protein | 0.0507 | 0.1319 | 0.1319 |
Loa Loa (eye worm) | hypothetical protein | 0.1077 | 0.2892 | 0.2902 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.1077 | 0.2892 | 0.2892 |
Echinococcus multilocularis | serine protein kinase ATM | 0.0036 | 0.0023 | 0.0023 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.1091 | 0.2928 | 0.2932 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0151 | 0.0338 | 0.0339 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0193 | 0.0453 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0143 | 0.0317 | 0.684 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0143 | 0.0317 | 1 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.1091 | 0.2928 | 0.2932 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0193 | 0.0453 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0114 | 0.0236 | 0.4963 |
Onchocerca volvulus | 0.1077 | 0.2892 | 1 | |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0193 | 0.0453 | 0.0454 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0023 | 0.0023 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0065 | 0.01 | 0.0271 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.0114 | 0.0114 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0193 | 0.0453 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0065 | 0.01 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0066 | 0.0066 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0066 | 0.0066 |
Toxoplasma gondii | non-specific serine/threonine protein kinase | 0.0041 | 0.0034 | 0.039 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0035 | 0.0017 | 0.0018 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.0065 | 0.01 | 0.01 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0153 | 0.0345 | 0.7477 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.0114 | 0.0114 |
Brugia malayi | Smad1 | 0.0035 | 0.0017 | 0.0017 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.0065 | 0.01 | 0.01 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.0114 | 0.0114 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.0065 | 0.01 | 0.01 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0193 | 0.0453 | 0.0453 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0104 | 0.0209 | 0.4316 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0143 | 0.0317 | 0.684 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0104 | 0.0209 | 0.4316 |
Schistosoma mansoni | microtubule-associated protein tau | 0.3651 | 0.9986 | 0.9986 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0507 | 0.1319 | 0.1324 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0114 | 0.0114 |
Echinococcus granulosus | serine:threonine protein kinase mig 15 | 0.3643 | 0.9964 | 0.9977 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0193 | 0.0453 | 0.0454 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0035 | 0.0017 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.1077 | 0.2892 | 0.2902 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0125 | 0.0267 | 0.5673 |
Echinococcus granulosus | Smad4 | 0.0035 | 0.0017 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.003 | 0.0031 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0193 | 0.0453 | 0.0455 |
Schistosoma mansoni | protein kinase | 0.3656 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0104 | 0.0209 | 0.4327 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0066 | 0.0066 |
Brugia malayi | MH1 domain containing protein | 0.0035 | 0.0017 | 0.0017 |
Echinococcus multilocularis | smad | 0.0035 | 0.0017 | 0.0018 |
Echinococcus granulosus | smad | 0.0035 | 0.0017 | 0.0018 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0129 | 0.0278 | 0.594 |
Entamoeba histolytica | hypothetical protein | 0.0151 | 0.0338 | 0.7326 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0091 | 0.0173 | 0.0525 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.0114 | 0.0115 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0115 | 0.024 | 0.5037 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0065 | 0.01 | 0.1803 |
Schistosoma mansoni | protein kinase | 0.2579 | 0.703 | 0.703 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0065 | 0.01 | 0.1803 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0193 | 0.0453 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0065 | 0.01 | 0.01 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.1091 | 0.2928 | 0.2932 |
Schistosoma mansoni | rap gtpase-activating protein | 0.1077 | 0.2892 | 0.2892 |
Entamoeba histolytica | hypothetical protein | 0.0151 | 0.0338 | 0.7326 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0035 | 0.0017 | 0.0017 |
Echinococcus multilocularis | Smad4 | 0.0035 | 0.0017 | 0.0018 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0065 | 0.01 | 0.1803 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.1091 | 0.2928 | 0.2932 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.1077 | 0.2892 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0114 | 0.0114 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0153 | 0.0345 | 0.7477 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.0114 | 0.0115 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0035 | 0.0017 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0222 | 0.0223 |
Loa Loa (eye worm) | hypothetical protein | 0.1077 | 0.2892 | 0.2902 |
Loa Loa (eye worm) | STE/STE20/MSN protein kinase | 0.2579 | 0.703 | 0.7056 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1091 | 0.2928 | 0.2928 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.0114 | 0.0115 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0193 | 0.0453 | 0.15 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0153 | 0.0345 | 0.6934 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0035 | 0.0017 | 0.0018 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0193 | 0.0453 | 0.0453 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.167 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.