Detailed information for compound 1608389

Basic information

Technical information
  • TDR Targets ID: 1608389
  • Name: [1-[(1R,6R)-7,9-bis(2,2-dimethylpropyl)-8-oxo -7,9-diaza-8$l^{5}-phosphabicyclo[4.3.0]nonan -8-yl]-3-phenylprop-2-enyl] acetate
  • MW: 474.616 | Formula: C27H43N2O3P
  • H donors: 0 H acceptors: 2 LogP: 6.56 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)OC(P1(=O)N(CC(C)(C)C)[C@H]2[C@H](N1CC(C)(C)C)CCCC2)/C=C/c1ccccc1
  • InChi: 1S/C27H43N2O3P/c1-21(30)32-25(18-17-22-13-9-8-10-14-22)33(31)28(19-26(2,3)4)23-15-11-12-16-24(23)29(33)20-27(5,6)7/h8-10,13-14,17-18,23-25H,11-12,15-16,19-20H2,1-7H3/b18-17+/t23-,24-,25?/m1/s1
  • InChiKey: KQTULTQMABLGLP-YOUGSHTCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1-[(1R,6R)-7,9-bis(2,2-dimethylpropyl)-8-oxo-7,9-diaza-8$l^{5}-phosphabicyclo[4.3.0]nonan-8-yl]-3-phenyl-prop-2-enyl] acetate
  • acetic acid [1-[(1R,6R)-7,9-bis(2,2-dimethylpropyl)-8-oxo-7,9-diaza-8$l^{5}-phosphabicyclo[4.3.0]nonan-8-yl]-3-phenylprop-2-enyl] ester
  • acetic acid [1-[(1R,6R)-8-keto-7,9-dineopentyl-7,9-diaza-8$l^{5}-phosphabicyclo[4.3.0]nonan-8-yl]-3-phenyl-prop-2-enyl] ester
  • [1-[(1R,6R)-7,9-bis(2,2-dimethylpropyl)-8-oxo-7,9-diaza-8$l^{5}-phosphabicyclo[4.3.0]nonan-8-yl]-3-phenyl-prop-2-enyl] ethanoate
  • NCI60_037567
  • NCI60_037568

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0082 0.0082
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.1528 0.2907 1
Schistosoma mansoni serine/threonine protein kinase 0.1547 0.2944 0.2944
Schistosoma mansoni protein kinase 0.3658 0.7037 0.7037
Loa Loa (eye worm) hypothetical protein 0.1528 0.2907 0.2918
Loa Loa (eye worm) hypothetical protein 0.0108 0.0153 0.0153
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.0012 0.0012
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0082 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0154 0.0243 0.7477
Brugia malayi TAR-binding protein 0.0071 0.0082 0.0082
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1547 0.2944 0.2954
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0194 0.032 0.032
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.0012 0.0012
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0154 0.0243 0.6934
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0194 0.032 0.1054
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0047 0.0047
Brugia malayi MH1 domain containing protein 0.0035 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0147 0.4327
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0065 0.007 0.019
Echinococcus multilocularis 0.3658 0.7037 0.9885
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.007 0.1803
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0082 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0116 0.0169 0.5037
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0092 0.0122 0.0369
Entamoeba histolytica hypothetical protein 0.0153 0.024 0.7372
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.0012 0.0012
Loa Loa (eye worm) Smad1 0.0035 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0196 0.594
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0065 0.007 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0194 0.032 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.007 0.1803
Echinococcus multilocularis Smad4 0.0035 0.0012 0.0017
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.0012 0.0017
Entamoeba histolytica hypothetical protein 0.0153 0.024 0.7372
Schistosoma mansoni rap gtpase-activating protein 0.1528 0.2907 0.2907
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.1547 0.2944 0.4135
Brugia malayi RNA binding protein 0.0071 0.0082 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0154 0.0243 0.7477
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0065 0.007 0.0099
Echinococcus granulosus smad 0.0035 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0023 0.0266
Loa Loa (eye worm) hypothetical protein 0.0053 0.0047 0.0048
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0194 0.032 0.032
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0065 0.007 0.007
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0082 0.0115
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0065 0.007 0.019
Brugia malayi Smad1 0.0035 0.0012 0.0012
Echinococcus granulosus microtubule associated protein 2 0.37 0.7119 0.7145
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0082 0.0082
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0194 0.032 0.0321
Loa Loa (eye worm) MH2 domain-containing protein 0.0513 0.0939 0.0942
Schistosoma mansoni microtubule-associated protein tau 0.37 0.7119 0.7119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0147 0.4316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0224 0.684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0147 0.4316
Schistosoma mansoni protein kinase 0.5186 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0194 0.032 0.0321
Loa Loa (eye worm) hypothetical protein 0.004 0.0021 0.0021
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.0012 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0188 0.5673
Loa Loa (eye worm) hypothetical protein 0.1528 0.2907 0.2918
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0224 0.684
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0194 0.032 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0153 0.024 0.0337
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.1547 0.2944 0.2954
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0037 0.0015 0.0015
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.1528 0.2907 0.2907
Loa Loa (eye worm) hypothetical protein 0.1528 0.2907 0.2918
Brugia malayi MH2 domain containing protein 0.0513 0.0939 0.0939
Loa Loa (eye worm) RNA binding protein 0.0071 0.0082 0.0082
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0082 0.0082
Onchocerca volvulus 0.1528 0.2907 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0167 0.4963
Trichomonas vaginalis PIKK family atypical protein kinase 0.0194 0.032 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1547 0.2944 0.4135
Toxoplasma gondii target of rapamycin (TOR), putative 0.0144 0.0224 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0047 0.0047
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0065 0.007 0.019
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0082 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0194 0.032 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0065 0.007 0.007
Echinococcus multilocularis serine protein kinase ATM 0.0037 0.0015 0.0021
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0194 0.032 0.045
Echinococcus granulosus tumor protein p63 0.0735 0.1368 0.1373
Loa Loa (eye worm) hypothetical protein 0.0036 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0147 0.4327
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0041 0.0023 0.039
Brugia malayi Temporarily assigned gene name protein 59 0.1528 0.2907 0.2907
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0167 0.4963
Schistosoma mansoni hypothetical protein 0.1528 0.2907 0.2907
Loa Loa (eye worm) hypothetical protein 0.0041 0.0023 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0224 0.684
Schistosoma mansoni vam6/vps39 related 0.1528 0.2907 0.2907
Echinococcus granulosus serine protein kinase ATM 0.0037 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.5168 0.9964 1
Echinococcus multilocularis tumor protein p63 0.0735 0.1368 0.1922
Loa Loa (eye worm) phosphatidylinositol 3 0.0065 0.007 0.0071
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0037 0.0015 0.0015
Giardia lamblia GTOR 0.0194 0.032 0.5
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0081 0.01 0.0294
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0012 0.0012
Onchocerca volvulus 0.0108 0.0153 0.0525
Schistosoma mansoni smad1 5 8 and 0.0035 0.0012 0.0012
Echinococcus granulosus protein kinase 0.3658 0.7037 0.7063
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1547 0.2944 0.4135
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0194 0.032 0.1054
Schistosoma mansoni fkbp-rapamycin associated protein 0.0037 0.0015 0.0015
Echinococcus granulosus serine:threonine protein kinase mig 15 0.5168 0.9964 1
Brugia malayi MH1 domain containing protein 0.0035 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0036 0.0015 0.0015
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0037 0.0015 0.0015
Brugia malayi hypothetical protein 0.1528 0.2907 0.2907
Trypanosoma cruzi target of rapamycin kinase 3 0.0154 0.0243 0.0789
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0224 0.684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0224 0.684
Schistosoma mansoni protein kinase 0.1547 0.2944 0.2944
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.1528 0.2907 0.2907
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0194 0.032 0.1054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0045 0.0976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0224 0.684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.007 0.1803
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.007 0.1803
Loa Loa (eye worm) transcription factor SMAD2 0.0513 0.0939 0.0942
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0194 0.032 1
Schistosoma mansoni serine/threonine protein kinase 0.1547 0.2944 0.2944
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0154 0.0243 0.0789
Trichomonas vaginalis PIKK family atypical protein kinase 0.0116 0.0169 0.5037
Echinococcus granulosus Vam6:Vps39 protein 0.1528 0.2907 0.2918
Brugia malayi hypothetical protein 0.0153 0.024 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0147 0.4316
Loa Loa (eye worm) hypothetical protein 0.0037 0.0015 0.0015
Brugia malayi MH2 domain containing protein 0.0035 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0153 0.024 0.024
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1547 0.2944 0.2954
Schistosoma mansoni Smad4 0.0035 0.0012 0.0012
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0082 0.0082
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0047 0.0048
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0194 0.032 0.1054
Brugia malayi MH2 domain containing protein 0.0035 0.0012 0.0012
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.1528 0.2907 1
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.3658 0.7037 0.7063
Schistosoma mansoni smad 0.0035 0.0012 0.0012
Echinococcus multilocularis smad 0.0035 0.0012 0.0017
Schistosoma mansoni cellular tumor antigen P53 0.0108 0.0153 0.0153
Entamoeba histolytica hypothetical protein 0.0153 0.024 0.7372
Echinococcus granulosus tar DNA binding protein 0.0071 0.0082 0.0082
Schistosoma mansoni smad1 5 8 and 0.0035 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.007 0.1803
Echinococcus multilocularis microtubule associated protein 2 0.37 0.7119 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0154 0.0243 0.7477
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0037 0.0015 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0154 0.0243 0.7477
Echinococcus granulosus Smad4 0.0035 0.0012 0.0012
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0194 0.032 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0037 0.0015 0.0015
Schistosoma mansoni smad1 5 8 and 0.0035 0.0012 0.0012
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.1547 0.2944 0.2954
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0082 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0147 0.4327
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0194 0.032 1
Schistosoma mansoni transcription factor LCR-F1 0.0153 0.024 0.024
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.1528 0.2907 0.2918
Trichomonas vaginalis PIKK family atypical protein kinase 0.0116 0.0169 0.5037
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0065 0.007 0.019
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.1528 0.2907 0.4084
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.1528 0.2907 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0224 0.684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0165 0.0265 0.8197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0154 0.0243 0.7477
Entamoeba histolytica hypothetical protein 0.0153 0.024 0.7372
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0153 0.024 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0147 0.4327
Brugia malayi Protein kinase domain containing protein 0.1547 0.2944 0.2944

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.378 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.286 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.279 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.27 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.243 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.201 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.152 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.144 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.121 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.12 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.112 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.091 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.011 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.984 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.982 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.959 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.92 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.909 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.884 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.867 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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