Detailed information for compound 1608566

Basic information

Technical information
  • TDR Targets ID: 1608566
  • Name: N'-[8-(2,3-dimethoxyphenyl)-7-methyl-7,8-dihy dro-6H-pyrano[6,5-f][1,3]benzodioxol-6-yl]-4- methylbenzenesulfonohydrazide
  • MW: 512.575 | Formula: C26H28N2O7S
  • H donors: 2 H acceptors: 2 LogP: 4.88 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cccc(c1OC)C1C(C)C(NNS(=O)(=O)c2ccc(cc2)C)Oc2c1cc1OCOc1c2
  • InChi: 1S/C26H28N2O7S/c1-15-8-10-17(11-9-15)36(29,30)28-27-26-16(2)24(18-6-5-7-20(31-3)25(18)32-4)19-12-22-23(34-14-33-22)13-21(19)35-26/h5-13,16,24,26-28H,14H2,1-4H3
  • InChiKey: NXTHYSFIBXFNOD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-[8-(2,3-dimethoxyphenyl)-7-methyl-7,8-dihydro-6H-pyrano[6,5-f][1,3]benzodioxol-6-yl]-4-methyl-benzenesulfonohydrazide
  • NSC667901
  • NCI60_023644
  • AIDS-144707
  • AIDS144707
  • N'-(8-(2,3-Dimethoxyphenyl)-7-methyl-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromen-6-yl)-4-methylbenzenesulfonohydrazide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Neuropeptide F receptor homolog 0.004 0.0372 0.024
Chlamydia trachomatis DNA topoisomerase I 0.0588 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0209 0.3348 0.5645
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0209 0.3348 0.3256
Brugia malayi TAR-binding protein 0.007 0.0906 0.0781
Brugia malayi AKH receptor 0.004 0.0372 0.024
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0334 0.5544 1
Leishmania major mitochondrial DNA polymerase beta 0.0334 0.5544 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0135 0.0424
Brugia malayi RNA binding protein 0.007 0.0906 0.0781
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0372 0.0136
Brugia malayi hypothetical protein 0.004 0.0372 0.024
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0158 0.2453 0.4284
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0588 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0372 0.0136
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0372 0.0136
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0135 0.0424
Schistosoma mansoni amine GPCR 0.004 0.0372 0.0136
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.004 0.0372 0.0136
Echinococcus granulosus somatostatin receptor 0.004 0.0372 0.0136
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0117
Echinococcus granulosus fmrfamide receptor 0.004 0.0372 0.0136
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0372 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.004 0.0372 0.0136
Onchocerca volvulus 0.004 0.0372 0.024
Trypanosoma brucei hypothetical protein, conserved 0.0209 0.3348 0.5645
Schistosoma mansoni neuropeptide receptor 0.004 0.0372 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.004 0.0372 0.0354
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.004 0.0372 0.0136
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.0372 0.0136
Echinococcus multilocularis SWI:SNF matrix associated 0.0588 1 1
Onchocerca volvulus 0.004 0.0372 0.024
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0895 0.077
Brugia malayi hypothetical protein 0.004 0.0372 0.024
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.1995 0.198
Echinococcus multilocularis g protein coupled receptor 0.004 0.0372 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0372 0.0136
Brugia malayi hypothetical protein 0.004 0.0372 0.024
Echinococcus multilocularis g protein coupled receptor 0.004 0.0372 0.0136
Schistosoma mansoni biogenic amine receptor 0.004 0.0372 0.0136
Echinococcus multilocularis tar DNA binding protein 0.007 0.0906 0.0683
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0372 0.0136
Echinococcus granulosus neuropeptide FF receptor 2 0.004 0.0372 0.0136
Onchocerca volvulus 0.004 0.0372 0.024
Brugia malayi SWIB/MDM2 domain containing protein 0.0588 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.004 0.0372 0.0136
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0372 0.0136
Echinococcus granulosus zinc finger protein Ran binding 0.0209 0.3348 0.3185
Loa Loa (eye worm) hypothetical protein 0.007 0.0895 0.0877
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0372 0.0354
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0372 0.0136
Brugia malayi hypothetical protein 0.004 0.0372 0.024
Schistosoma mansoni fusion 0.0209 0.3348 0.3185
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Onchocerca volvulus 0.0209 0.3348 0.3256
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Echinococcus multilocularis SWI:SNF matrix associated 0.0588 1 1
Echinococcus granulosus orexin receptor type 2 0.004 0.0372 0.0136
Echinococcus multilocularis fmrfamide receptor 0.004 0.0372 0.0136
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0135 0.0424
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.068 0.0358
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0372 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Chlamydia trachomatis SWIB complex protein 0.0588 1 1
Schistosoma mansoni amine GPCR 0.004 0.0372 0.0136
Trypanosoma brucei hypothetical protein, conserved 0.0209 0.3348 0.5645
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0372 0.0136
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0372 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0588 1 1
Loa Loa (eye worm) hypothetical protein 0.0209 0.3348 0.3335
Leishmania major hypothetical protein, conserved 0.0209 0.3348 0.5939
Schistosoma mansoni opsin-like receptor 0.004 0.0372 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Echinococcus granulosus g protein coupled receptor 0.004 0.0372 0.0136
Brugia malayi neuropeptide F receptor 0.004 0.0372 0.024
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.004 0.0372 0.0136
Echinococcus granulosus peptide allatostatin:somatostatin 0.004 0.0372 0.0136
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0372 0.0136
Echinococcus granulosus g-protein coupled receptor 0.004 0.0372 0.0136
Loa Loa (eye worm) brahma associated protein 0.0588 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0135 0.5
Onchocerca volvulus 0.004 0.0372 0.024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.1459 0.1342
Onchocerca volvulus 0.0209 0.3348 0.3256
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Mycobacterium tuberculosis Conserved hypothetical protein 0.0176 0.2766 1
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0209 0.3348 0.3185
Loa Loa (eye worm) follicle stimulating hormone receptor 0.004 0.0372 0.0354
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.0372 0.0136
Brugia malayi hypothetical protein 0.004 0.0372 0.024
Trypanosoma cruzi WLM domain containing protein, putative 0.0209 0.3348 0.5645
Brugia malayi ORL1-like opioid receptor 0.004 0.0372 0.024
Trypanosoma cruzi WLM domain containing protein, putative 0.0209 0.3348 0.5645
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0372 0.0136
Schistosoma mansoni histamine h1 receptor 0.004 0.0372 0.0136
Loa Loa (eye worm) hypothetical protein 0.0032 0.0239 0.0221
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.1459 0.1342
Brugia malayi larval opioid receptor 0.004 0.0372 0.024
Echinococcus multilocularis G-protein coupled receptor, putative 0.004 0.0372 0.0136
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0372 0.0136
Brugia malayi hypothetical protein 0.004 0.0372 0.024
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0372 0.0136
Echinococcus granulosus ring and YY1 binding protein 0.0209 0.3348 0.3185
Schistosoma mansoni myosin xvIII 0.004 0.0372 0.0136
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0209 0.3348 0.2907
Brugia malayi Melatonin receptor type 1A 0.004 0.0372 0.024
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0588 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0135 0.0424
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0372 0.0136
Schistosoma mansoni hypothetical protein 0.0588 1 1
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0372 0.0136
Loa Loa (eye worm) RNA binding protein 0.007 0.0906 0.0889
Brugia malayi Serotonin receptor 0.004 0.0372 0.024
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.004 0.0372 0.024
Echinococcus multilocularis zinc finger protein Ran binding 0.0209 0.3348 0.3185
Echinococcus multilocularis neuropeptide receptor 0.004 0.0372 0.0136
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0372 0.0136
Schistosoma mansoni tar DNA-binding protein 0.007 0.0906 0.0683
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0588 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0372 0.0136
Brugia malayi G-protein coupled receptor 0.004 0.0372 0.024
Brugia malayi G protein-coupled receptor F59B2.13 0.004 0.0372 0.024
Brugia malayi Dopamine receptor 0.004 0.0372 0.024
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Onchocerca volvulus 0.004 0.0372 0.024
Echinococcus multilocularis somatostatin receptor 0.004 0.0372 0.0136
Brugia malayi Tachykinin-like peptides receptor 99D 0.004 0.0372 0.024
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.004 0.0372 0.0136
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0239 0.0221
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0372 0.0136
Onchocerca volvulus 0.004 0.0372 0.024
Schistosoma mansoni tar DNA-binding protein 0.007 0.0906 0.0683
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0372 0.0136
Onchocerca volvulus 0.004 0.0372 0.024
Brugia malayi neuropeptide F receptor 0.004 0.0372 0.024
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0334 0.5544 1
Brugia malayi hypothetical protein 0.004 0.0372 0.024
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0117
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0906 0.0781
Schistosoma mansoni zinc finger protein 0.0209 0.3348 0.3185
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0372 0.0136
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0158 0.2453 0.3871
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.004 0.0372 0.0354
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0372 0.0136
Schistosoma mansoni hypothetical protein 0.004 0.0372 0.0136
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0372 0.0136
Onchocerca volvulus 0.004 0.0372 0.024
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0372 0.0136
Mycobacterium ulcerans hypothetical protein 0.0176 0.2766 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.004 0.0372 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Loa Loa (eye worm) hypothetical protein 0.0209 0.3348 0.3335
Echinococcus granulosus alpha 1A adrenergic receptor 0.004 0.0372 0.0136
Echinococcus granulosus dro:myosuppressin receptor 0.004 0.0372 0.0136
Trypanosoma cruzi hypothetical protein, conserved 0.0209 0.3348 0.5645
Echinococcus granulosus neuropeptide s receptor 0.004 0.0372 0.0136
Onchocerca volvulus 0.004 0.0372 0.024
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0372 0.0136
Onchocerca volvulus 0.004 0.0372 0.024
Brugia malayi sulfakinin receptor protein 0.004 0.0372 0.024
Echinococcus granulosus hypothetical protein 0.004 0.0372 0.0136
Toxoplasma gondii ran binding protein 0.0209 0.3348 0.2907
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0239 0.0105
Echinococcus multilocularis g-protein coupled receptor 0.004 0.0372 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0372 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0209 0.3348 0.5645
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.004 0.0372 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Leishmania major hypothetical protein, conserved 0.0209 0.3348 0.5939
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0372 0.0354
Echinococcus multilocularis alpha 1A adrenergic receptor 0.004 0.0372 0.0136
Echinococcus granulosus neuropeptide receptor 0.004 0.0372 0.0136
Echinococcus granulosus allatostatin A receptor 0.004 0.0372 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Onchocerca volvulus 0.004 0.0372 0.024
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Schistosoma mansoni neuropeptide receptor 0.004 0.0372 0.0136
Leishmania major hypothetical protein, conserved 0.0209 0.3348 0.5939
Brugia malayi hypothetical protein 0.004 0.0372 0.024
Onchocerca volvulus 0.004 0.0372 0.024
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0372 0.0136
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0372 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Schistosoma mansoni tar DNA-binding protein 0.007 0.0906 0.0683
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0588 1 1
Loa Loa (eye worm) hypothetical protein 0.0209 0.3348 0.3335
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0209 0.3348 0.3335
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Brugia malayi hypothetical protein 0.004 0.0372 0.024
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.004 0.0372 0.0136
Plasmodium vivax hypothetical protein, conserved 0.0588 1 1
Onchocerca volvulus 0.004 0.0372 0.024
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.1459 0.1443
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Brugia malayi Serotonin receptor 0.004 0.0372 0.024
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0135 0.5
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0588 1 1
Leishmania major hypothetical protein, conserved 0.0209 0.3348 0.5939
Echinococcus multilocularis allatostatin A receptor 0.004 0.0372 0.0136
Brugia malayi hypothetical protein 0.004 0.0372 0.024
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.004 0.0372 0.0136
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0019 0.0068
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.004 0.0372 0.0136
Echinococcus multilocularis neuropeptide FF receptor 2 0.004 0.0372 0.0136
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.004 0.0372 0.024
Schistosoma mansoni hypothetical protein 0.004 0.0372 0.0136
Brugia malayi Dopamine receptor protein 1 0.004 0.0372 0.024
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0135 0.5
Loa Loa (eye worm) TYRA-2 protein 0.004 0.0372 0.0354
Schistosoma mansoni peptide (allatostatin)-like receptor 0.004 0.0372 0.0136
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0372 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Loa Loa (eye worm) hypothetical protein 0.0102 0.1459 0.1443
Echinococcus granulosus sex peptide receptor 0.004 0.0372 0.0136
Loa Loa (eye worm) TAR-binding protein 0.007 0.0906 0.0889
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Brugia malayi RE15519p 0.004 0.0372 0.024
Brugia malayi G protein-coupled receptor 0.004 0.0372 0.024
Schistosoma mansoni growth hormone secretagogue receptor 0.004 0.0372 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0372 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Echinococcus multilocularis dro:myosuppressin receptor 0.004 0.0372 0.0136
Echinococcus granulosus tachykinin peptides receptor 99D 0.004 0.0372 0.0136
Schistosoma mansoni adenoreceptor 0.004 0.0372 0.0136
Onchocerca volvulus 0.004 0.0372 0.024
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0588 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0372 0.0136
Schistosoma mansoni RNA binding protein 0.0209 0.3348 0.3185
Schistosoma mansoni neuropeptide receptor 0.004 0.0372 0.0136
Onchocerca volvulus 0.004 0.0372 0.024
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0372 0.0136
Brugia malayi G-protein coupled receptor 0.004 0.0372 0.024
Echinococcus granulosus thyrotropin releasing hormone receptor 0.004 0.0372 0.0136
Schistosoma mansoni hypothetical protein 0.0588 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0372 0.0136
Schistosoma mansoni amine GPCR 0.004 0.0372 0.0136
Schistosoma mansoni alpha-1 adrenergic receptor 0.004 0.0372 0.0136
Schistosoma mansoni hypothetical protein 0.007 0.0895 0.0671
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0588 1 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0135 0.5
Schistosoma mansoni amine GPCR 0.004 0.0372 0.0136
Echinococcus granulosus serotonin receptor 0.004 0.0372 0.0136
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0372 0.0136
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0372 0.0136
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0372 0.0354
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Echinococcus multilocularis ring and YY1 binding protein 0.0209 0.3348 0.3185
Brugia malayi Dopamine receptor protein 2 0.004 0.0372 0.024
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.004 0.0372 0.0354
Echinococcus granulosus SWI:SNF matrix associated 0.0588 1 1
Loa Loa (eye worm) hypothetical protein 0.0209 0.3348 0.3335
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.0372 0.0136
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.004 0.0372 0.024
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0372 0.0136
Brugia malayi gonadotropin-releasing hormone receptor 2 0.004 0.0372 0.024
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0117
Schistosoma mansoni amine GPCR 0.004 0.0372 0.0136
Onchocerca volvulus 0.0209 0.3348 0.3256
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0239 0.0105
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0372 0.0136
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.004 0.0372 0.0354
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.004 0.0372 0.0136
Schistosoma mansoni hypothetical protein 0.0209 0.3348 0.3185
Onchocerca volvulus 0.004 0.0372 0.024
Echinococcus multilocularis neuropeptide s receptor 0.004 0.0372 0.0136
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0372 0.0136
Brugia malayi putative neuropeptide receptor NPR1 0.004 0.0372 0.024
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.004 0.0372 0.0136
Trypanosoma cruzi hypothetical protein, conserved 0.0209 0.3348 0.5645
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0209 0.3348 0.3256
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.004 0.0372 0.0136
Schistosoma mansoni hypothetical protein 0.004 0.0372 0.0136
Schistosoma mansoni biogenic amine receptor 0.004 0.0372 0.0136
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0906 0.0889
Loa Loa (eye worm) hypothetical protein 0.0209 0.3348 0.3335
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0372 0.0136
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0209 0.3348 0.5645
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0209 0.3348 0.5645
Brugia malayi putative neuropeptide receptor 0.004 0.0372 0.024
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0372 0.0136
Echinococcus multilocularis neuropeptide receptor A26 0.004 0.0372 0.0136
Schistosoma mansoni hypothetical protein 0.0588 1 1
Echinococcus granulosus G protein coupled receptor 139 0.004 0.0372 0.0136
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0372 0.0136
Schistosoma mansoni tar DNA-binding protein 0.007 0.0906 0.0683
Schistosoma mansoni opsin-like receptor 0.004 0.0372 0.0136
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0209 0.3348 0.3256
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0135 0.0424
Echinococcus granulosus g protein coupled receptor 0.004 0.0372 0.0136
Onchocerca volvulus 0.0588 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Brugia malayi GnHR receptor homolog 0.004 0.0372 0.024
Schistosoma mansoni TRABID protein (C64 family) 0.0209 0.3348 0.3185
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Echinococcus multilocularis fmrfamide receptor 0.004 0.0372 0.0136
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0135 0.0489
Schistosoma mansoni hypothetical protein 0.004 0.0372 0.0136
Echinococcus granulosus Zinc finger RanBP2 type 0.0209 0.3348 0.3185
Schistosoma mansoni biogenic amine receptor 0.004 0.0372 0.0136
Schistosoma mansoni opsin-like receptor 0.004 0.0372 0.0136
Schistosoma mansoni neuropeptide f receptor 76f 0.004 0.0372 0.0136
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0372 0.0136
Brugia malayi Serotonin/octopamine receptor family protein 7 0.004 0.0372 0.024
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Schistosoma mansoni tar DNA-binding protein 0.007 0.0906 0.0683
Echinococcus granulosus 7TM GPCR rhodopsin 0.004 0.0372 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0372 0.0136
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.004 0.0372 0.0136
Onchocerca volvulus 0.0209 0.3348 0.3256
Echinococcus multilocularis neuropeptide receptor 0.004 0.0372 0.0136
Mycobacterium ulcerans hypothetical protein 0.0026 0.0135 0.0424
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0209 0.3348 0.3256
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0372 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0209 0.3348 0.5645
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Echinococcus multilocularis orexin receptor type 2 0.004 0.0372 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0372 0.0354
Echinococcus granulosus neuropeptide receptor A26 0.004 0.0372 0.0136
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0209 0.3348 0.5645
Echinococcus granulosus neuropeptide receptor 0.004 0.0372 0.0136
Echinococcus granulosus g protein coupled receptor 0.004 0.0372 0.0136
Echinococcus granulosus tar DNA binding protein 0.007 0.0906 0.0683
Echinococcus multilocularis serotonin receptor 0.004 0.0372 0.0136
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0209 0.3348 0.3256
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0372 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0588 1 0.5
Echinococcus multilocularis g protein coupled receptor 0.004 0.0372 0.0136
Echinococcus multilocularis SWI:SNF matrix associated 0.0588 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0209 0.3348 0.5645
Brugia malayi YY1-associated factor 2 0.0209 0.3348 0.3256
Onchocerca volvulus 0.004 0.0372 0.024
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0135 0.0424
Schistosoma mansoni neuropeptide receptor 0.004 0.0372 0.0136
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.0372 0.0136
Echinococcus multilocularis sex peptide receptor 0.004 0.0372 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0372 0.0136
Leishmania major hypothetical protein, conserved 0.0209 0.3348 0.5939
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0334 0.5544 1
Echinococcus multilocularis G protein coupled receptor 139 0.004 0.0372 0.0136
Brugia malayi brahma associated protein 60 kDa 0.0588 1 1
Brugia malayi MH2 domain containing protein 0.0132 0.1995 0.1885
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0209 0.3348 0.5645
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0158 0.2453 0.3871
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.1995 0.198
Echinococcus multilocularis serotonin receptor 0.004 0.0372 0.0136
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0135 0.0489
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0209 0.3348 0.3185
Echinococcus multilocularis biogenic amine (5HT) receptor 0.004 0.0372 0.0136
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.004 0.0372 0.0136
Echinococcus granulosus 7tm_1 domain containing protein 0.004 0.0372 0.0136
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0372 0.0136
Brugia malayi follicle stimulating hormone receptor 0.004 0.0372 0.024
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0372 0.0136
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0135 0.5
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0135 0.0424
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.004 0.0372 0.024
Loa Loa (eye worm) melatonin receptor type 1A 0.004 0.0372 0.0354
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0209 0.3348 0.3185
Schistosoma mansoni brg-1 associated factor 0.0588 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.004 0.0372 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0354

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.847 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.667 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.64 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.58 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.557 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.548 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.527 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.495 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.472 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.443 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.392 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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