Detailed information for compound 1608571

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 390.432 | Formula: C23H22N2O4
  • H donors: 1 H acceptors: 2 LogP: 3.54 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)C1CC(=NN1C(=O)C)c1c(O)ccc2c1cccc2
  • InChi: 1S/C23H22N2O4/c1-14(26)25-19(16-9-11-21(28-2)22(12-16)29-3)13-18(24-25)23-17-7-5-4-6-15(17)8-10-20(23)27/h4-12,19,27H,13H2,1-3H3
  • InChiKey: AJPOORVEBHHPGL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi SWIB/MDM2 domain containing protein 0.0863 1 1
Echinococcus granulosus lamin 0.0029 0.0159 0.0143
Trypanosoma cruzi hypothetical protein, conserved 0.0307 0.3438 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0062 0.013
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.025 0.025
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0017 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0062 0.013
Schistosoma mansoni hypothetical protein 0.0863 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0137 0.0351
Echinococcus granulosus Niemann Pick C1 protein 0.0202 0.2201 0.2188
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0274 0.0258
Schistosoma mansoni hypothetical protein 0.0039 0.0274 0.0274
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0159 0.0159
Schistosoma mansoni RNA binding protein 0.0307 0.3438 0.3438
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0465 0.0465
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0017 0.0017
Echinococcus multilocularis dna polymerase eta 0.0021 0.0062 0.0045
Brugia malayi hypothetical protein 0.0018 0.0023 0.0023
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0137 0.012
Entamoeba histolytica hypothetical protein 0.0039 0.0274 0.0994
Brugia malayi MAP kinase sur-1 0.0055 0.0465 0.0465
Echinococcus granulosus survival motor neuron protein 1 0.0256 0.283 0.2818
Echinococcus multilocularis geminin 0.0183 0.1976 0.1962
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0062 0.013
Echinococcus granulosus Protein patched homolog 1 0.0087 0.0839 0.0824
Echinococcus granulosus dna polymerase eta 0.0021 0.0062 0.0045
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0017 0.0017
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0062 0.0544 0.0544
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0196 0.018
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0863 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0062 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0062 0.013
Entamoeba histolytica hypothetical protein 0.0039 0.0274 0.0994
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0465 0.131
Echinococcus multilocularis integrin alpha ps 0.0059 0.0515 0.0499
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0465 0.0465
Schistosoma mansoni integrin alpha-ps 0.0059 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.01 0.0995 0.0995
Giardia lamblia Kinase, NEK 0.0016 0.0006 0.0126
Echinococcus granulosus integrin alpha 3 0.0028 0.0151 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0839 0.0839
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0465 0.131
Onchocerca volvulus 0.0307 0.3438 0.3332
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0062 0.013
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0229 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0307 0.3438 0.3438
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0863 1 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0202 0.2201 0.2188
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0196 0.0196
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0307 0.3438 1
Echinococcus granulosus dna polymerase kappa 0.0021 0.0062 0.0045
Echinococcus granulosus intermediate filament protein 0.0029 0.0159 0.0143
Trichomonas vaginalis set domain proteins, putative 0.0256 0.2835 0.2835
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0465 0.0465
Echinococcus multilocularis SWI:SNF matrix associated 0.0863 1 1
Leishmania major hypothetical protein, conserved 0.0307 0.3438 1
Brugia malayi brahma associated protein 60 kDa 0.0863 1 1
Brugia malayi isocitrate dehydrogenase 0.0017 0.0017 0.0017
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0465 0.0449
Loa Loa (eye worm) hypothetical protein 0.0307 0.3438 0.3438
Loa Loa (eye worm) hypothetical protein 0.0106 0.107 0.107
Schistosoma mansoni hypothetical protein 0.0028 0.0151 0.0151
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0062 0.013
Echinococcus multilocularis integrin beta 2 0.0288 0.3211 0.3199
Loa Loa (eye worm) hypothetical protein 0.0028 0.0151 0.0151
Schistosoma mansoni intermediate filament proteins 0.0029 0.0159 0.0159
Leishmania major hypothetical protein, conserved 0.0307 0.3438 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0062 0.0062
Echinococcus multilocularis zinc finger protein Ran binding 0.0307 0.3438 0.3427
Schistosoma mansoni hypothetical protein 0.0037 0.025 0.025
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0196 0.018
Echinococcus granulosus integrin alpha ps 0.0028 0.0151 0.0134
Echinococcus granulosus Zinc finger RanBP2 type 0.0307 0.3438 0.3427
Plasmodium vivax SET domain protein, putative 0.0032 0.0196 0.0179
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0062 0.013
Brugia malayi Kelch motif family protein 0.0062 0.0544 0.0544
Schistosoma mansoni patched 1 0.0087 0.0839 0.0839
Leishmania major DNA polymerase kappa, putative 0.0021 0.0062 0.0179
Loa Loa (eye worm) integrin alpha pat-2 0.0131 0.1359 0.1359
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0307 0.3438 0.3332
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0465 0.131
Echinococcus multilocularis lamin dm0 0.0029 0.0159 0.0143
Loa Loa (eye worm) hypothetical protein 0.0307 0.3438 0.3438
Echinococcus multilocularis integrin alpha ps 0.0059 0.0515 0.0499
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0062 0.0062
Giardia lamblia DINP protein human, muc B family 0.0021 0.0062 0.1326
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0159 0.0159
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0465 0.0449
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0274 0.0274
Loa Loa (eye worm) brahma associated protein 0.0863 1 1
Loa Loa (eye worm) hypothetical protein 0.0307 0.3438 0.3438
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0202 0.2201 1
Loa Loa (eye worm) hypothetical protein 0.0307 0.3438 0.3438
Loa Loa (eye worm) hypothetical protein 0.0027 0.0137 0.0137
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0451 0.0451
Schistosoma mansoni hypothetical protein 0.0052 0.0431 0.0431
Schistosoma mansoni hypothetical protein 0.0863 1 1
Leishmania major hypothetical protein, conserved 0.0307 0.3438 1
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0465 0.0465
Schistosoma mansoni brg-1 associated factor 0.0863 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0137 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.0307 0.3438 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0153 0.0153
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0465 0.0449
Onchocerca volvulus 0.0032 0.0196 0.0037
Schistosoma mansoni hypothetical protein 0.0084 0.0802 0.0802
Loa Loa (eye worm) hypothetical protein 0.0256 0.283 0.283
Trypanosoma brucei protein kinase, putative 0.0055 0.0465 0.131
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0196 0.0196
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0863 1 1
Brugia malayi Integrin beta pat-3 precursor 0.0393 0.4453 0.4453
Echinococcus granulosus zinc finger protein Ran binding 0.0307 0.3438 0.3427
Onchocerca volvulus 0.0307 0.3438 0.3332
Echinococcus granulosus integrin beta 2 0.0288 0.3211 0.3199
Loa Loa (eye worm) pax transcription factor protein 2 0.026 0.2884 0.2884
Giardia lamblia Kinase, NEK 0.0016 0.0006 0.0126
Schistosoma mansoni hypothetical protein 0.0084 0.0802 0.0802
Brugia malayi YY1-associated factor 2 0.0307 0.3438 0.3438
Loa Loa (eye worm) hypothetical protein 0.0032 0.0196 0.0196
Onchocerca volvulus 0.0863 1 1
Echinococcus multilocularis musashi 0.0029 0.0159 0.0143
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0137 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0062 0.013
Trypanosoma cruzi WLM domain containing protein, putative 0.0307 0.3438 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0062 0.013
Onchocerca volvulus 0.0052 0.0431 0.0275
Echinococcus granulosus Niemann Pick C1 protein 0.0289 0.3225 0.3213
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0062 0.0062
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0465 0.0449
Echinococcus multilocularis expressed conserved protein 0.019 0.2056 0.2043
Schistosoma mansoni survival motor neuron protein 0.0052 0.0431 0.0431
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0062 0.013
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0431 0.0431
Brugia malayi hypoxia-induced factor 1 0.0147 0.1544 0.1544
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0307 0.3438 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0451 0.0451
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0274 0.0258
Echinococcus granulosus ring and YY1 binding protein 0.0307 0.3438 0.3427
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0307 0.3438 1
Schistosoma mansoni lamin 0.0029 0.0159 0.0159
Brugia malayi Integrin alpha cytoplasmic region family protein 0.01 0.0995 0.0995
Brugia malayi hypothetical protein 0.0062 0.0544 0.0544
Leishmania major DNA polymerase eta, putative 0.0021 0.0062 0.0179
Brugia malayi intermediate filament protein 0.0029 0.0159 0.0159
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0307 0.3438 1
Onchocerca volvulus 0.0307 0.3438 0.3332
Echinococcus multilocularis SWI:SNF matrix associated 0.0863 1 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0465 0.0465
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0159 0.0159
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0062 0.0045
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0017
Schistosoma mansoni single-minded 0.0047 0.0374 0.0374
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0465 0.1353
Schistosoma mansoni hypothetical protein 0.0017 0.0017 0.0017
Schistosoma mansoni TRABID protein (C64 family) 0.0307 0.3438 0.3438
Echinococcus granulosus single minded 2 0.0035 0.0229 0.0213
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0196 0.0179
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0465 0.131
Toxoplasma gondii ran binding protein 0.0307 0.3438 0.3427
Schistosoma mansoni fusion 0.0307 0.3438 0.3438
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0307 0.3438 0.3427
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0062 0.013
Echinococcus granulosus expressed conserved protein 0.019 0.2056 0.2043
Schistosoma mansoni DNA polymerase eta 0.0021 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0029 0.0159 0.0159
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0062 0.013
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0062 0.0062
Trypanosoma cruzi WLM domain containing protein, putative 0.0307 0.3438 1
Loa Loa (eye worm) hypothetical protein 0.0202 0.2201 0.2201
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0062 0.013
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0863 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.025 0.025
Trypanosoma cruzi hypothetical protein, conserved 0.0307 0.3438 1
Leishmania major hypothetical protein, conserved 0.0307 0.3438 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.1689 0.1689
Entamoeba histolytica hypothetical protein 0.0039 0.0274 0.0994
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0062 0.013
Trypanosoma brucei hypothetical protein, conserved 0.0307 0.3438 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0465 0.131
Brugia malayi CHE-14 protein 0.0087 0.0839 0.0839
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0863 1 1
Chlamydia trachomatis DNA topoisomerase I 0.0863 1 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.1338 0.1338
Leishmania major hypothetical protein, conserved 0.0307 0.3438 1
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0307 0.3438 0.3427
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0062 0.013
Echinococcus granulosus geminin 0.0183 0.1976 0.1962
Schistosoma mansoni integrin alpha 0.0059 0.0515 0.0515
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0451 0.0451
Schistosoma mansoni integrin beta subunit 0.0226 0.2483 0.2483
Brugia malayi MH2 domain containing protein 0.0129 0.1338 0.1338
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0307 0.3438 0.3427
Chlamydia trachomatis SWIB complex protein 0.0863 1 0.5
Schistosoma mansoni hypothetical protein 0.0084 0.0802 0.0802
Brugia malayi hypothetical protein 0.0039 0.0274 0.0274
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0017 0.0017
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0307 0.3438 0.3438
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0062 0.0062
Echinococcus granulosus SWI:SNF matrix associated 0.0863 1 1
Echinococcus multilocularis integrin alpha ps 0.0028 0.0151 0.0134
Echinococcus multilocularis protein patched 0.0087 0.0839 0.0824
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0307 0.3438 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0087 0.0839 0.0824
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0307 0.3438 0.3427
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0137 0.0351
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.1338 0.1338
Echinococcus multilocularis integrin alpha 3 0.0028 0.0151 0.0134
Loa Loa (eye worm) hypothetical protein 0.0062 0.0544 0.0544
Echinococcus multilocularis survival motor neuron protein 1 0.0256 0.283 0.2818
Schistosoma mansoni hypothetical protein 0.0017 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0183 0.1976 0.1976
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0062 0.013
Echinococcus multilocularis protein dispatched 1 0.0099 0.0984 0.0969
Echinococcus multilocularis SWI:SNF matrix associated 0.0863 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0062
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0451 0.0451
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0062 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0062 0.013
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0229 0.0229
Brugia malayi hypothetical protein 0.0159 0.1689 0.1689
Loa Loa (eye worm) integrin beta-2 0.0393 0.4453 0.4453
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0789 0.9125 0.9124
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0017 0.0017
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0863 1 1
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0465 0.0449
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0307 0.3438 0.3438
Brugia malayi Pre-SET motif family protein 0.0032 0.0196 0.0196
Schistosoma mansoni zinc finger protein 0.0307 0.3438 0.3438
Brugia malayi Pax transcription factor protein 2 0.026 0.2884 0.2884
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0863 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0062 0.013
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.2469 0.2469
Schistosoma mansoni hypothetical protein 0.0017 0.0017 0.0017
Leishmania major hypothetical protein, conserved 0.0027 0.0137 0.0398
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0137 0.012
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0465 1
Echinococcus granulosus lamin dm0 0.0029 0.0159 0.0143
Schistosoma mansoni hypothetical protein 0.0084 0.0802 0.0802
Brugia malayi Niemann-Pick C1 protein precursor 0.0202 0.2201 0.2201
Brugia malayi Integrin alpha pat-2 precursor 0.0059 0.0515 0.0515
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0062 0.0179
Schistosoma mansoni integrin alpha-ps 0.0031 0.018 0.018
Onchocerca volvulus 0.026 0.2884 0.2768
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0062 0.0045
Onchocerca volvulus 0.0307 0.3438 0.3332
Schistosoma mansoni hypothetical protein 0.0307 0.3438 0.3438
Brugia malayi Pre-SET motif family protein 0.0225 0.2469 0.2469
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0137 0.0351
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0062 0.013
Schistosoma mansoni lamin 0.0029 0.0159 0.0159
Brugia malayi PAS domain containing protein 0.0047 0.0374 0.0374
Schistosoma mansoni hypothetical protein 0.0183 0.1976 0.1976
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0196 0.018
Loa Loa (eye worm) hypothetical protein 0.0087 0.0839 0.0839
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0465 0.1353
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0307 0.3438 0.3438
Plasmodium vivax hypothetical protein, conserved 0.0863 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0465 0.0465
Trypanosoma brucei unspecified product 0.0021 0.0062 0.013
Echinococcus multilocularis lamin 0.0029 0.0159 0.0143
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0006 0.0006
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0062 0.0062
Echinococcus granulosus integrin alpha ps 0.0059 0.0515 0.0499
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0196 0.0196
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0182 0.0166
Entamoeba histolytica hypothetical protein 0.0039 0.0274 0.0994
Giardia lamblia Kinase 0.0016 0.0006 0.0126
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0196 0.0196
Trypanosoma brucei hypothetical protein, conserved 0.0307 0.3438 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0062 0.0062
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0031 0.018 0.018
Onchocerca volvulus 0.0256 0.2835 0.2719
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0229 0.0213
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0863 1 1
Schistosoma mansoni hypothetical protein 0.0017 0.0017 0.0017
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0307 0.3438 1
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0307 0.3438 0.3427
Brugia malayi hypothetical protein 0.0027 0.0137 0.0137
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0017 0.0017
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0205 0.2238 0.2238
Trichomonas vaginalis conserved hypothetical protein 0.0863 1 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0374 0.0374
Onchocerca volvulus 0.0035 0.0229 0.0071
Echinococcus granulosus sterol regulatory element binding protein 0.0087 0.0839 0.0824
Schistosoma mansoni hypothetical protein 0.0863 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0307 0.3438 0.3438
Echinococcus multilocularis Niemann Pick C1 protein 0.0289 0.3225 0.3213
Brugia malayi hypothetical protein 0.0256 0.283 0.283
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0087 0.0839 0.0839
Loa Loa (eye worm) hypoxia-induced factor 1 0.0147 0.1544 0.1544
Echinococcus multilocularis ring and YY1 binding protein 0.0307 0.3438 0.3427
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0307 0.3438 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0062 0.0045

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.729 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.683 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.66 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.636 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.631 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.577 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.556 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.508 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.451 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.441 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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