Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.0263 | 0.254 | 0.5 |
Giardia lamblia | Kinase, NEK | 0.002 | 0 | 0.5 |
Chlamydia trachomatis | SWIB complex protein | 0.0976 | 1 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0347 | 0.3424 | 0.5 |
Schistosoma mansoni | fusion | 0.0347 | 0.3424 | 0.3424 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0263 | 0.254 | 0.0001 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0976 | 1 | 1 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0976 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0976 | 1 | 1 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0347 | 0.3424 | 0.1186 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0347 | 0.3424 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.0976 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0347 | 0.3424 | 0.5 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0347 | 0.3424 | 0.1186 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0976 | 1 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0347 | 0.3424 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0976 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0347 | 0.3424 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0347 | 0.3424 | 0.5 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0347 | 0.3424 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0976 | 1 | 1 |
Schistosoma mansoni | brg-1 associated factor | 0.0976 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0347 | 0.3424 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0976 | 1 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0976 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0347 | 0.3424 | 0.5 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0347 | 0.3424 | 0.1186 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0347 | 0.3424 | 0.1186 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0347 | 0.3424 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.0263 | 0.254 | 0.0001 |
Giardia lamblia | Kinase, NEK | 0.002 | 0 | 0.5 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0976 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0347 | 0.3424 | 0.5 |
Schistosoma mansoni | RNA binding protein | 0.0347 | 0.3424 | 0.3424 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0347 | 0.3424 | 0.1186 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0347 | 0.3424 | 0.5 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0347 | 0.3424 | 0.5 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0976 | 1 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.0976 | 1 | 1 |
Giardia lamblia | Kinase | 0.002 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0347 | 0.3424 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0347 | 0.3424 | 0.3424 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0976 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0347 | 0.3424 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0263 | 0.254 | 0.254 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0976 | 1 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0347 | 0.3424 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0347 | 0.3424 | 0.3424 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0347 | 0.3424 | 0.1186 |
Schistosoma mansoni | hypothetical protein | 0.0976 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0976 | 1 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0976 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0976 | 1 | 0.5 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0347 | 0.3424 | 0.5 |
Onchocerca volvulus | 0.0976 | 1 | 1 | |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0347 | 0.3424 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0347 | 0.3424 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0263 | 0.254 | 0.5 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0347 | 0.3424 | 0.1186 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0976 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0976 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0976 | 1 | 1 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0347 | 0.3424 | 0.3424 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0347 | 0.3424 | 0.1186 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.