Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | TRABID protein (C64 family) | 0.0256 | 0.2563 | 0.0459 |
Entamoeba histolytica | bromodomain-containing protein | 0.0196 | 0.1603 | 0.5 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0256 | 0.2563 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0256 | 0.2563 | 0.5 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0256 | 0.2563 | 0.1143 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.2563 | 0.2563 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0719 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0256 | 0.2563 | 0.1658 |
Echinococcus multilocularis | Bromodomain containing protein | 0.0196 | 0.1603 | 0.0488 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0719 | 1 | 1 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0256 | 0.2563 | 0.1575 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0272 | 0.2819 | 0.1448 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0256 | 0.2563 | 0.5 |
Echinococcus granulosus | CREB binding protein | 0.0233 | 0.2205 | 0.1391 |
Schistosoma mansoni | brg-1 associated factor | 0.0719 | 1 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.0719 | 1 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0256 | 0.2563 | 0.5 |
Onchocerca volvulus | 0.0719 | 1 | 1 | |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0256 | 0.2563 | 0.1787 |
Brugia malayi | Bromodomain containing protein | 0.0435 | 0.5447 | 0.4893 |
Schistosoma mansoni | fusion | 0.0256 | 0.2563 | 0.0459 |
Onchocerca volvulus | 0.0256 | 0.2563 | 0.1143 | |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0719 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0256 | 0.2563 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0719 | 1 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0719 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0256 | 0.2563 | 0.0459 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0719 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0256 | 0.2563 | 0.5 |
Giardia lamblia | Kinase, putative | 0.0196 | 0.1603 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0256 | 0.2563 | 0.5 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0256 | 0.2563 | 0.1575 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0435 | 0.5447 | 0.4578 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.5447 | 0.5447 |
Leishmania major | hypothetical protein, conserved | 0.0256 | 0.2563 | 0.5 |
Schistosoma mansoni | RNA binding protein | 0.0256 | 0.2563 | 0.0459 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0256 | 0.2563 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.2563 | 0.2563 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0256 | 0.2563 | 0.1658 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0719 | 1 | 1 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0256 | 0.2563 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0719 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0256 | 0.2563 | 0.1658 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0719 | 1 | 1 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0256 | 0.2563 | 0.5 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0256 | 0.2563 | 0.1575 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0256 | 0.2563 | 0.5 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0256 | 0.2563 | 0.5 |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.0256 | 0.2563 | 0.1143 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.0272 | 0.2819 | 0.1448 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0256 | 0.2563 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0272 | 0.2819 | 0.1448 |
Onchocerca volvulus | 0.0256 | 0.2563 | 0.1143 | |
Brugia malayi | TAZ zinc finger family protein | 0.0233 | 0.2205 | 0.1257 |
Toxoplasma gondii | ran binding protein | 0.0256 | 0.2563 | 0.1143 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0435 | 0.5447 | 0.4578 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.2563 | 0.2563 |
Schistosoma mansoni | hypothetical protein | 0.0719 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0719 | 1 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0196 | 0.1603 | 0.1603 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0719 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.2563 | 0.2563 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0272 | 0.2819 | 0.1448 |
Onchocerca volvulus | 0.0256 | 0.2563 | 0.1143 | |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0719 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0272 | 0.2819 | 0.1448 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0256 | 0.2563 | 0.1575 |
Schistosoma mansoni | hypothetical protein | 0.0256 | 0.2563 | 0.0459 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0719 | 1 | 1 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0256 | 0.2563 | 0.1787 |
Echinococcus multilocularis | bromodomain containing 2 | 0.0435 | 0.5447 | 0.4842 |
Entamoeba histolytica | bromodomain-containing protein | 0.0196 | 0.1603 | 0.5 |
Echinococcus granulosus | bromodomain containing 2 | 0.0435 | 0.5447 | 0.4972 |
Onchocerca volvulus | 0.0256 | 0.2563 | 0.1143 | |
Entamoeba histolytica | bromodomain-containing protein | 0.0196 | 0.1603 | 0.5 |
Brugia malayi | YY1-associated factor 2 | 0.0256 | 0.2563 | 0.1658 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0719 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0239 | 0.23 | 0.0831 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0719 | 1 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0719 | 1 | 0.5 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0719 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.2563 | 0.2563 |
Loa Loa (eye worm) | CBP-B | 0.0171 | 0.1201 | 0.1201 |
Leishmania major | hypothetical protein, conserved | 0.0256 | 0.2563 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0719 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0719 | 1 | 1 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0256 | 0.2563 | 0.1787 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0256 | 0.2563 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0256 | 0.2563 | 0.5 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0256 | 0.2563 | 0.1787 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0256 | 0.2563 | 0.1658 |
Loa Loa (eye worm) | brahma associated protein | 0.0719 | 1 | 1 |
Schistosoma mansoni | bromodomain-containing protein 3 brd3 | 0.0435 | 0.5447 | 0.4159 |
Leishmania major | hypothetical protein, conserved | 0.0256 | 0.2563 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0256 | 0.2563 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0435 | 0.5447 | 0.4893 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6.033 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.857 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.852 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.797 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.796 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.764 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.754 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.74 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.716 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.475 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.961 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.