Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0474 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0134 | 0.2026 | 0.0988 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0474 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0169 | 0.2843 | 0.5 |
Loa Loa (eye worm) | brahma associated protein | 0.0474 | 1 | 1 |
Schistosoma mansoni | bromodomain-containing protein 3 brd3 | 0.0214 | 0.3914 | 0.2768 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0169 | 0.2843 | 0.2238 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0134 | 0.2026 | 0.0988 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0169 | 0.2843 | 0.2321 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0169 | 0.2843 | 0.1495 |
Brugia malayi | Bromodomain containing protein | 0.0214 | 0.3914 | 0.34 |
Onchocerca volvulus | 0.0169 | 0.2843 | 0.1911 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0118 | 0.1653 | 0.0567 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0474 | 1 | 1 |
Toxoplasma gondii | ran binding protein | 0.0169 | 0.2843 | 0.1911 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0169 | 0.2843 | 0.5 |
Entamoeba histolytica | bromodomain-containing protein | 0.0096 | 0.1152 | 0.5 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0474 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0474 | 1 | 0.5 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0474 | 1 | 0.5 |
Loa Loa (eye worm) | CBP-B | 0.0084 | 0.0863 | 0.0863 |
Onchocerca volvulus | 0.0169 | 0.2843 | 0.1911 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0169 | 0.2843 | 0.5 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0474 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.2843 | 0.2843 |
Schistosoma mansoni | RNA binding protein | 0.0169 | 0.2843 | 0.1495 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0169 | 0.2843 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.2843 | 0.2843 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0134 | 0.2026 | 0.0988 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0474 | 1 | 1 |
Echinococcus granulosus | bromodomain containing 2 | 0.0214 | 0.3914 | 0.3471 |
Entamoeba histolytica | bromodomain-containing protein | 0.0096 | 0.1152 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0214 | 0.3914 | 0.34 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0169 | 0.2843 | 0.5 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0096 | 0.1152 | 0.1152 |
Schistosoma mansoni | hypothetical protein | 0.0474 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0474 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0474 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.2843 | 0.2843 |
Leishmania major | hypothetical protein, conserved | 0.0169 | 0.2843 | 0.5 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0169 | 0.2843 | 0.5 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0474 | 1 | 1 |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.0169 | 0.2843 | 0.1911 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0169 | 0.2843 | 0.5 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0169 | 0.2843 | 0.5 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0169 | 0.2843 | 0.2184 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0169 | 0.2843 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0169 | 0.2843 | 0.5 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0169 | 0.2843 | 0.2321 |
Leishmania major | hypothetical protein, conserved | 0.0169 | 0.2843 | 0.5 |
Brugia malayi | TAZ zinc finger family protein | 0.0115 | 0.1585 | 0.0873 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0214 | 0.3914 | 0.3122 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0169 | 0.2843 | 0.5 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0169 | 0.2843 | 0.1911 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0474 | 1 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.0474 | 1 | 1 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.0134 | 0.2026 | 0.0988 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0169 | 0.2843 | 0.2184 |
Entamoeba histolytica | bromodomain-containing protein | 0.0096 | 0.1152 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0169 | 0.2843 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.2843 | 0.2843 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0169 | 0.2843 | 0.5 |
Brugia malayi | YY1-associated factor 2 | 0.0169 | 0.2843 | 0.2238 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.3914 | 0.3914 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0214 | 0.3914 | 0.3122 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0474 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0474 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0169 | 0.2843 | 0.2238 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0169 | 0.2843 | 0.2321 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0169 | 0.2843 | 0.2184 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.2843 | 0.2843 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0169 | 0.2843 | 0.2238 |
Echinococcus multilocularis | Bromodomain containing protein | 0.0096 | 0.1152 | 0.0338 |
Chlamydia trachomatis | SWIB complex protein | 0.0474 | 1 | 0.5 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0169 | 0.2843 | 0.2184 |
Echinococcus granulosus | CREB binding protein | 0.0115 | 0.1585 | 0.0972 |
Schistosoma mansoni | brg-1 associated factor | 0.0474 | 1 | 1 |
Onchocerca volvulus | 0.0169 | 0.2843 | 0.1911 | |
Leishmania major | hypothetical protein, conserved | 0.0169 | 0.2843 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0474 | 1 | 1 |
Onchocerca volvulus | 0.0474 | 1 | 1 | |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0134 | 0.2026 | 0.0988 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0169 | 0.2843 | 0.2321 |
Schistosoma mansoni | hypothetical protein | 0.0474 | 1 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0169 | 0.2843 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0169 | 0.2843 | 0.2238 |
Onchocerca volvulus | 0.0169 | 0.2843 | 0.1911 | |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0474 | 1 | 1 |
Echinococcus multilocularis | bromodomain containing 2 | 0.0214 | 0.3914 | 0.3355 |
Giardia lamblia | Kinase, putative | 0.0096 | 0.1152 | 0.5 |
Schistosoma mansoni | fusion | 0.0169 | 0.2843 | 0.1495 |
Schistosoma mansoni | zinc finger protein | 0.0169 | 0.2843 | 0.1495 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0474 | 1 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0169 | 0.2843 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0169 | 0.2843 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.2843 | 0.1495 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.434 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.321 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.959 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.905 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.856 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.811 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.778 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.777 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.622 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.512 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.