Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0365 | 0.9733 | 0.9596 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0375 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0375 | 1 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0375 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0375 | 1 | 1 |
Trypanosoma brucei | Casein kinase II | 0.0365 | 0.9733 | 1 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0365 | 0.9733 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0365 | 0.9733 | 0.5 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0365 | 0.9733 | 0.9596 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0375 | 1 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0375 | 1 | 0.5 |
Loa Loa (eye worm) | brahma associated protein | 0.0375 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0133 | 0.3394 | 0.3394 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0375 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0375 | 1 | 1 |
Schistosoma mansoni | brg-1 associated factor | 0.0375 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0375 | 1 | 1 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0375 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 0.3394 | 0.3394 |
Schistosoma mansoni | fusion | 0.0133 | 0.3394 | 0.3394 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0365 | 0.9733 | 0.9596 |
Brugia malayi | Casein kinase II, alpha chain | 0.0365 | 0.9733 | 0.9596 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0375 | 1 | 1 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0365 | 0.9733 | 0.9596 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0375 | 1 | 1 |
Onchocerca volvulus | 0.0375 | 1 | 1 | |
Entamoeba histolytica | casein kinase, putative | 0.0365 | 0.9733 | 0.5 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0375 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0375 | 1 | 1 |
Leishmania major | casein kinase II, putative | 0.0365 | 0.9733 | 1 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0375 | 1 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 0.0365 | 0.9733 | 1 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0365 | 0.9733 | 0.9596 |
Brugia malayi | brahma associated protein 60 kDa | 0.0375 | 1 | 1 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0375 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0375 | 1 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.0375 | 1 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0375 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0365 | 0.9733 | 0.9733 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0133 | 0.3394 | 0.3394 |
Schistosoma mansoni | RNA binding protein | 0.0133 | 0.3394 | 0.3394 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0375 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.