Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.0175 | 0.4469 | 0.4469 |
Schistosoma mansoni | hypothetical protein | 0.0356 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0036 | 0.0198 | 0.0198 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0127 | 0.2969 | 0.5 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0127 | 0.2969 | 0.2969 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0356 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0356 | 1 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0127 | 0.2969 | 0.2969 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0356 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.2969 | 0.2969 |
Toxoplasma gondii | ran binding protein | 0.0127 | 0.2969 | 0.2969 |
Schistosoma mansoni | brg-1 associated factor | 0.0356 | 1 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0356 | 1 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.003 | 0 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0127 | 0.2969 | 0.2969 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0127 | 0.2969 | 1 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0127 | 0.2969 | 0.2969 |
Chlamydia trachomatis | SWIB complex protein | 0.0356 | 1 | 0.5 |
Schistosoma mansoni | RNA binding protein | 0.0127 | 0.2969 | 0.2969 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0127 | 0.2969 | 0.2969 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0127 | 0.2969 | 0.2969 |
Giardia lamblia | Kinase, AGC AKT | 0.0175 | 0.4469 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.2969 | 0.2969 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0127 | 0.2969 | 0.5 |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.0127 | 0.2969 | 0.2969 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0127 | 0.2969 | 0.2969 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0127 | 0.2969 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.003 | 0 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0356 | 1 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0127 | 0.2969 | 0.2969 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0127 | 0.2969 | 1 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0127 | 0.2969 | 0.2969 |
Onchocerca volvulus | 0.0356 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0356 | 1 | 1 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0205 | 0.5363 | 0.5363 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0205 | 0.5363 | 0.5363 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0127 | 0.2969 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.2969 | 0.2969 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0127 | 0.2969 | 0.5 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0127 | 0.2969 | 0.2969 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.2969 | 0.2969 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0356 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0356 | 1 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0127 | 0.2969 | 0.5 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0205 | 0.5363 | 0.5363 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0356 | 1 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0127 | 0.2969 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0127 | 0.2969 | 0.2969 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0127 | 0.2969 | 0.2969 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0356 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0127 | 0.2969 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0127 | 0.2969 | 0.5 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0127 | 0.2969 | 0.5 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0356 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0356 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0356 | 1 | 1 |
Schistosoma mansoni | fusion | 0.0127 | 0.2969 | 0.2969 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.2969 | 0.2969 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0175 | 0.4469 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0127 | 0.2969 | 0.5 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0127 | 0.2969 | 0.2969 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0205 | 0.5363 | 0.5363 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0356 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0127 | 0.2969 | 0.2969 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0356 | 1 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.0356 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0127 | 0.2969 | 0.5 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0127 | 0.2969 | 0.2969 |
Plasmodium vivax | hypothetical protein, conserved | 0.0356 | 1 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.0356 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0356 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.2969 | 0.2969 |
Entamoeba histolytica | protein kinase, putative | 0.003 | 0 | 0.5 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0356 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.