Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0689 | 0 | 0.5 | |
Leishmania major | eukaryotic translation initiation factor-like | 0.0923 | 1 | 0.5 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0923 | 1 | 0.5 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0923 | 1 | 0.5 |
Echinococcus multilocularis | eukaryotic translation initiation factor 4E | 0.0923 | 1 | 1 |
Onchocerca volvulus | 0.0689 | 0 | 0.5 | |
Schistosoma mansoni | eukaryotic translation initiation factor 4e | 0.0923 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0923 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0689 | 0 | 0.5 |
Onchocerca volvulus | 0.0689 | 0 | 0.5 | |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0923 | 1 | 0.5 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-1 | 0.0923 | 1 | 0.5 |
Leishmania major | eukaryotic translation initiation factor-like protein | 0.0923 | 1 | 0.5 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0923 | 1 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.0923 | 1 | 0.5 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0923 | 1 | 0.5 |
Leishmania major | eukaryotic translation initiation factor eIF-4E, putative | 0.0923 | 1 | 0.5 |
Onchocerca volvulus | 0.0689 | 0 | 0.5 | |
Loa Loa (eye worm) | translation initiation factor 4E | 0.0923 | 1 | 1 |
Onchocerca volvulus | 0.0689 | 0 | 0.5 | |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0923 | 1 | 0.5 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E | 0.0923 | 1 | 1 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0923 | 1 | 0.5 |
Onchocerca volvulus | 0.0689 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.632 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.387 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.346 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.311 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.305 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.197 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.189 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.084 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.