Detailed information for compound 1611122

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 352.41 | Formula: C18H16N4O2S
  • H donors: 1 H acceptors: 3 LogP: 3.7 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNc1ncnc2c1c1ccn(c(=O)c1s2)c1ccc(cc1)OC
  • InChi: 1S/C18H16N4O2S/c1-3-19-16-14-13-8-9-22(11-4-6-12(24-2)7-5-11)18(23)15(13)25-17(14)21-10-20-16/h4-10H,3H2,1-2H3,(H,19,20,21)
  • InChiKey: UKPPGFGGYZRPPL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Metabotropic glutamate receptor 1 Starlite/ChEMBL References
Homo sapiens glutamate receptor, metabotropic 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum ko:K04606 glutamate receptor, metabotropic 3, putative Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum Metabotropic glutamate receptor precursor, putative Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi Metabotropic glutamate receptor precursor. Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0276 0.7603
Schistosoma mansoni microtubule-associated protein tau 0.3433 0.8067 0.8067
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.006 0.0081 0.0216
Brugia malayi RNA binding protein 0.0066 0.0093 0.0093
Schistosoma mansoni wnt-5 0.0032 0.0014 0.0014
Echinococcus granulosus protein Wnt 2 0.0032 0.0014 0.0014
Brugia malayi wnt family protein 0.0032 0.0014 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0276 0.7603
Loa Loa (eye worm) MH2 domain-containing protein 0.0476 0.1064 0.1068
Brugia malayi wnt family protein 0.0032 0.0014 0.0014
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0015 0.0015
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0038 0.0027 0.039
Schistosoma mansoni serine/threonine protein kinase 0.1267 0.2939 0.2939
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0018 0.0503
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.006 0.0081 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.0254 0.6999
Entamoeba histolytica hypothetical protein 0.0142 0.0273 0.7384
Loa Loa (eye worm) hypothetical protein 0.1252 0.2903 0.2913
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0093 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0168 0.4612
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.019 0.5217
Giardia lamblia GTOR 0.018 0.0363 0.5
Schistosoma mansoni rap gtpase-activating protein 0.1252 0.2903 0.2903
Schistosoma mansoni smad1 5 8 and 0.0032 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.1252 0.2903 0.2913
Schistosoma mansoni hypothetical protein 0.0142 0.0273 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0363 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0142 0.0273 0.0274
Echinococcus multilocularis protein Wnt 1 0.0032 0.0014 0.0017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.018 0.0363 0.0363
Loa Loa (eye worm) CWN-2 protein 0.0032 0.0014 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0276 0.7603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0192 0.5286
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.1267 0.2939 0.3643
Echinococcus multilocularis zinc finger transcription factor gli2 0.0735 0.1678 0.2079
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.018 0.0363 0.1197
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0093 0.0094
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.1267 0.2939 0.295
Schistosoma mansoni smad1 5 8 and 0.0032 0.0015 0.0015
Echinococcus granulosus protein Wnt 1 0.0032 0.0014 0.0014
Echinococcus multilocularis Smad4 0.0032 0.0015 0.0018
Brugia malayi MH1 domain containing protein 0.0032 0.0015 0.0015
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0143 0.0277 0.6934
Toxoplasma gondii target of rapamycin (TOR), putative 0.0134 0.0254 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0001 0.0001
Schistosoma mansoni smad 0.0032 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.019 0.5217
Loa Loa (eye worm) hypothetical protein 0.0049 0.0055 0.0055
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0034 0.0018 0.0023
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.1252 0.2903 0.3598
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0143 0.0277 0.0896
Echinococcus granulosus lamin dm0 0.0027 0.0001 0.0001
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1267 0.2939 0.295
Echinococcus granulosus serine protein kinase ATM 0.0034 0.0018 0.0018
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0142 0.0273 0.0339
Schistosoma mansoni protein kinase 0.2997 0.7035 0.7035
Brugia malayi MH2 domain containing protein 0.0032 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0034 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0034 0.0018 0.0018
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.1252 0.2903 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.018 0.0363 0.1197
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0085 0.0139 0.0419
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.006 0.0081 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0018 0.0503
Schistosoma mansoni transcription factor LCR-F1 0.0142 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.012 0.0223 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0168 0.4612
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0075 0.0115 0.0334
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.006 0.0081 0.0216
Brugia malayi Zinc finger, C2H2 type family protein 0.0735 0.1678 0.1678
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0111 0.0201 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0018 0.0503
Loa Loa (eye worm) glutamate receptor 0.0098 0.0169 0.017
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0001 0.0001
Brugia malayi MH2 domain containing protein 0.0476 0.1064 0.1064
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0034 0.0018 0.0018
Echinococcus multilocularis smad 0.0032 0.0015 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.1267 0.2939 0.2939
Echinococcus granulosus protein kinase 0.2997 0.7035 0.7061
Loa Loa (eye worm) hypothetical protein 0.4233 0.9964 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0034 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0363 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0055 0.0055
Echinococcus granulosus Smad4 0.0032 0.0015 0.0015
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0001 0.0001
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0015 0.0015
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.1252 0.2903 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0052 0.143
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0055 0.0055
Brugia malayi Smad1 0.0032 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.1252 0.2903 0.2913
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1267 0.2939 0.3643
Echinococcus multilocularis WNT 0.0032 0.0014 0.0017
Brugia malayi wnt family protein 0.0032 0.0014 0.0014
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0015 0.0015
Loa Loa (eye worm) phosphatidylinositol 3 0.018 0.0363 0.0365
Brugia malayi hypothetical protein 0.0142 0.0273 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0153 0.0301 0.8287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.0254 0.6999
Brugia malayi MH2 domain containing protein 0.0032 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.0254 0.6999
Brugia malayi TAR-binding protein 0.0066 0.0093 0.0093
Brugia malayi metabotropic glutamate receptor type 2 0.0048 0.0051 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0081 0.2215
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0015 0.0015
Echinococcus granulosus zinc finger transcription factor gli2 0.0735 0.1678 0.1684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0192 0.5286
Schistosoma mansoni metabotropic glutamate receptor 0.0048 0.0051 0.0051
Brugia malayi intermediate filament protein 0.0027 0.0001 0.0001
Echinococcus granulosus Protein Wnt-5 0.0032 0.0014 0.0014
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.006 0.0081 0.0081
Brugia malayi hypothetical protein 0.1252 0.2903 0.2903
Schistosoma mansoni Smad4 0.0032 0.0015 0.0015
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.1252 0.2903 0.2903
Echinococcus granulosus metabotropic glutamate receptor 5 0.012 0.0223 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0081 0.2215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.0254 0.6999
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0015 0.0015
Echinococcus granulosus Vam6:Vps39 protein 0.1252 0.2903 0.2913
Echinococcus granulosus intermediate filament protein 0.0027 0.0001 0.0001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0055 0.0055
Echinococcus granulosus serine:threonine protein kinase mig 15 0.4233 0.9964 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0015 0.0018
Schistosoma mansoni lamin 0.0027 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.1267 0.2939 0.2939
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.006 0.0081 0.0081
Echinococcus granulosus Protein Wnt-11b 0.0032 0.0014 0.0014
Entamoeba histolytica hypothetical protein 0.0142 0.0273 0.7384
Loa Loa (eye worm) transcription factor SMAD2 0.0476 0.1064 0.1068
Entamoeba histolytica hypothetical protein 0.0142 0.0273 0.7384
Brugia malayi Metabotropic glutamate receptor precursor. 0.0098 0.0169 0.0169
Schistosoma mansoni hypothetical protein 0.1252 0.2903 0.2903
Schistosoma mansoni vam6/vps39 related 0.1252 0.2903 0.2903
Loa Loa (eye worm) zinc finger protein 0.0735 0.1678 0.1684
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0089 0.0148 0.0148
Schistosoma mansoni smad1 5 8 and 0.0032 0.0015 0.0015
Echinococcus granulosus smad 0.0032 0.0015 0.0015
Echinococcus multilocularis metabotropic glutamate receptor 5 0.012 0.0223 0.0276
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.018 0.0363 1
Loa Loa (eye worm) Wnt2 protein 0.0032 0.0014 0.0014
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.1252 0.2903 0.2903
Schistosoma mansoni wnt related 0.0032 0.0014 0.0014
Schistosoma mansoni protein kinase 0.1267 0.2939 0.2939
Entamoeba histolytica hypothetical protein 0.0142 0.0273 0.7384
Echinococcus multilocularis lamin 0.0027 0.0001 0.0001
Echinococcus multilocularis lamin dm0 0.0027 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0081 0.2215
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0093 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0168 0.4612
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.018 0.0363 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.006 0.0081 0.0216
Brugia malayi Wnt-2 protein precursor 0.0032 0.0014 0.0014
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.018 0.0363 0.1197
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0093 0.0093
Loa Loa (eye worm) wnt-4 protein 0.0032 0.0014 0.0014
Echinococcus multilocularis protein Wnt 2 0.0032 0.0014 0.0017
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0093 0.0094
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0082 0.0132 0.0163
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.018 0.0363 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0081 0.2215
Schistosoma mansoni fkbp-rapamycin associated protein 0.0034 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0081 0.2215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0168 0.4612
Schistosoma mansoni wnt related 0.0032 0.0014 0.0014
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.018 0.0363 0.0451
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0093 0.0093
Echinococcus multilocularis musashi 0.0027 0.0001 0.0001
Loa Loa (eye worm) glutamate receptor 0.0038 0.0029 0.0029
Echinococcus granulosus tumor protein p63 0.0681 0.155 0.1556
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0192 0.5286
Echinococcus multilocularis microtubule associated protein 2 0.3433 0.8067 1
Schistosoma mansoni wnt related 0.0032 0.0014 0.0014
Echinococcus granulosus microtubule associated protein 2 0.3433 0.8067 0.8096
Schistosoma mansoni metabotropic glutamate receptor 0.0082 0.0132 0.0132
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.018 0.0363 0.0363
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0015 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.0254 0.6999
Loa Loa (eye worm) hypothetical protein 0.01 0.0174 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.0254 0.6999
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0756
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.1252 0.2903 0.2913
Echinococcus multilocularis wingless type MMTV integration site family 0.0032 0.0014 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0363 1
Schistosoma mansoni protein kinase 0.4249 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.006 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0034 0.0018 0.0018
Loa Loa (eye worm) Smad1 0.0032 0.0015 0.0015
Echinococcus granulosus lamin 0.0027 0.0001 0.0001
Onchocerca volvulus 0.01 0.0174 0.0595
Loa Loa (eye worm) phosphatidylinositol 3 0.006 0.0081 0.0081
Brugia malayi Wnt-4 protein precursor 0.0032 0.0014 0.0014
Echinococcus multilocularis 0.2997 0.7035 0.8721
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0093 0.0116
Echinococcus granulosus tar DNA binding protein 0.0066 0.0093 0.0094
Brugia malayi MH1 domain containing protein 0.0032 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.0254 0.6999
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0034 0.0018 0.0018
Echinococcus multilocularis serine protein kinase ATM 0.0034 0.0018 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0167 0.4602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0121 0.0223 0.6144
Schistosoma mansoni cellular tumor antigen P53 0.01 0.0174 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0276 0.7603
Loa Loa (eye worm) RNA binding protein 0.0066 0.0093 0.0094
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.018 0.0363 0.0365
Schistosoma mansoni lamin 0.0027 0.0001 0.0001
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0093 0.0093
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0034 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0276 0.7603
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0018 0.0018
Onchocerca volvulus 0.1252 0.2903 1
Schistosoma mansoni wnt related 0.0032 0.0014 0.0014
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1267 0.2939 0.295
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Echinococcus granulosus Protein Wnt-111 0.0032 0.0014 0.0014
Brugia malayi Temporarily assigned gene name protein 59 0.1252 0.2903 0.2903
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0167 0.4602
Brugia malayi wnt family protein 0.0032 0.0014 0.0014
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.1267 0.2939 0.295
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Echinococcus granulosus metabotropic glutamate receptor 2 0.0082 0.0132 0.0132
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.2997 0.7035 0.7061
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.1252 0.2903 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0117 0.0214 0.5891
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0001 0.0001
Echinococcus multilocularis WNT 0.0032 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0027 0.0001 0.0001
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.018 0.0363 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0167 0.4602
Echinococcus multilocularis wnt family member wnt11 2 0.0032 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1267 0.2939 0.3643
Echinococcus granulosus Protein Wnt-04 0.0032 0.0014 0.0014
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.018 0.0363 0.1197
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0028
Trypanosoma cruzi target of rapamycin kinase 3 0.0143 0.0277 0.0896
Echinococcus multilocularis tumor protein p63 0.0681 0.155 0.1922

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 34 nM Antagonist activity at human metabotropic glutamate receptor 1 ChEMBL. 22266036
Ki (functional) = 32 nM Antagonist activity at rat metabotropic glutamate receptor 1 ChEMBL. 22266036

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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