Detailed information for compound 1611717

Basic information

Technical information
  • TDR Targets ID: 1611717
  • Name: (cyclopentylideneamino) 2-[[2-[2-[(2-methylpr opan-2-yl)oxycarbonylamino]propanoylamino]-3- phenylpropanoyl]amino]acetate
  • MW: 474.55 | Formula: C24H34N4O6
  • H donors: 3 H acceptors: 4 LogP: 2.58 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(ON=C1CCCC1)CNC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)OC(C)(C)C)C
  • InChi: 1S/C24H34N4O6/c1-16(26-23(32)33-24(2,3)4)21(30)27-19(14-17-10-6-5-7-11-17)22(31)25-15-20(29)34-28-18-12-8-9-13-18/h5-7,10-11,16,19H,8-9,12-15H2,1-4H3,(H,25,31)(H,26,32)(H,27,30)
  • InChiKey: GIHGPMYOIHAAGA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (cyclopentylideneamino) 2-[[2-[2-(tert-butoxycarbonylamino)propanoylamino]-3-phenyl-propanoyl]amino]acetate
  • 2-[[2-[[2-[(tert-butoxy-oxomethyl)amino]-1-oxopropyl]amino]-1-oxo-3-phenylpropyl]amino]acetic acid (cyclopentylideneamino) ester
  • 2-[[2-[2-(tert-butoxycarbonylamino)propanoylamino]-3-phenyl-propanoyl]amino]acetic acid (cyclopentylideneamino) ester
  • (cyclopentylideneamino) 2-[[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoylamino]-3-phenyl-propanoyl]amino]ethanoate
  • NSC668595
  • tert-Butyl 2-((1-benzyl-2-((2-((cyclopentylideneamino)oxy)-2-oxoethyl)amino)-2-oxoethyl)amino)-1-methyl-2-oxoethylcarbamate
  • NCI60_023961
  • AIDS-144989
  • AIDS144989

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0292 0.0286
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0139 0.079 0.2343
Brugia malayi Pre-SET motif family protein 0.0464 0.2793 0.2793
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0072 0.0218
Leishmania major cysteine peptidase A (CPA) 0.0547 0.3308 0.9089
Loa Loa (eye worm) hypothetical protein 0.0139 0.079 0.079
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.1647 0.4496
Trypanosoma brucei cytochrome P450, putative 0.0021 0.0064 0.016
Brugia malayi cathepsin L precursor 0.0139 0.079 0.079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0154 0.0154
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0072 0.0072
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0255 0.0255
Brugia malayi hypothetical protein 0.0055 0.0272 0.0272
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.002 0.0038
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0464 0.2793 0.2793
Giardia lamblia Cathepsin L-like protease 0.0139 0.079 0.2129
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0072 0.0072
Brugia malayi ecdysteroid receptor 0.0022 0.0072 0.0072
Giardia lamblia Cathepsin L precursor 0.0139 0.079 0.2129
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0072 0.0072
Plasmodium vivax vivapain-1 0.0304 0.1811 0.5447
Echinococcus multilocularis cathepsin L 0.0304 0.1811 0.1811
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0008 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.1647 0.4496
Loa Loa (eye worm) hypothetical protein 0.0055 0.0272 0.0272
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0087 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.079 0.2129
Schistosoma mansoni cathepsin F (C01 family) 0.0547 0.3308 0.3308
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0139 0.079 0.2343
Brugia malayi Thioredoxin reductase 0.0039 0.0178 0.0178
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0178 0.0482
Entamoeba histolytica cysteine proteinase, putative 0.0304 0.1811 0.5218
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0272 0.0732
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0072 0.0072
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0139 0.079 0.079
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0067 0.0349 0.0349
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.0292 0.0292
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.002 0.0038
Giardia lamblia Hypothetical protein 0.0139 0.079 0.2129
Entamoeba histolytica cysteine protease, putative 0.0304 0.1811 0.5218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0547 0.3308 0.9085
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0139 0.079 0.2129
Brugia malayi Cathepsin L-like precursor 0.0166 0.0956 0.0956
Schistosoma mansoni cathepsin B (C01 family) 0.0139 0.079 0.079
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.009 0.0489 0.8866
Echinococcus granulosus histone lysine methyltransferase setb 0.0067 0.0349 0.0349
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.002 0.0014
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0601 0.3639 0.3635
Giardia lamblia Cysteine protease 0.0139 0.079 0.2129
Onchocerca volvulus 0.0547 0.3308 1
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.1058 0.287
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0547 0.3308 0.9085
Schistosoma mansoni coup transcription factor 0.0022 0.0072 0.0072
Echinococcus granulosus cysteine protease 0.0304 0.1811 0.1811
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0028 0.0028
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0304 0.1811 0.1811
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0072 0.0072
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0072 0.0072
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.002 0.0038
Echinococcus multilocularis cathepsin L cysteine protease 0.0547 0.3308 0.3308
Giardia lamblia Cathepsin B precursor 0.0601 0.3639 1
Onchocerca volvulus Cathepsin F homolog 0.0547 0.3308 1
Brugia malayi Cytochrome P450 family protein 0.0021 0.0064 0.0064
Echinococcus granulosus cathepsin L 0.0304 0.1811 0.1811
Onchocerca volvulus 0.0382 0.2287 0.6914
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.01 0.0551 1
Leishmania major cathepsin L-like protease 0.0547 0.3308 0.9089
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0037 0.0037
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0072 0.0072
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0299 0.0808
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0292 0.0752
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0006
Plasmodium vivax glutathione reductase, putative 0.0039 0.0178 0.0482
Giardia lamblia Cathepsin L precursor 0.0139 0.079 0.2129
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0547 0.3308 0.9085
Onchocerca volvulus 0.0031 0.0127 0.0383
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0139 0.079 0.2343
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0139 0.079 0.2129
Onchocerca volvulus 0.003 0.012 0.0362
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0547 0.3308 0.9085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0072 0.0072
Schistosoma mansoni cathepsin F (C01 family) 0.0382 0.2287 0.2287
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0072 0.0072
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.002 0.0038
Giardia lamblia Cathepsin L precursor 0.0139 0.079 0.2129
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0008
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0139 0.079 0.1958
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.079 0.079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0547 0.3308 0.9089
Echinococcus granulosus lamin dm0 0.0031 0.0127 0.0127
Echinococcus multilocularis cathepsin b 0.1634 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0139 0.079 0.079
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0304 0.1811 0.1811
Loa Loa (eye worm) cysteine protease 0.0547 0.3308 0.3308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0547 0.3308 0.9085
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0072 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.079 0.2129
Schistosoma mansoni cathepsin C 0.0139 0.079 0.079
Brugia malayi hypothetical protein 0.0012 0.0008 0.0008
Brugia malayi Cathepsin L-like precursor 0.0547 0.3308 0.3308
Schistosoma mansoni hypothetical protein 0.0016 0.0037 0.0037
Onchocerca volvulus Cathepsin L homolog 0.0139 0.079 0.2389
Plasmodium falciparum thioredoxin reductase 0.0039 0.0178 0.0482
Echinococcus granulosus cathepsin L cysteine proteinase 0.0547 0.3308 0.3308
Giardia lamblia Cysteine protease 0.0139 0.079 0.2129
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0072 0.0072
Onchocerca volvulus Cathepsin L homolog 0.0547 0.3308 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.0292 0.0292
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.002 0.0038
Plasmodium falciparum serine repeat antigen 5 0.0139 0.079 0.2343
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1634 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0547 0.3308 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0072
Trypanosoma cruzi major cysteine proteinase, putative 0.0139 0.079 0.0785
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0008 0.0008
Brugia malayi Cathepsin L-like precursor 0.0547 0.3308 0.3308
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0072 0.0072
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.002 0.002
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0361 0.0361
Toxoplasma gondii cathepsin CPL 0.0547 0.3308 0.9089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.079 0.2129
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.079 0.079
Plasmodium vivax vivapain-2 0.0547 0.3308 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0139 0.079 0.2343
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0139 0.079 0.2343
Toxoplasma gondii cathepsin CPC1 0.0139 0.079 0.2159
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0037 0.0037
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0139 0.079 0.2129
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.002 0.0014
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0139 0.079 0.2343
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.079 0.079
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.002 0.5
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.002 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0139 0.079 0.2129
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.0292 0.0286
Brugia malayi intermediate filament protein 0.0031 0.0127 0.0127
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0178 0.3161
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.1647 0.4496
Brugia malayi nuclear receptor NHR-88 0.0022 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0016 0.0037 0.0037
Brugia malayi Cathepsin L-like precursor 0.0382 0.2287 0.2287
Loa Loa (eye worm) hypothetical protein 0.0139 0.079 0.079
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.002 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0008
Entamoeba histolytica cysteine protease, putative 0.0139 0.079 0.1958
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0547 0.3308 0.9089
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.1647 0.4496
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0139 0.079 0.2129
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0014 0.002 0.0251
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0361 0.0361
Brugia malayi hypothetical protein 0.0035 0.0153 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0072 0.0072
Loa Loa (eye worm) fibroinase 0.0547 0.3308 0.3308
Brugia malayi cathepsin Z-like cysteine proteinase 0.0139 0.079 0.079
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0154 0.0154
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0601 0.3639 1
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0064 0.0064
Brugia malayi fibroinase precursor 0.0139 0.079 0.079
Plasmodium vivax vivapain-3 0.0304 0.1811 0.5447
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0349 0.0349
Brugia malayi Cathepsin L-like cysteine proteinase 0.0382 0.2287 0.2287
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0021 0.0064 1
Trichomonas vaginalis conserved hypothetical protein 0.0139 0.079 0.2129
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0139 0.079 0.079
Trypanosoma cruzi cysteine peptidase, putative 0.0547 0.3308 0.3304
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0008 0.0008
Schistosoma mansoni cathepsin S (C01 family) 0.0139 0.079 0.079
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0038 0.0038
Brugia malayi nuclear receptor RXR 0.0012 0.0008 0.0008
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.002 0.0038
Echinococcus multilocularis cathepsin L 0.0139 0.079 0.079
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0072 0.0072
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.002 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0072 0.0072
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0064 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0547 0.3308 0.9085
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0008
Giardia lamblia Cathepsin B precursor 0.0139 0.079 0.2129
Loa Loa (eye worm) cathepsin B 0.0601 0.3639 0.3639
Loa Loa (eye worm) hypothetical protein 0.0166 0.0956 0.0956
Plasmodium falciparum cysteine proteinase falcipain 3 0.0547 0.3308 1
Trypanosoma cruzi cysteine proteinase, putative 0.0304 0.1811 0.1806
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.079 0.2129
Plasmodium falciparum serine repeat antigen 3 0.0139 0.079 0.2343
Onchocerca volvulus 0.0031 0.0127 0.0383
Entamoeba histolytica cysteine proteinase, putative 0.0382 0.2287 0.674
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0072 0.0072
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0278 0.1647 0.1647
Leishmania major cathepsin L-like protease 0.0547 0.3308 0.9089
Trypanosoma cruzi major cysteine proteinase, putative 0.0139 0.079 0.0785
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0008 0.0008
Entamoeba histolytica cysteine proteinase 1, putative 0.0304 0.1811 0.5218
Echinococcus granulosus cathepsin l1 0.0547 0.3308 0.3308
Onchocerca volvulus 0.0547 0.3308 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0123
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0127 0.0127
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.002 0.0038
Brugia malayi Papain family cysteine protease containing protein 0.0304 0.1811 0.1811
Trypanosoma brucei protein kinase, putative 0.0058 0.0292 0.0787
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.002 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0139 0.079 0.2129
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0139 0.079 0.2343
Brugia malayi Papain family cysteine protease containing protein 0.0139 0.079 0.079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0547 0.3308 0.9089
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0037 0.0037
Leishmania major trypanothione reductase 0.0039 0.0178 0.0474
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0139 0.079 0.2129
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0072 0.0218
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.0292 0.0292
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.01 0.0551 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0072 0.0072
Loa Loa (eye worm) ctsf protein 0.0547 0.3308 0.3308
Entamoeba histolytica cysteine protease, putative 0.0304 0.1811 0.5218
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0361 0.0361
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0067 0.0349 0.0349
Brugia malayi cathepsin L-like cysteine proteinase 0.0139 0.079 0.079
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0139 0.079 0.2129
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0139 0.079 0.079
Plasmodium vivax serine-repeat antigen (SERA) 0.0139 0.079 0.2343
Brugia malayi cytochrome P450 0.0011 0.0006 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.002 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.1058 0.287
Brugia malayi Cathepsin L-like precursor 0.0547 0.3308 0.3308
Schistosoma mansoni intermediate filament proteins 0.0031 0.0127 0.0127
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0361 0.0361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0547 0.3308 0.9085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0547 0.3308 0.9085
Entamoeba histolytica cysteine protease, putative 0.0139 0.079 0.1958
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0547 0.3308 0.9085
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0139 0.079 0.2343
Toxoplasma gondii preprocathepsin c precursor, putative 0.0139 0.079 0.2159
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0547 0.3308 0.9085
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0139 0.079 0.2129
Plasmodium falciparum serine repeat antigen 8 0.0139 0.079 0.2343
Echinococcus granulosus cathepsin b 0.1634 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0177 0.0177
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.079 0.079
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0139 0.079 0.079
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.1647 0.4496
Giardia lamblia Kinase, CMGC MAPK 0.0058 0.0292 0.0752
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0272 0.0767
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0177 0.0177
Entamoeba histolytica cysteine protease, putative 0.0304 0.1811 0.5218
Plasmodium vivax vivapain-2 0.0547 0.3308 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.0292 0.0787
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0127 0.0127
Schistosoma mansoni hypothetical protein 0.0016 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0547 0.3308 0.9085
Echinococcus multilocularis 0.0011 0.0006 0.0006
Echinococcus multilocularis muscleblind protein 1 0.0155 0.0893 0.0893
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0547 0.3308 0.9085
Loa Loa (eye worm) hypothetical protein 0.0382 0.2287 0.2287
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0037 0.0037
Loa Loa (eye worm) glutathione reductase 0.0039 0.0178 0.0178
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0072 0.0218
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.002 0.0014
Entamoeba histolytica cysteine protease, putative 0.0304 0.1811 0.5218
Loa Loa (eye worm) hypothetical protein 0.0382 0.2287 0.2287
Toxoplasma gondii thioredoxin reductase 0.0039 0.0178 0.0474
Entamoeba histolytica cysteine protease, putative 0.0304 0.1811 0.5218
Mycobacterium tuberculosis Probable reductase 0.009 0.0489 0.8866
Plasmodium vivax unspecified product 0.0304 0.1811 0.5447
Trypanosoma cruzi cruzipain precursor, putative 0.0166 0.0956 0.0951
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0139 0.079 0.2343
Schistosoma mansoni cpg binding protein 0.003 0.012 0.012
Echinococcus multilocularis GPCR, family 2 0.0016 0.0037 0.0037
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0139 0.079 0.2343
Leishmania major cathepsin L-like protease 0.0547 0.3308 0.9089
Schistosoma mansoni hypothetical protein 0.0016 0.0037 0.0037
Entamoeba histolytica cysteine protease, putative 0.0304 0.1811 0.5218
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.009 0.0489 0.8866
Schistosoma mansoni lamin 0.0031 0.0127 0.0127
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0072 0.0072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0547 0.3308 0.9089
Loa Loa (eye worm) hypothetical protein 0.0052 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0008
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.009 0.0489 0.8866
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0177 0.0177
Entamoeba histolytica hypothetical protein 0.0139 0.079 0.1958
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0072 0.0072
Echinococcus granulosus GPCR family 2 0.0016 0.0037 0.0037
Brugia malayi glutathione reductase 0.0039 0.0178 0.0178
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.0292 0.0787
Trichomonas vaginalis set domain proteins, putative 0.0528 0.3187 0.8753
Mycobacterium tuberculosis Putative ferredoxin reductase 0.009 0.0489 0.8866
Plasmodium falciparum serine repeat antigen 1 0.0139 0.079 0.2343
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0072 0.0072
Entamoeba histolytica cysteine proteinase, putative 0.0547 0.3308 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0547 0.3308 0.9085
Trypanosoma cruzi cysteine peptidase, putative 0.0304 0.1811 0.1806
Echinococcus granulosus tar DNA binding protein 0.0069 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.1634 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0341 0.0341
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.012 0.012
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0072 0.0072
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0166 0.0956 0.0956
Brugia malayi cathepsin F-like cysteine proteinase 0.0166 0.0956 0.0956
Loa Loa (eye worm) RNA binding protein 0.0069 0.0361 0.0361
Brugia malayi Cathepsin L-like precursor 0.0547 0.3308 0.3308
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0547 0.3308 0.3308
Brugia malayi Cathepsin L-like precursor 0.0547 0.3308 0.3308
Plasmodium falciparum serine repeat antigen 9 0.0139 0.079 0.2343
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0292 0.0292
Brugia malayi Muscleblind-like protein 0.0155 0.0893 0.0893
Plasmodium vivax unspecified product 0.0166 0.0956 0.2848
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0139 0.079 0.1958
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0601 0.3639 0.3639
Entamoeba histolytica cysteine proteinase, putative 0.0304 0.1811 0.5218
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.1058 0.287
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0072
Plasmodium falciparum serine repeat antigen 6 0.0139 0.079 0.2343
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0292 0.0286
Onchocerca volvulus 0.0547 0.3308 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0127 0.0127
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0178 0.0172
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.1119 0.3037
Echinococcus granulosus cathepsin L cysteine protease 0.0304 0.1811 0.1811
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0382 0.2287 0.2282
Brugia malayi Cytochrome P450 family protein 0.0032 0.0132 0.0132
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0139 0.079 0.2343
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0072 0.0072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0547 0.3308 0.9089
Leishmania major hypothetical protein, conserved 0.0055 0.0272 0.0732
Giardia lamblia Cathepsin L precursor 0.0139 0.079 0.2129
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0037 0.0037
Brugia malayi Papain family cysteine protease containing protein 0.0139 0.079 0.079
Loa Loa (eye worm) cytochrome P450 0.0011 0.0006 0.0006
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0139 0.079 0.2343
Onchocerca volvulus 0.0547 0.3308 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0547 0.3308 0.9089
Schistosoma mansoni hypothetical protein 0.0039 0.0177 0.0177
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.002 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0072 0.0072
Brugia malayi CXXC zinc finger family protein 0.003 0.012 0.012
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0547 0.3308 0.3308
Brugia malayi TAR-binding protein 0.0069 0.0361 0.0361
Brugia malayi nuclear hormone receptor 0.0022 0.0072 0.0072
Brugia malayi Cathepsin L-like precursor 0.0382 0.2287 0.2287
Entamoeba histolytica cysteine proteinase, putative 0.0304 0.1811 0.5218
Loa Loa (eye worm) hypothetical protein 0.0139 0.079 0.079
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0072 0.0072
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0292 0.0752
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.002 0.0014
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1634 1 1
Echinococcus granulosus cpg binding protein 0.0032 0.013 0.013
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0139 0.079 0.079
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0547 0.3308 0.9085
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0014 0.002 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0072 0.0072
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0072 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0547 0.3308 0.9085
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1634 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0304 0.1811 0.1811
Schistosoma mansoni cytochrome P450 0.0011 0.0006 0.0006
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0166 0.0956 0.0956
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0547 0.3308 0.9089
Giardia lamblia Cysteine protease 0.0139 0.079 0.2129
Entamoeba histolytica cysteine protease, putative 0.0139 0.079 0.1958
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0072 0.0072
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0008 0.0008
Entamoeba histolytica cysteine protease, putative 0.0304 0.1811 0.5218
Giardia lamblia Cathepsin B precursor 0.0139 0.079 0.2129
Trypanosoma cruzi cruzipain precursor, putative 0.0547 0.3308 0.3304
Giardia lamblia Cathepsin L precursor 0.0139 0.079 0.2129
Trichomonas vaginalis conserved hypothetical protein 0.0139 0.079 0.2129
Schistosoma mansoni hypothetical protein 0.0035 0.0154 0.0154
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0178 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0547 0.3308 0.9085
Brugia malayi Cytochrome P450 family protein 0.0011 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0304 0.1811 0.4949
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0014 0.002 0.2359
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0008
Entamoeba histolytica cysteine protease, putative 0.0304 0.1811 0.5218
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0272 0.0266
Trypanosoma cruzi cysteine peptidase, putative 0.0547 0.3308 0.3304
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0304 0.1811 0.1806
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0547 0.3308 0.9085
Onchocerca volvulus 0.0139 0.079 0.2389
Giardia lamblia Cathepsin B precursor 0.0601 0.3639 1
Leishmania major cathepsin L-like protease 0.0547 0.3308 0.9089
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0072 0.0072
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0064 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0072
Echinococcus granulosus lamin 0.0031 0.0127 0.0127
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0127 0.0127
Giardia lamblia Encystation-specific protease 0.0139 0.079 0.2129
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0072 0.0072
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0292 0.0752
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0547 0.3308 0.9085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0547 0.3308 0.3308
Brugia malayi hypothetical protein 0.0012 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0072 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0361 0.0361
Giardia lamblia Cathepsin B precursor 0.0601 0.3639 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0547 0.3308 0.9085
Brugia malayi RNA binding protein 0.0069 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0547 0.3308 0.9085
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0181 0.0181
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0181 0.0181
Brugia malayi Papain family cysteine protease containing protein 0.0304 0.1811 0.1811
Giardia lamblia Cathepsin B precursor 0.0139 0.079 0.2129
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0072 0.0072
Plasmodium falciparum glutathione reductase 0.0039 0.0178 0.0482
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0072 0.0072
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1634 1 1
Echinococcus multilocularis muscleblind protein 0.0155 0.0893 0.0893
Entamoeba histolytica cysteine protease, putative 0.0547 0.3308 1
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0361 0.0361
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0067 0.0349 0.0944
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0139 0.079 0.2129
Giardia lamblia Cathepsin B precursor 0.0139 0.079 0.2129
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0072
Brugia malayi steroid hormone receptor 0.0022 0.0072 0.0072
Echinococcus multilocularis cathepsin b 0.1634 1 1
Loa Loa (eye worm) hypothetical protein 0.0166 0.0956 0.0956
Brugia malayi Pre-SET motif family protein 0.0067 0.0349 0.0349
Brugia malayi cathepsin L-like precursor 0.0382 0.2287 0.2287
Echinococcus granulosus cathepsin L 0.0139 0.079 0.079
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0278 0.1647 0.1647
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0006 0.0006
Plasmodium vivax unspecified product 0.0139 0.079 0.2343
Entamoeba histolytica cysteine protease, putative 0.0139 0.079 0.1958
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0292 0.0752
Giardia lamblia Cathepsin L precursor 0.0139 0.079 0.2129
Leishmania major cytochrome p450-like protein 0.0021 0.0064 0.016
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0072 0.0072
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0547 0.3308 0.3308
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1634 1 1
Entamoeba histolytica cysteine protease, putative 0.0139 0.079 0.1958
Echinococcus multilocularis lamin 0.0031 0.0127 0.0127
Giardia lamblia Cathepsin L-like protease 0.0139 0.079 0.2129
Brugia malayi Cytochrome P450 family protein 0.0021 0.0064 0.0064
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0087 0.0087
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0008 0.0008
Trypanosoma brucei trypanothione reductase 0.0039 0.0178 0.0474
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.009 0.0489 0.8866
Plasmodium falciparum serine repeat antigen 4 0.0139 0.079 0.2343
Loa Loa (eye worm) hypothetical protein 0.0016 0.0037 0.0037
Echinococcus multilocularis cysteine protease 0.0547 0.3308 0.3308
Entamoeba histolytica cysteine protease, putative 0.0139 0.079 0.1958
Loa Loa (eye worm) hypothetical protein 0.0155 0.0893 0.0893
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.1058 0.287
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0014 0.002 0.2359
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.1058 0.287
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.079 0.079
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.1647 0.4496
Entamoeba histolytica cysteine protease, putative 0.0304 0.1811 0.5218
Schistosoma mansoni lamin 0.0031 0.0127 0.0127
Echinococcus granulosus muscleblind protein 0.0155 0.0893 0.0893
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.002 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0139 0.079 0.2129
Plasmodium vivax SET domain protein, putative 0.0067 0.0349 0.1001
Brugia malayi MAP kinase sur-1 0.0058 0.0292 0.0292
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.033 0.033
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.002 0.0014
Giardia lamblia Cathepsin B precursor 0.0139 0.079 0.2129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0547 0.3308 0.9085
Mycobacterium tuberculosis Probable dehydrogenase 0.009 0.0489 0.8866
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.002 0.0014
Onchocerca volvulus Cathepsin L homolog 0.0547 0.3308 1
Echinococcus multilocularis musashi 0.0031 0.0127 0.0127
Giardia lamblia Hypothetical protein 0.0139 0.079 0.2129
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.1058 0.287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0382 0.2287 0.6265
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0547 0.3308 0.9089
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.002 0.0014
Leishmania major cathepsin L-like protease 0.0547 0.3308 0.9089
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0304 0.1811 0.4968
Leishmania major cathepsin L-like protease 0.0547 0.3308 0.9089
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.0292 0.0286
Loa Loa (eye worm) hypothetical protein 0.0139 0.079 0.079
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0361 0.0361
Entamoeba histolytica cysteine proteinase 2 0.0304 0.1811 0.5218
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0072 0.0072
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0132 0.0132
Plasmodium falciparum serine repeat antigen 7 0.0139 0.079 0.2343
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.002 0.002
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0547 0.3308 0.3308
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0072 0.0072
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0037 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0547 0.3308 0.9089
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0008 0.0008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0067 0.0349 0.0349
Brugia malayi Papain family cysteine protease containing protein 0.0547 0.3308 0.3308
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0139 0.079 0.2129
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0072 0.0072
Treponema pallidum NADH oxidase 0.0014 0.002 0.5
Onchocerca volvulus 0.0528 0.3187 0.9636
Brugia malayi cathepsin F-like cysteine proteinase 0.0139 0.079 0.079
Echinococcus granulosus cathepsin l cysteine peptidase 0.0547 0.3308 0.3308
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0547 0.3308 0.9085
Echinococcus granulosus intermediate filament protein 0.0031 0.0127 0.0127
Onchocerca volvulus 0.0547 0.3308 1
Trypanosoma cruzi cysteine peptidase, putative 0.0547 0.3308 0.3304
Entamoeba histolytica cysteine protease, putative 0.0304 0.1811 0.5218
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0272 0.0767
Onchocerca volvulus 0.0547 0.3308 1
Toxoplasma gondii cathepsin CPC2 0.0139 0.079 0.2159
Entamoeba histolytica cysteine protease, putative 0.0304 0.1811 0.5218
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0349 0.0349
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0072 0.0072
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0072 0.0072
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0037 0.0037
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.0292 0.0787
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0349 0.0349
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0139 0.079 0.079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0382 0.2287 0.6265
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0361 0.0361
Schistosoma mansoni hypothetical protein 0.0024 0.0087 0.0087
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.0292 0.0292
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0072 0.0072
Echinococcus granulosus cathepsin b 0.1634 1 1
Trypanosoma cruzi cysteine protease, putative 0.0304 0.1811 0.1806
Giardia lamblia Cysteine protease 0.0139 0.079 0.2129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.079 0.2129
Echinococcus multilocularis cpg binding protein 0.0032 0.013 0.013
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0072 0.0072
Leishmania major cathepsin L-like protease 0.0547 0.3308 0.9089
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0072
Schistosoma mansoni cathepsin F (C01 family) 0.0547 0.3308 0.3308
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0139 0.079 0.2129
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.002 0.002
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0139 0.079 0.079
Onchocerca volvulus 0.0547 0.3308 1
Schistosoma mansoni cpg binding protein 0.0032 0.013 0.013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0255 0.0255
Schistosoma mansoni cpg binding protein 0.0032 0.013 0.013
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0304 0.1811 0.4949
Loa Loa (eye worm) hypothetical protein 0.0166 0.0956 0.0956
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0139 0.079 0.2343
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0008 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.1119 0.3037
Loa Loa (eye worm) hypothetical protein 0.0139 0.079 0.079
Brugia malayi hypothetical protein 0.0039 0.0177 0.0177
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0072 0.0072
Trypanosoma cruzi cysteine peptidase, putative 0.0166 0.0956 0.0951
Echinococcus multilocularis cathepsin L cysteine protease 0.0547 0.3308 0.3308
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0072 0.0072
Entamoeba histolytica cysteine protease, putative 0.0304 0.1811 0.5218
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0601 0.3639 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0601 0.3639 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0008 0.0008
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.0292 0.0292
Onchocerca volvulus 0.0067 0.0349 0.1055
Plasmodium falciparum cysteine proteinase falcipain 1 0.0304 0.1811 0.5447
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0139 0.079 0.079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0547 0.3308 0.9085
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0072
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0361 0.0361
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0067 0.0349 0.0349
Entamoeba histolytica cysteine proteinase, putative 0.0304 0.1811 0.5218
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0072 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0139 0.079 0.2129
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.1058 0.287
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0008 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0547 0.3308 0.9089
Onchocerca volvulus 0.0022 0.0072 0.0218
Echinococcus multilocularis lamin dm0 0.0031 0.0127 0.0127
Onchocerca volvulus Glucosylceramidase homolog 0.0182 0.1058 0.3199
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0547 0.3308 0.9085
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0272 0.0266
Brugia malayi cathepsin Z-like cysteine proteinase 0.0139 0.079 0.079
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0064 0.0058
Plasmodium vivax serine-repeat antigen (SERA) 0.0139 0.079 0.2343
Plasmodium falciparum serine repeat antigen 2 0.0139 0.079 0.2343
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0139 0.079 0.2129
Brugia malayi Cathepsin L-like precursor 0.0547 0.3308 0.3308
Leishmania major cathepsin L-like protease 0.0547 0.3308 0.9089
Mycobacterium tuberculosis Probable oxidoreductase 0.01 0.0551 1
Trypanosoma cruzi cysteine peptidase, putative 0.0547 0.3308 0.3304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0547 0.3308 0.9085
Loa Loa (eye worm) hypothetical protein 0.0382 0.2287 0.2287
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.01 0.0551 1
Entamoeba histolytica cysteine protease, putative 0.0304 0.1811 0.5218
Brugia malayi Papain family cysteine protease containing protein 0.0139 0.079 0.079
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0255 0.0255
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0072 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.079 0.2129
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0547 0.3308 1
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0547 0.3308 0.9089
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0072 0.0072
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0072 0.0072
Trypanosoma cruzi cysteine proteinase, putative 0.0304 0.1811 0.1806
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0072 0.0072
Echinococcus granulosus cathepsin l1 0.0382 0.2287 0.2287
Entamoeba histolytica cysteine proteinase, putative 0.0547 0.3308 1
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0272 0.0732
Toxoplasma gondii cathepsin B 0.0601 0.3639 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0014 0.002 0.2359
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0155 0.0893 0.0893
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.0292 0.0787
Echinococcus multilocularis cysteine protease 0.0547 0.3308 0.3308
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0072 0.0072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0304 0.1811 0.4968
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0272 0.0767
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0064 0.0064
Schistosoma mansoni cathepsin s 0.0166 0.0956 0.0956

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.449 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.182 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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